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animals (116) 116
receptors, muscarinic - metabolism (49) 49
cricetinae (48) 48
carbachol - pharmacology (43) 43
pharmacology & pharmacy (42) 42
rats (41) 41
receptors, muscarinic - drug effects (40) 40
cho cells (39) 39
muscarinic receptors (36) 36
kinetics (34) 34
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humans (33) 33
mice (29) 29
muscarinic agonists - pharmacology (27) 27
muscarinic receptor (26) 26
neurosciences (25) 25
biochemistry & molecular biology (22) 22
in vitro techniques (22) 22
rats, inbred strains (21) 21
binding, competitive (20) 20
female (19) 19
ligands (19) 19
muscarinic acetylcholine receptors (18) 18
index medicus (17) 17
nitric oxide (17) 17
radioligand assay (17) 17
calcium - metabolism (16) 16
cricetulus (16) 16
phosphatidylinositols - metabolism (16) 16
brain (15) 15
dose-response relationship, drug (15) 15
n-methylscopolamine (15) 15
nitric oxide synthase (15) 15
thiadiazoles - pharmacology (15) 15
activation (14) 14
pyridines - pharmacology (14) 14
receptors, muscarinic - physiology (14) 14
binding (13) 13
binding sites (13) 13
down-regulation (13) 13
nitric oxide synthase - metabolism (13) 13
xanomeline (13) 13
alzheimers-disease (12) 12
atropine - pharmacology (12) 12
brain - metabolism (12) 12
cells, cultured (12) 12
cyclic gmp - biosynthesis (12) 12
muscarinic antagonists - pharmacology (12) 12
receptor, muscarinic m1 (12) 12
time factors (12) 12
transfection (12) 12
alzheimer's disease (11) 11
hydrolysis (11) 11
neuroblastoma - metabolism (11) 11
receptors (11) 11
scopolamine derivatives - metabolism (11) 11
signal transduction (11) 11
tritium (11) 11
affinity (10) 10
gallamine (10) 10
n-methylscopolamine - metabolism (10) 10
original paper (10) 10
quinuclidinyl benzilate - metabolism (10) 10
rat (10) 10
receptor, muscarinic m1 - metabolism (10) 10
acetylcholine (9) 9
desensitization (9) 9
neurons - enzymology (9) 9
nitric oxide synthase type i (9) 9
receptors, muscarinic - genetics (9) 9
science (9) 9
selectivity (9) 9
tumor cells, cultured (9) 9
allosteric modulation (8) 8
brain - drug effects (8) 8
cells (8) 8
chemistry (8) 8
cyclic gmp (8) 8
cyclic gmp - metabolism (8) 8
neuroblastoma (8) 8
pirenzepine - pharmacology (8) 8
proteins (8) 8
receptor subtypes (8) 8
subtypes (8) 8
acetylcholine - metabolism (7) 7
agonist (7) 7
agonist binding (7) 7
allosteric regulation (7) 7
binding, competitive - drug effects (7) 7
binding-properties (7) 7
cell line (7) 7
general tagging of cross-sectional technologies spanning over several sections of the ipc (7) 7
general tagging of new technological developments (7) 7
gtp-binding proteins - metabolism (7) 7
heterocyclic compounds (7) 7
human necessities (7) 7
hygiene (7) 7
inhibition (7) 7
inositol phosphates - metabolism (7) 7
ligand-binding (7) 7
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2008, Chicago guides to academic life, ISBN 9780226060644, 367
Embarking upon research as a graduate student or postdoc can be exciting and enriching - the start of a rewarding career. But the world of scientific research... 
Science | Vocational guidance | Research | Education
Book
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0214255
Allosteric ligands bind to receptors at sites that are distinct from those endogenous agonists and orthosteric pharmacological agents interact with. Both an... 
