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1. Full Text “S'ils n'ont pas de pain, qu'ils mangent de la brioche.” Focus on “Anaerobic respiration sustains mitochondrial membrane potential in a prolyl hydroxylase pathway-activated cancer cell line in a hypoxic microenvironment”
by Esumi, Hiroyasu
American Journal of Physiology-Cell Physiology, ISSN 0363-6143, 02/2014, Volume 306, Issue 4, pp. C320 - C321
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2. Full Text "S'ils n'ont pas de pain, qu'ils mangent de la brioche." Focus on "Anaerobic respiration sustains mitochondrial membrane potential in a prolyl hydroxylase pathway-activated cancer cell line in a hypoxic microenvironment"
by Esumi, Hiroyasu
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 02/2014, Volume 306, Issue 4, pp. C320 - C321
PHYSIOLOGY | CELL BIOLOGY | Luminescent Agents - analysis | Green Fluorescent Proteins - analysis | Luminescent Measurements - methods | Humans | Oxygen - analysis
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3. Full Text Autophagy and cancer: Dynamism of the metabolism of tumor cells and tissues
by Tsuchihara, Katsuya and Fujii, Satoshi and Esumi, Hiroyasu
Cancer Letters, ISSN 0304-3835, 2008, Volume 278, Issue 2, pp. 130 - 138
Abstract Autophagy is a dynamic process involving the bulk degradation of cytoplasmic organelles and proteins. Based on the function of “cellular recycling”,... 
Hematology, Oncology and Palliative Medicine | Energy metabolism | Tumor microenvironment | Autophagy | LC3 | SURVIVAL | SUPPRESSOR | APOPTOSIS | MATURATION | NUTRIENT DEPRIVATION | INHIBITION | THERAPY | BECLIN-1 | ONCOLOGY | TUMORIGENESIS | SELF-DIGESTION | Beclin-1 | Neoplasms - metabolism | Humans | Tumor Suppressor Protein p53 - physiology | Tumor Suppressor Proteins - physiology | Animals | Energy Metabolism | Membrane Proteins - physiology | Protein Kinases - physiology | Apoptosis Regulatory Proteins - physiology | TOR Serine-Threonine Kinases | Neoplasms - pathology | Apoptosis | Proteins | Analysis | Oncology, Experimental | Physiological aspects | Development and progression | Research | Cancer | Medical research | Cell culture | Cell division | Amino acids | Biology | Kinases | Metabolism | Microscopy | Quality control | Tumorigenesis | Tumors | Animal models
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4. Full Text An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system-a unique mitochondrial energy metabolism in tumour microenvironments
by Tomitsuka, Eriko and Kita, Kiyoshi and Esumi, Hiroyasu
Journal of Biochemistry, ISSN 0021-924X, 08/2012, Volume 152, Issue 2, pp. 171 - 183
Increased glycolysis is the principal explanation for how cancer cells generate energy in the absence of oxygen. However, in actual human tumour... 
complex I | NADH-fumarate reductase system | tumour microenvironments | complex II | pyrvinium pamoate | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN COMPLEX-II | FLAVOPROTEIN SUBUNIT | ANTITUMOR-ACTIVITY | GLUCOSE STARVATION | IN-VITRO | UNFOLDED PROTEIN RESPONSE | TCA CYCLE | SUCCINATE-UBIQUINONE REDUCTASE | ASCARIS-SUUM | Tumor Microenvironment - drug effects | Ascaris suum - drug effects | Mitochondria, Heart - metabolism | Humans | Enzyme Inhibitors - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria, Heart - drug effects | Hypoglycemia - drug therapy | Hypoglycemia - metabolism | Oxidoreductases Acting on CH-CH Group Donors - antagonists & inhibitors | Hypoxia - metabolism | Cell Hypoxia | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Animals | Energy Metabolism | Anthelmintics - pharmacology | Cattle | Electron Transport Complex II - metabolism | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Pyrvinium Compounds - pharmacology
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5. Full Text Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs
by Onozuka, Hiroko and Tsuchihara, Katsuya and Esumi, Hiroyasu
Cancer Science, ISSN 1347-9032, 05/2011, Volume 102, Issue 5, pp. 975 - 982
Tumor tissues are often hypoxic because of defective vasculature. We previously showed that tumor tissues are also often deprived of glucose. The efficacy of... 
