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Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, p. 4395
  In this paper, the authors revealed that newborns of dams exposed to low-protein diet (LP0.5) throughout pregnancy exhibited decreased insulin levels, a... 
Type 2 diabetes | Pancreatic beta cells | MicroRNA | Genetic aspects | Properties | Phosphotransferases | Risk factors | Transcription factors | Grants | Insulin | Pregnancy | Proteins | Studies | Nutrition research | Genotype & phenotype | Rodents | MicroRNAs | Cell cycle | DNA methylation | Diabetes | Metabolic disorders
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2019, Volume 294, Issue 35, pp. 13040 - 13050
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5745 - 11
Pancreatic beta-cells are exquisitely sensitive to developmental nutrient stressors, and alterations in nutrient sensing pathways may underlie changes observed... 
DIET | RAT | MULTIDISCIPLINARY SCIENCES | KINASE | RAF-1 | PREVENTS | BETA-CELL FUNCTION | PREGNANCY | Animal models | Calcium (intracellular) | Risk groups | Secretion | Diabetes mellitus | Body weight | Glucose | Gestation | Metabolism | Intrauterine exposure | Insulin | Potassium chloride | Glucose tolerance | Progeny | Metformin | Pancreas
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2006, Volume 103, Issue 51, pp. 19575 - 19580
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2008, Volume 283, Issue 4, p. 2407
The serine threonine kinase Raf-1 plays a protective role in many cell types, but its function in pancreatic β-cells has not been elucidated. In the present... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to... 
Obesity | Gels | Nonesterified fatty acids | Palmitates | Type 2 diabetes mellitus | Diabetes | Islets of Langerhans | Insulin | Fatty acids | Apoptosis | Type 2 diabetes | 2D difference gel electrophoresis proteomics | Hyperproinsulinemia | Mechanisms of β-cell lipotoxicity | Free fatty acids | LEVELS PREDICT | HUMAN PANCREATIC-ISLETS | ENZYME-ACTIVITY | MULTIDISCIPLINARY SCIENCES | mechanisms of beta-cell lipotoxicity | INSULIN-SECRETION | free fatty acids | ENDOPLASMIC-RETICULUM STRESS | type 2 diabetes | PYRUVATE-DEHYDROGENASE ACTIVITY | PROHORMONE CONVERTASES | FREE FATTY-ACIDS | LINE INS-1 | TRIGLYCERIDE ACCUMULATION | hyperproinsulinemia | Endoplasmic Reticulum - enzymology | Golgi Apparatus - enzymology | Cell Survival | Diabetes Mellitus, Type 2 - genetics | Humans | Cells, Cultured | Diabetes Mellitus, Type 2 - enzymology | Apoptosis - genetics | Proteome | Hyperglycemia - genetics | Insulin-Secreting Cells - ultrastructure | Animals | Insulin-Secreting Cells - drug effects | Mice, Mutant Strains | Palmitates - pharmacology | Carboxypeptidase H - metabolism | Hyperglycemia - enzymology | Hyperinsulinism - enzymology | Hyperinsulinism - genetics | Mice | Palmitates - metabolism | Carboxypeptidase H - genetics | Insulin-Secreting Cells - enzymology | Biological Sciences | mechanisms of β-cell lipotoxicity
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2008, Volume 7, Issue 10, pp. 1343 - 1347
Journal Article
BMC Cancer, ISSN 1471-2407, 11/2014, Volume 14, Issue 1, pp. 814 - 814
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2008, Volume 105, Issue 24, p. 8452
  Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used... 
Proteins | Obesity | Peptides | Diabetes | Cells | Apoptosis
Journal Article
Molecular Aspects of Medicine, ISSN 0098-2997, 04/2015, Volume 42, p. 19
Type 2 diabetes mellitus (T2D) is a complex disease characterized by [beta]-cell failure in the setting of insulin resistance. The current evidence suggests... 
Type 2 diabetes | Pancreatic beta cells | Insulin resistance
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2006, Volume 103, Issue 51, p. 19575
  Insulin is both a hormone regulating energy metabolism and a growth factor. We and others have shown that physiological doses of insulin initiate complex... 
Diabetes | Insulin | Cells | Apoptosis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, pp. 4395 - 4395
In this paper, the authors revealed that newborns of dams exposed to low-protein diet (LP0.5) throughout pregnancy exhibited decreased insulin levels, a lower... 
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 11/2018, Volume 315, Issue 5, pp. R867 - R878
The prevalence of obesity and type 2 (T2D) diabetes is a major health concern in the United States and around the world. T2D is a complex disease characterized... 
Diabetes | Islet | IUGR | Fetal programming | Insulin secretion | MAMMALIAN TARGET | PHYSIOLOGY | PRENATAL EXPOSURE | INSULIN-SECRETION | fetal programming | insulin secretion | islet | LOW-PROTEIN-DIET | MATERNAL LOW-PROTEIN | AMINO-ACID TRANSPORTER | ENDOCRINE PANCREAS | HORMONE-PROLACTIN | INTRAUTERINE GROWTH RESTRICTION | diabetes | GLUCOSE-TOLERANCE | Review
Journal Article