Neuron, ISSN 0896-6273, 04/2014, Volume 82, Issue 2, pp. 380 - 397
The colony-stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells. Genetic loss of the CSF1R blocks the normal population of...
MAINTENANCE | GROWTH | A-BETA | KINASE INHIBITOR | DIFFERENTIATION | EXPRESSION | FMS | PRECURSORS | NEUROSCIENCES | DEFICIENCY | LANGERHANS CELLS | Adult Stem Cells - physiology | Microglia - metabolism | Male | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Brain - metabolism | Time Factors | Cell Death - drug effects | Macrophage Colony-Stimulating Factor - genetics | Adult Stem Cells - drug effects | Animals, Newborn | Brain - cytology | Maze Learning - physiology | Gene Expression Regulation - genetics | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Macrophage Colony-Stimulating Factor - metabolism | Maze Learning - drug effects | Brain - drug effects | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Nervous system diseases | Macrophage colony stimulating factor | Intermediate filament proteins | Cells | Flow cytometry | Brain research | Rodents | Behavior | Kinases | Experiments | Animal cognition
MAINTENANCE | GROWTH | A-BETA | KINASE INHIBITOR | DIFFERENTIATION | EXPRESSION | FMS | PRECURSORS | NEUROSCIENCES | DEFICIENCY | LANGERHANS CELLS | Adult Stem Cells - physiology | Microglia - metabolism | Male | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Brain - metabolism | Time Factors | Cell Death - drug effects | Macrophage Colony-Stimulating Factor - genetics | Adult Stem Cells - drug effects | Animals, Newborn | Brain - cytology | Maze Learning - physiology | Gene Expression Regulation - genetics | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Macrophage Colony-Stimulating Factor - metabolism | Maze Learning - drug effects | Brain - drug effects | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Nervous system diseases | Macrophage colony stimulating factor | Intermediate filament proteins | Cells | Flow cytometry | Brain research | Rodents | Behavior | Kinases | Experiments | Animal cognition
Journal Article
Brain, ISSN 0006-8950, 04/2016, Volume 139, Issue 4, pp. 1265 - 1281
In addition to amyloid-beta plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered a key feature of Alzheimer's disease pathology....
amyloid | cognition | inflammation | Alzheimer's disease | microglia | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | COGNITIVE IMPAIRMENT | TAU PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | SENILE PLAQUES | BRAIN INFLAMMATION | SYNAPTIC LOSS | MOUSE MODEL | A-BETA | PLAQUE-FORMATION | TRANSGENIC MICE | Microglia - metabolism | Neurons - pathology | Plaque, Amyloid - pathology | Mice, Inbred C57BL | Male | Mice, Transgenic | Mice, 129 Strain | Alzheimer Disease - pathology | Brain - metabolism | Animals | Alzheimer Disease - prevention & control | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Female | Plaque, Amyloid - metabolism | Plaque, Amyloid - prevention & control | Mice | Neurons - metabolism
amyloid | cognition | inflammation | Alzheimer's disease | microglia | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | COGNITIVE IMPAIRMENT | TAU PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | SENILE PLAQUES | BRAIN INFLAMMATION | SYNAPTIC LOSS | MOUSE MODEL | A-BETA | PLAQUE-FORMATION | TRANSGENIC MICE | Microglia - metabolism | Neurons - pathology | Plaque, Amyloid - pathology | Mice, Inbred C57BL | Male | Mice, Transgenic | Mice, 129 Strain | Alzheimer Disease - pathology | Brain - metabolism | Animals | Alzheimer Disease - prevention & control | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Female | Plaque, Amyloid - metabolism | Plaque, Amyloid - prevention & control | Mice | Neurons - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122912
Microglia are the primary immune cell in the brain and are postulated to play important roles outside of immunity. Administration of the dual...
