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2004, ISBN 9780612917040
In Chapter one, a modified approach for mercury promoted synthesis of mono-, di- and tri-substituted 5-aminotetrazoles, and 5-oxo-tetrazoles is reported. This... 
Chemistry, Organic
eBook
Nature Communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, pp. 16081 - 16081
Journal Article
Organic Letters, ISSN 1523-7060, 01/2003, Volume 5, Issue 2, pp. 133 - 136
The formation of 2-aminobenzimidazoles via intramolecular C-N bond formation between an aryl halide and a guanidine moiety can be achieved using either copper... 
HALIDES | ARYLATION | NORASTEMIZOLE | AMINATION REACTION | AMIDATION | CHEMISTRY, ORGANIC | ANTIHISTAMINIC ACTIVITY | DERIVATIVES | BROMIDES | N-HETEROCYCLIC 4-PIPERIDINAMINES | ARYLAMINES | Copper - chemistry | Catalysis | Cyclization | Guanidine - chemistry | Palladium - chemistry | Benzimidazoles - chemical synthesis | Index Medicus
Journal Article
Chemical Communications, ISSN 1359-7345, 02/2004, Volume 4, Issue 4, pp. 446 - 447
Copper- and palladium-catalyzed intramolecular C-S bond formation by cross-coupling between an aryl halide and thiourea functionality is demonstrated for the... 
OXIDATION | CROSS-COUPLING REACTIONS | SULFIDES | CHEMISTRY, MULTIDISCIPLINARY | NUCLEOPHILIC-SUBSTITUTION | ARYL HALIDES
Journal Article
Journal Article
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2018, Volume 13, Issue 1, pp. 53 - 59
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 x 10(12) members composed of 4-20 natural and non-natural amino acids. Affinity... 
LEAD DISCOVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-PROTEIN INTERACTION | DRUG DISCOVERY | OPPORTUNITIES | ANTAGONISTS | SELECTION | IDENTIFICATION | TECHNOLOGY | CHEMICAL LIBRARIES | CYCLIC-PEPTIDES | Index Medicus
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 03/2006, Volume 71, Issue 5, pp. 1802 - 1808
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2013, Volume 4, Issue 10, pp. 942 - 947
To develop effective oral treatment for multiple sclerosis (MS), we discovered a series of alkyl-substituted biaryl amino alcohols as selective S1P1... 
prodrug | biaryl aminoalcohol | multiple sclerosis | mouse EAE model
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2016, Volume 59, Issue 15, pp. 7299 - 7304
Journal Article
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 04/2003, Volume 5, Issue 8, pp. 1201 - 1204
A modified Edman degradation procedure provides an effective means of introducing a heterocycle at the N-terminus of an (X-amino acid amide or peptide.... 
LIBRARIES | PEPTIDOMIMETICS | THIOUREAS | SOLID-PHASE SYNTHESIS | GUANIDINES | GUANYLATION | CHEMISTRY, ORGANIC | Thiocyanates - chemistry | Cyclization | Imines - chemistry | Amides - chemistry | Thiourea - chemistry | Oligopeptides - chemistry | Hydantoins - chemical synthesis | Index Medicus
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2011, Volume 2, Issue 10, pp. 758 - 763
The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38 alpha inhibitors is described. Application of... 
p38 inhibitor | inflammatory diseases | VX-745 | RHEUMATOID-ARTHRITIS | INTERLEUKIN-1 | CYTOKINES | CHEMISTRY, MEDICINAL | SPECIFICITY | PROTEIN-KINASE | P38 MAP KINASE | DISEASES | IMIDAZOLE INHIBITORS | STRUCTURAL BASIS | INFLIXIMAB
Journal Article
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