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science & technology (9) 9
humans (6) 6
life sciences & biomedicine (5) 5
biochemistry & molecular biology (4) 4
crispr-cas systems (4) 4
multidisciplinary sciences (4) 4
science & technology - other topics (4) 4
crispr (3) 3
genomics (3) 3
bacteria (2) 2
cell biology (2) 2
crispr-associated proteins - genetics (2) 2
crispr-associated proteins - metabolism (2) 2
deoxyribonucleic acid--dna (2) 2
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escherichia coli - genetics (2) 2
gene expression (2) 2
genetic engineering (2) 2
genetic engineering - methods (2) 2
genomes (2) 2
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methods (2) 2
microbiology (2) 2
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ribonuclease (2) 2
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rna (2) 2
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activation (1) 1
adaptor proteins (1) 1
adaptors (1) 1
amino acid motifs (1) 1
amino acid sequence (1) 1
amino acids (1) 1
amplification (1) 1
analysis (1) 1
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bicarbonates - metabolism (1) 1
binding (1) 1
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biochemistry, genetics and molecular biology (1) 1
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circulating tumor dna - analysis (1) 1
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clustered regularly interspaced short palindromic repeats (1) 1
clustered-regularly-interspaced-short-palindromic-repeats (1) 1
computational biology (1) 1
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e coli (1) 1
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electric properties (1) 1
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endonucleases - chemistry (1) 1
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1. Full Text RNA targeting with CRISPR-Cas13
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Essletzbichler, Patrick and Han, Shuo and Joung, Julia and Belanto, Joseph J and Verdine, Vanessa and Cox, David B. T and Kellner, Max J and Regev, Aviv and Lander, Eric S and Voytas, Daniel F and Ting, Alice Y and Zhang, Feng
Nature (London), ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 280 - 284
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR-Associated Proteins - chemistry | Biocatalysis | Plant Cells - metabolism | RNA - analysis | CRISPR-Associated Proteins - genetics | Cell Survival | Humans | Leptotrichia - enzymology | Stress, Physiological | Substrate Specificity | Genes, Reporter - genetics | Gene Knockdown Techniques - methods | Gene Editing | RNA - genetics | Leptotrichia - genetics | RNA Interference | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | HEK293 Cells | Cell Line, Tumor | RNA - metabolism | Binding | CRISPR | RNA-mediated interference | Genomics | Interference | Genomes | RNA polymerase | Mammals | Gene expression | Ribonucleic acid--RNA | Mammalian cells | Plant cells | E coli | Genetic engineering | Index Medicus
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2. Full Text Nucleic acid detection with CRISPR-Cas13a/C2c2
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Lee, Jeong Wook and Essletzbichler, Patrick and Dy, Aaron J and Joung, Julia and Verdine, Vanessa and Donghia, Nina and Daringer, Nichole M and Freije, Catherine A and Myhrvold, Cameron and Bhattacharyya, Roby P and Livny, Jonathan and Regev, Aviv and Koonin, Eugene V and Hung, Deborah T and Sabeti, Pardis C and Collins, James J and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. 438 - 442
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Circulating Tumor DNA - analysis | Zika Virus - genetics | Circulating Tumor DNA - genetics | Ribonucleases - chemistry | Humans | Bacterial Proteins - chemistry | RNA, Viral - analysis | RNA Cleavage | Zika Virus - isolation & purification | Dengue Virus - genetics | Bacteria - isolation & purification | RNA, Viral - genetics | Zika Virus Infection - diagnosis | Neoplasms - genetics | Point-of-Care Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA, Bacterial - analysis | Bacteria - pathogenicity | Dengue Virus - isolation & purification | Mutation | Dengue - diagnosis | Methods | Nucleotide sequencing | DNA sequencing | Vector-borne diseases | Pathogens | CRISPR | Target recognition | Nucleotide sequence | Dengue | Viruses | Zika virus | Nucleic acids | Ribonuclease | Recombinase | Ribonucleic acid--RNA | Sensitivity | Genotyping | Reagents | Bacteria | Deoxyribonucleic acid--DNA | Index Medicus | Amplification | Ribonucleic acids | Deoxyribonucleic acid
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3. Full Text Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
by Zetsche, Bernd and Gootenberg, Jonathan S and Abudayyeh, Omar O and Slaymaker, Ian M and Makarova, Kira S and Essletzbichler, Patrick and Volz, Sara E and Joung, Julia and van der Oost, John and Regev, Aviv and Koonin, Eugene V and Zhang, Feng
Cell (Cambridge), ISSN 0092-8674, 10/2015, Volume 163, Issue 3, pp. 759 - 771
Microbiological Laboratory | Microbiologie | VLAG | Microbiology | Laboratorium voor Microbiologie | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Genetic Engineering - methods | Amino Acid Sequence | Endonucleases - genetics | RNA, Guide - genetics | Humans | Molecular Sequence Data | Endonucleases - chemistry | Sequence Alignment | Francisella - enzymology | CRISPR-Cas Systems | HEK293 Cells | Nucleic Acid Conformation | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | Cells | Research institutes | Index Medicus
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4. Full Text Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28
by Smargon, Aaron A and Cox, David B.T and Pyzocha, Neena K and Zheng, Kaijie and Slaymaker, Ian M and Gootenberg, Jonathan S and Abudayyeh, Omar A and Essletzbichler, Patrick and Shmakov, Sergey and Makarova, Kira S and Koonin, Eugene V and Zhang, Feng
