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Cell Death and Differentiation, ISSN 1350-9047, 2019, Volume 26, Issue 10, pp. 2074 - 2085
Withdrawal of the growth factor interleukin-3 (IL-3) from IL-3-dependent myeloid cells causes them to undergo Bax/Bak1-dependent apoptosis, whereas... 
SURVIVAL | PROGENITORS | TXNIP | AUTOPHAGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Glucose transporter | CRISPR | Myeloid cells | Cell survival | Bax protein | Glucose | Thioredoxin | Autophagy | Interleukin 3 | Growth factors | Phagocytosis | Apoptosis | Glutamine
Journal Article
Stem Cell Research, ISSN 1873-5061, 07/2019, Volume 38, p. 101453
To develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we used a simultaneous reprogramming and CRISPR-Cas9 genome editing... 
STEM-CELLS | DIFFERENTIATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Osteogenesis imperfecta | Genetic aspects | Research | Gene expression | Stem cells
Journal Article
Stem Cell Research, ISSN 1873-5061, 05/2019, Volume 37, p. 101449
To develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we have used gene editing to produce a facsimile of the patient... 
STEM-CELLS | DIFFERENTIATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, p. E11180
Cortical interneurons (cINs) modulate excitatory neuronal activity by providing local inhibition. During fetal development, several cIN subtypes derive from... 
Enrichment | Brain | Networks | Chromatin | Transcription factors | Interneurons | Epilepsy | Genes | Gene regulation | Embryo cells | Regulatory sequences | Neurodevelopmental disorders | Remodeling | Tissue | Specifications | Fetuses | Cortex | Telencephalon | Gene expression | Chromatin remodeling | Stem cells | Neural stem cells | Mutation | Differentiation | Thyroid transcription factor 1
Journal Article
Stem Cell Research, ISSN 1873-5061, 04/2018, Volume 28, pp. 161 - 164
Mutations in are a known cause of X-linked early onset Parkinson's disease. Isogenic human embryonic stem cell lines carrying two independent deletions of were... 
MUTATIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Cancer Research, ISSN 0008-5472, 02/2016, Volume 76, Issue 3 Supplement, pp. B04 - B04
Journal Article
EBioMedicine, ISSN 2352-3964, 11/2017, Volume 25, Issue C, pp. 122 - 135
Journal Article
Cell Stem Cell, ISSN 1934-5909, 05/2013, Volume 12, Issue 5, pp. 573 - 586
Journal Article
Nature Biotechnology, ISSN 1087-0156, 11/2016, Volume 34, Issue 11, pp. 1168 - 1179
The ability to generate hematopoietic stem cells from human pluripotent cells would enable many biomedical applications. We find that hematopoietic CD34... 
Journal Article
Cell Stem Cell, ISSN 1934-5909, 05/2013, Volume 12, Issue 5, pp. 559 - 572
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 49 - 59
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse functions, including motility and epithelial permeability. Perturbations... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | GUT | COLON | LINEAGES | PHOX2B | CELL BIOLOGY | THERAPY | NEURONS | HIRSCHSPRUNG DISEASE | EXPRESSION | MOTILITY | Immunohistochemistry | Interstitial Cells of Cajal - physiology | Calcium - metabolism | Humans | Hirschsprung Disease - genetics | Myenteric Plexus - physiology | Submucous Plexus - physiology | Neural Crest | Enteric Nervous System - physiopathology | Gastrointestinal Motility | Organoids | Neurons - physiology | Intestines - physiology | Real-Time Polymerase Chain Reaction | Cell Line | Submucous Plexus - physiopathology | Tissue Engineering - methods | Hirschsprung Disease - physiopathology | Neuroglia - physiology | Permeability | Transcription Factors - genetics | Mice, SCID | Chick Embryo | Homeodomain Proteins - genetics | Myenteric Plexus - physiopathology | Microscopy, Confocal | Animals | Models, Biological | Neurogenesis - physiology | Mice | Intestines - physiopathology | Mutation | Enteric Nervous System - physiology | In Vitro Techniques | Induced Pluripotent Stem Cells | Usage | Motility | Intestine, Small | Gastrointestinal system | Stem cells | Models | Nervous system, Autonomic | Neurons | Calcium | Mesenchyme | Embryo cells | Interstitial cells | Nervous system | Glial cells | Waves | Contraction | Neuronal-glial interactions | Calcium signalling | Coupling (molecular) | Enteric nervous system | Wave propagation | Intestine | Submucosal plexus | Phox2b protein | Tissue engineering | Gastrointestinal tract | Rhythms | Interstitial cells of Cajal | Neural crest | Hirschsprung's disease | Pluripotency
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2015, Volume 17, Issue 5, pp. 580 - 591
The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic... 
PROGENITORS | SIGNALING PATHWAYS | DIFFERENTIATION CULTURES | HEMATOPOIETIC STEM-CELLS | NOTCH PATHWAY | SPECIFICATION | IDENTIFICATION | EXPRESSION | AORTIC ENDOTHELIUM | RUNX1 | CELL BIOLOGY | Antigens, CD34 - metabolism | Receptors, Notch - metabolism | Coculture Techniques | Humans | Multipotent Stem Cells - metabolism | Microscopy, Video | 5'-Nucleotidase - deficiency | Arteries - cytology | Arteries - metabolism | Endothelial Progenitor Cells - physiology | GPI-Linked Proteins - deficiency | Time Factors | Arteries - physiology | Hematopoietic Stem Cells - physiology | Cell Differentiation | Multipotent Stem Cells - physiology | Endothelial Progenitor Cells - metabolism | Biomarkers - metabolism | Cell Line | Precursor Cells, T-Lymphoid - physiology | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Pluripotent Stem Cells - physiology | Receptors, CXCR5 - deficiency | Hematopoietic Stem Cells - metabolism | Cell Separation - methods | Veins - cytology | Pluripotent Stem Cells - metabolism | Cell Lineage | Phenotype | Veins - physiology | Genetic research | Cellular signal transduction | Genetic aspects | Growth | Stem cells | RUNX1C | CD73 | multipotent progenitor | CD184 | Notch signalling | definitive haematopoiesis | haemogenic endothelium | arterial | pluripotent | venous | DLL4 | vascular endothelium | embryonic stem cell
Journal Article