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1. Full Text 5 year mortality predictors in 498 103 UK Biobank participants: a prospective population-based study
by Ganna, Andrea, PhD and Ingelsson, Erik, Prof and Science for Life Laboratory, SciLifeLab and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 9993, pp. 533 - 540
Summary Background To our knowledge, a systematic comparison of predictors of mortality in middle-aged to elderly individuals has not yet been done. We... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | HEALTH INFORMATION | LIFE-STYLE | OLDER-ADULTS | VALIDATION | COMPETING RISKS | DEATH CERTIFICATION | COHORT | MODEL | Predictive Value of Tests | Prognosis | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Survival Rate | United Kingdom | Cause of Death | Adult | Female | Aged | Blood Banks - statistics & numerical data | Cohort Studies | Sweden | Mortality | Analysis | Studies | Disease | Older people | Population | Age | Risk factors | Public health | Index Medicus | Abridged Index Medicus | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
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2. Full Text Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
by Mahajan, Anubha and Taliun, Daniel and Thurner, Matthias and Robertson, Neil R and Torres, Jason M and Rayner, N. William and Payne, Anthony J and Steinthorsdottir, Valgerdur and Scott, Robert A and Grarup, Niels and Cook, James P and Schmidt, Ellen M and Wuttke, Matthias and Sarnowski, Chloé and Mägi, Reedik and Nano, Jana and Gieger, Christian and Trompet, Stella and Lecoeur, Cécile and Preuss, Michael H and Prins, Bram Peter and Guo, Xiuqing and Bielak, Lawrence F and Below, Jennifer E and Bowden, Donald W and Chambers, John Campbell and Kim, Young Jin and Ng, Maggie C. Y and Petty, Lauren E and Sim, Xueling and Zhang, Weihua and Bennett, Amanda J and Bork-Jensen, Jette and Brummett, Chad M and Canouil, Mickaël and Ec kardt, Kai-Uwe and Fischer, Krista and Kardia, Sharon L. R and Kronenberg, Florian and Läll, Kristi and Liu, Ching-Ti and Locke, Adam E and Luan, Jian’an and Ntalla, Ioanna and Nylander, Vibe and Schönherr, Sebastian and Schurmann, Claudia and Yengo, Loïc and Bottinger, Erwin P and Brandslund, Ivan and Christensen, Cramer and Dedoussis, George and Florez, Jose C and Ford, Ian and Franco, Oscar H and Frayling, Timothy M and Giedraitis, Vilmantas and Hackinger, Sophie and Hattersley, Andrew T and Herder, Christian and Ikram, M. Arfan and Ingelsson, Martin and Jørgensen, Marit E and Jørgensen, Torben and Kriebel, Jennifer and Kuusisto, Johanna and Ligthart, Symen and Lindgren, Cecilia M and Linneberg, Allan and Lyssenko, Valeriya and Mamakou, Vasiliki and Meitinger, Thomas and Mohlke, Karen L and Morris, Andrew D and Nadkarni, Girish and Pankow, James S and Peters, Annette and Sattar, Naveed and Stančáková, Alena and Strauch, Konstantin and Taylor, Kent D and Thorand, Barbara and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Tuomilehto, Jaakko and Witte, Daniel R and Dupuis, Josée and Peyser, Patricia A and Zeggini, Eleftheria and Loos, Ruth J. F and Froguel, Philippe and Ingelsson, Erik and Lind, Lars and Groop, Leif and Laakso, Markku and Collins, Francis S and Jukema, J. Wouter and Palmer, Colin N. A and Grallert, Harald and Metspalu, Andres and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Geriatrik and Klinisk epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 11/2018, Volume 50, Issue 11, pp. 1505 - 1513
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density... 