Molecular cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 4, pp. 618 - 630.e7
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ribonucleases - genetics | Escherichia coli - enzymology | RNA, Guide - genetics | CRISPR-Associated Proteins - genetics | RNA, Guide - metabolism | Bacterial Proteins - genetics | Computational Biology | Databases, Genetic | Data Mining | Ribonucleases - metabolism | RNA Interference | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | RNA, Bacterial - genetics | Bacterial Proteins - metabolism | Gene Editing - methods | Gene Expression Regulation, Bacterial | RNA, Bacterial - metabolism | Electrical engineering | Computer science | RNA | Escherichia coli | Mineral industry | Ribonuclease | Research institutes | Mining industry | Electric properties | Index Medicus
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5. Full Text Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
by Essletzbichler, Patrick and Konopka, Tomasz and Santoro, Federica and Chen, Doris and Gapp, Bianca V and Kralovics, Robert and Brummelkamp, Thijn R and Nijman, Sebastian M. B and Bürckstümmer, Tilmann
Genome research, ISSN 1088-9051, 12/2014, Volume 24, Issue 12, pp. 2059 - 2065
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Genetic Engineering - methods | Cell Line | Haploidy | Sequence Deletion | Genomics | Humans | Gene Expression Profiling | CRISPR-Cas Systems - genetics | Karyotype | Genetic engineering | Research | Single nucleotide polymorphisms | Chromosomes | Cell lines | Index Medicus | Method
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6. Full Text TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
by Heinz, Leonhard X and Lee, JangEun and Kapoor, Utkarsh and Kartnig, Felix and Sedlyarov, Vitaly and Papakostas, Konstantinos and Cesar-Razquin, Adrian and Essletzbichler, Patrick and Goldmann, Ulrich and Stefanovic, Adrijana and Bigenzahn, Johannes W and Scorzoni, Stefania and Pizzagalli, Mattia D and Bensimon, Ariel and Mueller, Andre C and King, F. James and Li Jun and Girardi, Enrico and Mbow, M. Lamine and Whitehurst, Charles E and Rebsamen, Manuele and Superti-Furga, Giulio
Nature (London), ISSN 0028-0836, 05/2020, Volume 581, Issue 7808, pp. 316 - 322
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Nerve Tissue Proteins - deficiency | Interferon Regulatory Factors - metabolism | Lupus Erythematosus, Systemic - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Interferon Type I - immunology | Intracellular Signaling Peptides and Proteins - deficiency | Membrane Transport Proteins - deficiency | Lysosomes - metabolism | Membrane Transport Proteins - genetics | Female | Membrane Transport Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Toll-Like Receptor 7 - metabolism | Signal Transduction | Immunity, Innate | Nerve Tissue Proteins - genetics | Amino Acid Motifs | Nerve Tissue Proteins - metabolism | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Carrier proteins | Analysis | Toll-like receptors | Mechanical properties | Causes of | Lysosomes | Influence | Lupus erythematosus | Interferon | Plasma | Interferon-inducible protein | Residues | Amino acids | Activation | Defects | Proteins | Signal transduction | Clonal deletion | Localization | Immune system | Lupus | Adaptor proteins | Pathogens | NF-κB protein | TLR7 protein | MAP kinase | Adaptors | Gene expression | TLR9 protein | Signaling | Mutagenesis | Ligands | Autoimmune diseases | Transporter | Recognition | Index Medicus
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7. Full Text Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
by da Silva, Joana Ferreira and Salic, Sejla and Wiedner, Marc and Datlinger, Paul and Essletzbichler, Patrick and Hanzl, Alexander and Superti-Furga, Giulio and Bock, Christoph and Winter, Georg and Loizou, Joanna I
Scientific reports, ISSN 2045-2322, 10/2019, Volume 9, Issue 1, pp. 15751 - 10
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR | Genomes | DNA repair | DNA damage | Deoxyribonucleic acid--DNA | Non-homologous end joining | Index Medicus
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8. Full Text Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
by Bensimon, Ariel and Pizzagalli, Mattia D and Kartnig, Felix and Dvorak, Vojtech and Essletzbichler, Patrick and Winter, Georg E and Superti-Furga, Giulio
Cell chemical biology, ISSN 2451-9456, 06/2020, Volume 27, Issue 6, pp. 728 - 739.e9
proteasome | E3 ligase | transporter | targeted degradation | multi-pass transmembrane protein | SLC38A2 | solute carrier | proteolysis targeting chimera (PROTAC) | degrader | SLC9A1 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology
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9. Full Text The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
by Sedlyarov, Vitaly and Eichner, Ruth and Girardi, Enrico and Essletzbichler, Patrick and Goldmann, Ulrich and Nunes-Hasler, Paula and Srndic, Ismet and Moskovskich, Anna and Heinz, Leonhard X and Kartnig, Felix and Bigenzahn, Johannes W and Rebsamen, Manuele and Kovarik, Pavel and Demaurex, Nicolas and Superti-Furga, Giulio
Cell host & microbe, ISSN 1931-3128, 06/2018, Volume 23, Issue 6, pp. 766 - 774.e5
SLC4A7 | NBC3 | phagocytosis | intracellular bacterial killing | macrophages | NBCn1 | CRISPR screen | solute carrier | phagosome acidification | Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Humans | Phagosomes - metabolism | Sodium-Bicarbonate Symporters - genetics | THP-1 Cells | Transcriptome | Homeostasis | Cytoplasm - metabolism | Gene Knockout Techniques | Macrophages - metabolism | Cation Transport Proteins - metabolism | U937 Cells | CRISPR-Cas Systems | Bicarbonates - metabolism | Sodium-Bicarbonate Symporters - physiology | Phagocytosis | Hydrogen-Ion Concentration | Macrophages | Bacteria | Carbonates | Index Medicus
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