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Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 13, pp. 3790 - 3798.e7
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We... 
spermatogenesis | HSF2BP | meiosis | homologous recombination | BRCA2 | REPAIR | PROTEIN | RAD51 | GENE | CHROMOSOME SYNAPSIS | DNA-DAMAGE | GENOME-WIDE | HOMOLOGOUS RECOMBINATION | FANCONI-ANEMIA | CANCER | CELL BIOLOGY
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 2014, Volume 14, Issue 7, pp. 481 - 493
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2019, Volume 380, Issue 16, pp. 1499 - 1508
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 11/2007, Volume 14, Issue 11, pp. 1096 - 1104
Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve... 
CHECKPOINT KINASE CDS1 | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MAMMALIAN-CELLS | SACCHAROMYCES-CEREVISIAE | DAMAGE | CELL BIOLOGY | HOLLIDAY JUNCTION RESOLVASE | IN-VITRO | BIOPHYSICS | GENOME INTEGRITY | HOMOLOGOUS RECOMBINATION | Hydroxyurea - pharmacology | Endonucleases - genetics | Embryonic Stem Cells - cytology | Nucleic Acid Synthesis Inhibitors - pharmacology | Chromosomes, Mammalian - genetics | Humans | Endonucleases - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Aphidicolin - pharmacology | Embryonic Stem Cells - radiation effects | Nuclear Proteins - genetics | Nucleic Acid Conformation | Chromosomal Instability | Radiation, Ionizing | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Chromosomes, Mammalian - chemistry | DNA Replication | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Embryonic Stem Cells - physiology | Mice, Knockout | DNA Helicases | Animals | Embryonic Stem Cells - drug effects | Cell Cycle - physiology | Mice | Chromosomes, Mammalian - metabolism | Chromosome Aberrations - chemically induced | Physiological aspects | Nucleases | DNA replication | Research | DNA damage | Enzymes | Molecular structure | E coli | Molecular biology | Genomics
Journal Article
EMBO Journal, ISSN 0261-4189, 10/2006, Volume 25, Issue 20, pp. 4921 - 4932
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9851 - 9856
Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition... 
B lymphocytes | Homologous recombination | Cell lines | HeLa cells | Small interfering RNA | Immunoblotting | CHO cells | Hyperthermia | Cells | Tumors | Double-strand break | Anti-cancer treatment | RAD51 | PATHWAYS | NUDE-MICE | MUTANT | MECHANISM | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | COMBINATION | REPAIR | double-strand break | anti-cancer treatment | PHASE-I | SISTER-CHROMATID EXCHANGES | THERMAL RADIOSENSITIZATION | Embryonic Stem Cells - metabolism | Humans | Transplantation, Heterologous | DNA-Binding Proteins - metabolism | Neoplasms, Experimental - pathology | RNA Interference | Embryonic Stem Cells - radiation effects | Neoplasms, Experimental - genetics | Recombination, Genetic - genetics | Female | Cell Line | Cells, Cultured | Rats | Hot Temperature | DNA-Binding Proteins - genetics | Lactams, Macrocyclic - pharmacology | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Benzoquinones - pharmacology | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | Embryonic Stem Cells - drug effects | Tumor Burden - drug effects | Mice, Nude | DNA Repair | Cell Line, Tumor | Mice | Recombination, Genetic - radiation effects | HeLa Cells | Neoplasms, Experimental - metabolism | Quinazolines - pharmacology | BRCA2 Protein - genetics | Recombination, Genetic - drug effects | BRCA mutations | Proteolysis | Cancer cells | Genetic aspects | Research | Genetic recombination | Health aspects | Fever | Cancer | Biological Sciences
Journal Article
Journal Article