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The EMBO Journal, ISSN 0261-4189, 01/2013, Volume 32, Issue 1, pp. 86 - 99
Infection of macrophages by bacterial pathogens can trigger Toll‐like receptor (TLR) activation as well as Nod‐like receptors (NLRs) leading to inflammasome... 
pyroptosis | Toll‐like receptor | HMGB1 | inflammasome | Nod‐like receptor C4 | Nod-like receptor C4 | Toll-like receptor | APOPTOSIS | CASPASE-1 | INFLAMMASOME ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRC4 INFLAMMASOME | NLRP3 INFLAMMASOME | CELL-DEATH | CELL BIOLOGY | III SECRETION APPARATUS | INFECTION | CYTOKINE RELEASE | Inflammasomes - metabolism | Calcium-Binding Proteins - agonists | Molecular Sequence Data | Caspase 1 - metabolism | Neuronal Apoptosis-Inhibitory Protein - immunology | Protein Isoforms - metabolism | Calcium-Binding Proteins - immunology | HMGB1 Protein - metabolism | Cell Death | Acetylation | Toll-Like Receptors - metabolism | Macrophages - immunology | Macrophages - microbiology | Neuronal Apoptosis-Inhibitory Protein - agonists | Calcium-Binding Proteins - metabolism | Macrophage Activation - physiology | Macrophages - physiology | Amino Acid Sequence | Cell Line | Apoptosis Regulatory Proteins - immunology | Gene Expression | HMGB1 Protein - analysis | Signal Transduction | Toll-Like Receptors - immunology | Neuronal Apoptosis-Inhibitory Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Host-Pathogen Interactions | Animals | Inflammasomes - immunology | Apoptosis Regulatory Proteins - agonists | Bacterial Proteins - metabolism | Mice | Apoptosis | Molecular biology | Immunology | Index Medicus | Klinisk medicin | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Infektionsmedicin | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 26, pp. 11942 - 11947
During infection, vertebrates develop "sickness syndrome," characterized by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and... 
Anger | Cytokines | Cell lines | Toll like receptors | Antibodies | Fibroblasts | Sepsis | Inflammation | Macrophages | CHO cells | Infection | Innate immunity | Proximity ligation assay | Sterile inflammation | TNF | sterile inflammation | infection | PROTEIN | innate immunity | MULTIDISCIPLINARY SCIENCES | HIGH-MOBILITY-GROUP-BOX-1 | MOBILITY GROUP BOX-1 | proximity ligation assay | SEPSIS | HMG-1 | Cricetulus | Lymphocyte Antigen 96 - metabolism | Humans | Molecular Sequence Data | DNA Primers - genetics | HMGB1 Protein - immunology | HMGB1 Protein - genetics | Toll-Like Receptor 4 - deficiency | HMGB1 Protein - chemistry | Base Sequence | HMGB1 Protein - metabolism | Binding Sites | Macrophages - immunology | CHO Cells | Recombinant Proteins - metabolism | Amino Acid Sequence | Cricetinae | Mutagenesis, Site-Directed | Signal Transduction | Rats | Recombinant Proteins - chemistry | Toll-Like Receptor 4 - genetics | Recombinant Proteins - genetics | Cysteine - chemistry | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Macrophage Activation | Mice, Knockout | Macrophages - metabolism | Animals | Recombinant Proteins - immunology | Protein Binding | Mice | In Vitro Techniques | Cytokines - biosynthesis | Amino Acid Substitution | Cysteine | Immune response | Tumor necrosis factor | Research | Properties | Observations | Protein binding | Proteins | Leucocytes | Peptides | Cellular biology | Mutation | Immune system | Index Medicus | Biological Sciences
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 2011, Volume 13, Issue 4, pp. R136 - R136
Introduction: In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine... 
