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Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6099, pp. 1231 - 1235
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors... 
Exons | Neurons | Genes | REPORTS | Stem cells | Aneuploidy | Chromosomes | Cells | Tumors | Daughter cells | Cancer | ANEUPLOIDY | SELECTIVE INHIBITOR | POTENT | MULTIDISCIPLINARY SCIENCES | CANCER | RECEPTOR TYROSINE KINASE | DISCOVERY | CHROMOSOMAL INSTABILITY | FAMILY | Microtubule-Associated Proteins - chemistry | Neoplasm Transplantation | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Fetal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Spindle Apparatus - metabolism | Glioblastoma - genetics | Oncogene Fusion | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Nuclear Proteins - genetics | Chromosomal Instability | Pyrazoles - pharmacology | Protein Structure, Tertiary | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Enzyme Inhibitors - pharmacology | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Fetal Proteins - genetics | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Fetal Proteins - chemistry | Physiological aspects | Development and progression | Fibroblast growth factors | Genetic aspects | Research | Health aspects | Glioblastoma multiforme | Proteins | Kinases | Brain cancer | Genomics | Pharmaceutical sciences | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 3588 - 3588
Journal Article
Genome Biology, ISSN 1474-7596, 07/2017, Volume 18, Issue 1, pp. 141 - 141
We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding and non-coding single nucleotide... 
DNA methylation | Single nucleotide variants | Structural variants | Cancer drivers | Prostate cancer | Tissue-specific regulatory network | TRANSCRIPTION FACTORS | CHROMATIN ORGANIZATION | PTEN | ANDROGEN RECEPTOR CISTROME | GENOME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | MUTATIONAL LANDSCAPE | CELL-CYCLE | REPRESSOR | EXPRESSION | Prostatic Neoplasms - metabolism | Octamer Transcription Factor-2 - genetics | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Male | Gene Regulatory Networks | Carcinogenesis - metabolism | DNA Methylation | Deoxyribonuclease I | Prostatic Neoplasms - genetics | Binding Sites | Repressor Proteins - metabolism | Promoter Regions, Genetic | Prostatic Neoplasms - pathology | Carcinogenesis - genetics | Repressor Proteins - genetics | Chromosome Mapping | Organ Specificity | Nerve Tissue Proteins - genetics | Protein Interaction Mapping | Carcinogenesis - pathology | Nerve Tissue Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Algorithms | Octamer Transcription Factor-2 - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding | Polymorphism, Single Nucleotide | Deoxyribonuclease | Transcription factors | Integration | Genomics | Genomes | Gene expression | Androgens | Computer applications | Cell cycle | Epigenetics | Tumorigenesis | Mutation | Methylation | Prostate | Binding sites | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
by Shen, Hui and Shih, Juliann and Hollern, Daniel P and Hollern, Daniel and Wang, Zhining and Wang, Linghua and Bowlby, Reanne and Tickoo, Satish K and Thorsson, Vésteinn and Thorsson, Vesteinn and Mungall, Andrew J and Newton, Yulia and Hegde, Apurva M and Armenia, Joshua and Sánchez-Vega, Francisco and Pluta, John and Pyle, Louise C and Mehra, Rohit and Reuter, Victor E and Godoy, Guilherme and Jones, Jeffrey and Jones, Steven J.M and Jones, Corbin D and Shelley, Carl S and Feldman, Darren and Feldman, Darren R and Vidal, Daniel O and Lessel, Davor and Kulis, Tomislav and Cárcano, Flavio M and Leraas, Kristen M and Lichtenberg, Tara M and Brooks, Denise and Cherniack, Andrew D and Cho, Juok and Heiman, David I and Kasaian, Katayoon and Liu, Jia and Liu, Wenbin and Liu, Minwei and Noble, Michael S and Xi, Liu and Zhang, Jiashan (Julia) and Zhang, Jiashan and Zhang, Hailei and Zhou, Wanding and ZenKlusen, Jean C and Hutter, Carolyn M and Felau, Ina and Schultz, Nikolaus and Getz, Gad and Meyerson, Matthew and Stuart, Joshua M and Wheeler, David A and Wheeler, David and Hughes, Daniel and Covington, Kyle and Jayaseelan, Joy C and Korchina, Viktoriya and Lewis, Lora and Hu, Jianhong and Doddapaneni, HarshaVardhan and Muzny, Donna and Gibbs, Richard and Hoadley, Katherine A and Vincent, Benjamin G and Chai, Shengjie and Smith, Christof C and Auman, J. Todd and Shi, Yan and Meng, Shaowu and Skelly, Tara and Tan, Donghui and Veluvolu, Umadevi and Mieczkowski, Piotr A and Wilkerson, Matthew D and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Mose, Lisle E and Simons, Janae V and Soloway, Matthew G and Roach, Jeffrey and Parker, Joel S and Hayes, D. Neil and Perou, Amy H and Perou, Charles M and Saksena, Gordon and Cibulskis, Carrie and Schumacher, Steven E and Beroukhim, Rameen and Gabriel, Stacey B and Ally, Adrian and Balasundaram, Miruna and Carlsen, Rebecca and Cheung, Dorothy and Chuah, Eric and Dhalla, Noreen and Holt, Robert A and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 06/2018, Volume 23, Issue 11, pp. 3392 - 3406
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These... 
exome sequencing | miR-375 | KIT | DNA methylation | seminoma | nonseminoma | copy number | testicular germ cell tumors | The Cancer Genome Atlas | ENDOGENOUS RETROVIRUSES | KIT GENE | ADOLESCENTS | HIGH-RESOLUTION | MUTATIONS | SEMINOMA | EXPRESSION | HUMAN CANCER | GENOME | CARCINOMA IN-SITU | CELL BIOLOGY | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, pp. e20934 - e20934
Background: Huntington's disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The expanded CAG... 
