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JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 01/2010, Volume 30, Issue 1, pp. 99 - 109
Although it is well established that low-voltage-activated T-type Ca2+ channels play a key role in many neurophysiological functions and pathological states,... 
CHILDHOOD ABSENCE EPILEPSY | CELLS | PYRAMIDAL NEURONS | ANTAGONIST | RAT THALAMOCORTICAL NEURONS | CA2+ CHANNELS | MIBEFRADIL | CURRENTS | NEUROSCIENCES | SENSORY NEURONS | NICKEL BLOCK
Journal Article
PLOS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11
gamma-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of... 
ACTIVATION | A RECEPTOR | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | NEURONS | MOUSE DENTATE GYRUS | SUBUNIT ISOFORMS | RAT-BRAIN | BINDING-SITES | TONIC INHIBITION
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 01/2008, Volume 73, Issue 1, pp. 157 - 169
We hypothesized that lacosamide modulates voltage-gated sodium channels (VGSCs) at clinical concentrations (32-100 μM). Lacosamide reduced spiking evoked in... 
CORTEX IN-VITRO | RAT HIPPOCAMPAL-NEURONS | PHENYTOIN | LAMOTRIGINE | NA+ CHANNELS | BLOCK | BINDING-SITE | CARBAMAZEPINE | PHARMACOLOGY & PHARMACY | BLASTOMA CELLS | ANTIEPILEPTIC DRUGS | Action Potentials | Animals | Cells, Cultured | Rats | Acetamides - pharmacology | Sodium Channels - drug effects | Anticonvulsants - pharmacology | Ion Channel Gating - drug effects
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2009, Volume 15, Issue 12, pp. 1392 - 1398
The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but... 
MEDICINE, RESEARCH & EXPERIMENTAL | GAMMA-HYDROXYBUTYRIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNAPTIC-TRANSMISSION | MECHANISMS | CELL BIOLOGY | SPIKE | WAVE | SEIZURES | THALAMUS | MOUSE MODEL | RAT-BRAIN | RECEPTORS
Journal Article
JAMA, ISSN 0098-7484, 08/2016, Volume 316, Issue 5, pp. 509 - 518
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 02/2013, Volume 33, Issue 9, pp. 3780 - 3785
Tonic inhibitory GABA(A) receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal... 
SUBUNIT MESSENGER-RNAS | BETA SUBUNITS | NUCLEUS | NEURONS | DEPENDENT PROTEIN-KINASE | GAMMA-AMINOBUTYRIC-ACID | GYRUS GRANULE CELLS | TONIC INHIBITION | NEUROSCIENCES | MODULATION | RAT THALAMUS
Journal Article
Journal Article
Science, ISSN 0036-8075, 10/2014, Volume 346, Issue 6205, pp. 85 - 89
Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote... 
REPORTS | CELLS | MULTIDISCIPLINARY SCIENCES | ADAPTER | GENES | DEGRADATION | RECEPTOR | MUTATIONS | TUMORIGENESIS | DEK ONCOGENE | LIGASE | Development and progression | Genetic aspects | Gene mutations | Ubiquitin-proteasome system | Identification and classification | Prostate cancer | Tumorigenesis | Mutation | Genomics | Proteomics | Degradation | Proteins | Mutations | Effectors | Prostate | Substrates | Tumors | Cancer
Journal Article
EXPERIMENTAL NEUROLOGY, ISSN 0014-4886, 09/2013, Volume 247, pp. 1 - 7
Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition... 
THALAMOCORTICAL NEURONS | Dopamine | EXTRASYNAPTIC GABA(A) RECEPTORS | Absence epilepsy | BASAL GANGLIA | CELLULAR-DISTRIBUTION | RETICULAR NUCLEUS | Ventrobasal thalamus | Patch-clamp | NEUROSCIENCES | Tonic inhibition | LATERAL GENICULATE-NUCLEUS | CEREBELLAR GRANULE CELLS | GABA(A) receptors | INHIBITION | BRAIN
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 06/2011, Volume 31, Issue 23, pp. 8669 - 8680
Metabotropic glutamate receptors (mGluRs) play a crucial role in regulation of phasic inhibition within the visual thalamus. Here we demonstrate that... 
THALAMOCORTICAL NEURONS | IN-VITRO | GABAERGIC INHIBITION | CAT | METABOTROPIC GLUTAMATE RECEPTORS | GRANULE CELLS | OSCILLATION | NEUROSCIENCES | DENDRITIC OUTPUTS | LATERAL GENICULATE-NUCLEUS | RAT THALAMUS
Journal Article
Neuropharmacology, ISSN 0028-3908, 2006, Volume 50, Issue 8, pp. 1016 - 1029
Journal Article
Immunity, ISSN 1074-7613, 10/2017, Volume 47, Issue 4, pp. 739 - 751.e5
Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products... 
immunomodulation | allergy | parasite | asthma | helminth | IL-33 | PRODUCTS | INFLAMMATION | DNA | CCP MODULES | TYPE-2 IMMUNITY | ASTHMA | LARGE-SCALE | CYTOKINE | INNATE LYMPHOID-CELLS | IMMUNOLOGY | Strongylida Infections - metabolism | Humans | Nematospiroides dubius - metabolism | Eosinophils - immunology | Interleukin-33 - immunology | Nematospiroides dubius - immunology | Receptors, Interleukin - metabolism | Lymphocytes - immunology | Allergens - immunology | Strongylida Infections - parasitology | Strongylida Infections - immunology | Helminth Proteins - metabolism | Amino Acid Sequence | Nematospiroides dubius - genetics | Receptors, Interleukin - immunology | Mice, Inbred C57BL | Helminth Proteins - genetics | Host-Parasite Interactions - immunology | Protein Binding - immunology | Blotting, Western | Mice, Knockout | Sequence Homology, Amino Acid | Alternaria - immunology | Immunity, Innate - immunology | Interleukin-33 - genetics | Animals | Helminth Proteins - immunology | Interleukin-33 - metabolism | Mice, Inbred BALB C | Interleukins | Allergens | Autoimmunity | Allergy | Medical research | Resveratrol | Medicine, Experimental | Research institutes | Allergic reaction | Cells | Food allergies | Fractionation | Candidates | Immune response | Disease | Cytokines | Leukocytes (eosinophilic) | Interleukin | Hypersensitivity | Tethering | Infections | Parasites | Immunity | Asthma | Macular degeneration | Proteins | Studies | Gangrene | Deoxyribonucleic acid--DNA | Viral infections | Predictive control | Apoptosis | Recombinant | Life Sciences | Immunology
Journal Article