Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7503, pp. 162 - 166
PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been identified as the causal genes responsible for hereditary recessive...
MITOCHONDRIAL TRANSLOCATION | RECRUITMENT | DEFECTS | COMPLEX | DOMAIN | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DYSFUNCTION | MUTATIONS | DROSOPHILA-PINK1 | Protein Kinases - metabolism | Phosphorylation | Humans | Ubiquitin - chemistry | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Mutation - genetics | Phosphoserine - metabolism | Parkinson Disease | Ubiquitination | Animals | Membrane Potential, Mitochondrial | Fibroblasts | Mice | Enzyme Activation | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Parkinsonism | Physiological aspects | Genetic aspects | Phosphotransferases | Proteins | Studies | Cell culture | Mitochondria | Parkinsons disease | Mutation | Kinases
MITOCHONDRIAL TRANSLOCATION | RECRUITMENT | DEFECTS | COMPLEX | DOMAIN | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DYSFUNCTION | MUTATIONS | DROSOPHILA-PINK1 | Protein Kinases - metabolism | Phosphorylation | Humans | Ubiquitin - chemistry | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Mutation - genetics | Phosphoserine - metabolism | Parkinson Disease | Ubiquitination | Animals | Membrane Potential, Mitochondrial | Fibroblasts | Mice | Enzyme Activation | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Parkinsonism | Physiological aspects | Genetic aspects | Phosphotransferases | Proteins | Studies | Cell culture | Mitochondria | Parkinsons disease | Mutation | Kinases
Journal Article
1984, 16 leaves.
Book
Traffic, ISSN 1398-9219, 09/2014, Volume 15, Issue 9, pp. 933 - 945
In eukaryotic cells, complex membrane structures called organelles are highly developed to exert specialized functions. Mitochondria are one of such organelles...
membrane contact site | Ups protein | flippase | scramblase | mitochondria | ERMES | phospholipid | cardiolipin | Membrane contact site | Mitochondria | Phospholipid | Cardiolipin | Scramblase | Flippase | PHOSPHATIDYLSERINE TRANSPORT | INNER MEMBRANE | CARDIOLIPIN BIOSYNTHESIS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | PHOSPHATIDYLINOSITOL SYNTHASE | OUTER-MEMBRANE PROTEIN | INTERMEMBRANE-SPACE-PROTEIN | DYNAMIN-RELATED GTPASE | ENDOPLASMIC-RETICULUM | LIPID-TRANSFER | Endoplasmic Reticulum - metabolism | Biological Transport - physiology | Membrane Proteins - metabolism | Mitochondria - metabolism | Phospholipids - metabolism | Mitochondrial Membranes - metabolism | Membranes | Rodents
membrane contact site | Ups protein | flippase | scramblase | mitochondria | ERMES | phospholipid | cardiolipin | Membrane contact site | Mitochondria | Phospholipid | Cardiolipin | Scramblase | Flippase | PHOSPHATIDYLSERINE TRANSPORT | INNER MEMBRANE | CARDIOLIPIN BIOSYNTHESIS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | PHOSPHATIDYLINOSITOL SYNTHASE | OUTER-MEMBRANE PROTEIN | INTERMEMBRANE-SPACE-PROTEIN | DYNAMIN-RELATED GTPASE | ENDOPLASMIC-RETICULUM | LIPID-TRANSFER | Endoplasmic Reticulum - metabolism | Biological Transport - physiology | Membrane Proteins - metabolism | Mitochondria - metabolism | Phospholipids - metabolism | Mitochondrial Membranes - metabolism | Membranes | Rodents
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2018, Volume 37, Issue 4, p. n/a
Lipid trafficking is essential for biogenesis and maintenance of eukaryotic organelles. In this issue of The EMBO Journal, Saita et al () revealed that...
PHOSPHATIDYLCHOLINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Mitochondria | Intracellular Membranes | Membranes | Lecithin | Microbiology | Proteolysis | Lipids | Biosynthesis | Cytosol | Organelles | Metabolism | Membrane & Intracellular Transport | Views
PHOSPHATIDYLCHOLINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Mitochondria | Intracellular Membranes | Membranes | Lecithin | Microbiology | Proteolysis | Lipids | Biosynthesis | Cytosol | Organelles | Metabolism | Membrane & Intracellular Transport | Views
Journal Article
Current Genetics, ISSN 0172-8083, 10/2019, Volume 65, Issue 5, pp. 1161 - 1163
Mitochondrial biogenesis and functions rely on transport of their resident proteins as well as small molecules/ions across their membranes. The TOM complex...