RHEUMATOID-ARTHRITIS | PATHOGENESIS | COLLAGEN-INDUCED ARTHRITIS | ACTIVATION | NECROTIC CELLS | DENDRITIC CELLS | CYTOKINE | HMGB1 | RHEUMATOLOGY | HUMAN MONOCYTES | GLYCATION END-PRODUCTS | Immunohistochemistry | Interleukin-1beta - pharmacology | Interleukin-1alpha - immunology | Humans | Lipopolysaccharides - metabolism | Synovial Membrane - immunology | Interleukin-1alpha - metabolism | HMGB1 Protein - immunology | Synovial Membrane - drug effects | Lipopolysaccharides - immunology | Arthritis, Rheumatoid - metabolism | Inflammation - metabolism | HMGB1 Protein - pharmacology | Interleukin-1beta - metabolism | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Tumor Necrosis Factor-alpha - immunology | Osteoarthritis - pathology | Cytokines - immunology | Fibroblasts - metabolism | Inflammation Mediators - immunology | Enzyme-Linked Immunosorbent Assay | Osteoarthritis - immunology | Cells, Cultured | Interleukin-1beta - immunology | Osteoarthritis - metabolism | Inflammation - immunology | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Phenotype | Fibroblasts - drug effects | Lipopolysaccharides - pharmacology | Fibroblasts - immunology | Arthritis, Rheumatoid - immunology | Interleukin-1alpha - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Complications and side effects | Care and treatment | Rheumatoid arthritis | Fibroblasts | Physiological aspects | Research | Diagnosis | Index Medicus
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 10/2016, Volume 7, pp. 441 - 441
Postoperative neurocognitive disorders are common complications in elderly patients following surgery or critical illness. High mobility group box 1 protein... 
Aging | Inflammation | HMGB1 | Memory | Surgery | Microglia | memory | STERILE INFLAMMATION | MURINE SEPSIS SURVIVORS | RELEASE | IMMUNOLOGY | BLOOD-BRAIN-BARRIER | RECEPTOR 4 | COGNITIVE DECLINE | inflammation | MOBILITY GROUP BOX-1 | MICE | aging | PROTEIN HMGB1 | microglia | surgery | Monoclonal antibodies | Aged patients | Chromosomal proteins | Health aspects | Ageing
Journal Article
Molecular medicine (Cambridge, Mass.), ISSN 1076-1551, 05/2018, Volume 24, Issue 1, pp. 19 - 19
High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders.... 
Alarmin | Inflammation | HMGB1 | Receptor | Protein-protein interactions | TLR2 | Cell Line | Leukocytes, Mononuclear - metabolism | Animals | Cytokines - metabolism | HMGB1 Protein - metabolism | Humans | Protein Domains | Ligands | Mice | Toll-Like Receptor 2 - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 8, pp. 3068 - 3073
Extracellular high-mobility group box (HMGB)1 mediates inflammation during sterile and infectious injury and contributes importantly to disease pathogenesis.... 
Cytokines | Secretion | Cell nucleus | Disulfides | Inflammation | Pharmacology | Gene expression regulation | Acetylation | Macrophages | Cytoplasm | Pathogen-associated molecular pattern | Therapy | Innate immunity | Cytokine | Damage-associated molecular pattern | cytokine | CELLS | STERILE INFLAMMATION | therapy | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME | RECEPTOR 4 | innate immunity | IMMUNE-RESPONSES | damage-associated molecular pattern | GENE-EXPRESSION | MOBILITY GROUP BOX-1 | CYTOKINE RELEASE | PROTEIN HMGB1 | pathogen-associated molecular pattern | Immunohistochemistry | Enzyme-Linked Immunosorbent Assay | Active Transport, Cell Nucleus - physiology | Escherichia coli | Blotting, Western | Lipopolysaccharides | Janus Kinase 1 - metabolism | Tandem Mass Spectrometry | STAT1 Transcription Factor - metabolism | Animals | Cell Nucleus - metabolism | Analysis of Variance | Signal Transduction - drug effects | Interferon Type I - pharmacology | Active Transport, Cell Nucleus - drug effects | HMGB1 Protein - metabolism | Chromatography, Liquid | Benzimidazoles - pharmacology | Signal Transduction - physiology | Mice | Pyridones - pharmacology | Translocation (Genetics) | Interferon | Research | Properties | Protein kinases | Immunological research | Cellular biology | Pathogenesis | Mass spectrometry | Cells | Index Medicus | Biological Sciences
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 09/2009, Volume 86, Issue 3, pp. 655 - 662
A prototypic mechanism for enhancement of inflammation by an endogenous molecule is described. The nuclear protein HMGB1 has previously been demonstrated to... 