METAANALYSIS | SCORE | DISEASE | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENETIC ARCHITECTURE | PHENOTYPES | IDENTIFICATION | TRAITS | EXPRESSION | GENOME-WIDE ASSOCIATION | Body Mass Index | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Islets of Langerhans - pathology | Diabetes Mellitus, Type 2 - genetics | Epigenesis, Genetic | Gene Frequency | Humans | Genetic Loci - genetics | Male | Case-Control Studies | Genome, Human - genetics | Diabetes Mellitus, Type 2 - epidemiology | Linkage Disequilibrium | Islets of Langerhans - metabolism | Chromosome Mapping - methods | Sex Factors | Female | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | High-Throughput Screening Assays - methods | Type 2 diabetes | Medical colleges | Research | Genetic translation | Analysis | Genomics | Haplotypes | Obesity | Therapeutic applications | Diabetes mellitus | Risk | Genomes | Mapping | Conditional probability | Gene expression | Density | Loci | Annotations | Maps | Gene frequency | Alleles | Heritability | Diabetes | Islets of Langerhans | Gene mapping | Pancreas | Females | Diabetes mellitus (non-insulin dependent) | Bioinformatics | Index Medicus | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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3. Full Text Smoking is associated with mosaic loss of chromosome Y
by Dumanski, Jan P and Dumanski, Jan P and Rasi, Chiara and Lönn, Mikael and Davies, Hanna and Ingelsson, Martin and Giedraitis, Vilmantas and Lannfelt, Lars and Magnusson, Patrik K. E and Lindgren, Cecilia M and Morris, Andrew P and Cesarini, David and Johannesson, Magnus and Janson, Eva Tiensuu and Lind, Lars and Pedersen, Nancy L and Ingelsson, Erik and Forsberg, Lars A
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6217, pp. 81 - 83
Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that... 
UNITED-STATES | MORTALITY | SURVIVAL | CELLS | SWEDISH TWIN REGISTRY | MULTIDISCIPLINARY SCIENCES | SEX DISPARITIES | CANCER | GENOME | BLOOD | Genetic research | Care and treatment | Research | Chromosomes | Risk factors | Smoking | Genetics | Mutagenesis | Cancer | Blood cells | Men | Risk | Smoke | Risk analysis | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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4. Full Text Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
by Voight, Benjamin F, PhD and Peloso, Gina M, PhD and Orho-Melander, Marju, PhD and Frikke-Schmidt, Ruth, DMSc and Barbalic, Maja, PhD and Jensen, Majken K, PhD and Hindy, George, MD and Hólm, Hilma, MD and Ding, Eric L, ScD and Johnson, Toby, PhD and Schunkert, Heribert, Prof and Samani, Nilesh J, Prof and Clarke, Robert, MD and Hopewell, Jemma C, PhD and Thompson, John F, Prof and Li, Mingyao, PhD and Thorleifsson, Gudmar, PhD and Newton-Cheh, Christopher, MD and Musunuru, Kiran, MD and Pirruccello, James P, BS and Saleheen, Danish, MBBS and Chen, Li, MSc and Stewart, Alexandre FR, PhD and Schillert, Arne, PhD and Thorsteinsdottir, Unnur, PhD and Thorgeirsson, Gudmundur, MD and Anand, Sonia, Prof and Engert, James C, PhD and Morgan, Thomas, MD and Spertus, John, Prof and Stoll, Monika, Prof and Berger, Klaus, Prof and Martinelli, Nicola, MD and Girelli, Domenico, Prof and McKeown, Pascal P, Prof and Patterson, Christopher C, PhD and Epstein, Stephen E, MD and Devaney, Joseph, PhD and Burnett, Mary-Susan, PhD and Mooser, Vincent, MD and Ripatti, Samuli, PhD and Surakka, Ida, BSci and Nieminen, Markku S, Prof and Sinisalo, Juha, MD and Lokki, Marja-Liisa, PhD and Perola, Markus, Prof and Havulinna, Aki, PhD and de Faire, Ulf, Prof and Gigante, Bruna, MD and Ingelsson, Erik, PhD and Zeller, Tanja, PhD and Wild, Philipp, MD and de Bakker, Paul I W, Prof and Klungel, Olaf H, PhD and Maitland-van der Zee, Anke-Hilse, PhD and Peters, Bas J M, PhD and de Boer, Anthonius, Prof and Grobbee, Diederick E, Prof and Kamphuisen, Pieter W, PhD and Deneer, Vera H M, PhD and Elbers, Clara C, PhD and Onland-Moret, N Charlotte, PhD and Hofker, Marten H, Prof and Wijmenga, Cisca, Prof and Verschuren, WM Monique, PhD and Boer, Jolanda MA, PhD and van der Schouw, Yvonne T, Prof and Rasheed, Asif and Frossard, Philippe and