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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 4, pp. 1645 - 1661
Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important... 
IN-VITRO | CHEMISTRY, MEDICINAL | GSK-3 INHIBITORS | ASSAY | MECHANISM | MODELS | STRUCTURAL REQUIREMENTS | ANALOGS | DERIVATIVES | Microglia - metabolism | Humans | Cell Membrane Permeability | Nitrites - metabolism | Substrate Specificity | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Neurons - cytology | Structure-Activity Relationship | Neural Stem Cells - cytology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroprotective Agents - pharmacology | Swine | Thiadiazoles - chemistry | Imines - chemistry | Neurogenesis - drug effects | Neurons - metabolism | Cell Death - drug effects | Imines - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Neurons - drug effects | Thiadiazoles - pharmacology | Astrocytes - cytology | Microglia - cytology | Astrocytes - drug effects | Neuroprotective Agents - chemistry | Microglia - drug effects | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Membranes, Artificial | Models, Molecular | Rats | Hippocampus - cytology | Imines - pharmacology | Blood-Brain Barrier - metabolism | Neuroprotective Agents - chemical synthesis | Animals | Thiadiazoles - chemical synthesis | Cell Differentiation - drug effects | Lipopolysaccharides - pharmacology | Protein Binding | In Vitro Techniques | Astrocytes - metabolism
Journal Article
Synlett, ISSN 0936-5214, 10/2008, Volume 2008, Issue 17, pp. 2702 - 2704
Abstract A systematical investigation of the parameters influencing on mechanical processing, ball milling, of organic reactants has been carried out. As model... 
letter | Dihydrobenzopyran | Domino oxa-Michael-aldol reaction | Ball mill | Solvent-free | Tetrahydroxanthenone | domino oxa-Michael-aldol reaction | tetrahydroxanthenone | PROTOCOL | CHEMISTRY, ORGANIC | solvent-free | ALDEHYDES | MODEL | DIVERSONOL | TETRAHYDROXANTHENONES | CONDENSATION | ball mill | dihydrobenzopyran | ACCESS
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 1, pp. 495 - 510
The 2,4-disubstituted thiadiazolidinones (TDZD) were described as the first non-ATP competitive GSK-3β inhibitors. New modifications in this heterocyclic ring... 
GSK-3β inhibitor | Alzheimer disease | 1,2,4-Thiadiazole | TAU-PROTEIN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CHEMISTRY, ORGANIC | THIOUREAS | FACILE SYNTHESIS | 1,2,4-THIADIAZOLES | GSK-3 beta inhibitor | THERAPEUTIC TARGET | NITRILE SULFIDES | DRUG TARGET | INHIBITORS | 1,2,4-thiadiazole
Journal Article
RSC Drug Discovery Series, ISSN 2041-3203, 2016, Volume 2016-, Issue 50, pp. 132 - 146
Journal Article
Synthesis, ISSN 0039-7881, 7/2007, Volume 2007, Issue 14, pp. 2175 - 2185
Abstract A convenient route for the versatile preparation of 5-substituted 4-hydroxycyclohex-2-enones via the addition of an organocuprate to a... 
paper
Journal Article
European journal of organic chemistry, ISSN 1434-193X, 2014, Volume 2014, Issue 22, pp. 4861 - 4875
Mycotoxins of the tetrahydroxanthone class of natural products possess a large number of interesting biological properties. In this full paper, we present our... 
Domino reactions | Natural ­products | Total synthesis | Michael ­addition | Lactones | Michael addition | Natural products | CYANOTRIMETHYLSILANE | CHEMISTRY, ORGANIC | ALDEHYDES | REGIOSELECTIVITY | PERIODATE-PERMANGANATE OXIDATIONS | ALCOHOLS | ESTERS | SECALONIC ACID-D | TERATOGENICITY | CONJUGATE ADDITIONS | ACCESS | Synthesis | Oxalic acid | Crystals | Singers | Structure | Organic compounds
Journal Article
11/2007, Volume 2007, Issue 33, 6
The 1,2,4‐thiadiazole system was the subject of our research as a consequence of the pharmacological activity of some derivatives as GSK3 inhibitors.... 
Tautomerism | Density functional calculations | Sulfur heterocycles | Nitrogen heterocycles | tautomerism | density functional calculations | ENERGY | GSK-3 INHIBITORS | SOLVENTS | nitrogen heterocycles | sulfur heterocycles | GLYCOGEN-SYNTHASE KINASE-3 | DRUGS | CHEMISTRY, ORGANIC | DERIVATIVES
Book Review
European journal of organic chemistry, ISSN 1434-193X, 08/2014, Volume 2014, Issue 22, pp. 4861 - 4875
Journal Article
Chemical reviews, ISSN 0009-2665, 09/2009, Volume 109, Issue 9, p. 3903
  A study examining the chemistry and biology of mycotoxins and related fungal metaboslistes is presented. Some of the toxic fungal metabolites have been found... 
Fungi | Metabolites | Toxins | Molecular biology | Pharmaceutical sciences
Journal Article
11/2015, RSC drug discovery, ISBN 9781782620303, 487
One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds.... 
Other branches of medicine | Pharmaceutical chemistry | Life Sciences | Science | Biochemistry | Drug development | Molecular pharmacology
eBook
ChemInform, ISSN 0931-7597, 03/2015, Volume 46, Issue 10, pp. no - no
...ChemInform Abstract Scheme   Anne C. Meister , Arantxa Encinas , Huelya Sahin , Emilie M. C. Singer , Carl F. Nising , Martin Nieger , Stefan Braese , Total... 
other bioactive products | benzopyran derivatives | Synthesis | Organic compounds
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. LB-294 - LB-294
Journal Article
Synthesis, ISSN 0039-7881, 07/2007, Issue 14, pp. 2175 - 2185
A convenient route for the versatile preparation of 5-substituted 4-hydroxycyclohex-2-enones via the addition of an organocuprate to a cyclohex-2-enone is... 
Cyclohexenone | Michael addition | Natural products | Stereoselective synthesis | Domino reaction | cyclohexenone | natural products | METABOLITES | SECALONIC ACIDS | stereoselective synthesis | CHEMISTRY, ORGANIC | MUTTERKORN-FARBSTOFFE | domino reaction
Journal Article
ChemInform, ISSN 0931-7597, 12/2009, Volume 40, Issue 50, pp. no - no
...ChemInform Abstract [ca. 1100 refs.].   Stefan Braese , Arantxa Encinas , Julia Keck , Carl F. Nising , ChemInform Abstract: Chemistry and Biology... 
other bioactive products | biochemistry, review
Journal Article
ChemInform, ISSN 0931-7597, 06/2007, Volume 38, Issue 24, pp. no - no
...ChemInform Abstract [60 refs.].   Nicole Jung , Arantxa Encinas , Stefan Braese , Automated Synthesis of Heterocycles on Solid Supports , Curr. Opin. Drug... 
general (heterocyclic compounds) | organic chemistry, review | solid‐phase synthesis
Journal Article
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