ACTIVATION | IMMUNE-SYSTEM | ALZHEIMERS-DISEASE | INFLAMMATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MORRIS WATER MAZE | NEUROGENESIS | INFECTION | AGED MICE | BRAIN | Central Nervous System Diseases - pathology | Inflammation - pathology | Mice, Inbred C57BL | Cells, Cultured | Central Nervous System Diseases - immunology | Male | Cognition | Nerve Regeneration | Motor Activity | Inflammation - metabolism | Rotarod Performance Test | Animals | Maze Learning | Microglia - physiology | Cell Shape | Lipopolysaccharides - pharmacology | Brain - pathology | Female | Brain - immunology | Animal behavior | Mitogens | Brain | Neurosciences | Traumatic brain injury | Profiling | Memory | Neurobiology | Cognitive ability | Cytology | Central nervous system | Infections | Motor task performance | Kinases | Neurogenesis | Immunity | Lipopolysaccharides | Rodents | Colony-stimulating factor | Neurological disorders | Immune system | Repopulation | Macrophage colony-stimulating factor | Inflammation | Gene expression | c-Kit protein | Microglia | Polymerase chain reaction | Inhibitors | Diet | Morphology | Cells (biology) | Mice | Laboratory animals | Animal cognition
ACTIVATION | IMMUNE-SYSTEM | ALZHEIMERS-DISEASE | INFLAMMATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MORRIS WATER MAZE | NEUROGENESIS | INFECTION | AGED MICE | BRAIN | Central Nervous System Diseases - pathology | Inflammation - pathology | Mice, Inbred C57BL | Cells, Cultured | Central Nervous System Diseases - immunology | Male | Cognition | Nerve Regeneration | Motor Activity | Inflammation - metabolism | Rotarod Performance Test | Animals | Maze Learning | Microglia - physiology | Cell Shape | Lipopolysaccharides - pharmacology | Brain - pathology | Female | Brain - immunology | Animal behavior | Mitogens | Brain | Neurosciences | Traumatic brain injury | Profiling | Memory | Neurobiology | Cognitive ability | Cytology | Central nervous system | Infections | Motor task performance | Kinases | Neurogenesis | Immunity | Lipopolysaccharides | Rodents | Colony-stimulating factor | Neurological disorders | Immune system | Repopulation | Macrophage colony-stimulating factor | Inflammation | Gene expression | c-Kit protein | Microglia | Polymerase chain reaction | Inhibitors | Diet | Morphology | Cells (biology) | Mice | Laboratory animals | Animal cognition
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 08/2015, Volume 12, Issue 1, p. 139
Background: Microglia are dependent upon colony-stimulating factor 1 receptor (CSF1R) signaling for their survival in the adult brain, with administration of...
Neuroinflammation | Cognition | Alzheimer's disease | Therapeutics | CLEARANCE | ALZHEIMERS-DISEASE | MACROPHAGES | MOUSE | TREM2 | MODEL | IMMUNOLOGY | NEUROSCIENCES | TRAUMATIC BRAIN-INJURY | A-BETA | INFLAMMATORY RESPONSE | TRANSGENIC MICE | Memory - drug effects | Cell Line | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Plaque, Amyloid - pathology | Learning - drug effects | Cell Count | Humans | Anxiety - psychology | Alzheimer Disease - drug therapy | Motor Activity - drug effects | Mice, Transgenic | Chemotaxis - drug effects | Cognition Disorders - drug therapy | Alzheimer Disease - pathology | Brain - drug effects | Dose-Response Relationship, Drug | Animals | Cognition Disorders - etiology | Microglia - pathology | Mice | Alzheimer Disease - psychology | Cognition Disorders - psychology | Medicine, Experimental | Medical research | Advertising executives | Analysis
Neuroinflammation | Cognition | Alzheimer's disease | Therapeutics | CLEARANCE | ALZHEIMERS-DISEASE | MACROPHAGES | MOUSE | TREM2 | MODEL | IMMUNOLOGY | NEUROSCIENCES | TRAUMATIC BRAIN-INJURY | A-BETA | INFLAMMATORY RESPONSE | TRANSGENIC MICE | Memory - drug effects | Cell Line | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Plaque, Amyloid - pathology | Learning - drug effects | Cell Count | Humans | Anxiety - psychology | Alzheimer Disease - drug therapy | Motor Activity - drug effects | Mice, Transgenic | Chemotaxis - drug effects | Cognition Disorders - drug therapy | Alzheimer Disease - pathology | Brain - drug effects | Dose-Response Relationship, Drug | Animals | Cognition Disorders - etiology | Microglia - pathology | Mice | Alzheimer Disease - psychology | Cognition Disorders - psychology | Medicine, Experimental | Medical research | Advertising executives | Analysis
Journal Article
Aging Cell, ISSN 1474-9718, 12/2018, Volume 17, Issue 6, pp. e12832 - n/a
Microglia, the resident immune cell of the brain, can be eliminated via pharmacological inhibition of the colony‐stimulating factor 1 receptor (CSF1R)....
