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by Abarca-Gómez, Leandra and Abdeen, Ziad A and Hamid, Zargar Abdul and Abu-Rmeileh, Niveen M and Acosta-Cazares, Benjamin and Acuin, Cecilia and Adams, Robert J and Aekplakorn, Wichai and Afsana, Kaosar and Aguilar-Salinas, Carlos A and Agyemang, Charles and Ahmadvand, Alireza and Ahrens, Wolfgang and Ajlouni, Kamel and Akhtaeva, Nazgul and Al-Hazzaa, Hazzaa M and Al-Othman, Amani Rashed and Al-Raddadi, Rajaa and Al Buhairan, Fadia and Al Dhukair, Shahla and Ali, Osman and Ali, Mohamed M and Alkerwi, Ala'a and Alvarez-Pedrerol, Mar and Aly, Eman and Amarapurkar, Deepak N and Amouyel, Philippe and Amuzu, Antoinette and Andersen, Lars Bo and Anderssen, Sigmund A and Andrade, Dolores S and Ängquist, Lars H and Anjana, Ranjit Mohan and Aounallah-Skhiri, Hajer and Araújo, Joana and Ariansen, Inger and Aris, Tahir and Arlappa, Nimmathota and Arveiler, Dominique and Aryal, Krishna K and Aspelund, Thor and Assah, Felix K and Assunção, Maria Cecília F and Aung, May Soe and Avdicová, Mária and Azevedo, Ana and Azizi, Fereidoun and Babu, Bontha V and Bahijri, Suhad and Baker, Jennifer L and Balakrishna, Nagalla and Bamoshmoosh, Mohamed and Banach, Maciej and Bandosz, Piotr and Banegas, José R and Barbagallo, Carlo M and Barceló, Alberto and Barkat, Amina and Barros, Aluisio JD and Barros, Mauro VG and Bata, Iqbal and Batieha, Anwar M and Batista, Rosangela L and Batyrbek, Assembekov and Baur, Louise A and Beaglehole, Robert and Romdhane, Habiba Ben and Benedics, Judith and Benet, Mikhail and Bennett, James E and Bernabe-Ortiz, Antonio and Bernotiene, Gailute and Bettiol, Heloisa and Bhagyalaxmi, Aroor and Bharadwaj, Sumit and Bhargava, Santosh K and Bhatti, Zaid and Bhutta, Zulfiqar A and Bi, Hongsheng and Bi, Yufang and Biehl, Anna and Bikbov, Mukharram and Bista, Bihungum and Bjelica, Dusko J and Bjerregaard, Peter and Bjertness, Marius B and Bjertness, Espen and Björkelund, Cecilia and Blokstra, Anneke and Bo, Simona and Bobak, Martin and Boddy, Lynne M and Boehm, Bernhard O and Boeing, Heiner and Boggia, Jose G and Boissonnet, Carlos P and Bonaccio, Marialaura and Bongard, Vanina and Bovet, Pascal and Braeckevelt, Lien and ... and NCD Risk Factor Collaboration (NCD-RisC) and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Omvårdnad
The Lancet, ISSN 0140-6736, 12/2017, Volume 390, Issue 10113, pp. 2627 - 2642
Journal Article
The Lancet Oncology, ISSN 1470-2045, 01/2018, Volume 19, Issue 1, pp. 87 - 100
Activation of the PI3K/AKT/mTOR pathway occurs frequently in breast cancer that is resistant to endocrine therapy. Approved mTOR inhibitors effectively inhibit... 
ACTIVATION | EVEROLIMUS | PATHWAY | RESISTANCE | ENDOCRINE THERAPY | AKT | MUTATIONS | COMBINATION | TUMORS | BKM120 | ONCOLOGY | Estradiol - analogs & derivatives | TOR Serine-Threonine Kinases - metabolism | Estrogen Receptor Antagonists - administration & dosage | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Middle Aged | Aminopyridines - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptors, Estrogen - analysis | Protein Kinase Inhibitors - adverse effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Receptors, Progesterone - analysis | Breast Neoplasms - chemistry | Time Factors | Estradiol - adverse effects | Female | Phosphatidylinositol 3-Kinase - metabolism | Morpholines - adverse effects | Aminopyridines - administration & dosage | Double-Blind Method | Biomarkers, Tumor - analysis | Morpholines - administration & dosage | Estradiol - administration & dosage | Estrogen Receptor Antagonists - adverse effects | Treatment Outcome | Breast Neoplasms - drug therapy | Disease Progression | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Breast Neoplasms - mortality | Aged | Receptor, ErbB-2 - analysis | Antimitotic agents | Analysis | Clinical trials | Breast cancer | Product development | Postmenopausal women | Hormones | Antineoplastic agents | Life Sciences | Cancer
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2012, Volume 71, Issue 4, pp. 484 - 492
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2532 - 16
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The... 
Animal models | Epidermal growth factor receptors | Toxicity | Lung cancer | MEK inhibitors | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | MAP kinase | Raf protein | Tumor cell lines | Drug resistance | Kinases | Phosphatase | Ablation | Inhibitors | Clonal deletion | Rodents | Cell lines | Deletion | Inhibition | Dimerization | BIM protein | Tumors | Apoptosis
Journal Article
Implant dentistry, ISSN 1056-6163, 05/2019, Volume 28, Issue 5, pp. 510 - 513
Defects of the oral and maxillofacial region may arise from several reasons such as trauma, infection, cyst, tumor, medication related osteonecrosis of the... 
Journal Article