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Tetrahedron, ISSN 0040-4020, 08/2019, Volume 75, Issue 33, pp. 4458 - 4470
Influenza remains a health problem to humans. Peramivir is a FDA approved anti-influenza drug targeting the virus neuraminidase. The (3 + 2) cycloaddition... 
Organic synthesis | Peramivir | Nitrile oxide | Cycloaddition | Influenza | Drug approval | Olefins
Journal Article
ISSN 1477-9226, 6/2019, Volume 48, Issue 23, pp. 826 - 829
A Cu( ii )-[di(2-methylpyridyl)methylamino]coumarin fluorescence turn-on sensor (Cu- 1b ) is designed to detect phosphate ions with K ass = 1.4 × 10 5 M −1 in... 
Journal Article
ISSN 1477-0520, 10/2013, Volume 11, Issue 44, pp. 7687 - 7699
Using N -acetyl- d -glucosamine as a starting material, the anti-influenza drugs oseltamivir and tamiphosphor were synthesized via a pivotal intermediate of... 
Journal Article
Organic Letters, ISSN 1523-7060, 09/2016, Volume 18, Issue 17, pp. 4400 - 4403
The potent anti-influenza agents, zanamivir and, its phosphonate congener, are synthesized by using a nitro group as the latent amino group at C4 for... 
PERAMIVIR | ACID | INFLUENZA | CHEMISTRY, ORGANIC | CS-8958 | LANINAMIVIR | ACTING NEURAMINIDASE INHIBITOR | OSELTAMIVIR
Journal Article
ISSN 1477-0520, 5/2015, Volume 13, Issue 19, pp. 551 - 5519
Antroquinonol, which was first isolated from a mushroom, Antrodia cinnamomea , found in Taiwan, is an anticancer compound with a unique core structure of... 
Journal Article
ISSN 1359-7345, 1/2017, Volume 53, Issue 9, pp. 149 - 1493
A new fluorescence-forming probe, coumOCT, designed by fusing cyclooctyne with a coumarin fluorophore was successfully used for the imaging of... 
Journal Article
Organic Letters, ISSN 1523-7060, 04/2016, Volume 18, Issue 8, pp. 1724 - 1727
Ethyne-linked naphthyridine-aniline conjugated molecules are selective sensors of decylguanine in dichloromethane and guanosine monophosphate in water (K-ass =... 
GUANIDINIUM | LIGANDS | MOLECULAR RECOGNITION | COMPLEXES | CHEMISTRY, ORGANIC | 2-AMINO-1,8-NAPHTHYRIDINE | DUPLEXES | SENSORS | BINDING | BULGE | Guanosine Monophosphate - chemistry | Magnetic Resonance Imaging | Naphthyridines - chemistry | Acetamides - chemistry | Hydrogen Bonding | Fluorescence | Guanine - chemistry | Molecular Structure | Aniline Compounds - chemistry
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 04/2007, Volume 72, Issue 8, pp. 3141 - 3144
A series of primary alcohols and aldehydes were treated with iodine in ammonia water under microwave irradiation to give the intermediate nitriles, which... 
CLICK CHEMISTRY APPROACH | NITRILES | ORGANIC-REACTIONS | CHEMISTRY, ORGANIC | HUISGEN 1,3-DIPOLAR CYCLOADDITION | 5-SUBSTITUTED TETRAZOLES | INHIBITORS | AZIDE | IN-SITU | 2,4-DIAMINO-1,3,5-TRIAZINE DERIVATIVES | WATER | Alcohols - chemistry | Tetrazoles - chemistry | Water - chemistry | Triazines - chemistry | Hot Temperature | Microwaves | Aldehydes - chemistry
Journal Article
Dalton Transactions, ISSN 1477-9226, 2019, Volume 48, Issue 23, pp. 8026 - 8029
A Cu(ii)-[di(2-methylpyridyl)methylamino]coumarin fluorescence turn-on sensor (Cu-1b) is designed to detect phosphate ions with K-ass = 1.4 x 10(5) M-1 in... 