Demissie, Serkalem, PhD and Willer, Cristen, PhD and Do, Ron, PhD and Ordovas, Jose M, Prof and Abecasis, Gonçalo R, Prof and Boehnke, Michael, Prof and Mohlke, Karen L, PhD and Daly, Mark J, PhD and Guiducci, Candace, BS and Burtt, Noël P, BS and Surti, Aarti, BS and Gonzalez, Elena, BS and Purcell, Shaun, PhD and Gabriel, Stacey, PhD and Marrugat, Jaume, PhD and Peden, John, PhD and Erdmann, Jeanette, PhD and Diemert, Patrick, MD and Willenborg, Christina, MSc and König, Inke R, PhD and Fischer, Marcus, MD and Hengstenberg, Christian, MD and Ziegler, Andreas, PhD and Buysschaert, Ian, MD and Lambrechts, Diether, PhD and Van de Werf, Frans, Prof and Fox, Keith A, Prof and El Mokhtari, Nour Eddine, MD and Rubin, Diana, MD and Schrezenmeir, Jürgen, PhD and Schreiber, Stefan, Prof and ...
Lancet, The, ISSN 0140-6736, 08/2012, Volume 380, Issue 9841, pp. 572 - 580
Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear.... 
Internal Medicine | ENDOTHELIAL LIPASE | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | BLOOD CHOLESTEROL | ATHEROSCLEROSIS | GENETIC-VARIANTS | LOCI | CORONARY-HEART-DISEASE | HIGH-DENSITY-LIPOPROTEIN | ISCHEMIC CARDIOVASCULAR-DISEASE | ARTERY-DISEASE | Mendelian Randomization Analysis - methods | Myocardial Infarction - blood | Myocardial Infarction - genetics | Genetic Predisposition to Disease | Myocardial Infarction - epidemiology | Prospective Studies | Gene Frequency | Humans | Risk Factors | Biomarkers - blood | Case-Control Studies | Cholesterol, HDL - blood | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Myocardial Infarction - etiology | Lipase - genetics | Genetic aspects | High density lipoproteins | Health aspects | Heart attack | Risk factors | Studies | Plasma | Heart attacks | Diet | Cardiovascular disease | Lipids | Cholesterol | Index Medicus | Abridged Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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5. Full Text Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease
by Ingelsson, Erik, MD, PhD and Yin, Li, PhD and Bäck, Magnus, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 3, pp. 702 - 707.e2
Background The leukotriene pathway has been associated with an increased cardiovascular risk. However, the effects of the antileukotriene treatment used in... 
Allergy and Immunology | inflammation | stroke | Atherosclerosis | myocardial infarction | pharmacoepidemiology | PROMOTER GENOTYPE | ATHEROGENESIS | PROTEIN | RISK | IMMUNOLOGY | 5-LIPOXYGENASE PATHWAY | ALLERGY | ACUTE MYOCARDIAL-INFARCTION | ASTHMA | ASSOCIATION | Asthma - mortality | Acetates - adverse effects | Follow-Up Studies | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Male | Risk | Quinolines - administration & dosage | Drug Utilization | Socioeconomic Factors | Sweden | Leukotriene Antagonists - administration & dosage | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Female | Leukotriene Antagonists - adverse effects | Asthma - epidemiology | Cardiovascular Diseases - physiopathology | Asthma - physiopathology | Comorbidity | Asthma - drug therapy | Acetates - administration & dosage | Sex Factors | Survival Analysis | Aged | Quinolines - adverse effects | Cohort Studies | Enzymes | Medical research | Lung diseases, Obstructive | Analysis | Cardiac patients | Medicine, Experimental | Antiasthmatic agents | Respiratory tract diseases | Cardiovascular diseases | Stroke | Heart attacks | Drug therapy | Patients | Socioeconomic factors | Index Medicus | Abridged Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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6. Full Text Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes
by Zethelius, Björn and Berglund, Lars and Sundström, Johan and Ingelsson, Erik and Basu, Samar and Larsson, Anders and Venge, Per and Ärnlöv, Johan and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap and Klinisk nutrition och metabolism
The New England Journal of Medicine, ISSN 0028-4793, 05/2008, Volume 358, Issue 20, pp. 2107 - 2116
To predict the risk of death from cardiovascular causes in a community-based cohort of elderly men, the authors used a combination of biomarkers (troponin I,... 
