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BIOCHEMICAL JOURNAL, ISSN 0264-6021, 04/2019, Volume 476, Issue 7, pp. 1037 - 1051
The group A p21-activated kinases (PAKs) exist in an auto-inhibited form until activated by GTPase binding and auto-phosphorylation. In the auto-inhibited... 
P21-ACTIVATED KINASE | ACTIVATION | DOMAIN | GROUP-I | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MISSENSE MUTATION | CRYSTAL-STRUCTURES | SIZE-EXCLUSION CHROMATOGRAPHY | SEDIMENTATION | IONIZATION MASS-SPECTROMETRY | kinase | structure | SAXS
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2014, Volume 1140, pp. 325 - 336
A brief summary is made of some of the methods in structural genomics and drug discovery as they apply to protein kinases. 
Dephosphorylation | Differential scanning fluorimetry | Kinase inhibitors | Protein kinase | Crystallization | Protein Kinases - chemistry | Protein Kinases - genetics | Genome, Human | Drug Discovery | Humans | Computational Biology | Index Medicus
Journal Article
Journal Article
OPEN BIOLOGY, ISSN 2046-2441, 04/2019, Volume 9, Issue 4, pp. 190037 - 190037
The RIO kinases (RIOKs) are a universal family of atypical kinases that are essential for assembly of the pre-40S ribosome complex. Here, we present the... 
RIO kinase | inhibitor | ribosome assembly | BIOCHEMISTRY & MOLECULAR BIOLOGY | 40s | crystal structure | RIOK2 | PROTEINS | KINASES | FAMILY
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 2, p. 336
Journal Article
ISSN 1477-0520, 10/2017, Volume 15, Issue 4, pp. 8655 - 866
A series of 3-methylidene-1 H -indol-2(3 H )-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation... 
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 10/2017, Volume 15, Issue 40, pp. 8655 - 8660
A series of 3-methylidene-1 H -indol-2(3 H )-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation... 
Chemistry
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2016, Volume 12, Issue 10, pp. 876 - 884
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0181585 - e0181585
Journal Article
Science Signaling, ISSN 1945-0877, 05/2012, Volume 5, Issue 224, pp. pe21 - pe21
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 1 - 11
Aurora kinases B and C (AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP. Full activation requires phosphorylation of two serine... 
TPX2 | CHROMOSOMAL PASSENGER PROTEIN | B ACTIVATION | MULTIDISCIPLINARY SCIENCES | COMPLEXES | SPINDLE | C KINASE | INHIBITOR | IDENTIFICATION | Binding | Phosphorylation | Inhibitors | Protein folding | Serine | INCENP protein | Activation | Aurora kinase | Selectivity | Kinases | Substrates | Crystal structure
Journal Article
Journal Article