X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (9) 9
article (6) 6
acute myeloid-leukemia (5) 5
humans (5) 5
leukemia (5) 5
acute myeloid leukemia (4) 4
differentiation (4) 4
hematology (4) 4
multidisciplinary sciences (4) 4
myeloid leukemia (4) 4
oncology (4) 4
animals (3) 3
apoptosis (3) 3
care and treatment (3) 3
cells (3) 3
depletion (3) 3
expression (3) 3
female (3) 3
hemic and lymphatic diseases (3) 3
mice, inbred c57bl (3) 3
proteins (3) 3
stem cells (3) 3
-2-hydroxyglutarate (2) 2
binding (2) 2
bone marrow (2) 2
bone-marrow (2) 2
c-myc protein (2) 2
cancer (2) 2
cell biology (2) 2
development and progression (2) 2
diagnosis (2) 2
drugs (2) 2
enasidenib (2) 2
fate (2) 2
gene (2) 2
gene expression (2) 2
genetic aspects (2) 2
inhibition (2) 2
medical research (2) 2
medicine (2) 2
medicine, research & experimental (2) 2
mutations (2) 2
myc protein (2) 2
myelocytic leukemia (2) 2
nonlymphoid leukemia (2) 2
pathogenesis (2) 2
patients (2) 2
research (2) 2
rna (2) 2
rna-binding proteins - metabolism (2) 2
ruxolitinib (2) 2
science (2) 2
stem cell transplantation (2) 2
stem-cells (2) 2
strategy (2) 2
survival (2) 2
transplantation (2) 2
accurate docking (1) 1
acute myelogenous leukemia (1) 1
adenosine - analogs & derivatives (1) 1
adenosine - biosynthesis (1) 1
ag-120 (1) 1
ag-221 (1) 1
aged (1) 1
akt protein (1) 1
alleles (1) 1
allografts (1) 1
allosteric properties (1) 1
allosteric site - drug effects (1) 1
allosteric site - genetics (1) 1
aminopyridines - chemistry (1) 1
aminopyridines - pharmacology (1) 1
aminopyridines - therapeutic use (1) 1
aml (1) 1
antibody-drug conjugate (1) 1
antimitotic agents (1) 1
antineoplastic agents (1) 1
archives & records (1) 1
basic medicine (1) 1
binding proteins (1) 1
biochemistry & molecular biology (1) 1
biological products (1) 1
biology (1) 1
biophysics (1) 1
block (1) 1
bone marrow cells - cytology (1) 1
c-myc (1) 1
cancer metabolism (1) 1
cancer therapies (1) 1
case-control studies (1) 1
cd33 (1) 1
cell and molecular biology (1) 1
cell differentiation (1) 1
cell differentiation - physiology (1) 1
cell growth (1) 1
cell lines (1) 1
cell proliferation (1) 1
cell survival (1) 1
cell- och molekylärbiologi (1) 1
cells, cultured (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Genetics, ISSN 1061-4036, 06/2017, Volume 49, Issue 6, pp. 866 - 875
The identity of the RNA-binding proteins (RBPs) that govern cancer stem cells remains poorly characterized. The MSI2 RBP is a central regulator of translation... 
GENE-EXPRESSION | DETERMINANT | FATE | GENETICS & HEREDITY | HIERARCHY | Leukemia, Biphenotypic, Acute - pathology | Myeloid Progenitor Cells - metabolism | RNA-Binding Proteins - genetics | Cell Survival | Humans | Leukemia, Myeloid - genetics | Mice, Inbred C57BL | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Hematopoiesis - genetics | Myeloid Progenitor Cells - pathology | Gene Expression Regulation, Leukemic | Homeodomain Proteins - genetics | Mice, Knockout | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Leukemia, Myeloid - pathology | Xenograft Model Antitumor Assays | Animals | Female | RNA, Small Interfering | Leukemia, Biphenotypic, Acute - genetics | RNA-Binding Proteins - metabolism | Care and treatment | Myelocytic leukemia | Stem cells | Development and progression | Genetic aspects | Nonlymphoid leukemia | Binding proteins | Gene expression | Health aspects | Profiling | Transplants & implants | Transcription | Pathogenesis | Leukemia | Genes | Oncology | Biology | Proteins | Functional anatomy | Bone marrow | Genetics | Binding | Medical research | Hematology | Research & development--R&D | Myeloid leukemia | Biophysics | Medicine | Screening | Depletion | Ribonucleic acids | Medical prognosis | Leukemogenesis | Differentiation | Cancer | Apoptosis | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 125 - 129
Somatic mutations in the isocitrate dehydrogenase 2 gene (IDH2) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the... 