Biochemistry, general | Porin | Microbiology | Protein import | Cell Biology | Life Sciences | Mitochondria | TOM complex | Microbial Genetics and Genomics | Proteomics | Plant Sciences | Translocator | Assembly | OUTER-MEMBRANE | GENETICS & HEREDITY | Metabolites | Biosynthesis | Porins | Proteins | Membranes | Trimers | Dimers | Transport | Protein transport | Substrates
Biochemistry, general | Porin | Microbiology | Protein import | Cell Biology | Life Sciences | Mitochondria | TOM complex | Microbial Genetics and Genomics | Proteomics | Plant Sciences | Translocator | Assembly | OUTER-MEMBRANE | GENETICS & HEREDITY | Metabolites | Biosynthesis | Porins | Proteins | Membranes | Trimers | Dimers | Transport | Protein transport | Substrates
Journal Article
Nature Communications, ISSN 2041-1723, 08/2015, Volume 6, Issue 1, p. 7922
Eukaryotic cells are compartmentalized into membrane-bounded organelles whose functions rely on lipid trafficking to achieve membrane-specific compositions of...
SYNTHASE | SYSTEM | YEAST | INTERMEMBRANE-SPACE | PROTEIN | METABOLISM | UPS1P | MULTIDISCIPLINARY SCIENCES | INTRAMITOCHONDRIAL TRANSPORT | PHOSPHATIDIC-ACID | CARDIOLIPIN BIOSYNTHESIS | Protein Structure, Tertiary | Crystallization | Crystallography, X-Ray | Immunoblotting | Mitochondria - metabolism | Mitochondrial Membranes - metabolism | Mitochondrial Proteins - metabolism | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Phosphatidic Acids - metabolism | Liposomes | Phospholipids - metabolism | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins - chemistry
SYNTHASE | SYSTEM | YEAST | INTERMEMBRANE-SPACE | PROTEIN | METABOLISM | UPS1P | MULTIDISCIPLINARY SCIENCES | INTRAMITOCHONDRIAL TRANSPORT | PHOSPHATIDIC-ACID | CARDIOLIPIN BIOSYNTHESIS | Protein Structure, Tertiary | Crystallization | Crystallography, X-Ray | Immunoblotting | Mitochondria - metabolism | Mitochondrial Membranes - metabolism | Mitochondrial Proteins - metabolism | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Phosphatidic Acids - metabolism | Liposomes | Phospholipids - metabolism | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
The Journal of Biochemistry, ISSN 0021-924X, 02/2019, Volume 165, Issue 2, pp. 115 - 123
Abstract Since the 1950s, electron microscopic observations have suggested the existence of special regions where the distinct organelle membranes are closely...
PHOSPHATIDYLSERINE TRANSPORT | COMPLEX | vacuole | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMITOCHONDRIAL TRANSPORT | vCLAMP | YEAST | ORGANIZATION | OUTER-MEMBRANE PROTEIN | STRUCTURAL BASIS | BINDING PROTEINS | MAM | PHOSPHOLIPID TRANSFER | ERMES | phospholipid | ER-MITOCHONDRIA
PHOSPHATIDYLSERINE TRANSPORT | COMPLEX | vacuole | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMITOCHONDRIAL TRANSPORT | vCLAMP | YEAST | ORGANIZATION | OUTER-MEMBRANE PROTEIN | STRUCTURAL BASIS | BINDING PROTEINS | MAM | PHOSPHOLIPID TRANSFER | ERMES | phospholipid | ER-MITOCHONDRIA
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2009, Volume 185, Issue 6, pp. 1029 - 1045
Cardiolipin, a unique phospholipid composed of four fatty acid chains, is located mainly in the mitochondrial inner membrane (IM). Cardiolipin is required for...
