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1. Full Text Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline
by Ouellette, Daniel R., MD, FCCP and Patel, Sheena, MPH and Girard, Timothy D., MD and Morris, Peter E., MD, FCCP and Schmidt, Gregory A., MD, FCCP and Truwit, Jonathon D., MD, FCCP and Alhazzani, Waleed, MD and Burns, Suzanne M., RN, MSN, ACNP, RRT and Epstein, Scott K., MD, FCCP and Esteban, Andres, MD, PhD and Fan, Eddy, MD, PhD and Ferrer, Miguel, MD, PhD and Fraser, Gilles L., PharmD and Gong, Michelle Ng, MD and Hough, Catherine L., MD and Mehta, Sangeeta, MD and Nanchal, Rahul, MD, FCCP and Pawlik, Amy J., DPT and Schweickert, William D., MD and Sessler, Curtis N., MD, FCCP and Strøm, Thomas, MD and Kress, John P., MD, FCCP
Chest, ISSN 0012-3692, 2016, Volume 151, Issue 1, pp. 166 - 180
Background An update of evidence-based guidelines concerning liberation from mechanical ventilation is needed as new evidence has become available. The... 
Pulmonary/Respiratory | mechanical ventilation | guidelines | evidence-based medicine | T-TUBE | EXTUBATION | INTENSIVE-CARE-UNIT | BREATHING TRIALS | RESPIRATORY SYSTEM | PRESSURE SUPPORT | INVASIVE VENTILATION | DAILY INTERRUPTION | SEDATIVE INFUSIONS | NONINVASIVE VENTILATION | RESPIRATORY-FAILURE | CRITICAL CARE MEDICINE
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2. Full Text Neuromuscular Blockade in the 21st Century Management of the Critically Ill Patient
by deBacker, Julian, MSc and Hart, Nicholas, PhD and Fan, Eddy, MD, PhD
Chest, ISSN 0012-3692, 2016, Volume 151, Issue 3, pp. 697 - 706
Neuromuscular blockings agents (NMBAs) have a controversial role in the ventilatory and medical management of critical illness. The clinical concern... 
Pulmonary/Respiratory | critical care | mechanical ventilation | neuromuscular blocking agents | airway management | intensive care units | ABDOMINAL COMPARTMENT SYNDROME | HEART-ASSOCIATION GUIDELINES | BLOCKING-AGENTS | ACUTE LUNG INJURY | CARDIOPULMONARY-RESUSCITATION | RESPIRATORY-DISTRESS-SYNDROME | INTRAABDOMINAL HYPERTENSION | RESPIRATORY SYSTEM | CARDIAC ARREST CARE | EMERGENCY CARDIOVASCULAR CARE | CRITICAL CARE MEDICINE | Intensive Care Units | Respiration, Artificial - methods | Neuromuscular Blockade - methods | Humans | Neuromuscular Blocking Agents - therapeutic use | Critical Illness | Status Asthmaticus - therapy | Intubation, Intratracheal - methods | Respiratory Insufficiency - therapy | Hypothermia, Induced - methods | Critical Care | Disease Management | Heart Arrest - therapy | Intracranial Hypertension - therapy | Respiratory Distress Syndrome, Adult - therapy | Neuromuscular blocking agents | Care and treatment | Usage | Critically ill | Critical care medicine | Research | Health aspects
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3. Full Text Liberation From Mechanical Ventilation in Critically Ill Adults
by Schmidt, Gregory A., MD, FCCP and Girard, Timothy D., MD and Kress, John P., MD, FCCP and Morris, Peter E., MD, FCCP and Ouellette, Daniel R., MD, FCCP and Alhazzani, Waleed, MD and Burns, Suzanne M., RN, MSN, ACNP, RRT and Epstein, Scott K., MD, FCCP and Esteban, Andres, MD, PhD and Fan, Eddy, MD, PhD and Ferrer, Miguel, MD, PhD and Fraser, Gilles L., PharmD and Gong, Michelle Ng, MD and Hough, Catherine L., MD and Mehta, Sangeeta, MD and Nanchal, Rahul, MD, FCCP and Patel, Sheena, MPH and Pawlik, Amy J., DPT and Schweickert, William D., MD and Sessler, Curtis N., MD, FCCP and Strøm, Thomas, MD and Wilson, Kevin C., MD and Truwit, Jonathon D., MD, FCCP
Chest, ISSN 0012-3692, 2016, Volume 151, Issue 1, pp. 160 - 165
Background This clinical practice guideline addresses six questions related to liberation from mechanical ventilation in critically ill adults. It is the... 