MOLECULAR-MECHANISM | SITE | RECEPTOR | LIGAND-BINDING | ACETYLCHOLINE | MULTIDISCIPLINARY SCIENCES | Hypotension, Orthostatic | Tracers (Biology) | Analysis | Binding | Neurochemistry | Adenosine | Pharmacology | Selectivity | Hormones | Equilibrium | Neuromodulation | Modulators | Proteins | Receptors | Neurotransmitters | Allosteric properties | Researchers | Affinity | Ligands | Physiology | Kinetics | Added value | Coordination compounds | Binding sites
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2019, Volume 9, Issue 1, pp. 4637 - 14
Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is... 
AFFINITY | MULTIDISCIPLINARY SCIENCES | LOOP | PARAMETERS | RECEPTORS | ALLOSTERISM | BINDING | Acetylcholine receptors (muscarinic)
Journal Article
Neuropharmacology, ISSN 0028-3908, 05/2018, Volume 133, pp. 129 - 144
Xanomeline (3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole) is a muscarinic agonist that is considered to be functionally selective... 
Molecular dynamics | Xanomeline | Receptor activation | Membrane cholesterol | Muscarinic acetylcholine receptors | ACTIVATION | PROTEIN | ALZHEIMERS-DISEASE | SCHIZOPHRENIA | AGONIST XANOMELINE | ALLOSTERIC MODULATION | NEUROSCIENCES | ACETYLCHOLINE-RECEPTOR | ORGANIZATION | STRUCTURAL BASIS | PHARMACOLOGY & PHARMACY | BINDING
Journal Article
Pharmacological Research, ISSN 1043-6618, 07/2015, Volume 97, p. 27
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e88910
Journal Article
Pharmacological Research, ISSN 1043-6618, 07/2015, Volume 97, pp. 27 - 39
We mutated key amino acids of the human variant of the M 1 muscarinic receptor that target ligand binding, receptor activation, and receptor-G protein... 
Atypical agonists | Activation mechanism | Xanomeline | Muscarinic acetylcholine receptors | LIGAND-BINDING | PROTEIN | CRYSTAL-STRUCTURE | ALPHA(1B)-ADRENERGIC RECEPTOR | PERSISTENT BINDING | IDENTIFICATION | SITE-DIRECTED MUTAGENESIS | ALLOSTERIC AGONISM | AMINO-ACIDS | PHARMACOLOGY & PHARMACY
Journal Article
Neuromethods, ISSN 0893-2336, 2016, Volume 107, pp. 37 - 68
Journal Article
Neuromethods, ISSN 0893-2336, 2016, Volume 107, pp. 95 - 130
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2013, Volume 67, p. 272
The overproduction of [beta]-amyloid (A[beta]) fragments in transgenic APPswe/PS1dE9 mice results in formation of amyloid deposits in the cerebral cortex and... 
Disease transmission | Genes | Physiological aspects | Gene expression
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2013, Volume 67, pp. 272 - 283
The overproduction of beta -amyloid (A beta ) fragments in transgenic APPswe/PS1dE9 mice results in formation of amyloid deposits in the cerebral cortex and... 
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 606, Issue 1, pp. 50 - 60
We investigated the influence of membrane cholesterol content on preferential and non-preferential signaling through the M muscarinic acetylcholine receptor... 
Muscarinic receptor | cAMP | Agonist binding | Cholesterol | G-proteins coupling | Inositolphosphate | CELLS | SIGNALING PATHWAYS | ALZHEIMERS-DISEASE | PROTEIN-COUPLED RECEPTORS | POSITIVE COOPERATIVITY | CONFORMATIONS | ACETYLCHOLINE-RECEPTORS | SUBTYPE SELECTIVITY | AFFINITY | LIPID RAFTS | PHARMACOLOGY & PHARMACY
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2009, Volume 606, Issue 1-3, p. 50
We investigated the influence of membrane cholesterol content on preferential and non-preferential signaling through the M.sub.2 muscarinic acetylcholine... 
Analysis | Physiological aspects | Chemical properties | Permeability | Alzheimer's disease | Cholesterol
Journal Article
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