C-REACTIVE PROTEIN | SERUM CYSTATIN-C | MEDIATED INFLAMMATION | MEDICINE, GENERAL & INTERNAL | GENERAL-POPULATION | BRAIN NATRIURETIC PEPTIDE | RISK PREDICTION | MYOCARDIAL-INFARCTION | INSULIN-RESISTANCE | SURVIVAL ANALYSIS | 70-YEAR-OLD MEN | Risk Assessment - methods | Prognosis | Humans | Risk Factors | Proportional Hazards Models | Male | Myocardium - pathology | Biomarkers - blood | Cystatins - blood | Inflammation - blood | Troponin I - blood | Ventricular Dysfunction, Left - blood | Cystatin C | Peptide Fragments - blood | Cardiovascular Diseases - blood | Cardiovascular Diseases - mortality | Aged | C-Reactive Protein - analysis | Renal Insufficiency - blood | Longitudinal Studies | Natriuretic Peptide, Brain - blood | Evaluation | Aged men | Cardiovascular diseases | Biological markers | Health aspects | Patient outcomes | Disease prevention | Plasma | Peptides | Older people | Risk assessment | Biomarkers | Cardiovascular disease | Family medical history | Risk factors | Index Medicus | Abridged Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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7. Full Text Leveraging human genetics to understand the relation of LDL cholesterol with type 2 diabetes
by Ingelsson, Erik and Knowles, Joshua W
Clinical Chemistry, ISSN 0009-9147, 07/2017, Volume 63, Issue 7, pp. 1187 - 1189
[...]studies of variation in proprotein convertase subtilisin/kexin type 9 (PCSK9) have consistently predicted an effect of PCSK9 inhibitors on LDL-C-lowering... 
RISK | PCSK9 | MEDICAL LABORATORY TECHNOLOGY | VARIANTS | Human Genetics | Cholesterol, LDL | Diabetes Mellitus, Type 1 | Diabetes Mellitus, Type 2 | Triglycerides | Humans | Type 2 diabetes | Genetic aspects | Gene expression | Health aspects | Lipoproteins (low density) | Stroke | Diabetes mellitus | Genes | Cardiovascular disease | Lipids | Glucose | Metabolism | Cholesterol | Studies | Consortia | Coronary vessels | Genetics | Diabetes | Statins | Index Medicus
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8. Full Text Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
by Malik, Rainer and Chauhan, Ganesh and Traylor, Matthew and Sargurupremraj, Muralidharan and Okada, Yukinori and Mishra, Aniket and Rutten-Jacobs, Loes and Giese, Anne-Katrin and Van Der Laan, Sander W and Gretarsdottir, Solveig and Anderson, Christopher D and Chong, Michael and Adams, Hieab H. H and Ago, Tetsuro and Almgren, Peter and Amouyel, Philippe and Ay, Hakan and Bartz, Traci M and Benavente, Oscar R and Bevan, Steve and Boncoraglio, Giorgio B and Brown, Robert D and Butterworth, Adam S and Carrera, Caty and Carty, Cara L and Chasman, Daniel I and Chen, Wei-Min and Cole, John W and Correa, Adolfo and Cotlarciuc, Ioana and Cruchaga, Carlos and Danesh, John and De Bakker, Paul I. W and Destefano, Anita L and Den Hoed, Marcel and Duan, Qing and Engelter, Stefan T and Falcone, Guido J and Gottesman, Rebecca F and Grewal, Raji P and Gudnason, Vilmundur and Gustafsson, Stefan and Haessler, Jeffrey and Harris, Tamara B and Hassan, Ahamad and Havulinna, Aki S and Heckbert, Susan R and Holliday, Elizabeth