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Journal of Neuroscience, ISSN 0270-6474, 09/2006, Volume 26, Issue 37, pp. 9385 - 9393
Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such... 
Nociception | Pharmacology | Behavior | VR1 | Capsaicin | Osteoarthritis | osteoarthritis | nociception | VANILLOID RECEPTOR | INTRADERMAL INJECTION | WITHDRAWAL RESPONSES | NEUROSCIENCES | CAPSAICIN RECEPTOR | A-425619 1-ISOQUINOLIN-5-YL-3-(4-TRIFLUOROMETHYL-BENZYL)-UREA | MECHANICAL STIMULI | NEUROPATHIC PAIN | capsaicin | pharmacology | INFLAMMATORY THERMAL HYPERALGESIA | INTRAPLANTAR INJECTION | behavior | DORSAL HORN NEURONS | Central Nervous System - metabolism | Calcium - metabolism | Humans | Analgesics - metabolism | Male | Analgesics - pharmacokinetics | Arthralgia - physiopathology | Pain - metabolism | Sulfones - pharmacology | TRPV Cation Channels - metabolism | Pain - drug therapy | TRPV Cation Channels - antagonists & inhibitors | Urea - analogs & derivatives | Inflammation Mediators - antagonists & inhibitors | Disease Models, Animal | Injections, Spinal | Cell Line | Hyperalgesia - metabolism | Administration, Oral | Cells, Cultured | Rats | Treatment Outcome | Rats, Sprague-Dawley | TRPV Cation Channels - genetics | Hyperalgesia - physiopathology | Indazoles - pharmacology | Animals | Hyperalgesia - drug therapy | Arthralgia - metabolism | Pain - physiopathology | Central Nervous System - drug effects | Nociceptors - metabolism | Pyridines - pharmacology | Capsaicin - antagonists & inhibitors | Nociceptors - drug effects | Arthralgia - drug therapy | Urea - pharmacology
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 08/2012, Volume 342, Issue 2, pp. 416 - 428
Journal Article
NEUROSCIENCE, ISSN 0306-4522, 06/2007, Volume 146, Issue 4, pp. 1817 - 1828
Growing evidence supports a role for the immune system in the induction and maintenance of chronic pain. ATP is a key neurotransmitter in this process. Recent... 
DORSAL-HORN NEURONS | CENTRAL SENSITIZATION | WDR | INFLAMMATORY PAIN HYPERSENSITIVITY | SPINAL-CORD | NECROSIS-FACTOR-ALPHA | glia | NEUROSCIENCES | PERIPHERAL-NERVE INJURY | neuropathic pain | RESPONSE PROPERTIES | P2X RECEPTOR | purine | DIABETIC NEUROPATHY | ATP
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4926 - 4947
Journal Article
Pain, ISSN 0304-3959, 2011, Volume 152, Issue 5, pp. 1165 - 1172
Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation and body temperature regulation is not clear; the efficacy and... 
Blockade | Pain | Noxious cold | TRPA1 | Temperature regulation | Temperature sensation | ACTIVATION | TRPV1 | NEUROSCIENCES | SENSORY NEURONS | CLINICAL NEUROLOGY | THERMOREGULATION | INFLAMMATION | ION-CHANNEL | ANESTHESIOLOGY | HYPERALGESIA | TRPM8 | CONTRIBUTES | NOCICEPTION | Calcium Channels - metabolism | Body Temperature - drug effects | Calcium - metabolism | Humans | Male | Pain - metabolism | Drug Interactions | Pain - genetics | Transient Receptor Potential Channels - metabolism | Calcitonin Gene-Related Peptide - metabolism | Calcium Channels - genetics | Isothiocyanates - pharmacology | Disease Models, Animal | Body Temperature Regulation - physiology | Rats | Rats, Sprague-Dawley | Sensation - drug effects | Pain - physiopathology | Transient Receptor Potential Channels - genetics | Ganglia, Spinal - pathology | Mice | Body Temperature Regulation - genetics | Transient Receptor Potential Channels - antagonists & inhibitors | Sensation - physiology | Magnetic Resonance Imaging - methods | Oximes - therapeutic use | Tritium | Body Temperature - physiology | Heart Rate - drug effects | TRPV Cation Channels - metabolism | Pain - drug therapy | Reaction Time - drug effects | Heart Rate - physiology | Inhibitory Concentration 50 | Body Temperature Regulation - drug effects | Blood Pressure - drug effects | Blood Pressure - physiology | Neurons - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Cells, Cultured | Nerve Tissue Proteins - genetics | Cold Temperature - adverse effects | TRPV Cation Channels - genetics | Hyperalgesia - physiopathology | Nerve Tissue Proteins - metabolism | Pain Measurement - methods | Animals | Hyperalgesia - drug therapy | TRPA1 Cation Channel | Oximes - pharmacology | Sensory Thresholds - drug effects
Journal Article
Journal Article
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 12/2006, Volume 319, Issue 3, pp. 1376 - 1385
ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system. Activation of P2X7 receptors... 
OXIDIZED ATP | CELLS | ACTIVATED PROTEIN-KINASE | PHARMACOLOGICAL CHARACTERIZATION | INTERLEUKIN-1-BETA | INFLAMMATORY HYPERALGESIA | PHARMACOLOGY & PHARMACY | DEFICIENT MICE | RELEASE | EXPRESSION | NERVE GROWTH-FACTOR
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1376 - 1385
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2007, Volume 104, Issue 20, pp. 8520 - 8525
Activation of tetroclotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed... 
