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1. Full Text Fatal myelotoxicity following palliative chemotherapy with cisplatin and gemcitabine in a patient with Stage IV cholangiocarcinoma linked to post mortem diagnosis of fanconi anemia
by Engel, Nils W and Schliffke, Simon and Schüller, Ulrich and Frenzel, Christian and Bokemeyer, Carsten and Kubisch, Christian and Lessel, Davor
Frontiers in Oncology, ISSN 2234-943X, 2019, Volume 9, Issue MAY, p. 420
Unrecognized genome instability syndromes can potentially impede the rational treatment of cancer in rare patients. Identification of cancer patients with a... 
FANCA | myelotoxicity | fanconi anemia | genomic instability | cholangiocarcinoma | CHROMOSOME BREAKAGE | TOXICITY | CANCER | FLUDARABINE | ANDROGEN THERAPY | MALIGNANCY | ONCOLOGY | MUTATIONS | CARCINOMA | REGISTRY | Chemotherapy | Usage | Gemcitabine | Myelosuppression | Dosage and administration | Diagnosis | Research | Cisplatin | Fanconi's anemia | Cancer
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2. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Adriana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Rodriguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, Jürgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Andreas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and Driever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and Von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Gudrun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 469 - 474
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous... 
MOLECULAR CLASSIFICATION | MULTICENTER | ENTITY | GLIOMA | MULTIDISCIPLINARY SCIENCES | PILOCYTIC ASTROCYTOMA | CLASS PROBABILITY ESTIMATION | SUBGROUPS | MEDULLOBLASTOMA | EXPRESSION | BIOCONDUCTOR | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA
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3. Full Text Canonical Wnt signaling drives tumor-like lesions from Sox2-Positive precursors of the murine olfactory epithelium
by Engel, Nils W and Neumann, Julia E and Ahlfeld, Julia and Wefers, Annika K and Merk, Daniel J and Ohli, Jasmin and Schüller, Ulrich
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0166690
Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt... 
BETA-CATENIN GENE | PROGENITOR CELLS | STEM-CELLS | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | SMALL-INTESTINE | SINONASAL HEMANGIOPERICYTOMA | PROLIFERATION | MUTATIONS | EXPRESSION | CARCINOMA | Cell Proliferation | Wnt Signaling Pathway - physiology | Mice, Transgenic | Olfactory Mucosa - metabolism | Wnt Proteins - metabolism | Nose Neoplasms - genetics | beta Catenin - metabolism | beta Catenin - genetics | SOXB1 Transcription Factors - metabolism | Phosphorylation - genetics | Animals | Hyperplasia - genetics | Tamoxifen - pharmacology | Female | Mice | Enzyme Activation | Physiological aspects | Development and progression | Genetic engineering | Research | Epithelium | Wnt proteins | Tumors | Cell proliferation | CTNNB1 gene | Pediatrics | Phosphorylation | Wnt protein | Laboratories | Neuropathology | Pathogenesis | Hyperplasia | Stem cell transplantation | Activation | Neuroblastoma | Gene deletion | Neurogenesis | Stains & staining | Clonal deletion | Precursors | Transgenic animals | Rodents | Nose | Deletion | Lesions | Age | Immunoglobulins | Internal medicine | Transgenic mice | Embryos | Pathology | Signaling | Brain research | Stem cells | Mutation | Olfactory epithelium | Cancer | Apoptosis
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4. Full Text DNA methylation-based reclassification of olfactory neuroblastoma
by Capper, David and Engel, Nils W and Stichel, Damian and Lechner, Matt and Glöss, Stefanie and Schmid, Simone and Koelsche, Christian and Schrimpf, Daniel and Niesen, Judith and Wefers, Annika K and Jones, David T. W and Sill, Martin and Weigert, Oliver and Ligon, Keith L and Olar, Adriana and Koch, Arend and Forster, Martin and Moran, Sebastian and Tirado, Oscar M and Sáinz-Jaspeado, Miguel and Mora, Jaume and Esteller, Manel and Alonso, Javier and del Muro, Xavier Garcia and Paulus, Werner and Felsberg, Jörg and Reifenberger, Guido and Glatzel, Markus and Frank, Stephan and Monoranu, Camelia M and Lund, Valerie J and von Deimling, Andreas and Pfister, Stefan and Buslei, Rolf and Ribbat-Idel, Julika and Perner, Sven and Gudziol, Volker and Meinhardt, Matthias and Schüller, Ulrich
Acta Neuropathologica, ISSN 0001-6322, 8/2018, Volume 136, Issue 2, pp. 255 - 271
Olfactory neuroblastoma/esthesioneuroblastoma (ONB) is an uncommon neuroectodermal neoplasm thought to arise from the olfactory epithelium. Little is known... 
