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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2017, Volume 79, Issue 3, pp. 489 - 495
This phase 1 study evaluated the safety, tolerability, pharmacokinetics and efficacy of patritumab (U3-1287) Process 2, a new formulation of fully human... 
Medicine & Public Health | Patritumab | Anti-HER3 monoclonal antibody | Cancer Research | Oncology | Phase 1 study | Pharmacology/Toxicology | Pharmacokinetics | SURVIVAL | ADVANCED SOLID TUMORS | BREAST CARCINOMAS | TYROSINE KINASES | THERAPY | ERBB3 | ONCOLOGY | RESISTANCE | PHARMACOLOGY & PHARMACY | INHIBITOR | EXPRESSION | HER3 | Lung Neoplasms - genetics | Antibodies, Neutralizing - administration & dosage | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Injections, Intravenous | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Erlotinib Hydrochloride - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - administration & dosage | Biomarkers, Tumor - blood | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Receptor, ErbB-3 - immunology | Drug Compounding | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Chemotherapy | Epidermal growth factor | Erlotinib | Analysis | Monoclonal antibodies | Lung cancer, Small cell | Respiratory tract diseases | Skin | Lung cancer, Non-small cell | Cancer | Index Medicus | Original
Journal Article
Clinical Drug Investigation, ISSN 1173-2563, 6/2018, Volume 38, Issue 6, pp. 519 - 525
G protein-coupled receptor 119 (GPR119) agonists reduce plasma glucose by promoting insulin secretion in a glucose-dependent manner. We evaluated the safety... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | PHARMACOLOGY & PHARMACY | GLYCEMIC CONTROL | RELEASE | INSULIN-SECRETION | Peptides | Anemia | Glucose | Bioavailability | Males | Insulin | Studies | Proteins | Toxicology | Metabolites | Adults | Diabetes | Drug dosages | Endocrinology | Food | Index Medicus
Journal Article
European Journal of Cancer, ISSN 0959-8049, 11/2017, Volume 86, pp. 15 - 27
We have previously demonstrated that the prognostic significance of tumour-infiltrating CD8 T cells significantly differs according to histological type and... 
Adenocarcinoma | Immunosuppression | Smoking history | Tumour microenvironment | Non-small cell lung cancer | ACTIVATION | PD-1 BLOCKADE | MACROPHAGES | IMMUNOSCORE | CD8(+) T-CELLS | CANCER-THERAPY | RESPONSES | ONCOLOGY | FAVORABLE PROGNOSIS | EXPRESSION | Immunohistochemistry | Tumor Escape | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Lung Neoplasms - pathology | Male | T-Lymphocytes, Regulatory - immunology | Time Factors | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | GATA3 Transcription Factor - analysis | Macrophages - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | T-Lymphocytes, Cytotoxic - immunology | Carcinoma, Non-Small-Cell Lung - surgery | Biomarkers, Tumor - analysis | Carcinoma, Non-Small-Cell Lung - genetics | Adenocarcinoma - immunology | Kaplan-Meier Estimate | Gene Expression Profiling - methods | Carcinoma, Non-Small-Cell Lung - immunology | Disease-Free Survival | Lung Neoplasms - immunology | Forkhead Transcription Factors - analysis | Lung Neoplasms - surgery | Aged | Biomarkers, Tumor - genetics | CD8-Positive T-Lymphocytes - immunology | Adenocarcinoma - surgery | Lymphocytes, Tumor-Infiltrating - immunology | Interferon | Lung cancer, Non-small cell | T cells | Gene expression | Tumors | CD8 antigen | Lung cancer | Lung | Lymphocytes T | Macrophages | Metastases | Lymphocytes | Immunotherapy | Foxp3 protein | CCL17 protein | Cell survival | Immunoregulation | Non-small cell lung carcinoma | Patients | CD4 antigen | Immune systems | CD163 antigen | Immune checkpoint | Immunogenicity | γ-Interferon | GATA-3 protein | Infiltration | Smoking | Cancer | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2007, Volume 35, Issue 12, pp. 2166 - 2176
Olmesartan, a novel angiotensin II AT1-receptor antagonist, is excreted into both bile and urine, with minimal metabolism. Because olmesartan is a hydrophilic... 
PHARMACOKINETICS | INVOLVEMENT | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-4 | ORGANIC ANION TRANSPORTERS | EXCRETION | IDENTIFICATION | MEDOXOMIL | EXPRESSION | OATP1B1 | BLOCKER | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Membrane Transport Proteins - drug effects | Hepatocytes - metabolism | Imidazoles - pharmacokinetics | Neoplasm Proteins - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Sincalide - metabolism | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Prodrugs - metabolism | Tetrazoles - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Protein Isoforms - metabolism | Transfection | Liver - drug effects | Membrane Transport Proteins - genetics | Organic Anion Transporters, Sodium-Independent - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Imidazoles - metabolism | Olmesartan Medoxomil | Cell Line | Liver - metabolism | Probenecid - pharmacology | Penicillin G - pharmacology | Mice, Knockout | p-Aminohippuric Acid - pharmacology | Animals | Estrone - analogs & derivatives | Multidrug Resistance-Associated Proteins - deficiency | Prodrugs - pharmacokinetics | Estrone - metabolism | Dogs | Protein Binding | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | In Vitro Techniques | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Tetrazoles - pharmacokinetics | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 08/2012, Volume 46, Issue 5, pp. 367 - 373
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1533 - 1546
The ROP18 kinase has been identified as a key virulence determinant conferring a high mortality phenotype characteristic of type I Toxoplasma gondii strains.... 
MEDICINE, RESEARCH & EXPERIMENTAL | PARASITOPHOROUS VACUOLE | GAMMA-INTERFERON | IRG RESISTANCE GTPASES | PARASITE GENOTYPE | GENE-EXPRESSION | CD4(+) T-CELLS | INFECTION | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | TRANSCRIPTION FACTOR | MICE LACKING
Journal Article
Advances in Therapy, ISSN 0741-238X, 8/2018, Volume 35, Issue 8, pp. 1239 - 1250
The pharmacokinetics, safety, and tolerability of DS-8500a (a G protein receptor 119 agonist) up to 100 mg have been investigated in healthy Japanese adults.... 
Rheumatology | Internal Medicine | Oncology | DS-8500a | Hepatic impairment | Medicine & Public Health | Diabetes | Renal impairment | Safety | Cardiology | Pharmacology/Toxicology | Pharmacokinetics | Endocrinology | MEDICINE, RESEARCH & EXPERIMENTAL | GLYCEMIC CONTROL | PHARMACOLOGY & PHARMACY | GPR119 AGONIST | RELEASE
Journal Article
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2019, Volume 37, Issue 4_suppl, pp. 99 - 99
Journal Article
Journal Article
Clinical Drug Investigation, ISSN 1173-2563, 07/2019
BACKGROUNDNon-clinical study data suggest that DS-8500a, a G protein-coupled receptor 119 agonist, exhibits antidiabetic activity, inhibition of some... 
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A10941 - A10941
We previously showed that hepatic overexpression of endothelial lipase (EL) by adenoviral vectors markedly reduced plasma HDL levels but maintained macrophage... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 16, pp. 10945 - 10953
Journal Article