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by Vaccaro, Carlos Alberto and López‐Kostner, Francisco and Adriana, Della Valle and Palmero, Edenir Inez and Rossi, Benedito Mauro and Antelo, Marina and Solano, Angela and Carraro, Dirce Maria and Forones, Nora Manoukian and Bohorquez, Mabel and Lino‐Silva, Leonardo S and Buleje, Jose and Spirandelli, Florencia and Abe‐Sandes, Kiyoko and Nascimento, Ivana and Sullcahuaman, Yasser and Sarroca, Carlos and Gonzalez, Maria Laura and Herrando, Alberto Ignacio and Alvarez, Karin and Neffa, Florencia and Galvão, Henrique Camposreis and Esperon, Patricia and Golubicki, Mariano and Cisterna, Daniel and Cardoso, Florencia C and Torrezan, Giovana Tardin and Junior, Samuel Aguiar and Pimenta, Célia Aparecida Marques and Cruz Formiga, Maria Nirvana and Santos, Erika and Sá, Caroline U and Oliveira, Edite P and Fujita, Ricardo and Spirandelli, Enrique and Jimenez, Geiner and Guindalini, Rodrigo Santa Cruz and Azevedo, Renata Gondim Meira Velame and Bueno, Larissa Souza Mario and Santos Nogueira, Sonia Tereza and Loarte, Mariela Torres and Padron, Jorge and Carmen Castro‐Mujica, Maria and Monte, Julio Sanchez and Caballero, Carmelo and Peña, Carlos Mario Muñeton and Pinto, Joseph and Barletta‐Carrillo, Claudia and Melva, Gutiérrez Angulo and Piñero, Tamara and Beltran, Paola Montenegro and Ashton‐Prolla, Patricia and Rodriguez, Yenni and Quispe, Richard and Rossi, Norma Teresa and Martin, Claudia and Chialina, Sergio and Kalfayan, Pablo German and Bazo‐Alvarez, Juan Carlos and Cañete, Alcides Recalde and Dominguez‐Barrera, Constantino and Nuñez, Lina and Da Silva, Sabrina Daniela and Balavarca, Yesilda and Wernhoff, Patrik and Plazzer, John‐Paul and Møller, Pål and Hovig, Eivind and Dominguez‐Valentin, Mev and GETH and in collaboration with GETH
International Journal of Cancer, ISSN 0020-7136, 07/2019, Volume 145, Issue 2, pp. 318 - 326
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and... 
hereditary | colorectal cancer | lynch syndrome | Latin America | BREAST-CANCER | HEREDITARY CANCER | ONCOLOGY | MICROSATELLITE INSTABILITY | MUTATIONS | POLYMORPHISM | PREVALENCE | MLH1 | Genetic research | Research | Oncology, Experimental | Colorectal cancer | Cancer | MSH6 protein | MLH1 protein | Colorectal carcinoma | MSH2 protein | Genetic screening | Mini Review
Journal Article
Pharmacogenomics Journal, ISSN 1470-269X, 12/2018, Volume 18, Issue 6, pp. 689 - 703
Methotrexate (MTX), a structural analog of folic acid, is widely employed in the treatment of different cancers and autoimmune diseases. Despite the successful... 