repopulation | aging | colony‐stimulating factor 1 receptor | plx5622 | long‐term potentiation | microglia | colony-stimulating factor 1 receptor | long-term potentiation | PROTEIN | CELL | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Muscle proteins | Gene expression | Neurons | Potentiation | Phenotypes | Repopulation | Synaptogenesis | Spatial discrimination | Cognitive ability | Neurogenesis | Microglia | Dendritic spines | Actin | Cytoskeleton | Hippocampus | Age | Spatial memory | Original
repopulation | aging | colony‐stimulating factor 1 receptor | plx5622 | long‐term potentiation | microglia | colony-stimulating factor 1 receptor | long-term potentiation | PROTEIN | CELL | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Muscle proteins | Gene expression | Neurons | Potentiation | Phenotypes | Repopulation | Synaptogenesis | Spatial discrimination | Cognitive ability | Neurogenesis | Microglia | Dendritic spines | Actin | Cytoskeleton | Hippocampus | Age | Spatial memory | Original
Journal Article
Journal of Nutrition, ISSN 0022-3166, 11/2012, Volume 142, Issue 11, pp. 2050 - 2056
Iron deficiency is common throughout the world and has been linked to cognitive impairments. Using neonatal piglets to model human infants, we assessed the...
EARLY NUTRITION | ADULT-RAT HIPPOCAMPUS | NUTRITION & DIETETICS | T-MAZE TASK | NEUROTROPHIC FACTOR | GROWTH | CONSEQUENCES | ANEMIA | ALTERS | PLACE | BRAIN | Animals, Newborn | Swine Diseases - drug therapy | Spatial Behavior | Pregnancy Complications, Hematologic - veterinary | Nerve Growth Factors - metabolism | Anemia, Iron-Deficiency - veterinary | Behavior, Animal | Brain - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Pregnancy | Animals | Diet | Nerve Growth Factors - genetics | Swine | Skin Pigmentation | Female | Anemia, Iron-Deficiency - complications | Brain Chemistry | Real-Time Polymerase Chain Reaction | Animal Feed | Complications and side effects | Iron deficiency diseases | Spatial ability | Iron in the body | Cognition disorders | Health aspects | Risk factors
EARLY NUTRITION | ADULT-RAT HIPPOCAMPUS | NUTRITION & DIETETICS | T-MAZE TASK | NEUROTROPHIC FACTOR | GROWTH | CONSEQUENCES | ANEMIA | ALTERS | PLACE | BRAIN | Animals, Newborn | Swine Diseases - drug therapy | Spatial Behavior | Pregnancy Complications, Hematologic - veterinary | Nerve Growth Factors - metabolism | Anemia, Iron-Deficiency - veterinary | Behavior, Animal | Brain - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Pregnancy | Animals | Diet | Nerve Growth Factors - genetics | Swine | Skin Pigmentation | Female | Anemia, Iron-Deficiency - complications | Brain Chemistry | Real-Time Polymerase Chain Reaction | Animal Feed | Complications and side effects | Iron deficiency diseases | Spatial ability | Iron in the body | Cognition disorders | Health aspects | Risk factors
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 6, pp. 2120 - 2129
Environmental insults during sensitive periods can affect hippocampal development and function, but little is known about peripheral infection, especially in...
