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1. Full Text The Hunger Genes: Pathways to Obesity
by van der Klaauw, Agatha A and Farooqi, I. Sadaf
Cell, ISSN 0092-8674, 03/2015, Volume 161, Issue 1, pp. 119 - 132
The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major... 
WEIGHT REGULATION | CONGENITAL LEPTIN DEFICIENCY | MELANOCYTE-STIMULATING HORMONE | FTO GENE | MELANOCORTIN-4 RECEPTOR MUTATIONS | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BODY-MASS INDEX | EARLY-ONSET OBESITY | ADULT OBESITY | PRADER-WILLI-SYNDROME | CELL BIOLOGY | Animals | Diet | Energy Metabolism | Hypothalamus - physiology | Obesity - complications | Humans | Obesity - therapy | Feeding Behavior | Obesity - genetics | Obesity - metabolism | Obesity | Hunger | Genes | Type 2 diabetes | Physiological aspects | Prevalence studies (Epidemiology)
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2. Full Text Leptin: A pivotal regulator of human energy homeostasis
by Sadaf Farooqi, I and O'Rahilly, Stephen
American Journal of Clinical Nutrition, ISSN 0002-9165, 03/2009, Volume 89, Issue 3, pp. 980S - 984S
The identification of the hormone leptin by Friedman et al (1) in 1994 has proved to be a seminal observation in biomedical science. The discovery that a... 
SKELETAL-MUSCLE | RECOMBINANT LEPTIN | NUTRITION & DIETETICS | MELANOCORTIN RECEPTORS | MISSENSE MUTATION | MORBID-OBESITY | EARLY-ONSET OBESITY | PROOPIOMELANOCORTIN MESSENGER-RNA | FRAMESHIFT MUTATION | PLASMA LEPTIN | ARCUATE NUCLEUS | Energy Intake - physiology | Leptin - physiology | Adipose Tissue - metabolism | Animals | Homeostasis - physiology | Humans | Energy Metabolism - physiology | Leptin - deficiency | Physiological aspects | Homeostasis | Research | Leptin | Proteins | Genotype & phenotype | Signal transduction | Peptides | Nutrition | Hormones | Mutation
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3. Full Text Genetics of Obesity in Humans
by Farooqi, I. Sadaf and O’Rahilly, Stephen
Endocrine Reviews, ISSN 0163-769X, 12/2006, Volume 27, Issue 7, pp. 710 - 718
Considerable attention has focused on deciphering the hypothalamic pathways that mediate the behavioral and metabolic effects of leptin. We and others have... 
CONGENITAL LEPTIN DEFICIENCY | BODY-WEIGHT | RECOMBINANT LEPTIN | MELANOCYTE-STIMULATING HORMONE | FAMILIAL OBESITY | ENDOCRINOLOGY & METABOLISM | MISSENSE MUTATION | PROOPIOMELANOCORTIN GENE | MORBID-OBESITY | EARLY-ONSET OBESITY | FRAMESHIFT MUTATION | Proprotein Convertase 1 - genetics | Humans | Receptor, trkB - physiology | Obesity - physiopathology | Leptin - genetics | Receptor, Melanocortin, Type 4 - genetics | Receptor, trkB - genetics | Signal Transduction - genetics | Mutation - genetics | Body Weight - genetics | Obesity - genetics | Pro-Opiomelanocortin - physiology | Melanocortins - physiology | Leptin - physiology | Proprotein Convertase 1 - physiology | Mutation - physiology | Melanocortins - genetics | Signal Transduction - physiology | Body Weight - physiology | Pro-Opiomelanocortin - genetics | Neurosecretory Systems - physiopathology | Receptor, Melanocortin, Type 4 - physiology
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4. Full Text Genetic approaches to understanding human obesity
by Ramachandrappa, Shwetha and Farooqi, I. Sadaf
Journal of Clinical Investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2080 - 2086
Obesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONGENITAL LEPTIN DEFICIENCY | CENTRAL MELANOCORTIN SYSTEM | MELANOCYTE-STIMULATING HORMONE | FTO GENE | NEUROTROPHIC FACTOR | BARDET-BIEDL-SYNDROME | BODY-MASS INDEX | MORBID-OBESITY | EARLY-ONSET OBESITY | PRADER-WILLI-SYNDROME | Receptor, Melanocortin, Type 4 - deficiency | Dietary Fats - metabolism | Genomic Imprinting | Receptors, Leptin - genetics | Humans | Body Weight - genetics | Obesity - genetics | Melanocortins - physiology | Leptin - physiology | Adaptation, Physiological - genetics | Melanocortins - genetics | Mice, Mutant Strains | Obesity - etiology | Energy Metabolism - genetics | Energy Metabolism - physiology | Genome-Wide Association Study | Genetic Association Studies | Gene Dosage | Leptin - genetics | Receptor, Melanocortin, Type 4 - genetics | Syndrome | Obesity - metabolism | Animals | Receptors, Leptin - physiology | Obesity - epidemiology | Environment | Mice | Body Weight - physiology | Leptin - deficiency | Receptor, Melanocortin, Type 4 - physiology | Genetic research | Obesity | Body weight | Public health | Review
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5. Full Text Monogenic obesity in humans
by Farooqi, I. Sadaf and O'Rahilly, Stephen
Annual Review of Medicine, ISSN 0066-4219, 2005, Volume 56, Issue 1, pp. 443 - 458
Until relatively recently, the small number of identifiable inherited human diseases associated with marked obesity were complex, pleiotropic developmental... 