INDUCIBLE FACTOR-I | NUCLEOSIDE ANALOGS | SOLID TUMORS | ONCOLOGY | STALLED REPLICATION FORKS | NUTRIENT STARVATION | PREMATURE MITOSIS | HYPOXIA | GEMCITABINE | PANCREATIC-CANCER CELLS | CHECKPOINT ABROGATION | Tumor Microenvironment - drug effects | Cell Hypoxia - physiology | Humans | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Tumor Microenvironment - physiology | Hypoglycemia | Drug Resistance, Neoplasm - physiology | Blotting, Western | Drugs | Care and treatment | Drug delivery systems | Oncology, Experimental | Research | Glucose | Drug resistance | Antineoplastic agents | Dextrose | Vehicles | Antimitotic agents | DNA | Cancer | Indexing in process
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6. Full Text Effect of a poly(ADP‐ribose) polymerase‐1 inhibitor against esophageal squamous cell carcinoma cell lines
by Nasuno, Tomomitsu and Mimaki, Sachiyo and Okamoto, Makito and Esumi, Hiroyasu and Tsuchihara, Katsuya
Cancer Science, ISSN 1347-9032, 02/2014, Volume 105, Issue 2, pp. 202 - 210
Effective molecular target drugs that improve therapeutic efficacy with fewer adverse effects for esophageal cancer are highly anticipated. Poly(ADP‐ribose)... 
RNF8 | esophageal cancer | DNA repair | poly(ADP‐ribose) polymerase inhibitor | γ‐H2AX | γ-H2AX | Esophageal cancer | Poly(ADP-ribose) polymerase inhibitor | H2AX | ENDOSCOPIC MUCOSAL RESECTION | STRAND BREAK REPAIR | MUTANT-CELLS | SENSITIVITY | FANCONI-ANEMIA | CANCER | DEFICIENCY | poly(ADP-ribose) polymerase inhibitor | ONCOLOGY | ATM | HOMOLOGOUS RECOMBINATION | RADIOTHERAPY | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Molecular Sequence Data | G2 Phase - drug effects | DNA-Binding Proteins - metabolism | MCF-7 Cells | Esophageal Neoplasms - metabolism | Esophageal Squamous Cell Carcinoma | DNA Damage - drug effects | Carcinoma, Squamous Cell - enzymology | DNA Repair - drug effects | DNA-Binding Proteins - genetics | Mutation - genetics | Piperazines - adverse effects | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Cell Division - drug effects | Ubiquitin-Protein Ligases | Phthalazines - pharmacology | Esophageal Neoplasms - enzymology | Carcinoma, Squamous Cell - drug therapy | Histones - genetics | Mutation - drug effects | Esophageal Neoplasms - genetics | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Histones - metabolism | Esophageal Neoplasms - drug therapy | Phthalazines - adverse effects | Squamous cell carcinoma | Ligases | DNA damage | Development and progression | Sugars | Tumors | Monosaccharides | Growth rate | Toxicity | Cancer therapies | Comet assay | Defects | Ribose | Cell cycle | Tumorigenesis | Endoscopy | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Polyclonal antibodies | Cell survival | Poly(ADP-ribose) polymerase | Tumor cell lines | Double-strand break repair | Esophagus | Medical prognosis | Cell lines | Biomarkers | Software | Mutation | Index Medicus | Original
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7. Full Text The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
by Tomitsuka, Eriko and Kita, Kiyoshi and Esumi, Hiroyasu
Annals of the New York Academy of Sciences, ISSN 0077-8923, 07/2010, Volume 1201, Issue 1, pp. 44 - 49
Since deficiencies of critical nutrients and hypoxia are observed in hypovascular tumors, glycolysis alone cannot explain how cancer cells maintain their... 
tumor microenvironment | phosphorylation | mitochondria | complex II | energy metabolism | CANCER-CELLS | RESPIRATORY-CHAIN | MULTIDISCIPLINARY SCIENCES | REVERSIBLE PHOSPHORYLATION | PYRVINIUM PAMOATE | NUTRIENT STARVATION | IDENTIFICATION | IN-VITRO | COMPLEX-II | FLAVOPROTEIN | ANAEROBIC METABOLISM | Neoplasms - metabolism | Phosphorylation | Humans | Gene Expression Regulation, Neoplastic | Mitochondria - metabolism | Neoplasms - drug therapy | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Animals | Energy Metabolism | Models, Biological | Oxygen - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Pyrvinium Compounds - pharmacology | Antimitotic agents | Glucose metabolism | Care and treatment | Oncology, Experimental | Physiological aspects | Mitochondrial DNA | Research | Antineoplastic agents | Cancer | Medical research | Metabolism | Rodents | Human | Reductases | Therapy | Energy levels | Organisms | Tumors
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8. Full Text Phase I trial of GBS‐01 for advanced pancreatic cancer refractory to gemcitabine
by Ikeda, Masafumi and Sato, Akihiro and Mochizuki, Nobuo and Toyosaki, Kayo and Miyoshi, Chika and Fujioka, Rumi and Mitsunaga, Shuichi and Ohno, Izumi and Hashimoto, Yusuke and Takahashi, Hideaki and Hasegawa, Hiromi and Nomura, Shogo and Takahashi, Ryuji and Yomoda, Satoshi and Tsuchihara, Katsuya and Kishino, Satoshi and Esumi, Hiroyasu
Cancer Science, ISSN 1347-9032, 12/2016, Volume 107, Issue 12, pp. 1818 - 1824
GBS‐01, an extract from the fruit of Arctium lappa L. is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by... 
