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Science, ISSN 0036-8075, 02/2018, Volume 359, Issue 6378, pp. 920 - 926
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1445 - 9
Journal Article
Gut, ISSN 0017-5749, 08/2018, Volume 67, Issue 8, pp. 1484 - 1492
Journal Article
The Journal of Pathology, ISSN 0022-3417, 11/2013, Volume 231, Issue 3, pp. 301 - 310
The incidence of oesophagogastric junctional (OGJ) adenocarcinoma is rising rapidly in western countries, in contrast to the declining frequency of distal... 
drug targets | exome sequencing | actionable mutations | subclonal mutations | oesophagogastric junctional adenocarcinoma | EXOME | GASTROESOPHAGEAL CANCER | MICROSATELLITE INSTABILITY | PATHOLOGY | TUMORS | SOMATIC MUTATIONS | ESOPHAGEAL ADENOCARCINOMA | ONCOLOGY | GASTRIC-CANCER | COLORECTAL-CANCER | GENES | CARCINOMA | Immunohistochemistry | MutL Protein Homolog 1 | Microsatellite Instability | Adenocarcinoma - pathology | Nuclear Proteins - analysis | Prospective Studies | Humans | Middle Aged | MutL Proteins | DNA Repair Enzymes - genetics | DNA-Binding Proteins - analysis | Male | Stomach Neoplasms - pathology | Esophageal Neoplasms - pathology | Loss of Heterozygosity - genetics | Polymerase Chain Reaction - methods | Adenosine Triphosphatases - analysis | DNA Mutational Analysis | Adult | Female | Adenocarcinoma - genetics | Mismatch Repair Endonuclease PMS2 | Stomach Neoplasms - chemistry | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Stomach Neoplasms - genetics | Esophagogastric Junction - pathology | DNA Copy Number Variations - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | DNA Repair Enzymes - analysis | Genome, Human - genetics | Adaptor Proteins, Signal Transducing - analysis | Exome - genetics | Esophageal Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | Neoplasm Proteins - analysis | Adenosine Triphosphatases - genetics | Aged | DNA, Neoplasm - genetics | Neoplasm Staging | Genetic aspects | Cancer | Tumors
Journal Article
Gastroenterology, ISSN 0016-5085, 03/2018, Volume 154, Issue 4, pp. 1066 - 1079.e5
Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that... 
Organoid | Bile Duct Cancer | DNAJB5 | AUY922 | BILIARY-TRACT CANCER | INTRAHEPATIC CHOLANGIOCARCINOMA | ADVANCED SOLID TUMORS | PANCREATIC-CANCER | ACQUIRED-RESISTANCE | I DOSE-ESCALATION | TYROSINE KINASE INHIBITORS | HSP90 INHIBITORS | PROSTATE-CANCER | GASTROENTEROLOGY & HEPATOLOGY | MICRORNA EXPRESSION | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Cholangiocarcinoma - metabolism | Dose-Response Relationship, Drug | Transfection | Organoids | Time Factors | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Bile Duct Neoplasms - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | HSP40 Heat-Shock Proteins - metabolism | Bile Duct Neoplasms - metabolism | HSP40 Heat-Shock Proteins - genetics | Isocitrate Dehydrogenase - genetics | Transcription Factors - genetics | Mice, SCID | Xenograft Model Antitumor Assays | Cholangiocarcinoma - pathology | Drug Resistance, Neoplasm - genetics | Animals | Cholangiocarcinoma - drug therapy | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | Cholangiocarcinoma - genetics | HSP90 Heat-Shock Proteins - metabolism | Mice, Inbred NOD | MicroRNAs - genetics | Bile Duct Neoplasms - pathology | Mutation | FFPE, formalin-fixed paraffin-embedded | FGFR, fibroblast growth factor receptor | WT, wild type | PDO, patient-derived organoid | GI, growth inhibition | miRNA, microRNA | HTS, high-throughput screen | DMSO, dimethyl sulfoxide | HSP, heat shock protein | iCCA, intrahepatic cholantiocarcinoma | CCA, cholangiocarcinoma
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 3_suppl, pp. 78 - 78
Journal Article
Journal Article
Journal Article
Asian Journal of Plant Sciences, ISSN 1682-3974, 10/2003, Volume 2, Issue 10, pp. 756 - 760
Journal Article
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