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1. Full Text Mechanisms of acquired tumor drug resistance
by Aleksakhina, Svetlana N and Kashyap, Aniruddh and Imyanitov, Evgeny N
BBA - Reviews on Cancer, ISSN 0304-419X, 12/2019, Volume 1872, Issue 2, p. 188310
Systemic therapy often results in the reduction of tumor size but rarely succeeds in eradicating all cancer cells. Drug efflux, persistence of cancer stem... 
Tumor heterogeneity | Mutation | Drug resistance | Cancer
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2. Molecular Tests for the Choice of Cancer Therapy
by Sokolenko, Anna P and Imyanitov, Evgeny N
Current pharmaceutical design, 2017, Volume 23, Issue 32, pp. 4794 - 4806
There are over a dozen of approved cancer drugs, whose administration is tailored to predictive laboratory tests. The examples include estrogen and... 
cancer therapy | cytotoxic therapy | mutation | targeted therapy | Predictive markers | expression | Genome-Wide Association Study | Humans | Neoplastic Cells, Circulating - metabolism | Tumor Burden | Molecular Targeted Therapy | Genetic Testing - methods | Neoplasms - drug therapy | Animals | Neoplasms - genetics | DNA Repair | Drug Design | Antineoplastic Agents - pharmacology | High-Throughput Nucleotide Sequencing | Neoplasms - pathology
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3. Full Text Molecular diagnostics in clinical oncology
by Sokolenko, Anna P and Imyanitov, Evgeny N
Frontiers in Molecular Biosciences, ISSN 2296-889X, 08/2018, Volume 5, p. 76
There are multiple applications of molecular tests in clinical oncology. Mutation analysis is now routinely utilized for the diagnosis of hereditary cancer... 
Liquid biopsy | Molecular diagnostics | Predictive markers | Review | Carcinoma of unknown primary site | Hereditary cancer syndromes | TARGETED THERAPY | molecular diagnostics | ESTROGEN-RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVARIAN-CANCER | carcinoma of unknown primary site | CELL LUNG-CANCER | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | hereditary cancer syndromes | predictive markers | review | UNKNOWN PRIMARY SITE | COLORECTAL-CANCER | OF-AMERICAN-PATHOLOGISTS | CANCER SUSCEPTIBILITY GENE | liquid biopsy | Usage | Gene mutations | Molecular diagnostic techniques | Genetic aspects | Diagnosis | Research | Gene expression | Cancer
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4. Full Text Gene polymorphisms, apoptotic capacity and cancer risk
by Imyanitov, Evgeny N
Human Genetics, ISSN 0340-6717, 4/2009, Volume 125, Issue 3, pp. 239 - 246
Programmed cell death has been implicated in various aspects of cancer development. Apoptotic capacity is a subject of significant interindividual variations,... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | BREAST-CANCER | LUNG-CANCER | CHRONIC-LYMPHOCYTIC-LEUKEMIA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | FUNCTIONAL POLYMORPHISM | GENETICS & HEREDITY | PROMOTER REGION | NECROSIS-FACTOR-ALPHA | SINGLE NUCLEOTIDE POLYMORPHISM | BLOOD MONONUCLEAR-CELLS | RADIATION-INDUCED APOPTOSIS | Genes, p53 | Neoplasms - etiology | Neoplasms - genetics | Humans | Risk Factors | Apoptosis - genetics | Genotype | Polymorphism, Single Nucleotide | DNA Damage | Neoplasms - pathology | Case-Control Studies | Polymorphism, Genetic
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5. Full Text Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
