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Cancer Research, ISSN 0008-5472, 10/2008, Volume 68, Issue 19, pp. 8022 - 8030
Journal Article
Cancer Research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 429 - U192
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2013, Volume 123, Issue 6, pp. 2551 - 2563
The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, and is aberrantly activated in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | PROTEIN-KINASE | DUAL PI3K/MTOR INHIBITOR | RIBOSOMAL S6 KINASE | FUNCTIONAL-CHARACTERIZATION | RSK4 | PHASE-I | EXPRESSION | RNAI SCREEN | Gene Expression Regulation, Enzymologic - drug effects | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Open Reading Frames | Transcriptome | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Breast Neoplasms - enzymology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | MCF-7 Cells | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cell Survival - drug effects | Gene Expression | Signal Transduction | Morpholines - pharmacology | Imidazoles - pharmacology | Breast Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Aminopyridines - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | Physiological aspects | Breast cancer | Genetic aspects | Cellular signal transduction | Research | Drug therapy | Drug resistance | Risk factors | Proteins | Medical research | Kinases | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. LB-31 - LB-31
Journal Article
Cell Discovery, ISSN 2056-5968, 03/2016, Volume 2, Issue 1, pp. 16001 - 16001
The Hippo pathway has been identified as a key barrier for tumorigenesis, acting through downregulation of YAP/TAZ activity. Elevated YAP/TAZ activity has been... 
YAP | Hippo pathway | protein degradation | ubiquitin | LATS | PHOSPHORYLATION | PANCREATIC-CANCER | ACTIN-BINDING | CELL BIOLOGY | ORGAN SIZE | INHIBITION | IN-VIVO | YAP ONCOPROTEIN | TUMOR-SUPPRESSOR | DEGRADATION | FAM/USP9X
Journal Article
PLoS Genetics, ISSN 1553-7390, 12/2007, Volume 3, Issue 12
  Protein Phosphatase type 2A (PP2A) represents a family of holoenzyme complexes with diverse biological activities. Specific holoenzyme complexes are thought... 
Proteins | Phosphorylation | Regulation | Kinases | Cancer | Apoptosis
Journal Article
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 03/2014, Volume 124, Issue 3, pp. 1418 - 1418
Journal Article
PLoS Genetics, ISSN 1553-7390, 12/2007, Volume 3, Issue 12, pp. 2381 - 2394
Protein Phosphatase type 2A (PP2A) represents a family of holoenzyme complexes with diverse biological activities. Specific holoenzyme complexes are thought to... 
SIGNAL-TRANSDUCTION | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | SERINE/THREONINE PHOSPHATASE | N-TERMINAL KINASE | GENETICS & HEREDITY | FAMILY KINASES | MIDDLE TUMOR-ANTIGEN | ADENOVIRUS E4ORF4 PROTEIN | OKADAIC ACID | TYROSINE-PHOSPHATASE | Genetics and Genomics | In Vitro | Mammals | Homo (human)
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, p. 429
  In advanced cancer, including glioblastoma, the transforming growth factor β (TGF-β) pathway acts as an oncogenic factor and is considered to be a... 
Care and treatment | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Transforming growth factors | Glioblastoma multiforme | Risk factors | Proteins | Signal transduction | Cellular biology | Gene expression | Pathogenesis | Brain cancer
Journal Article
PLoS Genetics, ISSN 1553-7390, 2005, Volume preprint, Issue 2007, p. e218
Journal Article
Cancer research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Small molecule inhibitors of HER2 are clinically active in women with advanced HER2 positive breast cancer who have progressed on trastuzumab treatment.... 
lapatinib | PI3K pathway | Breast cancer | barcode screen | PI3K inhibitors
Journal Article