Arctigenin | phase I trial | pancreatic cancer | gemcitabine | chemotherapy | natural anticancer compound | CELLS | FOLFIRINOX | TOLERANCE | IDENTIFICATION | TUMORS | THERAPY | ONCOLOGY | S-1 | STARVATION | Humans | Middle Aged | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Male | Tomography, X-Ray Computed | Biomarkers, Tumor | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - administration & dosage | Deoxycytidine - therapeutic use | Neoplasm Metastasis | Adult | Female | Pancreatic Neoplasms - mortality | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacokinetics | Antineoplastic Agents, Phytogenic - adverse effects | Pancreatic Neoplasms - pathology | Neoplasm Recurrence, Local | Treatment Outcome | Maximum Tolerated Dose | Survival Analysis | Aged | Drug Monitoring | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Antimitotic agents | Chemotherapy | Hyperglycemia | Pancreatic cancer | Clinical trials | Product development | Bilirubin | Antineoplastic agents | Cancer | Gemcitabine | g-Glutamyltransferase | Toxicity | Oral administration | Metastasis | Bioavailability | Glucose | Cancer therapies | Patients | Fruits | Herbal medicine | Tomography | Antitumor activity | Hypoxia | Pharmacokinetics | Pharmaceutical industry | Drug dosages | Tumors | Index Medicus | Original
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9. Full Text The Development and Clinical Use of a Beam ON-LINE PET System Mounted on a Rotating Gantry Port in Proton Therapy
by Nishio, Teiji, Ph.D and Miyatake, Aya, M.Sc and Ogino, Takashi, M.D and Nakagawa, Keiichi, M.D and Saijo, Nagahiro, M.D and Esumi, Hiroyasu, M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 76, Issue 1, pp. 277 - 286
Purpose To verify the usefulness of our developed beam ON-LINE positron emission tomography (PET) system mounted on a rotating gantry port (BOLPs-RGp) for... 
Radiology | Hematology, Oncology and Palliative Medicine | Beam ON-LINE PET system on rotating gantry port (BOLPs-RGp) | Dose–volume delivery guided proton therapy (DGPT) | Target nuclear fragment reaction | Dose-volume delivery guided proton therapy (DGPT) | DISTRIBUTIONS | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | VERIFICATION | DELIVERY | Prostatic Neoplasms - radiotherapy | Reproducibility of Results | Brain Neoplasms - diagnostic imaging | Head and Neck Neoplasms - diagnostic imaging | Humans | Lung Neoplasms - radiotherapy | Protons - therapeutic use | Male | Technology, Radiologic - instrumentation | Positron-Emission Tomography - methods | Technology, Radiologic - methods | Neoplasms - diagnostic imaging | Online Systems | Positron-Emission Tomography - instrumentation | Equipment Design | Liver Neoplasms - diagnostic imaging | Rotation | Radiography | Algorithms | Liver Neoplasms - radiotherapy | Prostatic Neoplasms - diagnostic imaging | Lung Neoplasms - diagnostic imaging | Neoplasms - radiotherapy | Medical colleges | Pets | Research | Oncology, Experimental | Cancer | TOMOGRAPHY | HEAD | DIGESTIVE SYSTEM | EMISSION COMPUTED TOMOGRAPHY | LUNGS | NERVOUS SYSTEM | FERMIONS | MALE GENITALS | TUMOR CELLS | ANIMAL CELLS | MEDICINE | THERAPY | GLANDS | POSITRON COMPUTED TOMOGRAPHY | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | BRAIN | RADIOLOGY | PROSTATE | DIAGNOSTIC TECHNIQUES | NEOPLASMS | CENTRAL NERVOUS SYSTEM | PROTONS | COMPUTERIZED TOMOGRAPHY | ELEMENTARY PARTICLES | NUCLEAR MEDICINE | NUCLEONS | ACCURACY | ORGANS | DISEASES | RESPIRATORY SYSTEM | LIVER | NECK | BARYONS | BODY | HADRONS
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10. Full Text Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome
by Fujii, Satoshi and Mitsunaga, Shuichi and Yamazaki, Manabu and Hasebe, Takahiro and Ishii, Genichiro and Kojima, Motohiro and Kinoshita, Taira and Ueno, Takashi and Esumi, Hiroyasu and Ochiai, Atsushi
Cancer Science, ISSN 1347-9032, 09/2008, Volume 99, Issue 9, pp. 1813 - 1819
Because autonomous proliferating cancer cells are often exposed to hypoxic conditions, there must be an alternative metabolic pathway, such as autophagy, that... 