Brain | Cognition | Inflammation | Sickness behavior | PRRSV | T-MAZE TASK | cognition | SPINAL-CORD | brain | AUTISM SPECTRUM DISORDERS | PLACE | NEUROSCIENCES | IMMUNE-SYSTEM | sickness behavior | inflammation | SYNDROME VIRUS | INDUCED SICKNESS BEHAVIOR | CENTRAL-NERVOUS-SYSTEM | BRAIN GROWTH | INFLUENZA INFECTION | Animals, Newborn | Microglia - metabolism | Porcine respiratory and reproductive syndrome virus - physiology | Hippocampus - virology | Maze Learning - physiology | Porcine Reproductive and Respiratory Syndrome - metabolism | Spatial Behavior - physiology | Male | Hippocampus - metabolism | Animals | Swine | Microglia - virology | Female | Porcine Reproductive and Respiratory Syndrome - pathology
Brain | Cognition | Inflammation | Sickness behavior | PRRSV | T-MAZE TASK | cognition | SPINAL-CORD | brain | AUTISM SPECTRUM DISORDERS | PLACE | NEUROSCIENCES | IMMUNE-SYSTEM | sickness behavior | inflammation | SYNDROME VIRUS | INDUCED SICKNESS BEHAVIOR | CENTRAL-NERVOUS-SYSTEM | BRAIN GROWTH | INFLUENZA INFECTION | Animals, Newborn | Microglia - metabolism | Porcine respiratory and reproductive syndrome virus - physiology | Hippocampus - virology | Maze Learning - physiology | Porcine Reproductive and Respiratory Syndrome - metabolism | Spatial Behavior - physiology | Male | Hippocampus - metabolism | Animals | Swine | Microglia - virology | Female | Porcine Reproductive and Respiratory Syndrome - pathology
Journal Article
Animal Cognition, ISSN 1435-9448, 7/2012, Volume 15, Issue 4, pp. 667 - 676
Pigs are a valuable animal model for studying neurodevelopment in humans due to similarities in brain structure and growth. The development and validation of...
Life Sciences | Scopolamine | Human Physiology | Swine | Zoology | Behavioural Sciences | Memory | Cognition | Evolutionary Biology | Hippocampus | PIGS | WATER-MAZE | BEHAVIOR | ACQUISITION | VALIDATION | MODEL | RESPONSES | ZOOLOGY | CORTEX | BEHAVIORAL SCIENCES | RECEPTORS | Memory - drug effects | Scopolamine Hydrobromide - pharmacology | Animals | Space Perception - drug effects | Reaction Time - drug effects | Animals, Newborn - psychology | Female | Male | Hippocampus - drug effects | Maze Learning - drug effects | Swine - psychology | Cholinergic Antagonists - pharmacology | Analysis | Hogs | Brain | Animal memory | Animal cognition | swine | memory | hippocampus | scopolamine
Life Sciences | Scopolamine | Human Physiology | Swine | Zoology | Behavioural Sciences | Memory | Cognition | Evolutionary Biology | Hippocampus | PIGS | WATER-MAZE | BEHAVIOR | ACQUISITION | VALIDATION | MODEL | RESPONSES | ZOOLOGY | CORTEX | BEHAVIORAL SCIENCES | RECEPTORS | Memory - drug effects | Scopolamine Hydrobromide - pharmacology | Animals | Space Perception - drug effects | Reaction Time - drug effects | Animals, Newborn - psychology | Female | Male | Hippocampus - drug effects | Maze Learning - drug effects | Swine - psychology | Cholinergic Antagonists - pharmacology | Analysis | Hogs | Brain | Animal memory | Animal cognition | swine | memory | hippocampus | scopolamine
Journal Article
Aging Cell, ISSN 1474-9718, 12/2018, Volume 17, Issue 6, p. e12832
Journal Article
Brain, ISSN 0006-8950, 04/2016, Volume 139, Issue 4, pp. 1265 - 1281
Microglia-mediated inflammation is a driving force in Alzheimer’s disease pathogenesis. Spangenberg et al . show that elimination of microglia in 5xfAD mice...