by Couch, Fergus J and Wang, Xianshu and McGuffog, Lesley and Lee, Anew and Olswold, Curtis and Kuchenbaecker, Karoline B and Soucy, Penny and Fredericksen, Zachary and Barrowdale, Daniel and Dennis, Joe and Gaudet, Mia M and Dicks, Ed and Kosel, Matthew and Healey, Sue and Sinilnikova, Olga M and Lee, Adam and Bacot, François and Vincent, Daniel and Hogervorst, Frans B. L and Peock, Susan and Stoppa-Lyonnet, Dominique and Jakubowska, Anna and Radice, Paolo and Schmutzler, Rita Katharina and Domchek, Susan M and Piedmonte, Marion and Singer, Christian F and Friedman, Eitan and Thomassen, Mads and Hansen, Thomas V. O and Neuhausen, Susan L and Szabo, Csilla I and Blanco, Ignacio and Greene, Mark H and Karlan, Beth Y and Garber, Judy and Phelan, Catherine M and Weitzel, Jeffrey N and Montagna, Marco and Olah, Edith and Anulis, Irene L and Godwin, Anew K and Yannoukakos, koulis and Goldgar, David E and Caldes, Trinidad and Nevanlinna, Heli and Osorio, Ana and Terry, Mary Beth and Daly, Mary B and van Rensburg, Elizabeth J and Hamann, Ute and Ramus, Susan J and Toland, Amanda Ewart and Caligo, Maria A and Olopade, Olufunmilayo I and Tung, Nadine and Claes, Kathleen and Beattie, Mary S and Southey, Melissa C and Imyanitov, Evgeny N and Tischkowitz, Marc and Janavicius, Ramunas and John, Esther M and Kwong, Ava and Diez, Orland and Balmaña, Judith and Barkardottir, Rosa B and Arun, Banu K and Rennert, Gad and teo, Soo-Hwang and Ganz, Patricia A and Campbell, Ian and van der Hout, Annemarie H and van Deurzen, Carolien H. M and Seynaeve, Caroline and Gómez Garcia, Encarna B and van Leeuwen, Flora E and Meijers-Heijboer, Hanne E. J and Gille, Johannes J. P and Ausems, Margreet G. E. M and Blok, Marinus J and Ligtenberg, Marjolijn J. L and Rookus, Matti A and Devilee, Peter and Verhoef, Senno and van Os, Theo A. M and Wijnen, Juul T and Frost, Debra and Ellis, Steve and Fineberg, Elena and Platte, Radka and Evans, D. Gareth and Izatt, Louise and Eeles, Rosalind A and Adlard, Julian and Eccles, Diana M and Cook, Jackie and Brewer, Carole and Douglas, Fiona and Hodgson, Shirley and ... and KConFab Investigators and Ontario Canc Genetics Network and EMBRACE and GEMO Study Collaborators and CIMBA and HEBON and BCFR and SWE-BRCA and Ontario Cancer Genetics Network and kConFab Investigators and on behalf of CIMBA and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Onkologi and Hälsouniversitetet
PLoS genetics, ISSN 1553-7390, 2013, Volume 9, Issue 3, p. e1003212
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a... 
CONSORTIUM | COMMON VARIANTS | POPULATION | INVESTIGATORS | MODIFIERS | SUBTYPES | SUSCEPTIBILITY ALLELES | GENETICS & HEREDITY | GENETIC-VARIANTS | SELECTION | ZNF365 | Genetic Predisposition to Disease | Genome-Wide Association Study | Prognosis | Humans | Middle Aged | Risk Factors | Ovarian Neoplasms - pathology | Genotype | Ovarian Neoplasms - genetics | BRCA1 Protein - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Female | Heterozygote | Polymorphism, Single Nucleotide | Mutation | BRCA2 Protein - genetics | Gene mutations | Genomics | Physiological aspects | Breast cancer | Genetic aspects | Research | Risk factors | Ovarian cancer | Cancer | Càncer d'ovari | Càncer de mama | Malalties hereditàries | Genètica humana | Genetic diseases | Human genetics | Life Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medical research
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6. Full Text Use of elderly tumor-free subjects as a "supercontrol" for cancer epidemiological studies: pros and cons
by Imyanitov, Evgeny N
Mechanisms of Ageing and Development, ISSN 0047-6374, 01/2009, Volume 130, Issue 1-2, pp. 122 - 127
Search for cancer-predisposing single-nucleotide gene polymorphisms is complicated due to weakness of expected associations. We introduced a novel design for... 