Medicine & Public Health | Pathology | Neurosciences | DIFFERENTIAL-DIAGNOSIS | SINONASAL TRACT | PHENOTYPE | PATHOLOGY | TUMORS | NEUROSCIENCES | CLINICAL NEUROLOGY | MOLECULAR CLASSIFICATION | ESTHESIONEUROBLASTOMA | NEUROENDOCRINE CARCINOMA | CENTRAL-NERVOUS-SYSTEM | MUTATIONS | COMPARATIVE GENOMIC HYBRIDIZATION | Immunohistochemistry | Medical colleges | Squamous cell carcinoma | Genomics | Genomes | Keratin | Methyltransferases | Gene mutations | Analysis | DNA | Diagnosis | Tumor proteins | Methylation | Adenocarcinoma | Cytokeratin | Phenotypes | Copy number | p53 Protein | Embedding | Neuroblastoma | Epithelium | Reclassification | Chromosome 1 | DNA methylation | Stochasticity | Mutation | DNA fingerprinting | Olfactory epithelium | Deoxyribonucleic acid--DNA | DNA sequencing | CpG islands | Tumors
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5. Full Text Correction to: DNA methylation-based reclassification of olfactory neuroblastoma
by Capper, David and Engel, Nils W and Stichel, Damian and Lechner, Matt and Glöss, Stefanie and Schmid, Simone and Kölsche, Christian and Schrimpf, Daniel and Niesen, Judith and Wefers, Annika K and Jones, David T. W and Sill, Martin and Weigert, Oliver and Ligon, Keith L and Olar, Adriana and Koch, Arend and Forster, Martin and Moran, Sebastian and Tirado, Oscar M and Sáinz-Jaspeado, Miguel and Mora, Jaume and Esteller, Manel and Alonso, Javier and del Muro, Xavier Garcia and Paulus, Werner and Felsberg, Jörg and Reifenberger, Guido and Glatzel, Markus and Frank, Stephan and Monoranu, Camelia M and Lund, Valerie J and von Deimling, Andreas and Pfister, Stefan and Buslei, Rolf and Ribbat-Idel, Julika and Perner, Sven and Gudziol, Volker and Meinhardt, Matthias and Schüller, Ulrich
Acta Neuropathologica, ISSN 0001-6322, 9/2018, Volume 136, Issue 3, pp. 505 - 505
In the original publication, the second name of the twentieth author was incorrect. It should read as ‘Miguel Sáinz-Jaspeado’. The original publication of the... 
Medicine & Public Health | Pathology | Neurosciences | Methylation | DNA | DNA methylation | Neuroblastoma | Reclassification
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6. Full Text Unexpected success of watch and wait strategy in a ponatinib-intolerant patient with chronic myeloid leukemia
by Engel, Nils W and Constantin, André and Fowlkes, Sabrina and Assouline, Sarit
Journal of Oncology Practice, ISSN 1554-7477, 06/2016, Volume 12, Issue 6, pp. 592 - 594
TYROSINE KINASE INHIBITORS | ABL | ONCOLOGY | MUTATION | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Humans | Imidazoles - adverse effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | Treatment Outcome | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Remission Induction | Fusion Proteins, bcr-abl - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis | Time Factors | Antineoplastic Agents - adverse effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Watchful Waiting | Aged | Pyridazines - adverse effects
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7. Full Text Genomic Classification of Cutaneous Melanoma
by Akbani, Rehan and Akdemir, Kadir C and Aksoy, B. Arman and Albert, Monique and Ally, Adrian and Amin, Samirkumar B and Arachchi, Harindra and Arora, Arshi and Auman, J. Todd and Ayala, Brenda and Baboud, Julien and Balasundaram, Miruna and Balu, Saianand and Barnabas, Nandita and Bartlett, John and Bartlett, Pam and Bastian, Boris C and Baylin, Stephen B and Behera, Madhusmita and Belyaev, Dmitry and Benz, Christopher and Bernard, Brady and Beroukhim, Rameen and Bir, Natalie and Black, Aaron D and Bodenheimer, Tom and Boice, Lori and Boland, Genevieve M and Bono, Riccardo and Bootwalla, Moiz S and