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1. Full Text Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity
by Colle, Dirleise and Colle, Dirleise and Santos, Danúbia Bonfanti and Santos, Danúbia Bonfanti and Hartwig, Juliana Montagna and Hartwig, Juliana Montagna and Godoi, Marcelo and Godoi, Marcelo and Engel, Daiane Fátima and Engel, Daiane Fátima and de Bem, Andreza Fabro and de Bem, Andreza Fabro and Braga, Antonio L and Braga, Antonio L and Farina, Marcelo and Farina, Marcelo
Molecular Neurobiology, ISSN 0893-7648, 3/2016, Volume 53, Issue 2, pp. 1280 - 1295
Succinobucol (succinyl ester of probucol) is a lipid-lowering compound with anti-inflammatory and antioxidant properties. Recent experimental evidence has... 
Neurology | Oxidative stress | Neurosciences | Biomedicine | 3-nitropropionic acid | Mitochondrial dysfunction | Neurobiology | Glutamate cysteine ligase | Cell Biology | Succinobucol | Glutathione | MECHANISMS | HYPERCHOLESTEROLEMIA | NEUROSCIENCES | GAMMA-GLUTAMYLCYSTEINE SYNTHETASE | INHIBITION | PROBUCOL | BIOSYNTHESIS | GENE-EXPRESSION | ANIMAL-MODELS | BRAIN | HUNTINGTONS-DISEASE PATHOGENESIS | Buthionine Sulfoximine - pharmacology | Cell Survival - drug effects | Glutathione Peroxidase - metabolism | Glutathione - metabolism | Humans | RNA, Messenger - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Hydroquinones - pharmacology | Hypolipidemic Agents - pharmacology | RNA, Messenger - metabolism | Probucol - pharmacology | Up-Regulation - drug effects | Probucol - analogs & derivatives | Time Factors | Protective Agents - pharmacology | Nitro Compounds | Propionates | Cell Line, Tumor | Glutamate-Cysteine Ligase - genetics | Glutamate-Cysteine Ligase - metabolism | Cell Death - drug effects | Oxidative Stress - drug effects | Cysteine | Thiols | RNA | Anticholesteremic agents | Glutamate | Cystine | Cardiovascular agents | Antioxidants | Huntington's chorea | Ligases | Analysis | Physiological aspects | Prescription drugs | Brain | Lipids | Mitochondria
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2. Full Text Effects of traumatic brain injury of different severities on emotional, cognitive, and oxidative stress-related parameters in mice
by Schwarzbold, Marcelo L and Rial, Daniel and De Bem, Tatiana and MacHado, Daniele G and Cunha, Mauricio P and Dos Santos, Alessandra A and Dos Santos, Danúbia B and Figueiredo, Cláudia P and Farina, Marcelo and Goldfeder, Eliane M and Rodrigues, Ana Lúcia S and Prediger, Rui D.S and Walz, Roger
Journal of Neurotrauma, ISSN 0897-7151, 10/2010, Volume 27, Issue 10, pp. 1883 - 1893
Cognitive deficits and psychiatric disorders are significant sequelae of traumatic brain injury (TBI). Animal models have been widely employed in TBI research,... 