Yeasts | Mitochondria | Cell growth | Stem cells | Protein precursors | Immunoblotting | Phospholipids | Physiological regulation | Imports | Cardiolipins | YEAST MITOCHONDRIA | OUTER-MEMBRANE PROTEIN | PRESEQUENCE TRANSLOCASE | TIM23 PREPROTEIN TRANSLOCASE | INNER-MEMBRANE | DYNAMIN-RELATED GTPASE | RESPIRATORY-CHAIN SUPERCOMPLEXES | PROTEIN IMPORT MOTOR | INTERMEMBRANE SPACE PROTEIN | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Amino Acid Sequence | Membrane Proteins - genetics | Molecular Sequence Data | Cardiolipins - metabolism | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Mitochondria - ultrastructure | Protein Isoforms - metabolism | Membrane Transport Proteins - genetics | Mitochondrial Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Phospholipids - metabolism | Protein Isoforms - genetics
Yeasts | Mitochondria | Cell growth | Stem cells | Protein precursors | Immunoblotting | Phospholipids | Physiological regulation | Imports | Cardiolipins | YEAST MITOCHONDRIA | OUTER-MEMBRANE PROTEIN | PRESEQUENCE TRANSLOCASE | TIM23 PREPROTEIN TRANSLOCASE | INNER-MEMBRANE | DYNAMIN-RELATED GTPASE | RESPIRATORY-CHAIN SUPERCOMPLEXES | PROTEIN IMPORT MOTOR | INTERMEMBRANE SPACE PROTEIN | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Amino Acid Sequence | Membrane Proteins - genetics | Molecular Sequence Data | Cardiolipins - metabolism | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Mitochondria - ultrastructure | Protein Isoforms - metabolism | Membrane Transport Proteins - genetics | Mitochondrial Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Phospholipids - metabolism | Protein Isoforms - genetics
Journal Article
Biological Chemistry, ISSN 1431-6730, 08/2009, Volume 390, Issue 8, pp. 723 - 730
Mitochondria are two-membrane bounded organelles consisting of 1000-2000 different proteins, most of which are synthesized in the cytosol and subsequently...
Mitochondria | Motor protein | Chaperone | Protein import | Presequence | Protein sorting | Translocator | PRESEQUENCE TRANSLOCASE | motor protein | mitochondria | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | translocator | protein sorting | FUNCTIONAL COOPERATION | GENERAL IMPORT PORE | YEAST MITOCHONDRIA | OUTER-MEMBRANE PROTEINS | chaperone | STRUCTURAL BASIS | presequence | INNER-MEMBRANE | protein import | PREPROTEIN TRANSLOCASE | INTERMEMBRANE SPACE | Mitochondrial Membrane Transport Proteins - metabolism | Humans | Nuclear Proteins - metabolism | Mitochondria - metabolism | Protein Folding | Electron Transport Complex IV - metabolism | Mitochondrial Membranes - metabolism | Protein Transport | Mitochondrial Proteins - metabolism | Models, Biological | Cytosol - metabolism | HSP70 Heat-Shock Proteins - physiology | Molecular Motor Proteins - metabolism | Chemical properties | Carrier proteins | Structure
Mitochondria | Motor protein | Chaperone | Protein import | Presequence | Protein sorting | Translocator | PRESEQUENCE TRANSLOCASE | motor protein | mitochondria | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | translocator | protein sorting | FUNCTIONAL COOPERATION | GENERAL IMPORT PORE | YEAST MITOCHONDRIA | OUTER-MEMBRANE PROTEINS | chaperone | STRUCTURAL BASIS | presequence | INNER-MEMBRANE | protein import | PREPROTEIN TRANSLOCASE | INTERMEMBRANE SPACE | Mitochondrial Membrane Transport Proteins - metabolism | Humans | Nuclear Proteins - metabolism | Mitochondria - metabolism | Protein Folding | Electron Transport Complex IV - metabolism | Mitochondrial Membranes - metabolism | Protein Transport | Mitochondrial Proteins - metabolism | Models, Biological | Cytosol - metabolism | HSP70 Heat-Shock Proteins - physiology | Molecular Motor Proteins - metabolism | Chemical properties | Carrier proteins | Structure
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7637 - 11
Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by...
PATHWAYS | BINDING-SPECIFICITY | YEAST MITOCHONDRIA | TRANSLOCATION | PRECURSOR PROTEINS | HSP70 | MULTIDISCIPLINARY SCIENCES | MOTOR | OUTER | TIM23 | PREPROTEINS | Proteins | Mitochondria | Protein folding | Hsp70 protein | Membrane potential | Hydrophobicity | Protein transport | Membrane proteins
PATHWAYS | BINDING-SPECIFICITY | YEAST MITOCHONDRIA | TRANSLOCATION | PRECURSOR PROTEINS | HSP70 | MULTIDISCIPLINARY SCIENCES | MOTOR | OUTER | TIM23 | PREPROTEINS | Proteins | Mitochondria | Protein folding | Hsp70 protein | Membrane potential | Hydrophobicity | Protein transport | Membrane proteins
Journal Article
EMBO reports, ISSN 1469-221X, 06/2014, Volume 15, Issue 6, pp. 670 - 677
The membrane topology of Om45 in the yeast mitochondrial outer membrane (OM) is under debate. Here, we confirm that Om45 is anchored to the OM from the...