A(2A) RECEPTOR AGONIST | UREA CYCLE DEFICIENCY | SERUM DEPRIVATION | RAT PHEOCHROMOCYTOMA CELLS | LIGAND RECOGNITION | MULTIDISCIPLINARY SCIENCES | DEPRIVATION-INDUCED APOPTOSIS | CENTRAL-NERVOUS-SYSTEM | TRANSGENIC MOUSE MODEL | SITE-DIRECTED MUTAGENESIS | GASTRODIA-ELATA BLUME | Plant Extracts - chemistry | Plant Extracts - pharmacology | Humans | Peptides - genetics | Drugs, Chinese Herbal - pharmacology | Male | Peptides - metabolism | Adenosine - therapeutic use | Drug Design | Female | Receptor, Adenosine A2A - genetics | Adenosine - chemistry | Equilibrative Nucleoside Transporter 1 - chemistry | Huntington Disease - drug therapy | Drugs, Chinese Herbal - therapeutic use | Huntington Disease - physiopathology | Disease Models, Animal | Equilibrative Nucleoside Transporter 1 - genetics | Models, Molecular | Rats | Equilibrative Nucleoside Transporter 1 - metabolism | Adenosine - pharmacology | Receptor, Adenosine A2A - metabolism | Trinucleotide Repeat Expansion | Mice, Knockout | PC12 Cells - drug effects | Animals | Drugs, Chinese Herbal - chemistry | Adenosine - analogs & derivatives | Adenosine - metabolism | Receptor, Adenosine A2A - chemistry | Equilibrative Nucleoside Transporter 1 - antagonists & inhibitors | Mice | Plant Extracts - therapeutic use | Medicinal plants | Nervous system diseases | Analysis | Medicine, Botanic | Cyclic adenylic acid | Medicine, Herbal | Genetic engineering | High-definition television | Huntingtons disease | Drugs | Brain | Drinking water | Huntingtin | Drug development | Proteins | Rodents | Neostriatum | Dopamine transporter | Mathematical models | Trinucleotide repeat diseases | Adenosine | Automation | Polyglutamine | Dopamine | Neurodegenerative diseases | Serotonin | Transgenic mice | Cyclic AMP | Trinucleotide repeats | Adenine | Metabolism | Huntington's disease | Gene expression | Chromatography | Neurological diseases | Medicine | Herbal medicine | Brain research | Molecular modelling | Serotonin transporter | Microdialysis | Simulation | Pharmacy | In vivo methods and tests | Aberration | Transporter | Apoptosis | Index Medicus
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2013, Volume 104, Issue 2, pp. 171a - 171a
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 3270 - 3270
Journal Article
by Bailey, Matthew and Bailey, Matthew H and Tokheim, Collin and Porta-Pardo, Eduard and Sengupta, Sohini and Bertrand, Denis and Weerasinghe, Amila and Colaprico, Antonio and Wendl, Michael C and Kim, Jaegil and Reardon, Brendan and Ng, Kwok-Shing and Ng, Patrick Kwok-Shing and Jeong, Kang Jin and Cao, Song and Wang, Jioajiao and Wang, Timothy and Wang, Zhining and Wang, Zixing and Wang, Fang and Wang, Linghua and Wang, Jing and Wang, Min and Gao, Qingsong and Gao, Jianjiong and Gao, Galen F and Liu, Xiuping and Liu, Jia and Liu, Wenbin and Liu, Yuexin and Liu, Eric Minwei and Mularoni, Loris and Rubio-Perez, Carlota and Nagarajan, Niranjan and Cortés-Ciriano, Isidro and Zhou, Wanding and Zhou, Daniel Cui and Liang, Wen-Wei and Liang, Han and Hess, Julian M and Hess, Julian and Yellapantula, Venkata D and Tamborero, David and Gonzalez-Perez, Abel and Suphavilai, Chayaporn and Ko, Jia Yu and Khurana, Ekta and Park, Joong-Won and Park, Peter J and Van Allen, Eliezer M and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Yang, Ju Dong and Yang, Hannah and Yang, Ian and Yang, Liming and Zenklusen, Jean C and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Zhang, Jiexin and Zhang, Jiashan (Julia) and Zhang, Lizhi and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Sun, Yichao and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Miller, Christopher A and Miller, Judy and Reynolds, Sheila and ... and Canc Genome Atlas Res Network and MC3 Working Grp and MC3 Working Group and Cancer Genome Atlas Research Network
Cell, ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 371 - 385.e18
Journal Article