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1. Full Text RNA targeting with CRISPR-Cas13
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Essletzbichler, Patrick and Han, Shuo and Joung, Julia and Belanto, Joseph J and Verdine, Vanessa and Cox, David B. T and Kellner, Max J and Regev, Aviv and Lander, Eric S and Voytas, Daniel F and Ting, Alice Y and Zhang, Feng
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 280 - 284
RNA has important and diverse roles in biology, but molecular tools to manipulate and measure it are limited. For example, RNA interference(1-3) can... 
CELLS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | CAS SYSTEMS | INTERFERENCE | KNOCKOUT | EXPRESSION | Binding | CRISPR | RNA-mediated interference | Genomics | Interference | Genomes | RNA polymerase | Mammals | Gene expression | Ribonucleic acid--RNA | Mammalian cells | Plant cells | E coli | Genetic engineering
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2. Full Text Nucleic acid detection with CRISPR-Cas13a/C2c2
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Lee, Jeong Wook and Essletzbichler, Patrick and Dy, Aaron J and Joung, Julia and Verdine, Vanessa and Donghia, Nina and Daringer, Nichole M and Freije, Catherine A and Myhrvold, Cameron and Bhattacharyya, Roby P and Livny, Jonathan and Regev, Aviv and Koonin, Eugene V and Hung, Deborah T and Sabeti, Pardis C and Collins, James J and Zhang, Feng
Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. 438 - 442
Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided,... 
CRISPR-CAS SYSTEMS | AMPLIFICATION | CIRCULATING TUMOR DNA | PROTEINS | MULTIDISCIPLINARY SCIENCES | ZIKA VIRUS | Circulating Tumor DNA - analysis | Zika Virus - genetics | Circulating Tumor DNA - genetics | Ribonucleases - chemistry | Humans | Bacterial Proteins - chemistry | RNA, Viral - analysis | RNA Cleavage | Zika Virus - isolation & purification | Dengue Virus - genetics | Bacteria - isolation & purification | RNA, Viral - genetics | Zika Virus Infection - diagnosis | Neoplasms - genetics | Point-of-Care Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA, Bacterial - analysis | Bacteria - pathogenicity | Dengue Virus - isolation & purification | Mutation | Dengue - diagnosis | Methods | Nucleotide sequencing | DNA sequencing | Vector-borne diseases | Pathogens | CRISPR | Target recognition | Nucleotide sequence | Dengue | Viruses | Zika virus | Nucleic acids | Ribonuclease | Recombinase | Ribonucleic acid--RNA | Sensitivity | Genotyping | Reagents | Bacteria | Deoxyribonucleic acid--DNA | Amplification | Ribonucleic acids | Deoxyribonucleic acid
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3. Full Text Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
by Zetsche, Bernd and Gootenberg, Jonathan S and Abudayyeh, Omar O and Slaymaker, Ian M and Makarova, Kira S and Essletzbichler, Patrick and Volz, Sara E and Joung, Julia and van der Oost, John and Regev, Aviv and Koonin, Eugene V and Zhang, Feng
Cell, ISSN 0092-8674, 10/2015, Volume 163, Issue 3, pp. 759 - 771
The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1... 
ADAPTIVE IMMUNITY | STREPTOCOCCUS-THERMOPHILUS | BACTERIA | SPECIFICITY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TARGET DNA | SURVEILLANCE COMPLEX | CLEAVAGE | PROKARYOTES | CELL BIOLOGY | Genetic Engineering - methods | Amino Acid Sequence | Endonucleases - genetics | RNA, Guide - genetics | Humans | Molecular Sequence Data | Endonucleases - chemistry | Sequence Alignment | Francisella - enzymology | CRISPR-Cas Systems | HEK293 Cells | Nucleic Acid Conformation | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | Cells | Research institutes | Microbiological Laboratory | Microbiologie | Microbiology | VLAG | Laboratorium voor Microbiologie
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4. Full Text Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28
by Smargon, Aaron A and Cox, David B.T and Pyzocha, Neena K and Zheng, Kaijie and Slaymaker, Ian M and Gootenberg, Jonathan S and Abudayyeh, Omar A and Essletzbichler, Patrick and Shmakov, Sergey and Makarova, Kira S and Koonin, Eugene V and Zhang, Feng
Molecular Cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 4, pp. 618 - 630.e7
CRISPR-Cas adaptive immune systems defend microbes against foreign nucleic acids via RNA-guided endonucleases. Using a computational sequence database mining... 
