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Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2017, Volume 474, Issue 10, pp. 1705 - 1725
Corneal stromal dystrophies are a group of genetic disorders that may be caused by mutations in the transforming growth factor beta-induced (TGFBI) gene which... 
GENE-MUTATIONS | INDUCED PROTEIN TGFBIP | GROWTH-FACTOR-BETA | IN-VITRO | FIBRILS | NMR CHEMICAL-SHIFTS | KERATOEPITHELIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIGH3 GENE | CELL-ADHESION | AGGREGATION | Cornea - ultrastructure | Up-Regulation | Humans | Transforming Growth Factor beta1 - metabolism | Corneal Dystrophies, Hereditary - genetics | Eye Proteins - chemistry | Amyloidogenic Proteins - chemistry | Amyloid - chemistry | Chromatography, High Pressure Liquid | Transforming Growth Factor beta - chemistry | Amyloid - ultrastructure | Tandem Mass Spectrometry | Transforming Growth Factor beta1 - chemistry | Spectrometry, Mass, Electrospray Ionization | Amyloid - metabolism | Corneal Dystrophies, Hereditary - pathology | Nuclear Magnetic Resonance, Biomolecular | Cornea - cytology | Cornea - pathology | Protein Interaction Domains and Motifs | Eye Proteins - genetics | Protein Stability | Circular Dichroism | Peptide Fragments - genetics | Protein Aggregation, Pathological - genetics | Amyloidogenic Proteins - genetics | Amyloid - genetics | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Cells, Cultured | Transforming Growth Factor beta1 - genetics | Corneal Dystrophies, Hereditary - metabolism | Cornea - metabolism | Point Mutation | Amyloidogenic Proteins - metabolism | Peptide Fragments - chemistry | Transforming Growth Factor beta - genetics | Eye Proteins - metabolism | Kinetics | Transforming Growth Factor beta - metabolism | Protein Aggregation, Pathological - metabolism | Amino Acid Substitution | Index Medicus | corneal dystrophy | amyloid | amino acid substitution | β-sheet propensity | protein aggregation | TGFBIp
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2008, Volume 582, Issue 7, pp. 1097 - 1103
The polyketide synthase associated with the biosynthesis of enediyne-containing calicheamicin contains a putative phosphopantetheinyl transferase (PPTase)... 
Polyketide synthase | Phosphopantetheinyl transferase | Calicheamicin | Enediyne | Acyl carrier protein | phosphopantetheinyl transferase | ACP domain of the iterative PKS in calicheamicin biosynthesis | polyketide synthase | fatty acid synthesis pathway | carrier protein | B. brevis | PPTase | peptidyl carrier protein | non-ribosomal peptide synthase | acyl carrier protein | PCP domain of non-ribosomal peptide synthase (GrsA | E. coli | NRPS | ssp. | EACP | ACP domain from the modular PKS DEBS | ACP | acyl carrier protein synthase | DACP | fatty acid synthase | GPCP | ACP from | meACP | PKS | FAS | AcpS | PCP | M. echinospora | calicheamicin | RECOGNITION | MECHANISM | CRYSTAL-STRUCTURE | ACTIVE-SITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CELL BIOLOGY | BIOPHYSICS | BACILLUS-SUBTILIS | PSEUDOMONAS-AERUGINOSA | FATTY-ACID SYNTHASE | SFP | enediyne | Enediynes - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Acyl Carrier Protein - metabolism | Bacterial Proteins - chemistry | Molecular Sequence Data | Substrate Specificity | Aminoglycosides - chemistry | Acyl Carrier Protein - chemistry | Polyketide Synthases - chemistry | Polyketide Synthases - metabolism | Sequence Alignment | Transferases (Other Substituted Phosphate Groups) - metabolism | Carrier Proteins - metabolism | Aminoglycosides - biosynthesis | Bacterial Proteins - metabolism | Carrier Proteins - chemistry | Transferases (Other Substituted Phosphate Groups) - chemistry | Proteins | Physiological aspects | Synthesis | Fatty acids | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2008, Volume 130, Issue 26, pp. 8142 - 8143
We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the... 
GENE-CLUSTER | CHEMISTRY, MULTIDISCIPLINARY | Enediynes - chemistry | Malonyl Coenzyme A | Polyketide Synthases - metabolism | Polyenes | Aminoglycosides - biosynthesis | Aminoglycosides - chemistry | Enediynes - chemical synthesis | Carbonyl compounds | Polyketides | Chemical properties | Structure | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, pp. 23836 - 23836
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2010, Volume 398, Issue 3, pp. 500 - 505
The recent report of 2a super(2),3a super(2)-cAMP isolated from rat kidney is the first proof of its biological existence, which revived interest in this... 
Adenosine
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 07/2012, Volume 84, Issue 1, pp. 108 - 115
Journal Article
Scientific Reports (Nature Publisher Group), 03/2016, Volume 6, p. 23836
Most stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4th... 
Amyloidogenesis | Cornea | Light scattering | Transforming growth factor-b | Denaturation | Cytotoxicity | Thermal denaturation | Electron microscopy | pH effects | Corneal dystrophy | Temperature effects | Mutation | Dystrophy | Growth factors
Journal Article
ACS Biomaterials Science and Engineering, ISSN 2373-9878, 12/2015, Volume 1, Issue 12, pp. 1324 - 1334
Bacterial infection following implantation of an artificial corneal scaffold is a serious complication. Conventional antibiotic prophylaxis, which includes... 
antibiotic | collagen hydrogel | infection | inflammation | artificial cornea | in vivo | drug delivery | Staphylococcus aureus | DRUG | EYES | MATERIALS SCIENCE, BIOMATERIALS | KERATITIS | BOSTON TYPE-1 KERATOPROSTHESIS | DELIVERY | IN-VITRO | VANCOMYCIN | ENDOPHTHALMITIS | IMPLANTATION | MATRICES
Journal Article
Journal Article