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Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 06/2017, Volume 27, Issue 6, pp. 691 - 706
Introduction: The pursuit of small molecule mGlu 5 NAMs as treatments for a variety of psychiatric and neurodegenerative disorders has developed into a mature... 
negative allosteric modulator | anxiety | levodopa-induced dyskinesia | Parkinson's disease | fragile X syndrome | dipraglurant | Basimglurant | depression | mavoglurant | metabotropic glutamate receptor subtype 5 | Parkinson’s disease
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 06/2017, Volume 27, Issue 6, pp. 691 - 706
Journal Article
Expert opinion on therapeutic patents, 06/2017, Volume 27, Issue 6, p. 691
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 04/2013, Volume 23, Issue 4, pp. 393 - 408
Journal Article
Chemical Reviews, ISSN 0009-2665, 06/2016, Volume 116, Issue 11, pp. 6707 - 6707
Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery, filled with therapeutic promise yet fraught with caveats.... 
Receptors | Modulation | Bias | Strategy | Ligands | Pharmacology | Glutamates | Modulators
Journal Article
Chemical Reviews, ISSN 0009-2665, 06/2016, Volume 116, Issue 11, p. 6707
  Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery, filled with therapeutic promise yet fraught with caveats.... 
Molecules | Ligands | Pharmacology
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 04/2011, Volume 2, Issue 8, pp. 411 - 432
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) have remained attractive to researchers as potential therapies for a... 
Journal Article
Cell, ISSN 0092-8674, 06/2015, Volume 161, Issue 6, pp. 1252 - 1265
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2015, Volume 112, Issue 4, p. 1196
  Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the... 
Brain | Biological variation | Mental disorders | Animal behavior | Rodents | Animal cognition
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 12/2017, Volume 42, Issue 13, pp. 2553 - 2566
Activation of beta-adrenergic receptors (beta ARs) enhances both the induction of long-term potentiation (LTP) in hippocampal CA1 pyramidal cells and... 
KNOCK-OUT MICE | ACTIVATION | PSYCHIATRY | A ADENOSINE | NEUROSCIENCES | EXCITATORY SYNAPTIC-TRANSMISSION | ENDOGENOUS ADENOSINE | CULTURED ASTROCYTES | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | NEGATIVE ALLOSTERIC MODULATOR | GROWTH-FACTOR | EXCITOTOXIC NEURONAL DEATH | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Memory Consolidation - drug effects | Tissue Culture Techniques | Male | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Hippocampus - cytology | Cerebral Cortex - cytology | Rats, Sprague-Dawley | Cerebral Cortex - metabolism | Mice, Inbred ICR | Memory Consolidation - physiology | Mice, Knockout | Hippocampus - metabolism | Animals | Long-Term Potentiation - drug effects | Receptors, Metabotropic Glutamate - genetics | Neurotransmitter Agents - pharmacology | Long-Term Potentiation - physiology | Cerebral Cortex - drug effects | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Potentiation | Memory | Cognitive ability | Activation | Glutamic acid receptors | Isoproterenol | Neuromodulation | Modulators | Accumulation | Receptors | Allosteric properties | Rodents | Plasticity | Propranolol | Astrocytes | Long-term potentiation | Cyclic AMP | Plasticity (hippocampal) | Signaling | Plasticity (synaptic) | Pyramidal cells | Adrenergic receptors | Glutamic acid receptors (metabotropic) | Receptors (physiology) | Hippocampus | Original
Journal Article
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