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Cell, ISSN 0092-8674, 07/2013, Volume 154, Issue 1, p. 169
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2019, Volume 29, Issue 2, pp. 204 - 211
Promiscuous inhibitors of tyrosine protein kinases, proteases and phosphatases are useful reagents for probing regulatory pathways and stabilizing lysates as... 
USP9 | Mdm2 | USP7 | Bcr Abl | Activity profiling | APOPTOSIS | CELLS | STRUCTURE-GUIDED DEVELOPMENT | CHEMISTRY, MEDICINAL | CURCUMIN | CHEMISTRY, ORGANIC | IDENTIFICATION | CANCER | DISCOVERY | DEUBIQUITYLATING ENZYMES | SELECTIVITY
Journal Article
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1162 - 17
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 01/2012, Volume 19, Issue 1, pp. 62 - 72
Eight different types of ubiquitin linkages are present in eukaryotic cells that regulate diverse biological processes. Proteins that mediate specific assembly... 
ISOPEPTIDASE | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | CELL BIOLOGY | BIOPHYSICS | STRUCTURAL BASIS | DEGRADATION | CHEMICAL-SYNTHESIS | MOLECULAR-BASIS | DEUBIQUITINATION | A20 | Ubiquitin | Physiological aspects | Research | Structure | Ubiquitin-proteasome system | Proteins | Enzymes | Eukaryotes | Cellular biology | Molecular biology | Binding sites | Crystal structure
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 18
OTULIN (OTU Deubiquitinase With Linear Linkage Specificity) specifically hydrolyzes methionine1 (Met1)-linked ubiquitin chains conjugated by LUBAC (linear... 
MET1-LINKED UBIQUITINATION | RETROMER | PROTEIN | PDZ DOMAIN | GLUCOSE | MULTIDISCIPLINARY SCIENCES | LUBAC | BINDING | REVEALS | Ubiquitin | Cargo | Homeostasis | Chains | Catalytic activity | Cell surface | Spectrometry | Membrane trafficking | Recycling | Catalysis | Protein transport | Nexin | Assembly | Binding sites
Journal Article