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Acta Neuropathologica, ISSN 0001-6322, 4/2017, Volume 133, Issue 4, pp. 629 - 644
Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic... 
Pathology | Therapy | Neurosciences | IDH-mutated glioma | Medicine & Public Health | IDH1R132 inhibitor | Pharmacology | Drug development | Mouse xenograft | SELECTIVE-INHIBITION | GLIOMAS | ISOCITRATE DEHYDROGENASE | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | BRAIN-TUMORS | GLIOBLASTOMAS | TUMOR STEM-CELLS | MUTATIONS | DIFFERENTIATION | Benzimidazoles - toxicity | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Escherichia coli | Humans | Sarcoma - enzymology | Benzimidazoles - chemistry | Isocitrate Dehydrogenase - antagonists & inhibitors | Antineoplastic Agents - toxicity | Sf9 Cells | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Astrocytoma - drug therapy | HEK293 Cells | Astrocytoma - enzymology | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Sarcoma - genetics | Cell Survival - physiology | Astrocytoma - genetics | Recombinant Proteins - metabolism | Cell Survival - drug effects | Brain Neoplasms - enzymology | Aniline Compounds - pharmacology | Enzyme Inhibitors - pharmacology | Benzimidazoles - pharmacokinetics | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Recombinant Proteins - genetics | Aniline Compounds - pharmacokinetics | Aniline Compounds - toxicity | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Sarcoma - drug therapy | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Benzimidazoles - pharmacology | Isocitrate Dehydrogenase - metabolism | Colonic Neoplasms - enzymology | Glutarates - metabolism | Mice, Inbred BALB C | Aniline Compounds - chemistry | Mutation | Gliomas | Genetic aspects | Codon | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2018, Volume 24, Issue 8, pp. 1192 - 1203
Journal Article
Journal Article
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 99, pp. 96735 - 96742
Isocitrate dehydrogenase 1 (IDH1), catalyzing oxidative decarboxylation of isocitrate to provide energy for aerobic organisms, is an essential enzyme in the... 
MECHANISM | IDH1 | PHARMACOPHORE | ASSAY INTERFERENCE | MUTATIONS | LEUKEMIA | DIFFERENTIATION | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | 2-HYDROXYGLUTARATE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 10, pp. 8414 - 8424
To develop a novel attenuation strategy applicable to all influenza A viruses, we targeted the highly conserved protein-protein interaction of the viral... 
INTERFERON | TROPISM | H5N1 VIRUS | HEMAGGLUTININ | PANDEMIC INFLUENZA | BIOCHEMISTRY & MOLECULAR BIOLOGY | VACCINE | ADAPTATION | BINDING | RNA-POLYMERASE | SUBUNIT | Influenza A Virus, H5N1 Subtype - enzymology | Interferon-beta - immunology | Vaccines, Attenuated - biosynthesis | Virus Replication - genetics | Humans | RNA Replicase - metabolism | Viral Proteins - immunology | Influenza, Human - enzymology | Influenza A Virus, H5N1 Subtype - genetics | Viral Proteins - metabolism | Interferon-alpha - genetics | Influenza A Virus, H7N7 Subtype - enzymology | Influenza A Virus, H7N7 Subtype - immunology | Interferon-beta - genetics | Interferon-alpha - metabolism | RNA Replicase - genetics | Viral Proteins - genetics | Virus Replication - immunology | Interferon-alpha - immunology | Mice, Knockout | Vaccines, Attenuated - immunology | Animals | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Interferon-beta - metabolism | Influenza A Virus, H5N1 Subtype - immunology | Influenza Vaccines - biosynthesis | Influenza, Human - genetics | Dogs | Mice | Mice, Inbred BALB C | Influenza A Virus, H7N7 Subtype - genetics | Mutation | RNA Replicase - immunology | Influenza, Human - immunology | Vaccines, Attenuated - genetics | Protein Domains | Microbiology | Computer Modeling | Viral Polymerase | Protein Assembly | Protein-Protein Interactions
Journal Article
Antimicrobial Agents & Chemotherapy, ISSN 0066-4804, 01/2011, Volume 55, Issue 2, pp. 696 - 702
The influenza A virus polymerase complex, consisting of the subunits PB1, PB2, and PA, represents a promising target for the development of new antiviral... 
Journal Article
10/2016, Volume 6, Issue 99, pp. 96735 - 96742
Isocitrate dehydrogenase 1 (IDH1), catalyzing oxidative decarboxylation of isocitrate to provide energy for aerobic organisms, is an essential enzyme in the... 
Journal Article
Diabetes care, ISSN 0149-5992, 02/2019, Volume 42, Issue 2, pp. 192 - 199
Journal Article
International journal of sports physical therapy, ISSN 2159-2896, 12/2012, Volume 7, Issue 6, pp. 595 - 605
Researchers have observed differences in muscle activity patterns between males and females during functional exercises. The research methods employed have... 
gender | Original Research | gluteus medius | electromyography | functional exercises | gluteus maximus
Journal Article
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