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Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3840 - 10
Clozapine-N-oxide (CNO) has long been the ligand of choice for selectively activating Designer Receptors Exclusively Activated by Designer Drugs (DREADDs).... 
DOPAMINE-BETA-HYDROXYLASE | COCAINE | DESIGNER DRUGS | TYPICAL ANTIPSYCHOTIC-DRUGS | CHEMOGENETICS | MULTIDISCIPLINARY SCIENCES | Drug discrimination | Rodents | Clozapine
Journal Article
by Marshall, Christian and Howrigan, D.P and Merico, Daniele and Thiruvahinapuram, Bhooma and Wu, W and Greer, D.S and Antaki, D and Shetty, A and Holmans, Peter A and Pinto, Duane and Gujral, M and Brandler, W.M and Malhotra, D and Wang, Z and Fuentes Fajarado, K.V and Maile, M.S and Ripke, Stephan and Agartz, Ingrid and Albus, Margot and Alexander, M and Amin, Farooq and Atkins, J and Bacanu, Silviu and Belliveau, Richard A and Bergen, Sarah and Bertalan, M and Bevilacqua, Elizabeth and Bigdeli, T.B and Black, Donald and Bruggeman, Richard and Buccola, Nancy G and Buckner, M and Bulik-Sullivan, Brendan and Byerley, William F and Cahn, Wiepke and Cai, G and Cairns, Murray J and Campion, Dominique and Cantor, R.M and Carr, Vaughan and Carrera, Noa and Catts, Stanley and Chambert, Kimberly and Cheng, Wei and Cloninger, C Robert and Cohen, David J and Cormican, Paul and Craddock, Nick and Crespo-Facorro, Benedicto and Crowley, James and Curtis, David and Davidson, Michael and Davis, Kenneth and Degenhardt, F and Del-Favero, Jurgen and Delisi, Lynn and Dikeos, Dimitris and Dinan, Timothy and Djurovic, S and Donohoe, Dennis and peau, Elodie and Duan, Jubao and Dudbridge, Frank and Eichhammer, Peter and Hagen, Knut and Escott-Price, Valentina and Essioux, Laurent and Fanous, Ayman H and Farh, Kai-How and Farrell, Martilias and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson and Friedman, Joseph and Forstner, Aneas and Fromer, M and Genovese, Giulio and Georgieva, Irina and Gershon, E.S and Giegling, Ina and Giusti-Roíguez, Paola and Godard, S and Goldstein, Jacqueline and Gratten, Jacob and Haan, Lieuwe and Hamshere, Marian and Hansen, Mark and Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette M and Henskens, Frans and Herms, Stefan and Hirschhorn, Joel and Hoffmann, Per and Hofman, Anea and Huang, Hailiang and Ikeda, Masashi and Joa, Inge and Kähler, Jan and ... and Schizophrenia Working Grp and Psychosis Endophenotypes and CNV and Psychosis Endophenotypes International Consortium and CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium and Medicinska fakulteten and Institutionen för klinisk vetenskap and Psykiatri and Umeå universitet
Nature Genetics, ISSN 1061-4036, 01/2017, Volume 49, Issue 1, pp. 27 - 35
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7510, pp. 421 - 427
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7579, pp. 477 - 483
At least 120 non-olfactory G-protein-coupled receptors in the human genome are 'orphans' for which endogenous ligands are unknown, and many have no selective... 
EXTRACELLULAR ACIDIFICATION | ACTIVATION | COMPLEX | OGR1 | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | CAMP ACCUMULATION | SMOOTH-MUSCLE-CELLS | EXPRESSION | CANCER | Anti-Anxiety Agents - metabolism | Lorazepam - pharmacology | Memory - drug effects | Receptors, G-Protein-Coupled - metabolism | Humans | Anti-Anxiety Agents - analysis | Male | Receptors, G-Protein-Coupled - agonists | Lorazepam - analysis | Benzyl Alcohols - pharmacology | HEK293 Cells | Anti-Anxiety Agents - chemistry | Female | Triazines - chemistry | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Triazines - metabolism | Triazines - pharmacology | Lorazepam - metabolism | Anti-Anxiety Agents - pharmacology | Models, Molecular | Drug Discovery | Mice, Knockout | Triazines - analysis | Fear | Animals | Receptors, G-Protein-Coupled - deficiency | Signal Transduction - drug effects | Benzyl Alcohols - analysis | Allosteric Site | Lorazepam - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Conditioning, Classical | Benzyl Alcohols - metabolism | Ligands | Mice | Receptors, G-Protein-Coupled - chemistry | Physiological aspects | Cell receptors | Identification and classification | Ligands (Biochemistry) | Proteins | Yeast | Rodents | Physiology | Genomes | Kinases | proton-sensing | virtual screening | GPR68 | GPR65 | positive allosteric modulator (PAM) | functional selectivity | allosteric modulator
Journal Article