Genetic predisposition | Case-control studies | Gene polymorphisms | SNP | Ageing | Cancer | FREE SMOKERS | GENETIC POLYMORPHISMS | HUMAN LONGEVITY | DRUG-METABOLIZING-ENZYMES | P53 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | BREAST-CANCER | LUNG-CANCER | SUSCEPTIBILITY ALLELES | POOLED-ANALYSIS | ASSOCIATION | Neoplasms - genetics | Bias | Humans | Risk Factors | Aging | Aged | Genetic Predisposition to Disease - epidemiology | Case-Control Studies | Neoplasms - epidemiology | Analysis | Oncology, Experimental | Research | Tumor proteins | Epidemiology
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7. Full Text Identification of six new susceptibility loci for invasive epithelial ovarian cancer
by Kuchenbaecker, K.B and Ramus, S.J and Tyrer, J and Lee, A and Shen, H.C and Beesley, J and Lawrenson, K and McGuffog, L and Healey, S and Lee, J.M and Spindler, T.J and Lin, Y.G and Pejovic, T and Bean, Y and Li, Q and Coetzee, S and Hazelett, D and Miron, A and Southey, M and Terry, M.B and Goldgar, D.E and Buys, S.S and Janavicius, R and Dorfling, C.M and Rensburg, E.J. van and Neuhausen, S.L and Ding, Y.C and Hansen, T.V and Jonson, L and Gerdes, A.M and Ejlertsen, B and Barrowdale, D and Dennis, J and Benitez, J and Osorio, A and Garcia, M.J and Komenaka, I and Weitzel, J.N and Ganschow, P and Peterlongo, P and Bernard, L and Viel, A and Bonanni, B and Peissel, B and Manoukian, S and Radice, P and Papi, L and Ottini, L and Fostira, F and Konstantopoulou, I and Garber, J and Frost, D and Perkins, J and Platte, R and Ellis, S and Embrace and Godwin, A.K and Schmutzler, R.K and Meindl, A and Engel, C and Sutter, C and Sinilnikova, O.M and Damiola, F and Mazoyer, S and Stoppa-Lyonnet, D and Claes, K and Leeneer, K. De and Kirk, J and Roiguez, G.C and Piedmonte, M and O'Malley, D.M and Hoya, M. de la and Caldes, T and Aittomaki, K and Nevanlinna, H and Collee, J.M and Rookus, M.A and Oosterwijk, J.C and Tihomirova, L and Tung, N and Hamann, U and Isaccs, C and Tischkowitz, M and Imyanitov, E.N and Caligo, M.A and Campbell, I.G and Hogervorst, F.B and Olah, E and Diez, O and Blanco, I and Brunet, J and Lazaro, C and Pujana, M.A and Jakubowska, A and Gronwald, J and Lubinski, J and Sukiennicki, G and Massuger, L.F.A.G and Altena, A.M. van and Aben, K.K.H and ... and KConFab Investigators and EMBRACE and GEMO Study Collaborators and Breast Cancer Family Registry and Australian Ovarian Canc Study Grp and HEBON and Consortium Invest Modifiers BRCA1 and Australian Canc Study Ovarian Canc and Australian Cancer Study (Ovarian Cancer Investigators) and Australian Ovarian Cancer Study Group and Consortium of Investigators of Modifiers of BRCA1 and BRCA2 and the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Avdelningen för kliniska vetenskaper and Hälsouniversitetet
Nature Genetics, ISSN 1061-4036, 2015, Volume 47, Issue 2, pp. 164 - 171
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is... 
