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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 10, pp. 1779 - 1783
Persistent inhalation of mitragynine (MG), a major alkaloid in the leaves of Mitragyna speciosa, causes various systemic adverse effects such as seizure,... 
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2012, Volume 3, p. 5
The human aldo keto reductase AKR1B10, originally identified as an aldose reductase-like protein and human small intestine aldose reductase, is a cytosolic... 
Resistance | Aldo-keto Reductase 1B10 | Chemotherapy | Proliferation | PHARMACOLOGY & PHARMACY | proliferation | aldo-keto reductase 1B10 | chemotherapy | resistance | Aldo-keto reductase 1B10
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 04/2007, Volume 14, Issue 4, pp. 280 - 286
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 234 - 242
Journal Article
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2014, Volume 37, Issue 11, pp. 1848 - 1852
Five rabbit aldo-keto reductases (AKRs) that participate in the reduction of drug ketones and endogenous ketosteroids have recently been cloned and... 
Journal Article
Journal of Biochemistry, ISSN 0021-924X, 02/2015, Volume 158, Issue 5, pp. 425 - 434
The cDNAs for morphine 6-dehydrogenase (AKR1C34) and its homologous aldo-keto reductase (AKR1C35) were cloned from golden hamster liver, and their enzymatic... 
aldo-keto reductase | flavonoid | morphine 6-dehydrogenase | sexually dimorphic expression | 3β-hydroxysteroid dehydrogenase | SITE | INHIBITOR SENSITIVITY | PROTEIN | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | 3beta-hydroxysteroid dehydrogenase | IDENTIFICATION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | SUBSTRATE-SPECIFICITY | TISSUE DISTRIBUTION | SUPERFAMILY | Liver - enzymology | Substrate Specificity | Male | RNA, Messenger - metabolism | Alcohol Oxidoreductases - genetics | Estradiol Dehydrogenases - antagonists & inhibitors | Isoenzymes - metabolism | Alcohol Oxidoreductases - antagonists & inhibitors | Mesocricetus | Female | Flavonoids - pharmacology | NAD - metabolism | Binding, Competitive | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Isoenzymes - genetics | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Liver - metabolism | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Alcohol Oxidoreductases - metabolism | Mutant Proteins - metabolism | Sex Characteristics | Organ Specificity | Animals | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | Flavonoids - metabolism | Estradiol Dehydrogenases - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2010, Volume 33, Issue 5, pp. 886 - 890
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 05/2011, Volume 125, Issue 1-2, p. 105
a[paragraph] We review the current known inhibitors of human 20[alpha]-hydroxysteroid dehydrogenase (AKR1C1) and provide an update on the design of potent and... 
Care and treatment | Polycyclic aromatic hydrocarbons | Aldose reductase | Crystals | GABA | Structure | Sugars | Cancer | Monosaccharides
Journal Article
Toxicology, ISSN 0300-483X, 07/2017, Volume 386, p. 93
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.tox.2017.05.017 In this... 
Antioxidants | Cysteine | Neurons | Glutathione transferase | Apoptosis
Journal Article
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 10/2017, Volume 40, Issue 10, p. 1779
Persistent inhalation of mitragynine (MG), a major alkaloid in the leaves of Mitragyna speciosa, causes various systemic adverse effects such as seizure,... 
Hydrogen peroxide | Incubation | Toxicity | Liver | Diarrhea | Caspase | Permeability | Endothelial cells | Inhalation | Leaves | Lungs | Cell death | Aorta | N-Acetyl-L-cysteine | Colon | Respiration | Prostate | Viability | Apoptosis | Kidney transplantation
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2017, Volume 138, pp. 185 - 192
Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, reduces a variety of carbonyl compounds including... 
Carbonyl reductase | Acyl-CoA | Inhibitory selectivity | Food-drug interaction | Fatty acid | LIPID-PEROXIDATION | OMEGA-3-FATTY-ACIDS | DOXORUBICIN | IN-VITRO METABOLISM | POTENT INHIBITORS | IMPACT | WARFARIN | ENZYMES | PHARMACOLOGY & PHARMACY | HUMAN LIVER | UP-REGULATION | Oxidoreductases - antagonists & inhibitors | Palmitic Acid - metabolism | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Stearic Acids - metabolism | Alcohol Oxidoreductases - genetics | Sugar Alcohol Dehydrogenases - genetics | Fatty Acids, Nonesterified - metabolism | Intestinal Mucosa - enzymology | Alcohol Oxidoreductases - antagonists & inhibitors | Sugar Alcohol Dehydrogenases - antagonists & inhibitors | Acyl Coenzyme A - metabolism | Binding Sites | Sugar Alcohol Dehydrogenases - metabolism | Binding, Competitive | Recombinant Proteins - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Food-Drug Interactions | Palmitoyl Coenzyme A - metabolism | Recombinant Proteins - chemistry | Alcohol Oxidoreductases - metabolism | Myristic Acid - metabolism | Cell Line, Tumor | Mutation | Physiological aspects | Fatty acids | Monounsaturated fatty acids | Anthracyclines | Colon cancer | Cytochrome P-450 | Drug resistance | Saturated fatty acids | Omega-3 fatty acids | Index Medicus
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2012, Volume 35, Issue 9, pp. 1598 - 1602
Persistent inhalation of diesel exhaust particles results in damaged lung cells through formation of reactive oxygen species (ROS), but the details of the... 
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2013, Volume 36, Issue 9, pp. 1514 - 1518
In this study, we examined the substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase (AKR1C5), which plays a role in the... 
Journal Article