GAMMA-GLUTAMYL-HYDROLASE | REDUCED FOLATE CARRIER | HIGH-DOSE METHOTREXATE | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENETICS & HEREDITY | METHYLENETETRAHYDROFOLATE REDUCTASE GENE | MTHFR C677T POLYMORPHISM | TREATMENT RESPONSE | PHARMACOLOGY & PHARMACY | A1298C POLYMORPHISMS | RHEUMATOID-ARTHRITIS PATIENTS | SINGLE-NUCLEOTIDE POLYMORPHISMS | Predictive Value of Tests | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Immunosuppressive Agents - pharmacokinetics | Methotrexate - pharmacokinetics | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Reduced Folate Carrier Protein - metabolism | Antimetabolites, Antineoplastic - administration & dosage | Patient Selection | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Clinical Decision-Making | Pharmacogenomic Variants | Immunosuppressive Agents - administration & dosage | Pharmacogenetics - methods | Risk Assessment | Reduced Folate Carrier Protein - genetics | Thymidylate Synthase - metabolism | Pharmacogenomic Testing | Thymidylate Synthase - genetics | Polymorphism, Genetic | Methotrexate - adverse effects | Antimetabolites, Antineoplastic - adverse effects | Immunosuppressive Agents - adverse effects | Methotrexate - administration & dosage | Precision Medicine - methods | Efflux | Parameters | Toxicity | Decision making | Medical treatment | Medical services | Data processing | Pharmacology | Methylenetetrahydrofolate reductase | Folic acid | Genetic markers | Methotrexate | Autoimmune diseases | Index Medicus
Journal Article
Clinical Chemistry, ISSN 0009-9147, 11/2017, Volume 63, Issue 11, pp. 1734 - 1744
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2018, Volume 378, Issue 17, pp. 1573 - 1582
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 11/2017, Volume 109, pp. 480 - 485
Journal Article
Clinical chemistry, ISSN 0009-9147, 10/2014, Volume 60, Issue 10, pp. 1336 - 1345
Journal Article
Clinical Chemistry, ISSN 0009-9147, 10/2017
BACKGROUND:We sought to evaluate, in patients on a liver transplantation waiting list, potential biomarkers of the base calcineurin pathway activity with use... 
Life Sciences | Pharmaceutical sciences
Journal Article
by Campbell, Bruce C V and Campbell, N and Campbell, D and Campbell, Bruce CV and van Zwam, Wim H and Goyal, Mayank and Goyal, M and Menon, BK and Menon, Bijoy K and Dippel, Diederik W.J and Dippel, Diederik W J and Demchuk, AM and Demchuk, Andrew M and Bracard, Serge and Bracard, S and White, Philip and Dávalos, A and Dávalos, Antoni and Majoie, Charles B.L.M and Majoie, Charles B L M and van der Lugt, Aad and Ford, Ian and Ford, Gary and Ford, Gary A and de la Ossa, Natalia Pérez and Kelly, P and Kelly, Michael and Kelly, M and Bourcier, Romain and Donnan, Geoffrey A and Roos, Yvo B W E M and Roos, Yvo B.W.E.M and Bang, OY and Bang, Oh Young and Nogueira, Raul G and Devlin, T and Devlin, Thomas G and van den Berg, René and van den Berg, Lucie A and van den Berg, Jan S.P and Clarençon, Frédéric and Burns, PA and Burns, Paul and Carpenter, Jeffrey and Carpenter, JS and Berkhemer, Olvert A and Yavagal, Dileep R and Yavagal, D and Pereira, Vitor Mendes and Ducrocq, Xavier and Dixit, Anand and Quesada, H and Quesada, Helena and Epstein, Jonathan and Davis, Stephen M and Davis, T and Jansen, O and Jansen, Olav and Jansen, Ivo and Rubiera, Marta and Rubiera, M and Urra, Xabier and Urra, X and Micard, Emilien and Lingsma, Hester F and Naggara, Olivier and Brown, Scott and Brown, B and Brown, Martin M and Guillemin, Francis and Muir, Keith W and van Oostenbrugge, Robert J and Saver, Jeffrey L and Jovin, Tudor G and Jovin, TG and Hill, Michael D and Hill, MD and Mitchell, Peter J and Fransen, Puck SS and Beumer, Debbie and Yoo, Albert J and Yoo, J and Schonewille, Wouter J and Vos, Jan Albert and Nederkoorn, Paul J and Wermer, Marieke JH and van Walderveen, Marianne AA and Staals, Julie and Hofmeijer, Jeannette and van Oostayen, Jacques A and Lycklama à Nijeholt, Geert J and Boiten, Jelis and Brouwer, Patrick A and Emmer, Bart J and de Bruijn, Sebastiaan F and van Dijk, R and van Dijk, Lukas C and van Dijk, Ewoud J and Kappelle, Jaap and Lo, Rob H and ... and HERMES Collaborators and HERMES collaborators
The Lancet Neurology, ISSN 1474-4422, 01/2018, Volume 17, Issue 1, pp. 47 - 53
Journal Article