Syndromes | Genetics | Leptin | Receptor, Melanocortin, Type 4 - deficiency | Prognosis | Humans | Genetic Diseases, Inborn - genetics | Child, Preschool | Developmental Disabilities - genetics | Genetic Counseling | Obesity - genetics | Obesity, Morbid - genetics | DNA Mutational Analysis | Energy Metabolism - genetics | Child | Obesity, Morbid - therapy | Leptin - therapeutic use | Leptin - genetics | Signal Transduction - genetics | Developmental Disabilities - therapy | Syndrome | Phenotype | Animals | Adolescent | Obesity - therapy | Mice, Obese | Mice | Leptin - deficiency | Homeostasis - genetics | Obesity | Mutation | Rodents | Public health
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6. Full Text Obesity and the brain: How convincing is the addiction model?
by Ziauddeen, Hisham and Farooqi, I. Sadaf and Fletcher, Paul C
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2012, Volume 13, Issue 4, pp. 279 - 286
An increasingly influential perspective conceptualizes both obesity and overeating as a food addiction accompanied by corresponding brain changes. Because... 
DORSOLATERAL PREFRONTAL CORTEX | D2 RECEPTORS | LESS ACTIVATION | ACCUMBENS DOPAMINE | GENE TAQ1A POLYMORPHISM | DORSAL STRIATUM | FOOD ADDICTION | NEURAL BASIS | NEUROSCIENCES | DOPAMINE-RECEPTOR GENE | EATING BEHAVIORS | Models, Theoretical | Obesity - psychology | Brain - physiopathology | Humans | Hyperphagia - physiopathology | Obesity - physiopathology | Hyperphagia - psychology | Behavior, Addictive - psychology | Behavior, Addictive - physiopathology | Psychological aspects | Obesity | Care and treatment | Dopamine | Addiction | Compulsive eating | Physiological aspects | Reward (Psychology) | Health aspects
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7. The genetics of obesity syndromes
by Farooqi, I. Sadaf and O'Rahilly, S. (Stephen) and Beales, Philip L
2009, Oxford monographs on medical genetics, ISBN 0195300165, Volume no. 56., x, 288
Obesity | Genetic aspects | genetics | Syndrome | etiology
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8. Full Text EJE prize 2012: Obesity: From genes to behaviour
by Farooqi, I. Sadaf
European Journal of Endocrinology, ISSN 0804-4643, 11/2014, Volume 171, Issue 5, pp. R191 - R195
An increase in the consumption of highly palatable foods coupled with a reduction in the amount of voluntary exercise undertaken has contributed to the rising... 
Genes - physiology | Animals | Hypothalamus - physiology | Obesity - psychology | Humans | Environment | Obesity - physiopathology | Behavior - physiology | Body Weight - physiology | Neural Pathways - physiology | Obesity - genetics
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9. Full Text Leptin Regulates Striatal Regions and Human Eating Behavior
by I. Sadaf Farooqi and Edward Bullmore and Julia Keogh and Jonathan Gillard and Stephen O'Rahilly and Paul C. Fletcher
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1355 - 1355
Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation.... 
Graphics | Nucleus accumbens | Basal ganglia | Food intake | Average linear density | Images | Satiety | Hospital units | Food consumption | Food | Brevia | MULTIDISCIPLINARY SCIENCES | Eating | Visual Perception - drug effects | Visual Perception - physiology | Humans | Leptin - therapeutic use | Male | Nucleus Accumbens - physiology | Feeding Behavior - physiology | Feeding Behavior - drug effects | Satiation - physiology | Leptin - physiology | Magnetic Resonance Imaging | Adolescent | Brain Mapping | Corpus Striatum - drug effects | Corpus Striatum - physiology | Adult | Female | Leptin - deficiency | Brain | Signal transduction | NMR | Biochemistry | Nuclear magnetic resonance | Hormones | Behavior | Psychiatry
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10. Full Text The Hormonal Control of Food Intake
by Coll, Anthony P and Farooqi, I. Sadaf and O'Rahilly, Stephen
Cell, ISSN 0092-8674, 04/2007, Volume 129, Issue 2, pp. 251 - 262
Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic... 
