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Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7729 - 7740
Antagonist ligands of the melanocortin-3 and -4 receptors (MC3R, MC4R), including agouti-related protein (AGRP), are postulated to be targets for the treatment... 
OBESITY | CHEMISTRY, MEDICINAL | LIMBIC SYSTEM | SOLID-PHASE SYNTHESIS | IN-VIVO | MOUSE MODEL | INVERSE AGONIST | NMR STRUCTURE | MOLECULAR-CLONING | AMINO-PROTECTING GROUP | CYCLIC-PEPTIDES
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 12/2018, Volume 9, Issue 12, pp. 3015 - 3023
The melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R), endogenous agonists derived from the proopiomelanocortin gene transcript, and naturally... 
d -amino acids | AGRP | macrocycles | melanocortin receptors | CHEMISTRY, MEDICINAL | ALPHA-MELANOTROPIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DECAPEPTIDE | NEUROSCIENCES | D-amino acids | IN-VITRO | OBESITY | POTENT | HORMONE | PHARMACOLOGY | INVERSE AGONIST | MOLECULAR-CLONING | EXPRESSION
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 9/2018, Volume 61, Issue 17, pp. 7729 - 7740
Antagonist ligands of the melanocortin-3 and −4 receptors (MC3R, MC4R), including agouti-related protein (AGRP), are postulated to be targets for the treatment... 
structure-activity relationships | macrocycles | AGRP | melanocortin receptors
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 2, pp. 805 - 813
The melanocortin system consists of five receptor subtypes, endogenous agonists, and naturally occurring antagonists. These receptors and ligands have been... 
Animals | alpha-MSH - chemistry | Peptides, Cyclic - chemical synthesis | Agouti-Related Protein - chemistry | Humans | HEK293 Cells | Ligands | Peptides, Cyclic - pharmacology | Mice | Receptor, Melanocortin, Type 4 - agonists | Structure-Activity Relationship | alpha-MSH - analogs & derivatives
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2019
Journal Article
Molecules (Basel, Switzerland), 04/2019, Volume 24, Issue 8
The five melanocortin receptors (MC1R-MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In... 
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 1/2017, Volume 60, Issue 2, pp. 805 - 813
The melanocortin system consists of five receptor subtypes, endogenous agonists, and naturally occurring antagonists. These receptors and ligands have been... 
chimeric ligands | AGRP | NDP-MSH | macrocycles | obesity
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 08/2013, Volume 54, Issue 35, pp. 4746 - 4748
The convergent syntheses of homogeneous disulfide cross-linked polypeptides are reported. Reducible polypeptides were synthesized containing four and eight... 
Cysteine | Reducible polypeptides | Convergent synthesis | Acetamidomethyl | Thiazolidine | CHEMISTRY, ORGANIC | POTENT | MODELS | IN-VIVO | CONSTRUCTION | HETEROTRIMERIC COLLAGEN PEPTIDES | PROTEINS | EXPRESSION | DISULFIDE CROSS-LINKING | NONVIRAL GENE DELIVERY | Surgical implants | Silver | Polypeptides | Peptides | Genes | Disulfides | Crosslinking | Conjugation | thiazolidine | acetamidomethyl | convergent synthesis | cysteine
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 10/2017, Volume 1863, Issue 10, pp. 2414 - 2435
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2013, Volume 54, Issue 26, pp. 3440 - 3443
The syntheses of homogeneous penicillamine disulfide cross-linked polypeptides are reported. Dodecapeptides containing N-terminal, C-terminal, or N- and... 
Gene delivery | Reducible polypeptides | Penicillamine | Thiazolidine | STABILITY | CHEMISTRY, ORGANIC | DISULFIDE | CARRIERS | NUCLEIC-ACIDS | LINKING | STERIC HINDRANCE | CONSTRUCTION | HETEROTRIMERIC COLLAGEN PEPTIDES | LINKAGE | Biopolymers | Hydrolysis | Residues | Polypeptides | Genes | Disulfides | Tetrahedrons | Crosslinking | Amino acids | thiazolidine | gene delivery | penicillamine
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 05/2018, Volume 9, Issue 5, pp. 1141 - 1151
The melanocortin system has five receptors, and antagonists of the central melanocortin receptors (MC3R, MC4R) are postulated to be viable therapeutics for... 
AGRP | structure-activity relationships | melanocortin receptors | food intake
Journal Article