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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3676 - 3680
Beta-hemoglobinopathies such as sickle cell disease represent a major global unmet medical need. De-repression of fetal hemoglobin in erythrocytes is a... 
Benzoxaborole | Beta-thalassemia | Sickle cell anemia | Fetal hemoglobin | CPSF | CHEMISTRY, MEDICINAL | POLYADENYLATION SIGNAL | THALASSEMIA | CHEMISTRY, ORGANIC | Proteins | Glycosylated hemoglobin | RNA | Drug approval
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 4791 - 4791
Abstract Background: Eltrombopag, an orally bioavailable thrombopoietin receptor agonist, is approved for the treatment of chronic idiopathic thrombocytopenic... 
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 4726 - 4726
Abstract Abstract 4726 The thrombopoietin receptor agonists (TPO-RA), romiplostim and eltrombopag, are presently indicated for the treatment of certain patient... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2396 - 2409
The hypoxia-inducible transcription factors HIP-1 and HIF-2 mediate key cellular adaptions to hypoxia and contribute to renal homeostasis and pathophysiology;... 
CELL-ADHESION MOLECULE-1 | MEDICINE, RESEARCH & EXPERIMENTAL | HYPOXIA-INDUCIBLE FACTOR | HIF-2-ALPHA | INHIBITION | ANGIOGENESIS | REPERFUSION INJURY | GENE-EXPRESSION | ACUTE-RENAL-FAILURE | HIF-1-ALPHA | INDUCTION | Human Umbilical Vein Endothelial Cells | Ureteral Obstruction - complications | Kidney - blood supply | Humans | Male | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Mice, 129 Strain | Ischemia - prevention & control | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Basic Helix-Loop-Helix Transcription Factors - deficiency | Endothelial Cells - physiology | Ischemia - pathology | Kidney - physiopathology | Disease Models, Animal | Basic Helix-Loop-Helix Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Reperfusion Injury - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Vascular Cell Adhesion Molecule-1 - physiology | Ischemia - physiopathology | Kidney - injuries | Mice, Knockout | Animals | Reperfusion Injury - prevention & control | Integrin alpha4beta1 - physiology | Integrin alpha4beta1 - antagonists & inhibitors | Fibrosis | Reperfusion Injury - physiopathology | Mice | Mice, Inbred BALB C | Kidneys | Gene mutations | Physiological aspects | Vascular endothelium | Genetic aspects | Biological control systems | Injuries | Studies | Lungs | Ischemia | Pathogenesis | Rodents | Cloning | Mortality | Hypoxia | Software | Permeability | Endothelium
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2009, Volume 27, Issue 2, pp. 424 - 430
Journal Article
Blood, ISSN 0006-4971, 11/2007, Volume 110, Issue 11, pp. 4089 - 4089
Abstract Eltrombopag is a novel, oral platelet growth factor that interacts with the thrombopoietin receptor on bone marrow progenitors to stimulate... 
Journal Article
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 08/2010, Volume 56, Issue 2, pp. 147 - 155
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2396 - 2396
The hypoxia-inducible transcription factors HIF-1 and HIF-2 mediate key cellular adaptions to hypoxia and contribute to renal homeostasis and pathophysiology;... 
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2013, Volume 19, Issue 12, pp. 1745 - 1752
Journal Article