G and Howard, George and Hsu, Fang-Chi and Hyacinth, Hyacinth I and Ikram, M. Arfan and Ingelsson, Erik and Irvin, Marguerite R and Jian, Xueqiu and Jiménez-Conde, Jordi and Johnson, Julie A and Jukema, J. Wouter and Kanai, Masahiro and Keene, Keith L and Kissela, Brett M and Kleindorfer, Dawn O and Kooperberg, Charles and Kubo, Michiaki and Lange, Leslie A and Langefeld, Carl D and Langenberg, Claudia and Launer, Lenore J and Lee, Jin-Moo and Lemmens, Robin and Leys, Didier and Lewis, Cathryn M and Lin, Wei-Yu and Lindgren, Arne G and Lorentzen, Erik and Magnusson, Patrik K and Maguire, Jane and Manichaikul, Ani and McArdle, Patrick F and Meschia, James F and Mitchell, Braxton D and Mosley, Thomas H and Nalls, Michael A and Ninomiya, Toshiharu and O'Donnell, Martin J and Psaty, Bruce M and Pulit, Sara L and Rannikmäe, Kristiina and Reiner, Alexander P and Rexrode, Kathryn M and Rice, Kenneth and Rich, Stephen S and Ridker, Paul M and Rost, Natalia S and Rothwell, Peter M and Rotter, Jerome I and Rundek, Tatjana and Sacco, Ralph L and Sakaue, Saori and Sale, Michele M and ... and AFGen Consortium and UK Young Lacunar DNA Study and EPIC-CVD Consortium and Int Stroke Genetics Consortium ISG and INVENT Consortium and Int Genomics Blood Pressure iGEN and MEGASTROKE Consortium and COMPASS Consortium and METASTROKE Consortium and EPIC-InterAct Consortium and Cohorts Heart Aging Res Genomic and BioBank Japan Cooperative Hosp Grp and NINDS Stroke Genetics Network Si and STARNET and Neurology Working Grp Charge Con and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and International Stroke Genetics Consortium (ISGC) and NINDS Stroke Genetics Network (SiGN) and International Genomics of Blood Pressure (iGEN-BP) Consortium and BioBank Japan Cooperative Hospital Group and Neurology Working Group of the CHARGE Consortium and Science for Life Laboratory, SciLifeLab and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik och genomik and Geriatrik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 04/2018, Volume 50, Issue 4, pp. 524 - 537
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis... 
HUMAN GENETIC-VARIATION | SMALL-VESSEL DISEASE | GENETICS & HEREDITY | SUDDEN CARDIAC DEATH | SUSCEPTIBILITY LOCI | WHITE-MATTER HYPERINTENSITIES | ISCHEMIC-STROKE | COMPLEX TRAITS | CORONARY-ARTERY-DISEASE | HEMORRHAGIC STROKE | ATRIAL-FIBRILLATION | Genetic Predisposition to Disease | Genome-Wide Association Study | Epigenesis, Genetic | Humans | Risk Factors | Computational Biology | Databases, Genetic | Male | Genetic Loci | Gene Regulatory Networks | Stroke - physiopathology | INDEL Mutation | Stroke - genetics | Linkage Disequilibrium | Stroke - classification | Female | Models, Genetic | Polymorphism, Single Nucleotide | Stroke | Genes | Health risks | Risk | Cardiovascular disease | Genomes | Genetic diversity | Regression analysis | Loci | Meta-analysis | Consortia | Pleiotropy | Etiology | Blood pressure | Thromboembolism | Bioinformatics | Asians | Index Medicus | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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