traumatic brain injury | anxiety | depression | learning and memory | oxidative stress | BEHAVIORAL-TEST BATTERIES | TAIL SUSPENSION TEST | LIPID-PEROXIDATION | GLUTATHIONE-PEROXIDASE ACTIVITY | LOCOMOTOR-ACTIVITY | IMMATURE BRAIN | NEUROSCIENCES | CLINICAL NEUROLOGY | FLUID PERCUSSION INJURY | CORTICAL IMPACT | EXPERIMENTAL HEAD-INJURY | CRITICAL CARE MEDICINE | Emotions - physiology | Glutathione Peroxidase - metabolism | Motor Activity - physiology | Glutathione Reductase - metabolism | Oxidative Stress - physiology | Behavior, Animal - physiology | Male | Avoidance Learning - physiology | Brain Injuries - metabolism | Brain Injuries - physiopathology | Cerebral Cortex - metabolism | Cerebral Cortex - physiopathology | Injury Severity Score | Hippocampus - metabolism | Animals | Analysis of Variance | Statistics, Nonparametric | Mice | Brain Injuries - psychology | Hippocampus - physiopathology | Oxidative stress | Brain | Complications and side effects | Care and treatment | Patient outcomes | Physiological aspects | Research | Mental illness | Risk factors | Injuries | Brain damage | Head injuries | Rodents | Emotions | Animal cognition
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3. Full Text Honey bee and native solitary bee foraging behavior in a crop with dimorphic parental lines
by Estravis Barcala, Maria Cecilia and Palottini, Florencia and Farina, Walter Marcelo
PLoS ONE, ISSN 1932-6203, 10/2019, Volume 14, Issue 10, p. e0223865
Insect pollination is issential for hybrid seed production systems, among which, introduced and native bees are the primary pollinating agents transferring... 
Agricultural ecosystems | Nectar | Plant reproduction | Crops | Flowers | Foraging behavior | Bees | Pollination | Honey | Insects | Animal behavior | Agricultural production | Hybrid systems | Pollen | Sunflowers
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4. Full Text Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay
by Farina, Marcelo and Aschner, Michael
BBA - General Subjects, ISSN 0304-4165, 12/2019, Volume 1863, Issue 12, pp. 129285 - 129285
Methylmercury (MeHg) is a toxic chemical compound naturally produced mainly in the aquatic environment through the methylation of inorganic mercury catalyzed... 
Antioxidant system | Neurotoxicity | Thiols | Selenols | Methylmercury | Glutathione | PRIMARY ASTROCYTE CULTURES | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | N-ACETYLCYSTEINE | METHYL MERCURY | BIOPHYSICS | DIPHENYL DISELENIDE | PROTEIN THIOLS | NEURONAL CELLS | THIOREDOXIN REDUCTASE | MOLECULAR-MECHANISMS | Index Medicus
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5. Full Text Succinobucol, a Non-Statin Hypocholesterolemic Drug, Prevents Premotor Symptoms and Nigrostriatal Neurodegeneration in an Experimental Model of Parkinson's Disease
by Santos, DB and Colle, D and Moreira, ELG and Hort, MA and Godoi, M and Le Douaron, G and Braga, AL and Assreuy, J and Michel, PP and Prediger, RD and Raisman-Vozari, R and Farina, M
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 03/2017, Volume 54, Issue 2, pp. 1513 - 1530
Parkinson's disease (PD) is a neurodegenerative disorder characterized by non-motor and motor disabilities. This study investigated whether succinobucol (SUC)... 
MONOAMINE-OXIDASE | Intranasal MPTP | Parkinson's disease | DOPAMINERGIC NEUROTOXICITY | NEUROSCIENCES | Succinobucol | CELL-DEATH | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP | Neurodegeneration | PROBUCOL | MOUSE MODEL | NITRIC-OXIDE | MITOCHONDRIAL DYSFUNCTION | NONMOTOR FEATURES | COGNITIVE DEFICITS | Substantia Nigra - pathology | Probucol - therapeutic use | Memory Disorders - metabolism | Male | Substantia Nigra - metabolism | Neurodegenerative Diseases - drug therapy | Corpus Striatum - metabolism | Parkinsonian Disorders - metabolism | Probucol - pharmacology | Smell - drug effects | Smell - physiology | Probucol - analogs & derivatives | Parkinsonian Disorders - drug therapy | Female | Corpus Striatum - pathology | Memory Disorders - pathology | Neurodegenerative Diseases - pathology | Mice, Inbred C57BL | Rats | Neurodegenerative Diseases - metabolism | Random Allocation | Rats, Sprague-Dawley | Pregnancy | Substantia Nigra - drug effects | Animals | Anticholesteremic Agents - therapeutic use | Memory Disorders - drug therapy | Parkinsonian Disorders - pathology | Corpus Striatum - drug effects | Mice | Anticholesteremic Agents - pharmacology | Tyrosine | Interleukins | Statins | Drug therapy | Neurobiology | Parkinsons disease | Index Medicus
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6. Full Text Fracture resistance of endodontically treated teeth restored with intra-radicular post: The effects of post system and dentine thickness
by Barcellos, Ramiro Rocha and Correia, Débora Pereira Diniz and Farina, Ana Paula and Mesquita, Marcelo Ferraz and Ferraz, Caio Cezar Randi and Cecchin, Doglas
Journal of Biomechanics, ISSN 0021-9290, 2013, Volume 46, Issue 15, pp. 2572 - 2577
Abstract To investigate the influence of post system and amount of remaining root tissue on the fracture resistance of endodontically treated teeth. Seventy... 