LUNG-CANCER | CELLS | GEFITINIB | MUTANT IDH2 | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DIFFERENTIATION | (R)-2-HYDROXYGLUTARATE | ENASIDENIB | Triazines - therapeutic use | Humans | Glutarates - blood | Isocitrate Dehydrogenase - antagonists & inhibitors | Aminopyridines - chemistry | Aminopyridines - therapeutic use | Enzyme Inhibitors - chemistry | HEK293 Cells | Protein Multimerization - genetics | Leukemia, Myeloid, Acute - drug therapy | Female | Triazines - chemistry | Mutant Proteins - antagonists & inhibitors | Allosteric Site - genetics | Triazines - pharmacology | Allosteric Site - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Mutant Proteins - genetics | Models, Molecular | Isocitrate Dehydrogenase - genetics | Leukemia, Myeloid, Acute - blood | Enzyme Inhibitors - therapeutic use | Disease Progression | Isoleucine - genetics | Drug Resistance, Neoplasm - genetics | Animals | Aminopyridines - pharmacology | Alleles | Glutamine - genetics | Glutarates - metabolism | Mice | Mutation | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Pharmaceutical research | Research | Drug resistance | Antineoplastic agents | Glutamine | Plasma | Pathogenesis | Leukemia | Lung cancer | Cloning | Neutrophils | Kinases | Cancer therapies | Patients | Proteins | Disease resistance | Allosteric properties | Inhibitors | Bone marrow | Dimers | Inhibition | Target acquisition | Isocitrate dehydrogenase | Isoleucine | Neutropenia | AG-120 | cancer metabolism | leukemia | AG-221 | metabolite | enasidenib | epigenetic | IDH1 | IDH2 | glioma | ivosidenib
Journal Article
JOURNAL OF HEMATOLOGY & ONCOLOGY, ISSN 1756-8722, 08/2019, Volume 12, Issue 1, pp. 85 - 4
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia... 
GEMTUZUMAB OZOGAMICIN | METAANALYSIS | ONCOLOGY | ACUTE MYELOID-LEUKEMIA | IMPACTS | HEMATOLOGY | Acute myeloid leukemia | EXPRESSION | CD33 | Antibody-drug conjugate | Drugs | Monoclonal antibodies | Biological products | Single nucleotide polymorphisms | Single-nucleotide polymorphism | Splicing | Myeloid leukemia | Gene polymorphism | Survival
Journal Article
Nature medicine, ISSN 1078-8956, 11/2017, Volume 23, Issue 11, pp. 1369 - 1376
N 6 -methyladenosine (m 6 A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it... 
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 08/2019, Volume 25, Issue 16, pp. 4898 - 4906
Purpose: Myelofibrosis is characterized by bone marrow fibrosis, atypical megakaryocytes, splenomegaly, constitutional symptoms, thrombotic and hemorrhagic... 
ONCOLOGY | MYELOPROLIFERATIVE NEOPLASMS | RUXOLITINIB
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 09/2019, Volume 11, Issue 508, p. eaaw8828
Targeted inhibitors to oncogenic kinases demonstrate encouraging clinical responses early in the treatment course; however, most patients will relapse because... 
MEDICINE, RESEARCH & EXPERIMENTAL | INTERNAL TANDEM DUPLICATION | WILD-TYPE | CELLS | FLT3 INHIBITORS | GM-CSF | BONE-MARROW | TYROSINE KINASE INHIBITOR | ACUTE MYELOID-LEUKEMIA | GROWTH-FACTOR | FLT3-ACTIVATING MUTATIONS | CELL BIOLOGY
Journal Article
Cancer discovery, ISSN 2159-8274, 06/2019, Volume 9, Issue 6, pp. 756 - 777
Isocitrate dehydrogenase 1 (IDH1) is important for reductive carboxylation in cancer cells, and the IDH1 R132H mutation plays a pathogenic role in cancers... 
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1540 - 1546
Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase (IDH1 or IDH2, respectively) contribute to oncogenesis via production of... 
IDH2 MUTATIONS | ONCOLOGY | GENOMIC ANALYSIS | BLOCK | DIFFERENTIATION | (R)-2-HYDROXYGLUTARATE | ENASIDENIB
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 06/2019, Volume 104, Issue 7, pp. 1378 - 1387
Measurable residual disease is associated with inferior outcomes in patients with acute myeloid leukemia (AML). Measurable residual disease monitoring enhances... 
AML | RELAPSE | DIAGNOSIS | PROGNOSTIC IMPACT | IMMUNOPHENOTYPIC ANALYSIS | MULTIPARAMETER FLOW-CYTOMETRY | BONE-MARROW | GRADE MYELODYSPLASTIC SYNDROMES | RISK | HEMATOLOGY | TRANSPLANTATION
Journal Article
2016 IEEE Systems and Information Engineering Design Symposium (SIEDS), 04/2016, pp. 130 - 135
The healthcare field is facing new challenges and opportunities with an upsurge of telehealth and remote monitoring solutions. Hospitals are working with the... 
Measurement | Collaborative Filtering | Logistic Regression | Personalization | Collaboration | Predictive models | Healthcare | Electronic mail | Recommender systems | Logistics | Health care | Filtering | Communication systems | Feasibility studies | Personalized | Strategy | World Wide Web | Patients
Conference Proceeding
Blood advances, ISSN 2473-9529, 12/2018, Volume 2, Issue 23, pp. 3526 - 3539
The genetic aberrations that drive mixed phenotype acute leukemia (MPAL) remain largely unknown, with the exception of a small subset of MPALs harboring and... 
Journal Article