X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry (144) 144
organic chemistry (143) 143
heterocyclic compounds (142) 142
metallurgy (142) 142
human necessities (133) 133
hygiene (129) 129
medical or veterinary science (129) 129
preparations for medical, dental, or toilet purposes (120) 120
specific therapeutic activity of chemical compounds ormedicinal preparations (60) 60
index medicus (47) 47
structure-activity relationship (44) 44
positive allosteric modulator (39) 39
animals (33) 33
humans (30) 30
chemistry, medicinal (29) 29
agriculture (28) 28
animal husbandry (28) 28
biocides, e.g. as disinfectants, as pesticides, as herbicides (28) 28
fishing (28) 28
forestry (28) 28
hunting (28) 28
pest repellants or attractants (28) 28
plant growth regulators (28) 28
preservation of bodies of humans or animals or plants or partsthereof (28) 28
trapping (28) 28
muscarinic acetylcholine receptor (26) 26
article (25) 25
chemistry, organic (21) 21
drug discovery (19) 19
rats (18) 18
schizophrenia (17) 17
neurosciences (13) 13
receptors, metabotropic glutamate - metabolism (11) 11
allosteric regulation (10) 10
molecular structure (10) 10
series (10) 10
discovery (9) 9
dose-response relationship, drug (9) 9
glutamate (9) 9
hek293 cells (8) 8
metabotropic glutamate receptor (8) 8
optimization (8) 8
parkinson's disease (8) 8
protein binding (8) 8
allosteric regulation - drug effects (7) 7
m-4 (7) 7
medical colleges (7) 7
mglu (7) 7
mice (7) 7
parkinson’s disease (7) 7
potentiators (7) 7
amides - chemistry (6) 6
biochemistry & molecular biology (6) 6
brain - metabolism (6) 6
cho cells (6) 6
cricetulus (6) 6
mglur4 (6) 6
negative allosteric modulator (6) 6
pharmacology (6) 6
positive allosteric modulators (6) 6
potassium channels (6) 6
activation (5) 5
challenges (5) 5
male (5) 5
parkinsons-disease (5) 5
pharmacology & pharmacy (5) 5
piperidines - chemistry (5) 5
rats, sprague-dawley (5) 5
receptor, muscarinic m4 - antagonists & inhibitors (5) 5
receptor, muscarinic m4 - metabolism (5) 5
receptors, metabotropic glutamate - genetics (5) 5
allosteric modulator (4) 4
amides - pharmacology (4) 4
analysis (4) 4
brain - drug effects (4) 4
disease (4) 4
disease models, animal (4) 4
hippocampus (4) 4
in-vivo (4) 4
letter (4) 4
lubrication and lubricants (4) 4
metabotropic (4) 4
mglu4 (4) 4
muscarinic acetylcholine-receptor (4) 4
picolinic acids - pharmacology (4) 4
piperidines - chemical synthesis (4) 4
piperidines - pharmacology (4) 4
receptor (4) 4
receptors, metabotropic glutamate - agonists (4) 4
receptors, metabotropic glutamate - antagonists & inhibitors (4) 4
structure–activity relationship (4) 4
transfection (4) 4
allosteric (3) 3
antiparkinson agents - pharmacology (3) 3
basal ganglia (3) 3
catalepsy - chemically induced (3) 3
catalepsy - drug therapy (3) 3
cell line (3) 3
central nervous system - drug effects (3) 3
central nervous system - metabolism (3) 3
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (255) 255
French (52) 52
German (21) 21
Portuguese (10) 10
Spanish (8) 8
Chinese (6) 6
Korean (5) 5
Danish (2) 2
Hungarian (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2224 - 2228
This letter describes progress towards an M-4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant... 
