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Nature Immunology, ISSN 1529-2908, 2008, Volume 9, Issue 12, pp. 1347 - 1355
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 623 - 634
Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4 FoxP3 T regulatory (Treg) cell survival and T... 
EFFECTOR | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | TGF-BETA | IL-9 PRODUCTION | MAST-CELLS | IN-VIVO | GATA3 EXPRESSION | DIFFERENTIATION | IMMUNOLOGY | INTRACELLULAR DOMAIN | T-Lymphocytes, Regulatory - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Receptor, Notch2 - genetics | Smad3 Protein - metabolism | T-Lymphocytes, Regulatory - immunology | Interleukin-9 - biosynthesis | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-9 - metabolism | Jagged-2 Protein | Female | Cell Differentiation | Membrane Proteins - metabolism | Transforming Growth Factor beta | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Signal Transduction | Mice, Inbred C57BL | Receptor, Notch2 - metabolism | Cell Communication | Receptor, Notch1 - metabolism | Animals | Receptors, Interleukin-9 - genetics | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Receptor, Notch1 - genetics | Autoimmunity | Medical colleges | Antigens | Nervous system diseases | Interleukins | Analysis | Oncology, Experimental | Research | Transforming growth factors | T cells | Protein binding | Cancer | Ligands | Transcription factors | Mutagenesis | Mammals | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 02/2017, Volume 101, Issue 2, pp. 493 - 505
CD47 is known to play an important role in CD4+ T cell homeostasis. We recently reported a reduction in mice deficient in the Cd47 gene (Cd47−/−) CD4+ T cell... 
T lymphocytes | TCR activation | autoimmune | neuroinflammation | Neuroinflammation | Autoimmune | IMMUNE-RESPONSE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | DENDRITIC CELLS | TRANSENDOTHELIAL MIGRATION | ALPHA SIRP-ALPHA | IMMUNOLOGY | CELL BIOLOGY | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | CD47 BLOCKADE | HEMATOLOGY | EXPRESSION | Myelin-Oligodendrocyte Glycoprotein - immunology | Integrin alpha4beta1 - metabolism | Lymph Nodes - pathology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Lymphocyte Function-Associated Antigen-1 - metabolism | Adoptive Transfer | CD28 Antigens - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Female | Lymph Nodes - drug effects | Chemokines - pharmacology | Immunization | Encephalomyelitis, Autoimmune, Experimental - pathology | Receptors, Antigen, T-Cell - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | CD47 Antigen - metabolism | Antigen Presentation - immunology | Cell Adhesion - drug effects | Intercellular Adhesion Molecule-1 - metabolism | Animals | Lymphocyte Activation - drug effects | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Vascular Cell Adhesion Molecule-1 - metabolism | CD4-Positive T-Lymphocytes - drug effects | Cell proliferation | Oligodendrocyte-myelin glycoprotein | Encephalomyelitis | Leukocyte migration | Homeostasis | Activation | Lymphocytes T | VLA-4 antigen | LFA-1 antigen | Defects | Recruitment | T-cell receptor | Cell activation | Lymphocytes | Cell adhesion | Cell survival | Myelin | Glycoprotein | Crosslinking | T cell receptors | Adhesion | Experimental allergic encephalomyelitis | CD4 antigen | Mice | Auditory defects | Cell migration | Integrins | Inflammation, Extracellular Mediators, & Effector Molecules
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1248 - 1253
Interleukin-9 (IL-9) is a T cell cytokine that acts through a gamma C-family receptor on target cells and is associated with inflammation and allergy. We... 
MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | ANTITUMOR RESPONSES | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LARGE ESTABLISHED MELANOMA | CELL BIOLOGY | T(H)17 CELLS | IL-9 PRODUCTION | IN-VIVO | ROR-GAMMA | GROWTH | DIFFERENTIATION | T-Lymphocyte Subsets - immunology | Humans | Neoplasm Proteins - physiology | Receptors, Interleukin - deficiency | Vaccination | Carcinoma, Lewis Lung - immunology | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Gene Expression Profiling | Interleukin-9 - physiology | Interleukin-9 - biosynthesis | Melanoma, Experimental - immunology | Cancer Vaccines | Nuclear Receptor Subfamily 1, Group F, Member 3 - deficiency | Neoplasm Proteins - genetics | Melanoma - chemistry | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Interleukin-9 - analysis | Skin - immunology | Skin Neoplasms - pathology | Mast Cells - immunology | Immunotherapy, Adoptive | Skin Neoplasms - immunology | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Lymphatic Metastasis | Radiation Chimera | Melanoma - pathology | Tumor Burden | Mast Cells - drug effects | Receptors, Interleukin - genetics | Disease Progression | Homeodomain Proteins - genetics | Melanoma - secondary | Mice, Knockout | Animals | Interleukin-9 - genetics | Melanoma - immunology | T-Lymphocyte Subsets - metabolism | Carcinoma, Lewis Lung - pathology | Neoplasm Proteins - analysis | Mice | Lymphocytes, Tumor-Infiltrating - immunology | Care and treatment | Melanoma | Interleukin-9 | Genetic aspects | Cellular immunity | Research | Diagnosis | T cells | Health aspects | Metastasis | Cytokines | Gene expression | Lymphocytes | Skin cancer | Immune system
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2014, Volume 193, Issue 1, pp. 198 - 207
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 08/2012, Volume 37, Issue 2, pp. 249 - 263
Inflammation-mediated neurodegeneration occurs in the acute and the chronic phases of multiple sclerosis (MS) and its animal model, experimental autoimmune... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NITRIC-OXIDE PRODUCTION | INHIBITION | MULTIPLE-SCLEROSIS | PATHWAY | O-GLYCANS | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | T-CELLS | NEURONAL DYSFUNCTION | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Central Nervous System - metabolism | Galectin 1 - immunology | Leukocyte Common Antigens - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Galectin 1 - metabolism | NF-kappa B - metabolism | Central Nervous System - immunology | Multiple Sclerosis - physiopathology | Microglia - immunology | Female | Chemokine CCL2 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Multiple Sclerosis - metabolism | Microglia - cytology | Mice, Inbred C57BL | Mice, Knockout | Polysaccharides - metabolism | Encephalomyelitis, Autoimmune, Experimental - therapy | Animals | Galectin 1 - therapeutic use | Cyclic AMP Response Element-Binding Protein - metabolism | Multiple Sclerosis - immunology | Protein Binding | Mice | Central Nervous System - physiopathology | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Multiple sclerosis | Nervous system diseases | Neurosciences | Phosphatases | Analysis | Proteins | Statistical analysis | Neurodegeneration | Rodents | Lectins | Regulation | Kinases | Phosphatase | Immune system | Antigens, CD45 | Astrocytes | Nitric Oxide Synthase Type II | Tumor Necrosis Factor-alpha | Interleukin-6 | Microglia | Multiple Sclerosis | Life Sciences | Encephalomyelitis, Autoimmune, Experimental | Polysaccharides | NF-kappa B | Central Nervous System | Immunology | Chemokine CCL2 | Cyclic AMP Response Element-Binding Protein | p38 Mitogen-Activated Protein Kinases | Galectin 1
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2017, Volume 9, Issue 421, p. eaai7635
Microglia are emerging as a key cell type in neurodegenerative diseases, yet human microglia are challenging to study in vitro. We developed an in vitro cell... 
PLURIPOTENT STEM-CELLS | ADULT MICROGLIA | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | TGF-BETA | ALZHEIMERS-DISEASE | AMYLOID-BETA | CENTRAL-NERVOUS-SYSTEM | IDIOPATHIC PARKINSONS-DISEASE | BLOOD-BRAIN-BARRIER | MONOCYTE-DERIVED MICROGLIA | CELL BIOLOGY
Journal Article