ENERGY-BALANCE | CAUSES HYPERPHAGIA | MELANOCYTE-STIMULATING HORMONE | ENHANCED LEPTIN SENSITIVITY | NEUROTROPHIC FACTOR | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MELANOCORTIN-4 RECEPTOR GENE | BODY-WEIGHT REGULATION | ONSET OBESITY | DIET-INDUCED OBESITY | CELL BIOLOGY | Leptin - physiology | Eating | Animals | Appetite Regulation | Humans | Islets of Langerhans - chemistry | Hormones - physiology | Gastrointestinal Hormones - physiology | Gastrointestinal Tract - chemistry | Peptide Hormones - physiology | Steroids - physiology | Adipocytes - chemistry | Review
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11. Full Text Genetic, molecular and physiological mechanisms involved in human obesity: Society for Endocrinology Medal Lecture 2012
by Farooqi, Sadaf I
Clinical Endocrinology, ISSN 0300-0664, 01/2015, Volume 82, Issue 1, pp. 23 - 28
The health consequences of obesity represent one of the major public health challenges of our time. Whilst the role of environmental drivers such as reduced... 
CONGENITAL LEPTIN DEFICIENCY | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | RESISTANCE | EARLY-ONSET OBESITY | RECEPTOR GENE | DYSFUNCTION | MUTATIONS | SPECTRUM | SIM1 | BRAIN | Obesity - genetics | Humans | Obesity - metabolism | Genetic research | Physiological aspects | Obesity | Body weight | Medical research | Society
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12. Defining the neural basis of appetite and obesity: from genes to behaviour
by Farooqi, I Sadaf
Clinical Medicine, ISSN 1470-2118, 06/2014, Volume 14, Issue 3, pp. 286 - 289
Obesity represents one of the biggest public health challenges facing us today. Urbanisation, sedentary lifestyles and the availability of inexpensive, highly... 
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13. Full Text Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis
by Ahmed, Rebekah and Farooqi, I Sadaf
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue 12, pp. 1006 - 1007
The hypothalamus contains neurons that regulate eating behaviour and autonomic function and has functional projections to the striatum, thalamus, brainstem,... 
metabolic disease | frontotemporal dementia | motor neuron disease | SURGERY | EATING BEHAVIOR | FITNESS | PSYCHIATRY | FRONTOTEMPORAL DEMENTIA | ALS | CLINICAL NEUROLOGY | Amyotrophic lateral sclerosis | Mutation | Neurodegeneration | Rodents
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14. Full Text Obesity Associated Genetic Variation in FTO Is Associated with Diminished Satiety
by Wardle, Jane and Carnell, Susan and Haworth, Claire M. A and Farooqi, I. Sadaf and O'Rahilly, Stephen and Plomin, Robert
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 09/2008, Volume 93, Issue 9, pp. 3640 - 3643
Context: Polymorphisms within the FTO gene have consistently been associated with obesity across multiple populations. However, to date, it is not known... 
EATING BEHAVIOR QUESTIONNAIRE | VARIANTS | SUSCEPTIBILITY | ENDOCRINOLOGY & METABOLISM | HUMANS | BODY-MASS INDEX | ADIPOSITY | ADULT OBESITY | CHILDHOOD | Body Mass Index | Appetite - genetics | Genetic Predisposition to Disease | Gene Frequency | Humans | Risk Factors | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Genotype | Male | Obesity - genetics | Down-Regulation - genetics | Satiation - physiology | Genetic Variation | Proteins - genetics | Obesity - epidemiology | Female | Child | Cohort Studies
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15. Full Text Leptin Mediates the Increase in Blood Pressure Associated with Obesity
by Simonds, Stephanie E and Pryor, Jack T and Ravussin, Eric and Greenway, Frank L and Dileone, Ralph and Allen, Andrew M and Bassi, Jaspreet and Elmquist, Joel K and Keogh, Julia M and Henning, Elana and Myers, Martin G and Licinio, Julio and Brown, Russell D and Enriori, Pablo J and O’Rahilly, Stephen and Sternson, Scott M and Grove, Kevin L and Spanswick, David C and Farooqi, I. Sadaf and Cowley, Michael A
Cell, ISSN 0092-8674, 12/2014, Volume 159, Issue 6, pp. 1404 - 1416
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin... 
POMC NEURONS | CENTRAL MELANOCORTIN SYSTEM | SYMPATHETIC ACTIVATION | DORSOMEDIAL HYPOTHALAMIC NUCLEUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | WEIGHT-LOSS | EARLY-ONSET OBESITY | MICE | BROWN ADIPOSE-TISSUE | KAPPA-B | HYPERTENSION | CELL BIOLOGY | Animals | Receptors, Leptin - genetics | Signal Transduction | Leptin - metabolism | Mice, Inbred C57BL | Leptin - genetics | Neurons - metabolism | Mutation | Receptors, Leptin - metabolism | Hypertension - metabolism | Obesity - metabolism | Obesity - pathology | Physiological aspects | Obesity | Blood pressure | Leptin
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