Pulmonary/Respiratory | mechanical ventilation | guidelines | evidence-based medicine | RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE
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4. Full Text Anticoagulation practices and the prevalence of major bleeding, thromboembolic events, and mortality in venoarterial extracorporeal membrane oxygenation (VA-ECMO): A systematic review and meta-analysis
by Sy, Eric, MD and Sklar, Michael C., MD and Lequier, Laurence, MD and Fan, Eddy, MD, PhD and Kanji, Hussein D., MD, MSc, MPH
Journal of Critical Care, ISSN 0883-9441, 2017, Volume 39, pp. 87 - 96
Abstract Purpose To evaluate the safety of anticoagulation in venoarterial extracorporeal membrane oxygenation (VA-ECMO). Design We performed a systematic... 
Critical Care | Anticoagulants | Systematic review | Extracorporeal membrane oxygenation | Heparin | Meta-analysis | ADULT PATIENTS | NAFAMOSTAT MESILATE | RISK | RESPIRATORY-DISTRESS-SYNDROME | LIFE-SUPPORT | CARDIAC-ARREST | TRANSFUSION | MASSIVE PULMONARY-EMBOLISM | POSTCARDIOTOMY CARDIOGENIC-SHOCK | CRITICAL CARE MEDICINE | Prevalence | Hospital Mortality | Humans | Hemorrhage - mortality | Anticoagulants - therapeutic use | Extracorporeal Membrane Oxygenation - adverse effects | Practice Patterns, Physicians | Thromboembolism - etiology | Thromboembolism - mortality | Extracorporeal Membrane Oxygenation - mortality | Thromboembolism - prevention & control | Hemorrhage - etiology | Female | Blood Coagulation - physiology | Anticoagulants (Medicine) | Thromboembolism | Health aspects | Mortality | Analysis
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5. Full Text Venoarterial extracorporeal membrane oxygenation for patients in shock or cardiac arrest secondary to cardiotoxicant poisoning: A cost-effectiveness analysis
by St-Onge, Maude, MD, FRCPC, MSc and Fan, Eddy, MD, PhD and Mégarbane, Bruno, MD, PhD and Hancock-Howard, Rebecca, BSc, MSc, PhD and Coyte, Peter C., PhD
Journal of Critical Care, ISSN 0883-9441, 2014, Volume 30, Issue 2, pp. 437.e7 - 437.e14
Abstract Purpose Venoarterial extracorporeal membrane oxygenation represents an emerging and recommended option to treat life-threatening cardiotoxicant... 
Critical Care | Extracorporeal membrane oxygenation | Poisoning | Overdose | Cost analysis | Cardiotoxins | Extracorporeal circulation | DRUG INTOXICATION | PREVENTION | RANDOMIZED CONTROLLED-TRIAL | LIFE-SUPPORT | ECONOMIC-EVALUATION | SUICIDE | RESPIRATORY-FAILURE | CRITICAL CARE MEDICINE | Cardiotoxins - poisoning | Shock, Cardiogenic - therapy | Humans | Middle Aged | Decision Support Techniques | Male | Treatment Outcome | Shock, Cardiogenic - chemically induced | Heart Arrest - economics | Canada | Health Care Costs | Cost-Benefit Analysis | Extracorporeal Membrane Oxygenation - economics | Adult | Female | Aged | Heart Arrest - chemically induced | Shock, Cardiogenic - economics | Monte Carlo Method | Heart Arrest - therapy | Cost benefit analysis | Analysis | Cardiac patients | Cardiac arrest | Index Medicus
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6. Full Text Current and Future Status of Extracorporeal Cardiopulmonary Resuscitation (E-CPR) for In-Hospital Cardiac Arrest
by Singal, Rohit K., MD MSc and Singal, Deepa, MSc and Bednarczyk, Joseph, MD and Lamarche, Yoan, MD MSc and Singh, Gurmeet, MD MSc and Rao, Vivek, MD PhD and Kanji, Hussein, MD MSc MPH and Arora, Rakesh C., MD PhD and Manji, Rizwan A., MD PhD MBA and Fan, Eddy, MD PhD and Nagpal, A. Dave, MD
Canadian Journal of Cardiology, ISSN 0828-282X, 2016, Volume 33, Issue 1, pp. 51 - 60
Abstract Numerous series, propensity matched trials and meta-analyses suggest appropriate use of extracorporeal cardiopulmonary resuscitation (E-CPR) for... 