amyloid | Alzheimer’s disease | cognition | inflammation | Original | microglia | 1060
amyloid | Alzheimer’s disease | cognition | inflammation | Original | microglia | 1060
Journal Article
Ethology, ISSN 0179-1613, 10/2013, Volume 119, Issue 10, pp. 803 - 806
Many high‐priority and high‐interest species are challenging to study due to the difficulty in accessing animals and/or obtaining sufficient sample sizes. The...
BEHAVIORAL SCIENCES | ZOOLOGY | Animal behavior | Social media | Social networks
BEHAVIORAL SCIENCES | ZOOLOGY | Animal behavior | Social media | Social networks
Journal Article
Applied Animal Behaviour Science, ISSN 0168-1591, 2010, Volume 123, Issue 1, pp. 7 - 15
Comfortable flooring may impact many aspects of an animal's welfare, including lying behavior, an animal's ability to change postures, and incidence of...
Group-housed | Rubber mat | Behavior | Welfare | Comfort | Sows | FINISHING PIGS | AGRICULTURE, DAIRY & ANIMAL SCIENCE | FOOT LESIONS | AMBIENT-TEMPERATURE | DAIRY-COWS | STALLS | GESTATING SOWS | PIGLETS | PREFERENCES | BEHAVIORAL SCIENCES | VETERINARY SCIENCES | STRAW | Breeding
Group-housed | Rubber mat | Behavior | Welfare | Comfort | Sows | FINISHING PIGS | AGRICULTURE, DAIRY & ANIMAL SCIENCE | FOOT LESIONS | AMBIENT-TEMPERATURE | DAIRY-COWS | STALLS | GESTATING SOWS | PIGLETS | PREFERENCES | BEHAVIORAL SCIENCES | VETERINARY SCIENCES | STRAW | Breeding
Journal Article
PLoS ONE, 04/2015, Volume 10, Issue 4
Microglia are the primary immune cell in the brain and are postulated to play important roles outside of immunity. Administration of the dual...
Journal Article
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Full Text
Abstracts of the HIV Research for Prevention Meeting, HIVR4P, 21-25 October, 2018, Madrid
AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2018, Volume 34, Issue S1, pp. 1 - 407
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AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2016, Volume 32, Issue S1, pp. 1 - 409
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, p. e0184316
Ecological niche models (ENMs) have increasingly been used to estimate the potential effects of climate change on species' distributions worldwide. Recently,...
SCALED QUAIL | COLINUS-VIRGINIANUS | CONSERVATION | WEATHER | LAND-COVER | EXTINCTION RISK | HABITAT USE | MULTIDISCIPLINARY SCIENCES | ECOLOGICAL-NICHE MODELS | RANGE | PREDICTION | Models, Theoretical | Climate | Reproducibility of Results | Algorithms | Climate Change | Ecosystem | Population Density | Forecasting | Population Dynamics | Climate effects | Climatic conditions | Abundance | Ecology | Climate models | Endangered & extinct species | Variables | Climate change | Conservation biology | Vegetation | Predictions | Population | Wildfowl | Trends | Species | Circulation | Environmental protection
SCALED QUAIL | COLINUS-VIRGINIANUS | CONSERVATION | WEATHER | LAND-COVER | EXTINCTION RISK | HABITAT USE | MULTIDISCIPLINARY SCIENCES | ECOLOGICAL-NICHE MODELS | RANGE | PREDICTION | Models, Theoretical | Climate | Reproducibility of Results | Algorithms | Climate Change | Ecosystem | Population Density | Forecasting | Population Dynamics | Climate effects | Climatic conditions | Abundance | Ecology | Climate models | Endangered & extinct species | Variables | Climate change | Conservation biology | Vegetation | Predictions | Population | Wildfowl | Trends | Species | Circulation | Environmental protection
Journal Article