NUTRIENT DEPRIVATION | SURVIVAL | PROGNOSTIC INDICATORS | ONCOLOGY | DUCTAL ADENOCARCINOMA | RESECTION | TOLERANCE | HYPOXIA | MATURATION | TUMOR-GROWTH | CARCINOMA | Immunohistochemistry | Gene Expression | Microtubule-Associated Proteins - metabolism | Neoplasm Invasiveness | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - surgery | Male | Pancreaticoduodenectomy | Autophagy | Disease-Free Survival | Biomarkers | Female | Aged | Neoplasm Staging | Research | Pancreatic cancer | Patient outcomes | Oncology, Experimental | Cancer cells | Cancer
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11. Full Text Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry
by Kami, Kenjiro and Kami, Kenjiro and Fujimori, Tamaki and Fujimori, Tamaki and Sato, Hajime and Sato, Hajime and Sato, Mutsuko and Sato, Mutsuko and Yamamoto, Hiroyuki and Yamamoto, Hiroyuki and Ohashi, Yoshiaki and Ohashi, Yoshiaki and Sugiyama, Naoyuki and Sugiyama, Naoyuki and Ishihama, Yasushi and Ishihama, Yasushi and Onozuka, Hiroko and Onozuka, Hiroko and Ochiai, Atsushi and Ochiai, Atsushi and Esumi, Hiroyasu and Esumi, Hiroyasu and Soga, Tomoyoshi and Soga, Tomoyoshi and Tomita, Masaru and Tomita, Masaru
Metabolomics, ISSN 1573-3882, 4/2013, Volume 9, Issue 2, pp. 444 - 453
Metabolic microenvironment of tumor cells is influenced by oncogenic signaling and tissue-specific metabolic demands, blood supply, and enzyme expression. To... 
Life Sciences | Biochemistry, general | Metabolomics | CE-MS | Phosphoproteomics | Tumor microenvironment | Lung cancer | Molecular Medicine | Developmental Biology | Prostate cancer | Biomedicine general | Cell Biology | CANCER-CELLS | SYSTEM | PHOSPHORYLATION SITES | PYRUVATE-DEHYDROGENASE | FUMARATE REDUCTASE | PEPTIDES | ENDOCRINOLOGY & METABOLISM | ENRICHMENT | METAL-OXIDE CHROMATOGRAPHY | PROTEOMICS | KINASES | Lactates | Glucose metabolism | Enzymes | Squamous cell carcinoma | Metabolites | Branched chain amino acids | Analysis | Electrophoresis | Universities and colleges | Mass spectrometry | Tumors | Original
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12. Full Text Critical Role of H2O2 Generated by NOX4 during Cellular Response under Glucose Deprivation
by Owada, Satoshi and Shimoda, Yuko and Tsuchihara, Katsuya and Esumi, Hiroyasu
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e56628
Glucose is the most efficient energy source, and various cancer cells depend on glycolysis for energy production. For maintenance of survival and... 