Cardiovascular | SURVIVAL | SUPPORT | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | RESCUE | ADULTS | EXPERIENCE | QUALITY-OF-LIFE | MEMBRANE-OXYGENATION | PROPENSITY ANALYSIS | CARDIOGENIC-SHOCK | Cardiopulmonary Resuscitation - methods | Time Factors | Extracorporeal Membrane Oxygenation - trends | Cardiopulmonary Resuscitation - trends | Humans | Heart Arrest - therapy
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7. Full Text Prolonged mechanical ventilation in Canadian intensive care units: A national survey
by Rose, Louise, RN, PhD and Fowler, Robert A., MD, MSc and Fan, Eddy, MD, PhD and Fraser, Ian, MD, FRCP and Leasa, David, MD, FRCP and Mawdsley, Cathy, RN, MSc and Pedersen, Cheryl, MSc and Rubenfeld, Gordon, MD, MSc and CANuVENT Grp and CANuVENT group
Journal of Critical Care, ISSN 0883-9441, 2014, Volume 30, Issue 1, pp. 25 - 31
Abstract Background We sought to describe prevalence and care practices for patients experiencing prolonged mechanical ventilation (PMV), defined as... 
Critical Care | Mobilization | Intensive care | Prolonged mechanical ventilation | Rehabilitation | Weaning | Mechanical ventilation | ANXIETY | OUTCOMES | SCALE | TRACHEOSTOMY | CRITICAL CARE MEDICINE | Bed Occupancy - statistics & numerical data | Acute Lung Injury - therapy | Humans | Middle Aged | Patient Discharge | Child, Preschool | Infant | Intensive Care Units - statistics & numerical data | Male | Young Adult | Deglutition | Time Factors | Aged, 80 and over | Adult | Female | Ventilator Weaning - methods | Child | Ventilator Weaning - statistics & numerical data | Infant, Newborn | Respiration, Artificial - standards | Communication | Respiratory Therapy | Ventilator Weaning - standards | Cross-Sectional Studies | Referral and Consultation - statistics & numerical data | Canada | Sepsis - therapy | Adolescent | Respiration, Artificial - statistics & numerical data | Aged | Health Care Surveys - statistics & numerical data | Practice Guidelines as Topic
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8. Full Text Early Physical Medicine and Rehabilitation for Patients With Acute Respiratory Failure: A Quality Improvement Project
by Needham, Dale M., MD, PhD and Korupolu, Radha, MBBS, MS and Zanni, Jennifer M., PT, MSPT and Pradhan, Pranoti, MBBS, MPH and Colantuoni, Elizabeth, PhD and Palmer, Jeffrey B., MD and Brower, Roy G., MD and Fan, Eddy, MD
Archives of Physical Medicine and Rehabilitation, ISSN 0003-9993, 2010, Volume 91, Issue 4, pp. 536 - 542
Abstract Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E. Early physical medicine and rehabilitation for patients with... 
Physical Medicine and Rehabilitation | Critical care | Muscle weakness | artificial | Rehabilitation | Respiration | Early ambulation | SPORT SCIENCES | CRITICAL ILLNESS | DISTRESS-SYNDROME | RANDOMIZED-TRIAL | MOBILIZING PATIENTS | MECHANICALLY VENTILATED PATIENTS | SKELETAL-MUSCLE | INTENSIVE-CARE-UNIT | CRITICALLY-ILL PATIENTS | BED REST | BLOOD-STREAM INFECTIONS | Length of Stay | Prospective Studies | Respiration, Artificial - methods | Humans | Middle Aged | Quality of Health Care - organization & administration | Male | Intensive Care Units - organization & administration | Academic Medical Centers | Drug Utilization | Personnel Staffing and Scheduling | Patient Care Team - organization & administration | Occupational Therapy - organization & administration | Respiratory Distress Syndrome, Adult - rehabilitation | Physical Therapy Modalities | Adult | Benzodiazepines - administration & dosage | Female | Aged | Deep Sedation - utilization | Delirium - chemically induced | Practice Guidelines as Topic | Respiratory Distress Syndrome, Adult - therapy | Acute respiratory distress syndrome | Care and treatment | Respiratory insufficiency | Physical therapy | Quality control | Therapeutics, Physiological
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9. Full Text Rehabilitation therapy and outcomes in acute respiratory failure: An observational pilot project
by Zanni, Jennifer M., PT, MSPT and Korupolu, Radha, MBBS, MS and Fan, Eddy, MD and Pradhan, Pranoti, MBBS, MPH and Janjua, Kashif, MD and Palmer, Jeffrey B., MD and Brower, Roy G., MD and Needham, Dale M., MD, PhD
Journal of Critical Care, ISSN 0883-9441, 2010, Volume 25, Issue 2, pp. 254 - 262
Abstract Purpose The aim of this study was to describe the frequency, physiologic effects, safety, and patient outcomes associated with traditional... 