Physical Medicine and Rehabilitation | Endodontically treated teeth | Glass fiber post | Root fracture | Fracture resistance | Cast post and core | ENGINEERING, BIOMEDICAL | BIOMECHANICAL BEHAVIOR | ANTERIOR TEETH | RESTORATIONS | FAILURE | COMPOSITE | CORE SYSTEMS | PLACEMENT | BIOPHYSICS | ROOTS | GLASS-FIBER POSTS | FINITE-ELEMENT-ANALYSIS | Materials Testing - methods | Crowns | Humans | Tooth Fractures - pathology | Tooth Fractures - prevention & control | Adult | Female | Male | Incisor | Root Canal Filling Materials | Tooth Fractures - physiopathology | Testing equipment | Physicians (General practice) | Analysis | Alloys | Fibers | Studies | Dentin | Mechanical properties | Irrigation | Fiberglass | Sealing compounds
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7. Full Text Effects of sublethal doses of imidacloprid on young adult honeybee behaviour
by Goñalons, Carolina Mengoni and Farina, Walter Marcelo
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0140814 - e0140814
Imidacloprid (IMI), a neonicotinoid used for its high selective toxicity to insects, is one of the most commonly used pesticides. However, its effect on... 
ODORS | INCOMING NECTAR | MEMORY | FORAGERS | MULTIDISCIPLINARY SCIENCES | RECEIVING NECTAR | SUCROSE RESPONSIVENESS | RESPONSE THRESHOLDS | TOXICITY | INSECT | BEES | Insecticides - pharmacology | Memory - drug effects | Animals | Conditioning, Classical - drug effects | Bees - drug effects | Neonicotinoids | Nitro Compounds - pharmacology | Behavior, Animal - drug effects | Imidazoles - pharmacology | Appetitive Behavior - drug effects | Association Learning - drug effects | Honeybee | Dosage and administration | Imidacloprid | Research | Mammals | Neurotoxic agents | Agricultural ecosystems | Management science | Sucrose | Laboratories | Toxicity | Memory | Life assessment | Insecticides | Nervous system | Occupational exposure | Bees | Learning | Metabolites | Reinforcement | Physiology | Proboscis | Age | Food | Nectar | Young adults | Colonies | Pesticides | Beneficial arthropods | Associative learning | Exposure | Foraging behavior | Honey | Insects | Animal behavior | Workers (insect caste) | Adults | Inflow | Index Medicus
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8. Full Text Biomarkers of mercury toxicity: Past, present, and future trends
by Branco, Vasco and Caito, Sam and Farina, Marcelo and Teixeira da Rocha, João and Aschner, Michael and Carvalho, Cristina
Journal of Toxicology and Environmental Health, Part B, ISSN 1093-7404, 04/2017, Volume 20, Issue 3, pp. 119 - 154
Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial... 
