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1. Full Text Soluble HLA‐G levels in seminal plasma are associated with HLA‐G 3′UTR genotypes and haplotypes
by Craenmehr, Moniek H. C and Haasnoot, Geert W and Drabbels, Jos J. M and Spruyt‐Gerritse, Marijke J and Cao, Milo and Keur, Carin and Kapsenberg, Johanna M and Uyar‐Mercankaya, Merve and Beelen, Els and Meuleman, Tess and Hoorn, Marie‐Louise P and Heidt, Sebastiaan and Claas, Frans H. J and Eikmans, Michael
HLA : immune response genetics, ISSN 2059-2302, 10/2019, Volume 94, Issue 4, pp. 339 - 346
recurrent miscarriage | seminal plasma | soluble HLA‐G | immunology | pregnancy | Pathology | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Original
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2. Full Text Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
by Devree, Brian T and Mahoney, Jacob P and Vélez-Ruiz, Gisselle A and Rasmussen, Soren G. F and Kuszak, Adam J and Edwald, Elin and Fung, Juan-Jose and Manglik, Aashish and Masureel, Matthieu and Du, Yang and Matt, Rachel A and Pardon, Els and Steyaert, Jan and Kobilka, Brian K and Sunahara, Roger K
Nature (London), ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 182 - 186
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Allosteric Regulation - drug effects | GTP-Binding Protein alpha Subunits, Gs - metabolism | Single-Chain Antibodies - pharmacology | GTP-Binding Protein alpha Subunits, Gs - pharmacology | Allosteric Site - drug effects | Humans | Protein Conformation - drug effects | Adrenergic beta-2 Receptor Agonists - metabolism | Models, Molecular | Receptors, Adrenergic, beta-2 - immunology | Receptors, Adrenergic, beta-2 - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Guanine - metabolism | Guanine - pharmacology | Protein Binding - drug effects | Adrenergic beta-2 Receptor Antagonists - metabolism | Ligands | Kinetics | Single-Chain Antibodies - immunology | G proteins | Observations | Health aspects | Protein-protein interactions | Proteins | Cellular biology | Binding sites | Cells | Index Medicus | nucleotide-free | receptor conformation | GPCR
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3. Full Text Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
by Gulati, Sahil and Jin, Hui and Masuho, Ikuo and Orban, Tivadar and Cai, Yuan and Pardon, Els and Martemyanov, Kirill A and Kiser, Philip D and Stewart, Phoebe L and Ford, Christopher P and Steyaert, Jan and Palczewski, Krzysztof and Argonne National Lab. (ANL), Argonne, IL (United States)
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1996 - 15
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | GTP-Binding Protein gamma Subunits - metabolism | GTP-Binding Protein alpha Subunits - metabolism | GTP-Binding Protein gamma Subunits - chemistry | Signal Transduction | Single-Domain Antibodies - metabolism | GTP-Binding Protein alpha Subunits - chemistry | Humans | GTP-Binding Protein gamma Subunits - genetics | GTP-Binding Protein alpha Subunits - genetics | Guanosine Triphosphate - metabolism | GTP-Binding Protein beta Subunits - chemistry | Single-Domain Antibodies - chemistry | Protein Binding | GTP-Binding Protein beta Subunits - metabolism | Binding Sites | Dimerization | GTP-Binding Protein beta Subunits - genetics | Proteins | Signaling | Receptors | Side effects | G protein-coupled receptors | Deactivation | Inactivation | Binding sites | Regulatory proteins | GDP/GTP exchange factors | Cancer | Index Medicus | Biochemistry | BASIC BIOLOGICAL SCIENCES | Structural biology | Membrane proteins
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4. Full Text Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
by Staus, Dean P and Strachan, Ryan T and Manglik, Aashish and Pani, Biswaranjan and Kahsai, Alem W and Kim, Tae Hun and Wingler, Laura M and Ahn, Seungkirl and Chatterjee, Arnab and Masoudi, Ali and Kruse, Andrew C and Pardon, Els and Steyaert, Jan and Weis, William I and Prosser, R. Scott and Kobilka, Brian K and Costa, Tommaso and Lefkowitz, Robert J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature (London), ISSN 0028-0836, 07/2016, Volume 535, Issue 7612, pp. 448 - 452
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Allosteric Regulation - drug effects | Drug Partial Agonism | Allosteric Site - drug effects | Humans | Protein Conformation - drug effects | Models, Molecular | Crystallography, X-Ray | Receptors, Adrenergic, beta-2 - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | Single-Domain Antibodies - pharmacology | Isoproterenol - pharmacology | Protein Stability - drug effects | Nuclear Magnetic Resonance, Biomolecular | Ligands | Physiological aspects | G proteins | Analysis | Protein binding | Proteins | Spectrum analysis | Binding sites | Cells | Index Medicus | X-ray crystallography | BASIC BIOLOGICAL SCIENCES | Receptor pharmacology