Critical Care | Muscle weakness | Respiratory insufficiency | Critical care | Rehabilitation | Early ambulation | Contracture | Respiration, artificial | MULTICENTER | CRITICAL ILLNESS | INACTIVITY | RELIABILITY | NEUROMUSCULAR DYSFUNCTION | INTENSIVE-CARE-UNIT | SEDATION | ICU | BED REST | SURVIVORS | CRITICAL CARE MEDICINE | Muscle Weakness - etiology | Health Services Accessibility - statistics & numerical data | Respiratory Insufficiency - physiopathology | Acute Disease | Intensive Care Units | Prospective Studies | Humans | Middle Aged | Respiratory Insufficiency - rehabilitation | Male | Treatment Outcome | Respiratory Insufficiency - therapy | Respiration, Artificial | Pilot Projects | Range of Motion, Articular | Observation | Adult | Female | Safety regulations
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10. Full Text Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
by Laffey, John G, Prof and Madotto, Fabiana, PhD and Bellani, Giacomo, MD and Pham, Tài, MD and Fan, Eddy, MD and Brochard, Laurent, Prof and Amin, Pravin, Prof and Arabi, Yaseen, Prof and Bajwa, Ednan K, MD and Bruhn, Alejandro, MD and Cerny, Vladimir, Prof and Clarkson, Kevin, MB and Heunks, Leo, Prof and Kurahashi, Kiyoyasu, Prof and Laake, Jon Henrik, MD and Lorente, Jose A, Prof and McNamee, Lia, BSc and Nin, Nicolas, MD and Palo, Jose Emmanuel, MD and Piquilloud, Lise, MD and Qiu, Haibo, Prof and Jiménez, Juan Ignacio Silesky, Prof and Esteban, Andres, MD and McAuley, Daniel F, Prof and van Haren, Frank, Prof and Ranieri, Marco, Prof and Rubenfeld, Gordon, Prof and Wrigge, Hermann, Prof and Slutsky, Arthur S, Prof and Pesenti, Antonio, Prof and ESICM Trials Grp and LUNG SAFE Investigators and ESICM Trials Group
The Lancet Respiratory Medicine, ISSN 2213-2600, 2017, Volume 5, Issue 8, pp. 627 - 638
Summary Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute... 
Pulmonary/Respiratory | Pulmonary and Respiratory Medicine | BREAST-CANCER | MORTALITY | GEOGRAPHIC-VARIATION | RESPIRATORY SYSTEM | DISEASE | ACUTE MYOCARDIAL-INFARCTION | INJURY | CRITICALLY-ILL PATIENTS | UNITS | INTENSIVE-CARE | HOSPITALIZATION | CRITICAL CARE MEDICINE | Income - statistics & numerical data | Prospective Studies | Comorbidity | Developing Countries - statistics & numerical data | Humans | Middle Aged | Risk Factors | Europe - epidemiology | Intensive Care Units - statistics & numerical data | Male | Patient Outcome Assessment | Developed Countries - statistics & numerical data | Respiratory Distress Syndrome, Adult - economics | Geography, Medical | Female | Aged | Respiratory Distress Syndrome, Adult - epidemiology | Delivery of Health Care - statistics & numerical data | Acute respiratory distress syndrome | Demographic aspects | Patient outcomes | Analysis | Clinical trials | Epidemiology | Risk factors
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11. Full Text Long-term Outcome of Globus Pallidus Internus Deep Brain Stimulation in Patients With Tourette Syndrome
by Zhang, Jian-Guo, MD, PhD and Ge, Yan, MD and Stead, Matt, MD, PhD and Zhang, Kai, MD and Yan, Shuang-shuang, MD and Hu, Wei, MD, PhD and Meng, Fan-Gang, MD, PhD
Mayo Clinic Proceedings, ISSN 0025-6196, 2014, Volume 89, Issue 11, pp. 1506 - 1514
Abstract Objective To evaluate the effectiveness of deep brain stimulation (DBS) of the globus pallidus internus (GPi) on tic severity and common comorbidities... 
Internal Medicine | Abbreviations and Acronyms CM-Pfc centromedian-parafascicular complex DBS deep brain stimulation GPi globus pallidus internus TS Tourette syndrome TSQOL Gilles de la Tourette Syndrome-Quality of Life Scale YGTSS Yale Global Tic Severity Scale | SURGERY | TRIAL | MEDICINE, GENERAL & INTERNAL | TICS | COMPLEXITIES | THALAMIC-STIMULATION | DISEASE | DISORDERS | SCALE | DYSTONIA | Severity of Illness Index | Tourette Syndrome - therapy | Humans | Globus Pallidus - physiology | Male | Treatment Outcome | Deep Brain Stimulation - methods | Young Adult | China | Adolescent | Quality of Life | Adult | Female | Retrospective Studies | Tourette's syndrome | Complications and side effects | Care and treatment | Comorbidity | Patient outcomes | Research | Brain stimulation | Health aspects
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