MYCOBACTERIUM-TUBERCULOSIS | PHOSPHATE | GLGE | FLUORESCENCE | CHEMOSENSORS | ANION RECOGNITION | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Tetrahedron, ISSN 0040-4020, 01/2015, Volume 71, Issue 2, pp. 266 - 270
Journal Article
ISSN 1477-0520, 11/2017, Volume 15, Issue 46, pp. 991 - 9922
Peramivir is an effective anti-influenza drug in the clinical treatment of influenza, but its efficacy toward the H275Y mutant is reduced. The previously... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 710 - 721
Tamiflu readily undergoes endogenous hydrolysis to give oseltamivir carboxylic acid (OC) as the active anti-influenza agent to inhibit the viral neuraminidase... 
Oseltamivir | Trifluoroborate | Neuraminidase inhibitor | Bioisosteres | Sulfone | Influenza | Boronic acid | Sulfinic acid | Sulfonic acid | DESIGN | CHEMISTRY, MEDICINAL | ZANAMIVIR | ANALOGS | INFLUENZA NEURAMINIDASE INHIBITOR | PHOSPHONATE CONGENERS | POTENT | TAMIFLU | SIALIDASE | DERIVATIVES
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2014, Volume 136, Issue 28, pp. 9953 - 9961
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2019, Volume 294, Issue 27, pp. 10686 - 10697
The yeast Candida albicans is the most prevalent opportunistic fungal pathogen in humans. Drug resistance among C. albicans isolates poses a common challenge,... 
Candida albicans | SYSTEM | AZOLES | GENETIC-CONTROL | DNA damage | BIOCHEMISTRY & MOLECULAR BIOLOGY | nucleoside | MECHANISMS | nucleotide analogue | SACCHAROMYCES-CEREVISIAE | 5-FLUOROURACIL | CELL-DIVISION CYCLE | substrate specificity | RESISTANCE | drug resistance | EXPRESSION | thymidylate kinase | INSIGHTS
Journal Article
ChemBioChem, ISSN 1439-4227, 04/2018, Volume 19, Issue 8, pp. 764 - 764
The front cover picture shows a feasible strategy that makes use of a steric self‐protection effect for the site‐selective modification of a bacterial... 
self-assembly | antigens | steric hindrance | flagellins | conjugate vaccines
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 181, p. 111551
An 8-oxopurine-6-carboxamide compound ( ) was previously identified as an inhibitor of non-small cell lung cancer (NSCLC). In this study, more than 30... 
Purine amide | Hydroxamate | Microtubule | Lung cancer | Amidoxime
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2016, Volume 2016, Issue 22, pp. 3809 - 3816
(+)‐Antroquinonol is an anticancer agent that was first isolated from the rare mushroom Antrodia cinnamomea , which is indigenous to Taiwan. In this study,... 
Michael addition | Quinones | Asymmetric synthesis | Enantioselectivity | Natural products | AGENT | ANTRODIA-CAMPHORATA | CHEMISTRY, ORGANIC | GRIGNARD-REAGENTS | ANTROQUINONOL | CONJUGATE ADDITION | (+/-)-ANTROQUINONOL | Enantiomers | Quinone
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2016, Volume 57, Issue 38, pp. 4293 - 4296
A reactive diene, ethyl 2-methylene-4-(pent-3-oxy)but-2-enoate, bearing electron-withdrawing carboxy and electron-donating pentoxy substituents is prepared and... 
Oseltamivir | Dienophile | Influenza | Diels–Alder reaction | Butadiene | PRACTICAL SYNTHESIS | ACID | OSELTAMIVIR PHOSPHATE TAMIFLU | CHEMISTRY, ORGANIC | DIMERIZATION | ALDEHYDES | NEURAMINIDASE INHIBITORS | Oseltamivit | DIENE | Diels-Alder reaction | (-)-OSELTAMIVIR | ACTIVATED DOUBLE-BONDS
Journal Article
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