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EMBO Molecular Medicine, ISSN 1757-4676, 02/2018, Volume 10, Issue 2, pp. 276 - 293
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2013, Volume 71, Issue Suppl 3, pp. 49 - 49
Interstitial lung diseases, most importantly idiopathic pulmonary fibrosis (IPF) share similar pathomechanistic principles, including progressive fibrosis of... 
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2016, Volume 193, Issue 11, pp. 1230 - 1241
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 44, pp. 17880 - 17885
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6722 - 6722
An imbalance between neutrophil-derived proteases and extracellular inhibitors is widely regarded as an important pathogenic mechanism for lung injury. Despite... 
PROTEINASE-INHIBITORS | CHYMOTRYPSIN | EVOLUTION | DISEASES | SERINE PROTEASES | ALPHA-PROTEINASE INHIBITOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | EMPHYSEMA | HUMAN-LEUKOCYTE ELASTASE | ALPHA-1-ANTITRYPSIN DEFICIENCY | Leukocyte Elastase - metabolism | Small Molecule Libraries - pharmacology | Peptides - antagonists & inhibitors | Humans | Molecular Sequence Data | Leukocyte Elastase - antagonists & inhibitors | Peptides - administration & dosage | Pulmonary Emphysema - chemically induced | Lung - enzymology | Leukocyte Elastase - administration & dosage | Peptides - metabolism | Proteolysis | HEK293 Cells | Female | Neutrophils - pathology | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Gene Expression | Lung - pathology | Macrophages - pathology | Neutrophils - enzymology | Peptides - chemistry | Mice, Inbred C57BL | Neutrophils - drug effects | Pulmonary Emphysema - pathology | Recombinant Proteins - chemistry | Pulmonary Emphysema - drug therapy | Recombinant Proteins - administration & dosage | Sequence Homology, Amino Acid | Proteinase Inhibitory Proteins, Secretory - pharmacology | Animals | Leukocyte Elastase - chemistry | Lung - drug effects | alpha 1-Antitrypsin - pharmacology | Macrophages - drug effects | Mice | Cytokines - biosynthesis | Pulmonary Emphysema - enzymology | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 1, pp. 143 - 163
Journal Article
by De Angelis, Martin Hrabě and Nicholson, George and Selloum, Mohammed and White, Jacqueline K and Morgan, Hugh and Ramirez-Solis, Ramiro and Sorg, Tania and Wells, Sara and Fuchs, Helmut and Fray, Martin and Adams, David J and Adams, Niels C and Adler, Thure and Aguilar-Pimentel, Antonio and Ali-Hadji, Dalila and Amann, Gregory and André, Philippe and Atkins, Sarah and Auburtin, Aurelie and Ayadi, Abdel and Becker, Julien and Becker, Lore and Bedu, Elodie and Bekeredjian, Raffi and Birling, Marie-Christine and Blake, Andrew and Bottomley, Joanna and Bowl, Michael R and Brault, Véronique and Busch, Dirk H and Bussell, James N and Calzada-Wack, Julia and Cater, Heather and Champy, Marie-France and Charles, Philippe and Chevalier, Claire and Chiani, Francesco and Codner, Gemma F and Combe, Roy and Cox, Roger and Dalloneau, Emilie and Dierich, André and Di Fenza, Armida and Doe, Brendan and Duchon, Arnaud and Eickelberg, Oliver and Esapa, Chris T and Fertak, Lahcen El and Feigel, Tanja and Emelyanova, Irina and Estabel, Jeanne and Favor, Jack and Flenniken, Ann and Gambadoro, Alessia and Garrett, Lilian and Gates, Hilary and Gerdin, Anna-Karin and Gkoutos, George and Greenaway, Simon and Glasl, Lisa and Goetz, Patrice and Da Cruz, Isabelle Goncalves and Götz, Alexander and Graw, Jochen and Guimond, Alain and Hans, Wolfgang and Hicks, Geoff and Hölter, Sabine M and Höfler, Heinz and Hancock, John M and Hoehndorf, Robert and Hough, Tertius and Houghton, Richard and Hurt, Anja and Ivandic, Boris and Jacobs, Hughes and Jacquot, Sylvie and Jones, Nora and Karp, Natasha A and Katus, Hugo A and Kitchen, Sharon and Klein-Rodewald, Tanja and Klingenspor, Martin and Klopstock, Thomas and Lalanne, Valerie and Leblanc, Sophie and Lengger, Christoph and Le Marchand, Elise and Ludwig, Tonia and Lux, Aline and McKerlie, Colin and Maier, Holger and Mandel, Jean-Louis and Marschall, Susan and Mark, Manuel and Melvin, David G and Meziane, Hamid and Micklich, Kateryna and Mittelhauser, Christophe and Monassier, Laurent and ... and EUMODIC Consortium
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 969 - 978
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 11/2012, Volume 303, Issue 9, pp. 814 - 823
Cigarette smoke mediates DNA damage, lipid peroxidation, and modification and misfolding of proteins, thereby inducing severe cellular damage. The ubiquitin... 
Oxidative stress | Chronic obstructive pulmonary disease | Protein quality control | Ubiquitin proteasome system | Cigarette smoke | SYSTEM | PHYSIOLOGY | UBIQUITIN | ubiquitin proteasome system | ANTIGEN PRESENTATION | cigarette smoke | 20S PROTEASOME | CARDIOMYOPATHIES | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | protein quality control | DEGRADATION | INHIBITORS | PROTEINS | oxidative stress | chronic obstructive pulmonary disease | Smoking - adverse effects | Protein Carbonylation | Oxidative Stress | Apoptosis - drug effects | Humans | Smoke | Polyubiquitin | Lung - enzymology | Protein Processing, Post-Translational - drug effects | Plant Preparations - pharmacology | Female | Ubiquitinated Proteins - metabolism | Gene Expression | Oxidation-Reduction | Proteasome Inhibitors - pharmacology | Cell Survival | Mice, Inbred C57BL | Alveolar Epithelial Cells - metabolism | Alveolar Epithelial Cells - drug effects | Proteasome Inhibitors - toxicity | Proteasome Endopeptidase Complex - physiology | Tobacco - toxicity | Proteasome Endopeptidase Complex - genetics | Plant Preparations - toxicity | Animals | Lung - drug effects | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Alveolar Epithelial Cells - physiology | Glutathione - blood | Physiological aspects | Lungs | Ubiquitin-proteasome system | Health aspects | DNA damage | Rodents | Lipids | Oxidation | Cells | Smoking | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 06/2016, Volume 23, Issue 6, pp. 1026 - 1037
Journal Article