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5. Full Text Nanobody‐Enabled Reverse Pharmacology on G‐Protein‐Coupled Receptors
by Pardon, Els and Betti, Cecilia and Laeremans, Toon and Chevillard, Florent and Guillemyn, Karel and Kolb, Peter and Ballet, Steven and Steyaert, Jan
Angewandte Chemie (International ed.), ISSN 1433-7851, 05/2018, Volume 57, Issue 19, pp. 5292 - 5295
inhibitors | nanobodies | drug discovery | fragment screening | GPCRs | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Dose-Response Relationship, Drug | Humans | Receptors, G-Protein-Coupled - antagonists & inhibitors | Nanostructures - chemistry | Adrenergic Agonists - chemistry | Adrenergic Agonists - pharmacology | Molecular Structure | Receptors, G-Protein-Coupled - agonists | Drug Discovery | Adrenergic Antagonists - chemistry | Adrenergic Antagonists - pharmacology | Pharmacology | Drug discovery | Protein binding | Proteins | Signaling | Receptors | Adrenergic receptors | Protein structure | Screens | Mimicry | Index Medicus
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6. Full Text Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor
by Bender, Brian Joseph and Vortmeier, Gerrit and Ernicke, Stefan and Bosse, Mathias and Kaiser, Anette and Els-Heindl, Sylvia and Krug, Ulrike and Beck-Sickinger, Annette and Meiler, Jens and Huster, Daniel
Structure (London), ISSN 0969-2126, 03/2019, Volume 27, Issue 3, pp. 537 - 544.e4
G protein-coupled receptor | GHSR | ghrelin | peptide docking | lipid modification | magic-angle spinning NMR | STD NMR | Rosetta | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Chlorocebus aethiops | Mutagenesis, Site-Directed | Magnetic Resonance Spectroscopy | Humans | Ghrelin - chemistry | Models, Molecular | Ghrelin - metabolism | Animals | HEK293 Cells | Protein Binding | Receptors, Ghrelin - metabolism | Protein Conformation | Binding Sites | COS Cells | Somatotropin | Analysis | Physiological aspects | Nuclear magnetic resonance spectroscopy | Models | G proteins | Membrane proteins | Protein binding | Index Medicus
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7. Full Text P1‐203: Verification of the Analytical Performance of the Fully Automated Lumipulse g β‐Amyloid 1‐42 and Lumipulse g Total TAU Assays
by Vandersteen, Annelies and Pereson, Sandra and Gorteman, Kathleen and Vandezande, Wim and Dekeyser, Filip and Dumont, Tinne and Moonen, Roger and Huyck, Els and Vandijck, Manu and Dauwe, Martine and Kostanjevecki, Vesna and Jannes, Geert
Alzheimer's & dementia, ISSN 1552-5260, 07/2016, Volume 12, pp. P483 - P483
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8. Full Text The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism
by Buckles, Thomas C and Ohashi, Yohei and Tremel, Shirley and McLaughlin, Stephen H and Pardon, Els and Steyaert, Jan and Gordon, Moshe T and Williams, Roger L and Falke, Joseph J
Biophysical journal, ISSN 0006-3495, 12/2020, Volume 119, Issue 11, pp. 2205 - 2218
Proteins | Phosphates | Analysis | Physiological aspects | Phospholipids | G proteins | Molecular biology | Index Medicus
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9. Full Text Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs
by Girard-Gagnepain, Anais and Amirache, Fouzia and Costa, Caroline and Lev́y, Camille and Frecha, Cecilia and Fusil, Floriane and Neg̀re, Didier and Lavillette, Dimitri and Cosset, François-Löic and Verhoeyen, Els
Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 8, pp. 1221 - 1231
Life Sciences & Biomedicine | Hematology | Science & Technology | Antigens, CD34 | Cell Line | Viral Envelope Proteins - genetics | Transduction, Genetic | Humans | Hematopoietic Stem Cells - metabolism | Mice, SCID | Genetic Vectors - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Hematopoietic Stem Cells - cytology | Lentivirus - genetics | Mice, Inbred NOD | Macaca | Mice | Betaretrovirus - genetics | Genetic Therapy - methods | Index Medicus | Abridged Index Medicus
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10. Full Text Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways
by Poiroux, Guillaume and Barre, Annick and Simplicien, Mathias and Pelofy, Sandrine and Segui, Bruno and Van Damme, Els J M and Rougé, Pierre and Benoist, Hervé
International journal of molecular sciences, ISSN 1422-0067, 01/2019, Volume 20, Issue 1, p. 230
T/Tn antigen | Morniga-G | Jurkat cells | apoptosis | O-glycosylation | plant lectin | cancer cell death | TRAIL/DR5 pathway | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Toxicity | Leukemia | Blocking antibodies | Antibodies | Cytotoxicity | Cell viability | Cell surface | Experiments | FADD protein | Pathways | Lymphocytes | Peripheral blood | Tumor necrosis factor-TNF | Antigens | Immunoglobulins | Cytokines | Cultivation | Caspase | FasL protein | Tumor necrosis factor | Cell death | Lectins | Ligands | Mutation | Cancer | Apoptosis | Index Medicus
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