innate cell‐mediated immunity | cell activation | Innate cell-mediated immunity | Cell activation | CELLS | ACTIVATION | RECEPTOR | IMMUNOLOGY | innate cell-mediated immunity | HUMAN MONOCYTES | CELL BIOLOGY | GROUP CHROMOSOMAL-PROTEINS | AMPHOTERIN | DNA | HIGH-MOBILITY-GROUP-BOX-1 | MOBILITY GROUP BOX-1 | HEMATOLOGY | BINDING | Coculture Techniques | Cytokines - analysis | Humans | Synovial Membrane - immunology | HMGB1 Protein - immunology | HMGB1 Protein - isolation & purification | Lipopolysaccharides - immunology | HMGB1 Protein - genetics | Recombinant Proteins - isolation & purification | Toll-Like Receptor 9 - immunology | Signal Transduction - immunology | HMGB1 Protein - pharmacology | Leukocytes, Mononuclear - immunology | Fibroblasts - metabolism | Inflammation Mediators - immunology | Cell Survival - drug effects | Biotinylation | Leukocytes, Mononuclear - drug effects | Oligodeoxyribonucleotides - immunology | Cells, Cultured | Interleukin-1beta - immunology | Rats | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Recombinant Proteins - pharmacology | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Animals | Recombinant Proteins - immunology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Interleukin-6 - biosynthesis | Toll-Like Receptor 2 - immunology | Fibroblasts - immunology | Ligands | Toll-Like Receptor 1 - immunology | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 11/2016, Volume 64, Issue 5, pp. 1699 - 1710
Journal Article
Annals of Neurology, ISSN 0364-5134, 04/2017, Volume 81, Issue 4, pp. 572 - 582
Objective: Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although... 
POSITRON-EMISSION-TOMOGRAPHY | MICROGLIAL ACTIVATION | PROTEIN 18 KDA | TRANSLOCATOR PROTEIN | IN-VIVO | POSTOPERATIVE COGNITIVE DYSFUNCTION | BENZODIAZEPINE-RECEPTORS | NEUROFILAMENT LIGHT | CEREBROSPINAL-FLUID | NEUROSCIENCES | VIVO RADIOLIGAND BINDING | CLINICAL NEUROLOGY | Biomarkers - metabolism | Brain - diagnostic imaging | Gray Matter - immunology | Follow-Up Studies | Brain - physiopathology | Down-Regulation | Humans | Middle Aged | Male | Positron-Emission Tomography - methods | Prostatectomy - adverse effects | Cognitive Dysfunction - etiology | Cognitive Dysfunction - physiopathology | Abdomen - surgery | Gray Matter - diagnostic imaging | Brain - metabolism | Gray Matter - metabolism | Gray Matter - physiopathology | Aged | Brain - immunology | Neuroimaging | Brain | Correlation | Cognitive ability | Emission | Inflammatory response | Stimulation | Activation | Males | Substantia grisea | Blood | Lipopolysaccharides | Signal transduction | Cell activation | Surgery | Imaging | Tomography | Anesthesia | Standard deviation | Bioindicators | Activation analysis | Immune system | Binding | Abdominal surgery | Immune response | Color | Positron emission | T cell receptors | Inflammation | Patients | Immune systems | Tumor necrosis factor | Launches | Biomarkers | Immunoreactivity | Positron emission tomography | Index Medicus | in-vivo | Neurosciences | postoperative cognitive dysfunction | Neurosciences & Neurology | neurofilament light | cerebrospinal-fluid | protein 18 kda | translocator protein | positron-emission-tomography | benzodiazepine-receptors | vivo radioligand binding | Neurovetenskaper | microglial activation
Journal Article
Journal Article