Aldehyde oxidase (AO) | CHEMISTRY, MEDICINAL | SERIES | PRECLINICAL CANDIDATE | CHEMISTRY, ORGANIC | RECEPTOR | CHALLENGES | Muscarinic acetylcholine receptor | Structure-activity relationship (SAR) | VIVO TOOL COMPOUND | M-4 | Positive allosteric modulator (PAM) | POSITIVE ALLOSTERIC MODULATORS | OPTIMIZATION | POTENTIATORS
Journal Article
Drug Discovery Today: Technologies, ISSN 1740-6749, 2013, Volume 10, Issue 2, pp. e269 - e276
Allosteric modulation has emerged as an innovative pharmacological approach to selectively activate or inhibit several Class C GPCRs. Of the Class C GPCRs,... 
Animals | Receptors, G-Protein-Coupled - metabolism | Allosteric Regulation | Humans | Central Nervous System Diseases - drug therapy | negative allosteric modulator (NAM) | G-protein coupled receptor | metabotropic glutamate receptor | positive allosteric modulator (PAM)
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 07/2018, Volume 43, Issue 8, pp. 1763 - 1771
Highly selective positive allosteric modulators (PAMs) of the M1 subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for... 
Cortex (prefrontal) | Biotechnology | Effectiveness | Mental disorders | Acetylcholine receptors (muscarinic) | Cognitive ability | Schizophrenia | Activation | Pharmacology | Cognition | Pattern recognition | Object recognition | Modulators | Allosteric properties | Cognition & reasoning | Cell lines | Dependence | Convulsions
Journal Article
Biological Psychiatry, ISSN 0006-3223, 06/2019, Volume 85, Issue 12, p. 989
The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In... 
Neurosciences | Analysis | Depression, Mental | Post-traumatic stress disorder | Drug discovery
Journal Article
Biological Psychiatry, ISSN 0006-3223, 06/2019, Volume 85, Issue 12, pp. 989 - 1000
The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In... 
Fear extinction | Positive allosteric modulator | Posttraumatic stress disorder | Prefrontal cortex | M1 muscarinic receptor | Synaptic plasticity | PTSD | Fear | Neuroanatomy | Psychopharmacology | Conditioned Emotional Responses | Animal Models | Hippocampus | Prefrontal Cortex
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3248 - 3252
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2020, Volume 30, Issue 3, p. 126812
This Letter details our efforts to discover structurally unique M PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of... 
Structure activity relationship (SAR) | Positive allosteric modulator (PAM) | Muscarinic acetylcholine receptor
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 07/2018, Volume 43, Issue 8, pp. 1763 - 1771
Highly selective positive allosteric modulators (PAMs) of the M-1 subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for... 
EFFICACY | PSYCHIATRY | SCHIZOPHRENIA | XANOMELINE | SELECTIVE ACTIVATION | NEUROSCIENCES | PREFRONTAL CORTEX | DISCOVERY | MUSCARINIC ACETYLCHOLINE-RECEPTOR | MEMORY | NEURONS | PHARMACOLOGY & PHARMACY | SUBTYPE 5
Journal Article
Biological Psychiatry, ISSN 0006-3223, 06/2019, Volume 85, Issue 12, pp. 989 - 1000
Background: The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given... 
Fear extinction | Positive allosteric modulator | Posttraumatic stress disorder | Prefrontal cortex | muscarinic receptor | Synaptic plasticity
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1211 - 1214
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
mGlu | Negative allosteric modulator (NAM) | Structure-activity relationship (SAR) | VU6019278 | Metabotropic glutamate receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1211 - 1214
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
Negative allosteric modulator (NAM) | Structure-activity relationship (SAR) | mGlu7 | VU6019278 | Metabotropic glutamate receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, p. 1211
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
Surveys | Medical colleges | Neurosciences | Lubrication and lubricants | Drug discovery | Glutamate | Blood proteins | Protein binding
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e110772 - e110772
Journal Article
Science Translational Medicine, ISSN 1946-6234, 08/2017, Volume 9, Issue 403
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein 2 ( MECP2 ) gene. The cognitive impairments seen in... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1690 - 1695
Herein, we report the discovery of a new, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu ) negative allosteric modulator (NAM)... 
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.