ROOT GANGLION NEURONS | NA+ CURRENTS | MULTIDISCIPLINARY SCIENCES | sensory neurons | NERVE-INJURY | TETRODOTOXIN-RESISTANT | VISCERAL PAIN | allodynia | electrophysiology | SNS | SNS/PN3 | hyperalgesia | PRIMARY SENSORY NEURONS | EXPRESSION
Journal Article
BRAIN RESEARCH, ISSN 0006-8993, 08/2005, Volume 1052, Issue 1, pp. 63 - 70
The P2X(7) receptor is an ATP-sensitive ligand-gated cation channel, expressed predominantly in cells with immune origin. Recent studies have demonstrated that... 
EXTRACELLULAR ATP | pain | ACTIVATED PROTEIN-KINASE | PHARMACOLOGICAL CHARACTERIZATION | HUMAN MACROPHAGES | A-317491 | dorsal root ganglia | PORE FORMATION | MICROGLIAL CELLS | NEUROSCIENCES | glial | NEUROPATHIC PAIN | sensory neuron | IL-1-BETA RELEASE | P2X | INFLAMMATORY PAIN | XENOPUS OOCYTES
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2008, Volume 324, Issue 3, pp. 1204 - 1211
We have recently reported that systemic delivery of A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], a selective Na-v 1.8 sodium... 
PERIPHERAL-NERVE INJURY | AFFERENT NEURONS | SYSTEMIC LIDOCAINE | NA(V)1.8 | INTRAVENOUS LIDOCAINE | SENSITIZATION | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | INFLAMMATORY PAIN | EXPRESSION | SENSORY NEURONS
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 02/2008, Volume 27, Issue 3, pp. 605 - 611
Transient receptor potential (TRP)A1 channel has been implicated in various physiological processes, including thermosensation and pain. A recent study of... 
hypertonic solution | mechanosensitive channels | dorsal root ganglia neurons | rat transient receptor potential A1‐expressing cells | single channel | CELLS | TRPA1 | ROOT GANGLION NEURONS | CATION CHANNEL | TRANSDUCTION | NEUROSCIENCES | SENSORY NEURONS | COVALENT MODIFICATION | TOUCH | COLD | rat transient receptor potential A1-expressing cells | CONTRIBUTES | Calcium Channels - metabolism | Calcium Signaling - physiology | Humans | Ion Channels - drug effects | Water-Electrolyte Balance - drug effects | Hypertonic Solutions - pharmacology | Mechanotransduction, Cellular - physiology | Osmolar Concentration | Cell Membrane - metabolism | Camphor - pharmacology | Calcium Channels - genetics | Mechanoreceptors - metabolism | Action Potentials - drug effects | Cell Membrane - drug effects | Isothiocyanates - pharmacology | Animals, Newborn | Calcium Channels - drug effects | Membrane Potentials - drug effects | Neurons, Afferent - drug effects | Cell Line | Water-Electrolyte Balance - physiology | TRPC Cation Channels | Cells, Cultured | Rats | Membrane Potentials - physiology | Action Potentials - physiology | Patch-Clamp Techniques | Animals | Ion Channels - metabolism | Ruthenium Red - pharmacology | Calcium Signaling - drug effects | Mechanoreceptors - drug effects | TRPA1 Cation Channel | Ankyrins | Neurons, Afferent - metabolism | Touch - physiology | Ganglia, Spinal - drug effects | Ganglia, Spinal - metabolism | Single channel | Rat transient receptor potential A1-expressing cells | Dorsal root ganglia neurons | Mechanosensitive channels | Hypertonic solution
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2006, Volume 49, Issue 12, pp. 3659 - 3666
1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X(7) receptor. Structure-activity relationship (SAR) studies were conducted around... 
EXTRACELLULAR ATP | POTENT ANTAGONIST | NEUROPATHIC PAIN | CELLS | ACTIVATION | CHEMISTRY, MEDICINAL | NUCLEOTIDE RECEPTORS | RAT | PERSISTENT PAIN | RELEASE | P-2Z RECEPTOR
Journal Article
Molecular Pain, ISSN 1744-8069, 1/2009, Volume 5, Issue 1, pp. 3 - 3
Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of... 
CELLS | ACTIVATION | PAIN | INHIBITION | ACID | NOCICEPTIVE NEURONS | CAPSAICIN RECEPTOR TRPV1 | SELECTIVITY | NEUROSCIENCES | Lidocaine - pharmacology | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Calcium - metabolism | Calcium Signaling - physiology | Humans | Porins - metabolism | Anesthetics, Local - pharmacology | Calcium Channels - physiology | Ion Channel Gating - physiology | Movement - physiology | Aldehydes - pharmacology | Thiocyanates - pharmacology | Transient Receptor Potential Channels - physiology | Benzamides - pharmacology | Transient Receptor Potential Channels - metabolism | Carbamates - pharmacology | Membrane Potentials - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - physiology | Quinolinium Compounds - pharmacokinetics | Nerve Tissue Proteins - agonists | Cells, Cultured | Rats | TRPM Cation Channels - agonists | Allyl Compounds - pharmacology | Calcium Channel Blockers - pharmacology | Membrane Potentials - physiology | TRPM Cation Channels - physiology | Transient Receptor Potential Channels - agonists | Nerve Tissue Proteins - metabolism | Lidocaine - analogs & derivatives | Animals | TRPA1 Cation Channel | TRPM Cation Channels - metabolism | HeLa Cells | Benzoxazoles - pharmacokinetics | Ion Channel Gating - drug effects | Physiological aspects | Sensory receptors | Ion channels | Genetic aspects | Research
Journal Article