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NATURE, ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 37 - 38
The authors used cryo-electron microscopy to obtain two high-resolution structures of the synaptic a1ß2y2 GABAA receptor (see Fig. 1 of the paper3), which they... 
LIGANDS | MULTIDISCIPLINARY SCIENCES | Drugs | Proteins | Brain | Researchers | Microscopy | Biology | Binding sites
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 37 - 38
Proteins called GABA.sub.A receptors have a pivotal role in neuronal inhibition, and are targets of several drugs. Structures of the most abundant GABA.sub.A... 
gamma-Aminobutyric Acid | Signal Transduction | Neurons | Humans | Receptors | Analysis | Innovations | GABA | Neural transmission | Drug discovery | Properties | Structure
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 37 - 38
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 48, pp. 40224 - 40231
The GABA A receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits... 
Membrane Proteins | Cys Loop Receptors | Ion Channels | Neurobiology | Minireviews | GABA Receptors | Protein Purification | Benzodiazepines
Journal Article
Current topics in medicinal chemistry, ISSN 1568-0266, 2002, Volume 2, Issue 8, pp. 833 - 839
Ligands of the benzodiazepine binding site of the GABAA receptor come in three flavors: positive allosteric modulators, negative allosteric modulators and... 
Protein Subunits | Allosteric Regulation | Electrophysiology | Receptors, Cholinergic - chemistry | Point Mutation | Animals | Protein Isoforms | Receptors, GABA-A - genetics | Receptors, GABA-A - physiology | Ligands | Protein Conformation | Receptors, GABA-A - metabolism | Benzodiazepines - metabolism | Binding Sites
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 07/2018, Volume 39, Issue 7, pp. 659 - 671
Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal systems. The most prominent players in neuronal inhibition are... 
GABA | GABAA receptor | receptor subtypes | benzodiazepine | receptor
Journal Article
TRENDS IN PHARMACOLOGICAL SCIENCES, ISSN 0165-6147, 07/2018, Volume 39, Issue 7, pp. 659 - 671
Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal systems. The most prominent players in neuronal inhibition are... 
GAMMA | ACTIVATION | LIGANDS | CHANNEL | SUBTYPES | ALPHA-5 SUBUNIT | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | AMINOBUTYRIC ACID(A) RECEPTORS | SUBUNIT COMPOSITION | ALLOSTERIC MODULATION
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 07/2018
Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal systems. The most prominent players in neuronal inhibition are... 
Benzodiazepines
Journal Article
PloS one, 2017, Volume 12, Issue 1, p. e0170572
The major subunit isoform of GABAA receptors is α1β2γ2. The subunits are thought to surround an ion pore with the counterclockwise arrangement α1γ2β2α1β2 as... 
Receptors, GABA-A - physiology | Female | Receptors, GABA-A - metabolism | Animals | Oocytes - metabolism | Xenopus laevis
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2012, Volume 51, Issue 42, pp. 10500 - 10504
Shine and rise! GABAA receptors are ligand‐gated chloride ion channels that respond to γ‐aminobutyric acid (GABA), which is the major inhibitory... 
photochromism | azo compounds | GABA receptors | ion channels | photopharmacology | SUBTYPES | CHEMISTRY, MULTIDISCIPLINARY | IONOTROPIC GLUTAMATE RECEPTORS | PHARMACOLOGY | CHANNELS | PHOTOSWITCH | BINDING | VISUAL RESPONSES | GABA | Azo compounds | Care and treatment | Pain | Universities and colleges | Analgesics | azobenzenes | propofol
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0170572
The major subunit isoform of GABAA receptors is α1β2γ2. The subunits are thought to surround an ion pore with the counterclockwise arrangement α1γ2β2α1β2 as... 
Stoichiometry | Channel opening | γ-Aminobutyric acid A receptors | Biochemistry | Benzodiazepines | Oocytes | Receptors | Properties (attributes) | γ-Aminobutyric acid | Acids | Affinity | Receptor mechanisms | Binding sites | Diazepam
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2016, Volume 291, Issue 35, pp. 18474 - 18483
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2016, Volume 138, Issue 5, pp. 722 - 730
γ‐aminobutyric type A (GABAA) receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically important drugs... 
benzodiazepines | electrophysiology | chloride channels | Xenopus oocyte | GABAA receptors | Electrophysiology | GABA | Chloride channels | receptors | Benzodiazepines
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 1997, Volume 18, Issue 11, pp. 425 - 429
The GABA(A) receptor belongs, along with the nicotinic acetylcholine receptor, the glycine receptor and the 5-HT3 receptor, to a family of homologous... 
binding pocket | expression | allosteric protein | GABA receptor | agonist | benzodiazepine | allosteric modulation | POINT MUTATIONS | AMINO-ACID | A RECEPTOR | ALPHA-SUBUNIT | SUBTYPES | AFFINITY | PHARMACOLOGY | SEQUENCE | PHARMACOLOGY & PHARMACY | CHANNELS | PROTEINS
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2016, Volume 138, Issue 5, p. 722
[gamma]-aminobutyric type A (GABA.sub.A) receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically... 
GABA | Antianxiety agents | Benzodiazepines | Rodents | Binding sites | Mutation
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 656 - 10
Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F) G representing the ionic selectivity... 
XENOPUS-LAEVIS | CELLS | FUNCTIONAL EXPRESSION | MEMBRANE | MULTIDISCIPLINARY SCIENCES | GROWTH | OOCYTES | MOLECULAR-CLONING | K+ CHANNEL | PROTEINS | MODULATION | Barium | Prokaryotes | Amino acid sequence | Ions | Homology | Parasites | Potassium channels | Glycine | Organelles | Oocytes | Osmotic stress | Volutin granules | Sodium | Potassium | Life cycles
Journal Article
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