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Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7657, pp. 254 - 258
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 7
Here we report an efficient method to generate multiple co-structures of the A2A G protein-coupled receptor (GPCR) with small-molecules from a single... 
Ligands | Affinity | G protein-coupled receptors | Crystallography | Theophylline | Crystals
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7602, pp. 274 - 277
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2011, Volume 7, Issue 9, pp. 631 - 638
A previously determined crystal structure of the ternary complex of trehalose-6-phosphate synthase identified a putative transition state-like arrangement... 
Models, Molecular | Catalytic Domain | Catalysis | Hydrogen Bonding | Glucosyltransferases - chemistry | Chemical bonds | Biochemistry | Biosynthesis | Catalysts
Journal Article
Structure, ISSN 0969-2126, 08/2017, Volume 25, Issue 8, pp. 1275 - 1285.e4
The adenosine A1 and A2A receptors belong to the purinergic family of G protein-coupled receptors, and regulate diverse functions of the cardiovascular,... 
caffeine | PSB36 | xanthine | theophylline | adenosine A1 receptor structure | adenosine A2A receptor structure
Journal Article
Structure, ISSN 0969-2126, 09/2011, Volume 19, Issue 9, pp. 1283 - 1293
Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via... 
Journal Article
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 12/2012, Volume 7, Issue 12, pp. 2064 - 2073
Fragment-based drug discovery (FBDD) has proven a powerful method to develop novel drugs with excellent oral bioavailability against challenging pharmaceutical... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 1904 - 1909
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4312 - 4323
A new approach to generating information on ligand receptor interactions within the binding pocket of G protein-coupled receptors has been developed, called... 
Triazoles - chemistry | Models, Molecular | Binding Sites - genetics | Pyrimidines - chemistry | Xanthines - chemistry | Small Molecule Libraries | Drug Design | Receptor, Adenosine A2A - chemistry | Ligands | Receptor, Adenosine A2A - genetics | Triazines - chemistry | Mutation | Adenosine A2 Receptor Antagonists - chemistry
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7665, p. 122
This corrects the article DOI: 10.1038/nature22800. 
Journal Article
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