IMMUNITY | COMPLEX | TRANSCRIPTOME | ALIGNMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEINS | SYSTEMS | IDENTIFICATION | THERMUS-THERMOPHILUS | PYROCOCCUS-FURIOSUS | PREDICTION | CELL BIOLOGY | Ribonucleases - genetics | Escherichia coli - enzymology | RNA, Guide - genetics | CRISPR-Associated Proteins - genetics | RNA, Guide - metabolism | Bacterial Proteins - genetics | Computational Biology | Databases, Genetic | Data Mining | Ribonucleases - metabolism | RNA Interference | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | RNA, Bacterial - genetics | Bacterial Proteins - metabolism | Gene Editing - methods | Gene Expression Regulation, Bacterial | RNA, Bacterial - metabolism | Electrical engineering | Computer science | RNA | Escherichia coli | Mineral industry | Ribonuclease | Research institutes | Mining industry | Electric properties
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5. Full Text Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
by Essletzbichler, Patrick and Konopka, Tomasz and Santoro, Federica and Chen, Doris and Gapp, Bianca V and Kralovics, Robert and Brummelkamp, Thijn R and Nijman, Sebastian M. B and Bürckstümmer, Tilmann
Genome Research, ISSN 1088-9051, 12/2014, Volume 24, Issue 12, pp. 2059 - 2065
Near-haploid human cell lines are instrumental for genetic screens and genome engineering as gene inactivation is greatly facilitated by the absence of a... 
DERIVATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | GENETIC SCREENS | GENETICS & HEREDITY | CHROMOSOMAL DELETIONS | CRISPR-CAS9 | CAS9 | LEUKEMIA | INVERSIONS | NUCLEASES | Genetic Engineering - methods | Cell Line | Haploidy | Sequence Deletion | Genomics | Humans | Gene Expression Profiling | CRISPR-Cas Systems - genetics | Karyotype | Genetic engineering | Research | Single nucleotide polymorphisms | Chromosomes | Cell lines | Method
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6. Full Text The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
by Sedlyarov, Vitaly and Eichner, Ruth and Girardi, Enrico and Essletzbichler, Patrick and Goldmann, Ulrich and Nunes-Hasler, Paula and Srndic, Ismet and Moskovskich, Anna and Heinz, Leonhard X and Kartnig, Felix and Bigenzahn, Johannes W and Rebsamen, Manuele and Kovarik, Pavel and Demaurex, Nicolas and Superti-Furga, Giulio
Cell Host & Microbe, ISSN 1931-3128, 06/2018, Volume 23, Issue 6, pp. 766 - 774.e5
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we... 
SLC4A7 | NBC3 | phagocytosis | intracellular bacterial killing | macrophages | NBCn1 | CRISPR screen | solute carrier | phagosome acidification | COTRANSPORTER NBCN1 | SODIUM/BICARBONATE COTRANSPORTER | HUMAN NEUTROPHILS | CYTOPLASMIC PH | IMMUNOMETABOLISM | MICROBIOLOGY | FUNCTIONAL-CHARACTERIZATION | MATURATION | VIROLOGY | DIFFERENTIATION | CELL | PARASITOLOGY | EXCHANGER | Humans | Phagosomes - metabolism | Sodium-Bicarbonate Symporters - genetics | THP-1 Cells | Transcriptome | Homeostasis | Cytoplasm - metabolism | Gene Knockout Techniques | Macrophages - metabolism | Cation Transport Proteins - metabolism | U937 Cells | CRISPR-Cas Systems | Bicarbonates - metabolism | Sodium-Bicarbonate Symporters - physiology | Phagocytosis | Hydrogen-Ion Concentration | Macrophages | Bacteria | Carbonates
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7. Full Text RNA targeting with CRISPRCas13
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Essletzbichler, Patrick and Han, Shuo and Joung, Julia and Belanto, Joseph J and Verdine, Vanessa and Cox, David B. T and Kellner, Max J and Regev, Aviv and Lander, Eric S and Voytas, Daniel F and Ting, Alice Y and Zhang, Feng
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, p. 280
RNA sequencing | Methods
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8. Full Text RNA targeting with CRISPR-Cas13a
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Essletzbichler, Patrick and Han, Shuo and Joung, Julia and Belanto, Joseph J and Verdine, Vanessa and Cox, David B.T and Kellner, Max J and Regev, Aviv and Lander, Eric S and Voytas, Daniel F and Ting, Alice Y and Zhang, Feng
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 280 - 284
RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. For example, RNA interference (RNAi) 1 - 3 can... 
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