Bosenberg, Marcus and Bowen, Jay and Bowlby, Reanne and Bristow, Christopher A and Brockway-Lunardi, Laura and Brooks, Denise and Brzezinski, Jakub and Bshara, Wiam and Buda, Elizabeth and Burns, William R and Butterfield, Yaron S.N and Button, Michael and Calderone, Tiffany and Cappellini, Giancarlo Antonini and Carter, Candace and Carter, Scott L and Cherney, Lynn and Cherniack, Andrew D and Chevalier, Aaron and Chin, Lynda and Cho, Juok and Cho, Raymond J and Choi, Yoon-La and Chu, Andy and Chudamani, Sudha and Cibulskis, Kristian and Ciriello, Giovanni and Clarke, Amanda and Coons, Stephen and Cope, Leslie and Crain, Daniel and Curley, Erin and Danilova, Ludmila and D’Atri, Stefania and Davidsen, Tanja and Davies, Michael A and Delman, Keith A and Demchok, John A and Deng, Qixia A and Deribe, Yonathan Lissanu and Dhalla, Noreen and Dhir, Rajiv and DiCara, Daniel and Dinikin, Michael and Dubina, Michael and Ebrom, J. Stephen and Egea, Sophie and Eley, Greg and Engel, Jay and Eschbacher, Jennifer M and Fedosenko, Konstantin V and Felau, Ina and Fennell, Timothy and Ferguson, Martin L and Fisher, Sheila and Flaherty, Keith T and Frazer, Scott and Frick, Jessica and Fulidou, Victoria and Gabriel, Stacey B and Gao, Jianjiong and Gardner, Johanna and Garraway, Levi A and Gastier-Foster, Julie M and Gaudioso, Carmelo and Gehlenborg, Nils and Genovese, Giannicola and Gerken, Mark and Gershenwald, Jeffrey E and Getz, Gad and ... and Canc Genome Atlas Network and Cancer Genome Atlas Network
Cell, ISSN 0092-8674, 06/2015, Volume 161, Issue 7, pp. 1681 - 1696
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas... 
METASTATIC MELANOMA | RAF INHIBITION | TERT PROMOTER MUTATIONS | STAGE-III MELANOMA | NODE BIOPSY | LANDSCAPE | SAFETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | ADJUVANT THERAPY | CANCER | CELL BIOLOGY | Skin Neoplasms - classification | Melanoma - genetics | United States | Humans | Skin Neoplasms - genetics | Databases, Genetic | National Cancer Institute (U.S.) | Mutation | Melanoma - classification | RNA | Gene mutations | Gene expression | Analysis | Melanoma
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8. Full Text The Immune Landscape of Cancer
by Thorsson, Vesteinn and Thorsson, Vésteinn and Gibbs, Richard A and Gibbs, David L and Brown, Scott D and Wolf, Gregory and Wolf, Denise and Bortone, Dante S and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Gao, Jianjiong and Plaisier, Christopher L and Eddy, James A and Ziv, Elad and Culhane, Aedin C and Paull, Evan O and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Wenbin and Liu, Jianfang and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Rader, Janet and Dhankani, Varsha and Reynolds, Sheila and Reynolds, Sheila M and Bowlby, Reanne and Califano, Andrea and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Newman, Aaron M and Rao, Arvind and Chen, Amy and Chen, Chu and Chen, Ken and Krasnitz, Alexander and Hu, Jianhong and Hu, Hai and Malta, Tathiane M and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Ojesina, Akinyemi I and Lamb, Andrew and Zhou, Wanding and Shen, Hui and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Saltz, Joel and Holt, Robert and Holt, Robert A and Rabkin, Charles S and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Jioajiao and Wang, Min and Wang, Linghua and Wang, Zhining and Wang, Timothy and Wang, Jing and Yang, Ju Dong and Yang, Hannah and Yang, Liming and Yang, Ian and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Zhang, Jiexin and Zhang, Lizhi and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Yichao and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
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