BRCA2 MUTATION CARRIERS | BREAST-CANCER | COMMON VARIANTS | METAANALYSIS | HIGH-RISK | MYOPODIN | GENETICS & HEREDITY | HUMAN ELG1 | ABO BLOOD-GROUP | SINGLE NUCLEOTIDE POLYMORPHISMS | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Genotype | Risk | Ovarian Neoplasms - genetics | Young Adult | BRCA1 Protein - genetics | Neoplasms, Glandular and Epithelial - genetics | Adolescent | Alleles | Carcinoma, Ovarian Epithelial | Adult | Female | Heterozygote | Polymorphism, Single Nucleotide | Mutation | Genome-Wide Association Study - methods | Quantitative Trait Loci | BRCA2 Protein - genetics | Genes, Reporter | Quantitative trait loci | Genetic aspects | Identification and classification | Health aspects | Ovarian cancer | Haplotypes | Accuracy | Population | Hormone replacement therapy | Genomes | Meta-analysis | Cèl·lules epitelials | Càncer d'ovari | Developmental genetics | Human genome | Epithelial cells | Genètica del desenvolupament | Nucleotides | Genoma humà | Nucleòtids | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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8. Full Text Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
by Bojesen, Stig E and Pooley, Karen A and Johnatty, Sharon E and Beesley, Jonathan and Michailidou, Kyriaki and Tyrer, Jonathan P and Edwards, Stacey L and Pickett, Hilda A and Shen, Howard C and Smart, Chanel E and Hillman, Kristine M and Mai, Phuong L and Lawrenson, Kate and Stutz, Michael D and Lu, Yi and Karevan, Rod and Woods, Nicholas and Johnston, Rebecca L and French, Juliet D and Chen, Xiaoqing and Weischer, Maren and Nielsen, Sune F and Maranian, Melanie J and Ghoussaini, Maya and Ahmed, Shahana and Baynes, Caroline and Bolla, Manjeet K and Wang, Qin and Dennis, Joe and McGuffog, Lesley and Barrowdale, Daniel and Lee, Anew and Healey, Sue and Lush, Michael and Tessier, Daniel C and Vincent, Daniel and Bacot, Françis and Vergote, Ignace and Lambrechts, Sanina and Despierre, Evelyn and Risch, Harvey A and González-Neira, Anna and Rossing, Mary Anne and Pita, Guillermo and Doherty, Jennifer A and Alvarez, Nuria and Larson, Melissa C and Fridley, Brooke L and Schoof, Nils and Chang-Claude, Jenny and Cicek, Mine S and Peto, Julian and Kalli, Kimberly R and Broeks, Annegien and Armasu, Sebastian M and Schmidt, Marjanka K and Braaf, Linde M and Winterhoff, Boris and Nevanlinna, Heli and Konecny, Gottfried E and Lambrechts, Diether and Rogmann, Lisa and Guénel, Pascal and Teoman, Attila and Milne, Roger L and Garcia, Joaquin J and Cox, Angela and Shridhar, Vijayalakshmi and Burwinkel, Barbara and Marme, Frederik and Hein, Rebecca and Sawyer, Elinor J and Haiman, Christopher A and Wang-Gohrke, Shan and Anulis, Irene L and Moysich, Kirsten B and Hopper, John L and Odunsi, Kunle and Lindblom, Annika and Giles, Graham G and Brenner, Hermann and Simard, Jacques and Lurie, Galina and Fasching, Peter A and Carney, Michael E and Radice, Paolo and Wilkens, Lynne R and Swerdlow, Anthony and Goodman, Marc T and Brauch, Hiltrud and Garcia-Closas, Montserrat and Hillemanns, Peter and Winqvist, Robert and Dürst, Matthias and Devilee, Peter and Runnebaum, Ingo and Jakubowska, Anna and Lubinski, Jan and Mannermaa, Arto and Butzow, Ralf and ... and Gene Environm Interactimi Breast and Kathleen Cuningham Fdn Consortium and Australian Ovarian Canc Study and Epidemiological Study BRCA1 and Hereditary Breast Ovarian Canc Res and Genetic Modifiers Canc Risk BRCA1 and Australian Canc Study and Swedish Breast Canc Study SWE-BRCA and The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO) and Gene Environment Interaction and Breast Cancer (GENICA) and Swedish Breast Cancer Study (SWE-BRCA) and Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE) and Australian Ovarian Cancer Study and Australian Cancer Study and Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) and Medicinska fakulteten and Umeå universitet and Institutionen för strålningsvetenskaper
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 4, pp. 371 - 384
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we... 
BUCCAL CELLS | GENETIC-VARIATION | COMMON VARIANTS | TERT-CLPTM1L LOCUS | REVERSE-TRANSCRIPTASE | SEQUENCE | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | POLYMORPHISM | FIBROBLASTS | GENOME-WIDE ASSOCIATION | Breast cancer | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Ovarian cancer | Genetics | Mutation | Càncer de mama | Càncer d'ovari | Telòmer | Telomere | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
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