by Gusev, Alexander and Lee, S. Hong and Trynka, Gosia and Finucane, Hilary and Vilhjálmsson, Bjarni J and Xu, Han and Zang, Chongzhi and Ripke, Stephan and Bulik-Sullivan, Brendan and Stahl, Eli and Ripke, Stephan and Neale, Benjamin M and Corvin, Aiden and Walters, James T.R and Farh, Kai-How and Holmans, Peter A and Lee, Phil and Bulik-Sullivan, Brendan and Collier, David A and Huang, Hailiang and Pers, Tune H and Agartz, Ingrid and Agerbo, Esben and Albus, Margot and Alexander, Madeline and Amin, Farooq and Bacanu, Silviu A and Begemann, Martin and Belliveau, Richard A and Bene, Judit and Bergen, Sarah E and Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W and Børglum, Anders D and Bruggeman, Richard and Buccola, Nancy G and Buckner, Randy L and Byerley, William and Cahn, Wiepke and Cai, Guiqing and Campion, Dominique and Cantor, Rita M and Carr, Vaughan J and Carrera, Noa and Catts, Stanley V and Chambert, Kimberly D and Chan, Raymond C.K and Chen, Ronald Y.L and Chen, Eric Y.H and Cheng, Wei and Cheung, Eric F.C and Chong, Siow Ann and Cloninger, C. Robert and Cohen, David and Cohen, Nadine and Cormican, Paul and Craddock, Nick and Crowley, James J and Curtis, David and Davidson, Michael and Davis, Kenneth L and Degenhardt, Franziska and Del Favero, Jurgen and DeLisi, Lynn E and Demontis, Ditte and Dikeos, Dimitris and Dinan, Timothy and Djurovic, Srdjan and Donohoe, Gary and Drapeau, Elodie and Duan, Jubao and Dudbridge, Frank and Durmishi, Naser and Eichhammer, Peter and Eriksson, Johan and Escott-Price, Valentina and Essioux, Laurent and Fanous, Ayman H and Farrell, Martilias S and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson B and Friedl, Marion and Friedman, Joseph I and Fromer, Menachem and Genovese, Giulio and Georgieva, Lyudmila and Gershon, Elliot S and Giegling, Ina and Giusti-Rodrguez, Paola and Godard, Stephanie and Goldstein, Jacqueline I and Golimbet, Vera and Gopal, Srihari and Gratten, Jacob and Grove, Jakob and de Haan, Lieuwe and Hammer, Christian and ... and Psychosis Endophenotypes International Consortium and Wellcome Trust Case Control Consortium and Schizophrenia Working Group of the Psychiatric Genomics Consortium and SWE-SCZ Consortium and Psychiat Genomics Consortium
The American Journal of Human Genetics, ISSN 0002-9297, 11/2014, Volume 95, Issue 5, pp. 535 - 552
Journal Article
Frontiers in Integrative Neuroscience, ISSN 1662-5145, 12/2011, Volume 5, Issue DECEMBER, p. 87
Journal Article
by Vilhjálmsson, Bjarni J and Yang, Jian and Finucane, Hilary K and Gusev, Alexander and Lindström, Sara and Ripke, Stephan and Genovese, Giulio and Loh, Po-Ru and Bhatia, Gaurav and Do, Ron and Hayeck, Tristan and Won, Hong-Hee and Ripke, Stephan and Neale, Benjamin M and Corvin, Aiden and Walters, James T.R and Farh, Kai-How and Holmans, Peter A and Lee, Phil and Bulik-Sullivan, Brendan and Collier, David A and Huang, Hailiang and Pers, Tune H and Agartz, Ingrid and Agerbo, Esben and Albus, Margot and Alexander, Madeline and Amin, Farooq and Bacanu, Silviu A and Begemann, Martin and Belliveau, Richard A and Bene, Judit and Bergen, Sarah E and Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W and Bruggeman, Richard and Buccola, Nancy G and Buckner, Randy L and Byerley, William and Cahn, Wiepke and Cai, Guiqing and Campion, Dominique and Cantor, Rita M and Carr, Vaughan J and Carrera, Noa and Catts, Stanley V and Chambert, Kimberly D and Chan, Raymond C.K and Chen, Ronald Y.L and Chen, Eric Y.H and Cheng, Wei and Cheung, Eric F.C and Chong, Siow Ann and Cloninger, C. Robert and Cohen, David and Cohen, Nadine and Cormican, Paul and Craddock, Nick and Crowley, James J and Curtis, David and Davidson, Michael and Davis, Kenneth L and Degenhardt, Franziska and Del Favero, Jurgen and DeLisi, Lynn E and Demontis, Ditte and Dikeos, Dimitris and Dinan, Timothy and Djurovic, Srdjan and Donohoe, Gary and Drapeau, Elodie and Duan, Jubao and Dudbridge, Frank and Durmishi, Naser and Eichhammer, Peter and Eriksson, Johan and Escott-Price, Valentina and Essioux, Laurent and Fanous, Ayman H and Farrell, Martilias S and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson B and Friedl, Marion and Friedman, Joseph I and Fromer, Menachem and Genovese, Giulio and Georgieva, Lyudmila and Gershon, Elliot S and Giegling, Ina and Giusti-Rodrguez, Paola and Godard, Stephanie and Goldstein, Jacqueline I and Golimbet, Vera and Gopal, Srihari and Gratten, Jacob and Grove, Jakob and de Haan, Lieuwe and ... and Psychosis Endophenotypes International Consortium and Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study and Wellcome Trust Case Control Consortium and Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and Schizophrenia Working Group of the Psychiatric Genomics Consortium and Discovery Biol Risk Inherited and Psychiat Genomics Consortium and Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study
The American Journal of Human Genetics, ISSN 0002-9297, 10/2015, Volume 97, Issue 4, pp. 576 - 592
Journal Article