URINARY PORPHYRIN EXCRETION | OXIDATIVE STRESS | LIPID-PEROXIDATION | THIOREDOXIN REDUCTASE INHIBITION | D-ASPARTATE RECEPTORS | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PRENATAL METHYLMERCURY EXPOSURE | IN-VIVO | DNA MICROARRAY ANALYSIS | SELF-REPORTED SYMPTOMS | TOXICOLOGY | THIMEROSAL-CONTAINING VACCINES | Environmental Exposure - adverse effects | Mercury - toxicity | Mercury Compounds - toxicity | Animals | Risk Assessment | Humans | Biomarkers - analysis | Methylmercury Compounds - toxicity | Environmental Pollutants - toxicity | Hair | Weighing | Dental amalgams | Toxicity | Health risks | Exposure | Dimethylmercury | Vaccines | Amalgams | Epidemiology | Human populations | Dental restorative materials | Side effects | Toxicology | Molecular modelling | Risk assessment | Mercury vapor | Biomarkers | Mercury | Mercury (metal) | Index Medicus
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9. Full Text Search for dark matter and other new phenomena in events with an energetic jet and large missing transverse momentum using the ATLAS detector
by Aaboud, M and Aad, G and Abbott, B and Abdinov, O and Abeloos, B and Abidi, S.H and Alderweireldt, S.C and Caron, S and Colasurdo, L and Groot, N. de and Fabiani, V and Filthaut, F and Galea, C and Igonkina, O and Konig, A.C and Nektarijevic, S and Schouwenberg, J.F.P and Zhu, J and Nedden, M.zur and Zwalinski, L and ATLAS Collaboration and The ATLAS collaboration and SLAC National Accelerator Lab., Menlo Park, CA (United States) and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) and Oak Ridge National Laboratory, Oak Ridge Leadership Computing Facility (OLCF) and Partikel- och astropartikelfysik and Skolan för teknikvetenskap (SCI) and KTH and Fysik
Journal of High Energy Physics, ISSN 1126-6708, 2018, Volume 2018, Issue 1, pp. 1 - 53
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses proton-proton... 
Quantum Physics | Quantum Field Theories, String Theory | Hadron-Hadron scattering (experiments) | Classical and Quantum Gravitation, Relativity Theory | Physics | Elementary Particles, Quantum Field Theory | PARTON DISTRIBUTIONS | STATES | SUPERSYMMETRY | DECAY | FIELD-THEORY | MODEL | CANDIDATES | ROOT-S=13 | PHYSICS | SQUARK | PHYSICS, PARTICLES & FIELDS | Standard model (particle physics) | Supersymmetry | Dark matter | Large Hadron Collider | Leptons | Particle collisions | Searching | Transverse momentum | Luminosity | Collision dynamics | Physics - High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Fysik | Physical Sciences | Naturvetenskap | Natural Sciences
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10. Full Text Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury
by Farina, Marcelo and Avila, Daiana Silva and da Rocha, João Batista Teixeira and Aschner, Michael
Neurochemistry International, ISSN 0197-0186, 04/2013, Volume 62, Issue 5, pp. 575 - 594
► Oxidative stress (OS), particularly in mitochondria, is a common feature of iron (Fe), Mn and Hg toxicity. ► The primary molecular targets triggering of OS... 
Oxidative stress | Iron | Mercury | Manganese | Glutathione | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | GLUTAMATE UPTAKE INHIBITION | CEREBELLAR GRANULE CELLS | MITOCHONDRIAL PERMEABILITY TRANSITION | ELEMENTAL MERCURY | METHYLMERCURY-INDUCED NEUROTOXICITY | IN-VIVO | AMINO-ACID CARRIER | RAT-BRAIN | PARKINSONS-DISEASE | Manganese - metabolism | Neurodegenerative Diseases - metabolism | Oxidative Stress | Iron - metabolism | Humans | Mercury - metabolism | Mitochondrial DNA | Index Medicus
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