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Biotechnology and Bioengineering, ISSN 0006-3592, 10/2016, Volume 113, Issue 10, pp. 2241 - 2253
ABSTRACT The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety... 
epigenome | DNA‐methylation | histone modifications | genome variation | Chinese hamster ovary cells | Genome variation | Histone modifications | DNA-methylation | Epigenome | RECOMBINANT ANTIBODY | READ ALIGNMENT | WIDE DNA METHYLATION | PROTEIN-PRODUCTION | MAMMALIAN-CELLS | LINES | HAMSTER OVARY CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SODIUM-BUTYRATE | PRODUCTIVITY | GENE-EXPRESSION | CHO Cells - physiology | Cricetulus | Genome - genetics | Selection, Genetic - genetics | Animals | Time Factors | Adaptation, Physiological - genetics | Epigenesis, Genetic - genetics | Polymorphism, Single Nucleotide - genetics | CHO Cells - classification | Genetic Variation - genetics | Genomic Instability - genetics | Evolution, Molecular | Proteins | Epigenetic inheritance | Analysis | Genes | Genomics | Genetic aspects | Genomes | Single nucleotide polymorphisms | Methylation | Gene expression | Bioengineering | Epigenetics | Evolution | Cell culture | Biotechnology | Batch culture | Chromatin | Media (culture) | Adaptability | Single-nucleotide polymorphism | DNA methylation | Deoxyribonucleic acid--DNA | Adaptation | Productivity | Stability | Phase transformations | Nucleotide sequence | Media (selective) | Media | Perturbation | Steady state | Cell lines | Perturbation methods | Evolutionary | Histones | Constants | Culture
Journal Article
Immunity, ISSN 1074-7613, 02/2011, Volume 34, Issue 2, pp. 213 - 223
Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet the mechanisms of action are largely unknown. Here we showed that... 
FAMILIAL MEDITERRANEAN FEVER | MULTIPLE-SCLEROSIS | CASPASE-1 | HOST-DEFENSE | INNATE | CRYSTALS | RECOMBINANT INTERLEUKIN-1 | MICE | BACTERIAL-INFECTION | IMMUNOLOGY | RECEPTOR ANTAGONIST | Interleukin-1 - genetics | Inflammasomes - metabolism | STAT1 Transcription Factor - deficiency | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Monocytes - metabolism | Monocytes - immunology | Interleukin-10 - physiology | Interleukin-1 - biosynthesis | Interferon-beta - therapeutic use | Interferon Type I - biosynthesis | STAT3 Transcription Factor - physiology | Candida albicans - physiology | Interferon Type I - physiology | Caspase 1 - physiology | Candidiasis - immunology | Carrier Proteins - physiology | Peritonitis - etiology | STAT1 Transcription Factor - physiology | Poly I-C - pharmacology | Disease Susceptibility | Mice, Inbred C57BL | Peritonitis - immunology | STAT1 Transcription Factor - genetics | Gene Expression Regulation - drug effects | Animals | Candidiasis - etiology | Caspase 1 - genetics | Caspase 1 - deficiency | Interferon Type I - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Apoptosis Regulatory Proteins - physiology | Cells, Cultured - metabolism | Mice | Interferon Inducers - pharmacology | Multiple Sclerosis - drug therapy | Interferon | Infections | Cytokines | Viral infections | Molecular weight | Immune system
Journal Article
Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6304, pp. aaf4238 - aaf4238
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 06/2017, Volume 24, Issue 6, pp. 953 - 954
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2017, Volume 20, Issue 2, pp. 176 - 188
Journal Article
Journal Article