CELLS | ACTIVATION | PROTEIN | INDUCED APOPTOSIS | PATHWAY | TYROSINE KINASE | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | PYRVINIUM PAMOATE | AKT | Oxidative stress | Yeasts | Phosphorylation | Hydrogen peroxide | Acetylcysteine | AKT protein | Oncology | Lipids | Chemoreception | Glucose | Kinases | Machinery | Deoxyglucose | Cell adhesion & migration | Mammalian cells | Machinery and equipment | Proteins | Antioxidants | Hyperglycemia | Metabolic flux | Cell growth | NOX4 protein | Metabolites | Fibroblasts | Physiology | Glucose transporter | Deprivation | Cell survival | Intracellular levels | RNA-mediated interference | Gene expression | Ribonucleic acid--RNA | Fructose | 1-Phosphatidylinositol 3-kinase | Pancreatic cancer | Glycolysis | Hypoxia | Intracellular | Galactose | Detection | Transporter | Cancer | Apoptosis | RNA | Ribonucleic acid
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13. Full Text Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: The Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study
by Shinozaki, Eiji and Yoshino, Takayuki and Yamazaki, Kentaro and Muro, Kei and Yamaguchi, Kensei and Nishina, Tomohiro and Yuki, Satoshi and Shitara, Kohei and Bando, Hideaki and Mimaki, Sachiyo and Nakai, Chikako and Matsushima, Koutatsu and Suzuki, Yutaka and Akagi, Kiwamu and Yamanaka, Takeharu and Nomura, Shogo and Fujii, Satoshi and Esumi, Hiroyasu and Sugiyama, Masaya and Nishida, Nao and Mizokami, Masashi and Koh, Yasuhiro and Abe, Yukiko and Ohtsu, Atsushi and Tsuchihara, Katsuya
British Journal of Cancer, ISSN 0007-0920, 11/2017, Volume 117, Issue 10, pp. 1450 - 1458
Background: Patients with BRAF(V600E)-mutated metastatic colorectal cancer (mCRC) have a poorer prognosis as well as resistance to anti-EGFR antibodies.... 
LOCATION | PRIMARY TUMORS | PLUS CETUXIMAB | anti-epidermal growth factor receptor monoclonal antibody | RAS mutation | BRAF(non-V600E) mutation | CHEMOTHERAPY | PANITUMUMAB | BRAF(V600E) mutation | GENE | ONCOLOGY | RAS MUTATIONS | metastatic colorectal cancer | KRAS | Colorectal Neoplasms - mortality | ErbB Receptors - antagonists & inhibitors | Colorectal Neoplasms - genetics | Genomics | Humans | Middle Aged | Panitumumab | Kaplan-Meier Estimate | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - drug therapy | Adult | Female | Aged | Biomarkers, Tumor - genetics | Mutation | Cohort Studies | Epidermal growth factor receptors | Colorectal carcinoma | Colorectal cancer | Monoclonal antibodies | Biomarkers | Inference | Metastasis | Patients | Cancer | K-Ras protein | Metastases | BRAFnon-V600E mutation | Clinical Study | BRAFV600E mutation
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14. Full Text Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer
by Fujioka, Rumi and Mochizuki, Nobuo and Ikeda, Masafumi and Sato, Akihiro and Nomura, Shogo and Owada, Satoshi and Yomoda, Satoshi and Tsuchihara, Katsuya and Kishino, Satoshi and Esumi, Hiroyasu
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, p. e0198219
Arctigenin is evaluated for antitumor efficacy in patients with pancreatic cancer. It has an inhibitory activity on mitochondrial complex I .Therefore, plasma... 
SPRAGUE-DAWLEY RATS | NUTRIENT DEPRIVATION | CELLS | THERAPY | METABOLISM | PATHWAY | TOLERANCE | GLUCOSE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | STARVATION | Area Under Curve | Lactic Acid - blood | Gluconeogenesis - drug effects | Humans | Carcinoma, Adenosquamous - drug therapy | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Liver - physiopathology | Furans - therapeutic use | Lignans - therapeutic use | Oxidative Phosphorylation - drug effects | Pancreatic Neoplasms - drug therapy | Furans - pharmacokinetics | Arctium - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacokinetics | Drugs, Chinese Herbal - therapeutic use | Kidney - physiopathology | Pancreatic Neoplasms - blood | Kaplan-Meier Estimate | Biomarkers - blood | Mitochondria - drug effects | Carcinoma, Adenosquamous - blood | Carcinoma, Pancreatic Ductal - blood | Carcinoma, Pancreatic Ductal - drug therapy | Drugs, Chinese Herbal - pharmacokinetics | Lignans - pharmacokinetics | Cell Line, Tumor | Plant Extracts - therapeutic use | Deoxycytidine - analogs & derivatives | Drug Screening Assays, Antitumor | Lactates | Development and progression | Care and treatment | Genetic aspects | Identification and classification | Pancreatic cancer | Plasma | Diabetic retinopathy | Gemcitabine | Liver | Clinical trials | Oncology | Colorimetry | Kinases | Cancer therapies | Anticancer properties | Electron transport chain | Mitochondria | Rodents | Surgery | Pharmaceutical industry | NADH-ubiquinone oxidoreductase | Statistical analysis | Pharmacology | Metabolism | Patients | Chemotherapy | Biomarkers | Antitumor activity | Hypoxia | Lactic acid | Respiration | Alzheimers disease | Pharmacokinetics | Cancer
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