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Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1 - 11
Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders,... 
Phenotypes | Bivariate analysis | Statistical analysis | Mental disorders | Schizophrenia | Bipolar disorder | Genomes | Single-nucleotide polymorphism | Educational attainment | Education | Venn diagrams | Influence | Heritability | Polygenic inheritance
Journal Article
Human genetics, ISSN 0340-6717, 09/2019, pp. 1 - 10
In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated... 
Neurological diseases | Phenotypes | Etiology | Cognitive ability | Single-nucleotide polymorphism | Gene loci | Genomes | Statistics | Bayesian analysis | Polygenic inheritance | Genetic relationship
Journal Article
Bioinformatics (Oxford, England), ISSN 1367-4803, 08/2019
Genome-wide association study (GWAS) analyses, at sufficient sample sizes and power, have successfully revealed biological insights for several complex traits.... 
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5296 - 7
Spatial mapping is a promising strategy to investigate the mechanisms underlying the incidence of psychosis. We analyzed a case-cohort study (n = 24,028),... 
FAMILIAL LIABILITY | CONFOUNDERS | BIRTH | URBAN-RURAL DIFFERENCES | MULTIDISCIPLINARY SCIENCES | DENMARK | Mental disorders | Risk groups | Schizophrenia | Risk | Mapping | Environmental risk | Synergism | Environmental effects | Psychosis | Liability | Etiology | Environment | Gene mapping | Population density
Journal Article
Neurobiology of aging, ISSN 0197-4580, 03/2019
The risk of APOE for Alzheimer's disease (AD) is modified by age. Beyond APOE, the polygenic architecture may also be heterogeneous across age. We aim to... 
Journal Article
ISSN 0340-6717, 2019
In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated... 
Journal Article
ACTA NEUROPATHOLOGICA, ISSN 0001-6322, 01/2018, Volume 135, Issue 1, pp. 85 - 93
There is an urgent need for identifying nondemented individuals at the highest risk of progressing to Alzheimer's disease (AD) dementia. Here, we evaluated... 
BIOMARKERS | METAANALYSIS | MEMORY | DISEASE | Tau | COGNITIVE IMPAIRMENT | Amyloid | PATHOLOGY | Polygenic risk | Alzheimer's disease | NEUROSCIENCES | CLINICAL NEUROLOGY | Advertising executives | Medical research | PET imaging | Medicine, Experimental | Genetic aspects | Apolipoproteins
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2019, Volume 37, Issue 7_suppl, pp. 181 - 181
Journal Article
Psychiatric Genetics, ISSN 0955-8829, 10/2019, Volume 29, Issue 5, pp. 152 - 159
Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major... 
Genetic research | Genome-wide association studies | Usage | Genetic aspects | Research | Mental illness
Journal Article
CANCERS, ISSN 2072-6694, 02/2019, Volume 11, Issue 2, p. 127
Breast cancer is the most common cancer for women in Taiwan and post-lumpectomy radiotherapy is one of the therapeutic strategies for this malignancy. Although... 
PATHWAYS | ONCOLOGY | Notch1 | RESISTANCE | TRIB3 | triple negative breast cancer | PROLIFERATION | IDENTIFICATION | INHIBITOR | EXPRESSION | radioresistance | TRB3 INTERACTS
Journal Article
ACTA NEUROPATHOLOGICA, ISSN 0001-6322, 02/2019, Volume 137, Issue 2, pp. 209 - 226
Cardiovascular (CV)- and lifestyle-associated risk factors (RFs) are increasingly recognized as important for Alzheimer's disease (AD) pathogenesis. Beyond the... 
COMMON VARIANTS | Cardiovascular | Lipids | SCHIZOPHRENIA | Polygenic enrichment | PATHOLOGY | IDENTIFICATION | NEUROSCIENCES | CLINICAL NEUROLOGY | CHOLESTEROL-METABOLISM | Genetic pleiotropy | OVERLAP | PLEIOTROPY | TRAITS | Alzheimer's disease | ASSOCIATION | EXPRESSION | IMPLICATE
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 03/2018, Volume 9, p. 77
With the availability of high-throughput sequencing data, identification of genetic causal variants accurately requires the efficient incorporation of function... 
Mixture model | Fine-mapping | SNP discovery | Optimization | Effect sizes | effect sizes | RISK | mixture model | VARIABLE SELECTION | JOINT ANALYSIS | HERITABILITY | PREDICTION | optimization | LASSO | DISEASE | REGIONS | GENETICS & HEREDITY | fine-mapping | GENOME-WIDE ASSOCIATION | Genetic research | Genome-wide association studies | Genetic variation | Identification and classification | Methods
Journal Article