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2006, 1. Aufl., Methods and principles in medicinal chemistry, ISBN 9783527312917, Volume 34., xxii, 369
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously... 
Drug development | Ligands (Biochemistry)
Book
2012, 2012, Topics in Current Chemistry, ISBN 3642275397, Volume 317, 32
Book Chapter
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2015, Volume 58, Issue 5, pp. 2088 - 2090
Journal Article
2016, Methods and principles in medicinal chemistry, ISBN 3527683615, Volume 67
Web Resource
2016, Methods and Principles in Medicinal Chemistry, ISBN 3527683615
Web Resource
2016, Methods and principles in medicinal chemistry, ISBN 3527683615, Volume 67
Web Resource
Topics in Current Chemistry, ISSN 0340-1022, 2012, Volume 317, pp. 1 - 32
Conference Proceeding
Nature Reviews Drug Discovery, ISSN 1474-1776, 08/2016, Volume 15, Issue 9, pp. 605 - 619
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2013, Volume 23, Issue 10, pp. 2844 - 2852
Journal Article
Molecules, ISSN 1420-3049, 07/2016, Volume 21, Issue 7, p. 926
Pacific, which is derived from the Latin pac, means peaceful. [...]. 
CHEMISTRY, ORGANIC | Drug Discovery - methods | Humans | Quantitative Structure-Activity Relationship | n/a
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2019, Volume 62, Issue 8, pp. 3857 - 3872
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 5, pp. 1774 - 1784
The popularity of fragment-based drug discovery (FBDD) is demonstrated by the number of recent successful fragment-to-lead (F2L) publications. This... 
Journal Article
Circulation, ISSN 0009-7322, 08/2013, Volume 128, Issue 8, pp. 845 - 853
BACKGROUND—Proton pump inhibitors (PPIs) are gastric acid–suppressing agents widely prescribed for the treatment of gastroesophageal reflux disease. Recently,... 
dimethylarginine dimethylaminohydrolase | endothelium | proton pump inhibitors | nitric oxide | N,N dimethylarginine | N dimethylarginine | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | ENDOTHELIAL DYSFUNCTION | MYOCARDIAL-INFARCTION | NITRIC-OXIDE SYNTHASE | ACID SUPPRESSION | ADMA | DIMETHYLAMINOHYDROLASE DDAH | PERIPHERAL VASCULAR DISEASE | CORONARY-HEART-DISEASE | STAGE RENAL-DISEASE | ARTERY-DISEASE | Proton Pump Inhibitors - pharmacology | Humans | Esomeprazole - adverse effects | Esomeprazole - pharmacology | Endothelium, Vascular - drug effects | Male | Arginine - analogs & derivatives | Esomeprazole - therapeutic use | Cardiovascular Diseases - epidemiology | Nitric Oxide Synthase Type III - metabolism | Gastroesophageal Reflux - drug therapy | Disease Models, Animal | Amidohydrolases - metabolism | Proton Pump Inhibitors - adverse effects | Cardiovascular Diseases - metabolism | Mice, Inbred C57BL | Risk Factors | Cells, Cultured | Biomarkers - blood | Proton Pump Inhibitors - therapeutic use | Animals | Lansoprazole - adverse effects | Endothelium, Vascular - metabolism | Arginine - blood | Lansoprazole - pharmacology | Endothelium, Vascular - pathology | Mice | Vasodilation - drug effects | Lansoprazole - therapeutic use | Gastroesophageal reflux | Complications and side effects | Usage | Care and treatment | Patient outcomes | Proton pump inhibitors | Cardiovascular diseases | Drug therapy | Health aspects | Risk factors
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 1, pp. 89 - 99
Fragment-based drug discovery (FBDD) is now well-established as a technology for generating new chemical leads and drags. This. Miniperspective provides a... 
POTENT | CHEMISTRY, MEDICINAL | SMALL-MOLECULE INHIBITORS | DRUG DISCOVERY | PROTEIN-PROTEIN INTERACTIONS | OPTIMIZATION | IDENTIFICATION | ATAD2 BROMODOMAIN INHIBITORS | PARALLEL SYNTHESIS | STRUCTURE-BASED DESIGN | LEUCINE-ZIPPER KINASE | Drug Discovery | Chemistry, Pharmaceutical | Publishing
Journal Article
RSC Drug Discovery Series, ISSN 2041-3203, 2015, Volume 2015-, Issue 47, pp. xix - xxx
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 1, pp. 89 - 99
Fragment-based drug discovery (FBDD) is now well-established as a technology for generating new chemical leads and drugs. This Miniperspective provides a... 
Journal Article
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