Om45 | translocator | mitochondria | yeast | TIM50 | PRESEQUENCE TRANSLOCASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Mitochondrial Membrane Transport Proteins - metabolism | Saccharomyces cerevisiae - genetics | Electrophoresis, Polyacrylamide Gel | Models, Molecular | Immunoblotting | Mitochondrial Membranes - metabolism | Saccharomyces cerevisiae - metabolism | Fluorescent Antibody Technique | Saccharomyces cerevisiae Proteins - metabolism | Hydrophobic and Hydrophilic Interactions | Membrane Potential, Mitochondrial - physiology | Octoxynol | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Mitochondria | Membranes | Bacterial proteins | Bacteriology | Scientific Reports
Om45 | translocator | mitochondria | yeast | TIM50 | PRESEQUENCE TRANSLOCASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Mitochondrial Membrane Transport Proteins - metabolism | Saccharomyces cerevisiae - genetics | Electrophoresis, Polyacrylamide Gel | Models, Molecular | Immunoblotting | Mitochondrial Membranes - metabolism | Saccharomyces cerevisiae - metabolism | Fluorescent Antibody Technique | Saccharomyces cerevisiae Proteins - metabolism | Hydrophobic and Hydrophilic Interactions | Membrane Potential, Mitochondrial - physiology | Octoxynol | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Mitochondria | Membranes | Bacterial proteins | Bacteriology | Scientific Reports
Journal Article
BIOCHEMICAL SOCIETY TRANSACTIONS, ISSN 0300-5127, 10/2019, Volume 47, Issue 5, pp. 1269 - 1277
Mitochondria are essential eukaryotic organelles responsible for primary cellular energy production. Biogenesis, maintenance, and functions of mitochondria...
UPS2-MDM35 | YEAST | OUTER-MEMBRANE | TRANSLOCATION | IMPORT | TOM CORE COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPID TRANSFER | PHOSPHATIDIC-ACID | UPS1-MDM35 | INSIGHTS
UPS2-MDM35 | YEAST | OUTER-MEMBRANE | TRANSLOCATION | IMPORT | TOM CORE COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPID TRANSFER | PHOSPHATIDIC-ACID | UPS1-MDM35 | INSIGHTS
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 6175 - 13
Functional integrity of eukaryotic organelles relies on direct physical contacts between distinct organelles. However, the entity of organelle-tethering...
YEAST | GREEN FLUORESCENT PROTEIN | MITOCHONDRIAL OUTER-MEMBRANE | NUCLEUS-VACUOLE JUNCTIONS | DNA | MULTIDISCIPLINARY SCIENCES | ER-MITOCHONDRIA | LIPID HOMEOSTASIS | SACCHAROMYCES-CEREVISIAE | MTDNA NUCLEOIDS | CELLULAR-METABOLISM | Mitochondria | Peroxisomes | Organelles | Mammalian cells
YEAST | GREEN FLUORESCENT PROTEIN | MITOCHONDRIAL OUTER-MEMBRANE | NUCLEUS-VACUOLE JUNCTIONS | DNA | MULTIDISCIPLINARY SCIENCES | ER-MITOCHONDRIA | LIPID HOMEOSTASIS | SACCHAROMYCES-CEREVISIAE | MTDNA NUCLEOIDS | CELLULAR-METABOLISM | Mitochondria | Peroxisomes | Organelles | Mammalian cells
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 2010, Volume 1803, Issue 6, pp. 706 - 714
Mitochondria are surrounded by two biological membranes. The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB/SAM...
Mitochondria | Receptor | Protein import | Outer membrane | Chaperone | Translocator | IMPORT RECEPTORS TOM20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETING SEQUENCES | RAT-LIVER CYTOSOL | CELL BIOLOGY | TAIL-ANCHORED PROTEINS | YEAST MITOCHONDRIA | PRECURSOR PROTEINS | ASSEMBLY MACHINERY | BETA-BARREL PROTEINS | PREPROTEIN TRANSLOCASE | NEUROSPORA-CRASSA | Mitochondrial DNA | Membrane proteins
Mitochondria | Receptor | Protein import | Outer membrane | Chaperone | Translocator | IMPORT RECEPTORS TOM20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETING SEQUENCES | RAT-LIVER CYTOSOL | CELL BIOLOGY | TAIL-ANCHORED PROTEINS | YEAST MITOCHONDRIA | PRECURSOR PROTEINS | ASSEMBLY MACHINERY | BETA-BARREL PROTEINS | PREPROTEIN TRANSLOCASE | NEUROSPORA-CRASSA | Mitochondrial DNA | Membrane proteins
Journal Article