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science & technology (23) 23
humans (22) 22
life sciences & biomedicine (22) 22
melanoma (18) 18
braf (13) 13
melanoma - drug therapy (13) 13
melanoma - pathology (13) 13
oncology (12) 12
proto-oncogene proteins b-raf - antagonists & inhibitors (11) 11
neoplasms (10) 10
dermatology (9) 9
melanoma - genetics (9) 9
proto-oncogene proteins b-raf - genetics (9) 9
cell line, tumor (8) 8
mutation (8) 8
protein kinase inhibitors - pharmacology (8) 8
melanoma - metabolism (7) 7
animals (6) 6
biochemistry & molecular biology (6) 6
cell biology (6) 6
proto-oncogene proteins b-raf - metabolism (6) 6
skin neoplasms - drug therapy (6) 6
skin neoplasms - pathology (6) 6
digestive system diseases (5) 5
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membrane proteins - genetics (5) 5
molecular targeted therapy (5) 5
skin neoplasms - genetics (5) 5
biological and medical sciences (4) 4
care and treatment (4) 4
drug resistance, neoplasm (4) 4
gene mutations (4) 4
gtp phosphohydrolases - genetics (4) 4
indoles - pharmacology (4) 4
medical sciences (4) 4
proteomics (4) 4
resistance (4) 4
signal transduction (4) 4
sulfonamides - pharmacology (4) 4
tumors (4) 4
tumors of the skin and soft tissue. premalignant lesions (4) 4
vemurafenib (4) 4
antineoplastic agents (3) 3
antineoplastic agents - therapeutic use (3) 3
biochemical research methods (3) 3
drug resistance (3) 3
endocrine system diseases (3) 3
fibroblasts (3) 3
genetic aspects (3) 3
health aspects (3) 3
medicine, research & experimental (3) 3
metastasis (3) 3
mice (3) 3
mitogen-activated protein kinase kinases - metabolism (3) 3
nras (3) 3
pharmacology. drug treatments (3) 3
phosphatidylinositol 3-kinases - antagonists & inhibitors (3) 3
phosphatidylinositol 3-kinases - metabolism (3) 3
proteins (3) 3
research (3) 3
research & experimental medicine (3) 3
signal transduction - drug effects (3) 3
amuvatinib (2) 2
analysis (2) 2
antineoplastic agents - pharmacology (2) 2
apoptosis (2) 2
azabicyclo compounds - pharmacology (2) 2
biochemistry (2) 2
cancer (2) 2
cell cycle (2) 2
cellular signal transduction (2) 2
development and progression (2) 2
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gene expression regulation, neoplastic (2) 2
genetics & heredity (2) 2
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immunotherapy (2) 2
indoles - therapeutic use (2) 2
kinases (2) 2
ligands (2) 2
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mapk (2) 2
melanoma - enzymology (2) 2
melanoma - physiopathology (2) 2
microenvironment (2) 2
mitogen-activated protein kinase kinases - antagonists & inhibitors (2) 2
molecular biology (2) 2
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multiple tumors. solid tumors. tumors in childhood (2) 2
neoplasm metastasis (2) 2
pharmacology & pharmacy (2) 2
phenotype (2) 2
phthalic acids - pharmacology (2) 2
prognosis (2) 2
protein kinase inhibitors - therapeutic use (2) 2
proto-oncogene proteins c-akt - antagonists & inhibitors (2) 2
proto-oncogene proteins c-akt - metabolism (2) 2
pten phosphohydrolase - deficiency (2) 2
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1. Full Text Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel
by Lishko, Polina V and Botchkina, Inna L and Fedorenko, Andriy and Kirichok, Yuriy
Cell (Cambridge), ISSN 0092-8674, 2010, Volume 140, Issue 3, pp. 327 - 337
HUMDISEASE | DEVBIO | SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sperm Motility | Humans | Male | Spermatozoa - metabolism | Ion Channels - antagonists & inhibitors | Acrosome Reaction | Sperm Tail - metabolism | Animals | Ion Channels - metabolism | Sperm Capacitation | Female | Mice | Spermatozoa - cytology | Hydrogen-Ion Concentration | Spermatozoa | Index Medicus
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2. Full Text Paradoxical oncogenesis-the long-term effects of BRAF inhibition in melanoma
by Gibney, Geoffrey T and Messina, Jane L and Fedorenko, Inna V and Sondak, Vernon K and Smalley, Keiran S. M
Nature reviews. Clinical oncology, ISSN 1759-4774, 07/2013, Volume 10, Issue 7, pp. 390 - 399
Life Sciences & Biomedicine | Oncology | Science & Technology | Melanoma - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Prognosis | Antineoplastic Agents - adverse effects | Humans | Melanoma - drug therapy | Cell Transformation, Neoplastic - chemically induced | Melanoma - pathology | Care and treatment | Gene mutations | Melanoma | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
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3. Full Text BRAF Inhibition Generates a Host–Tumor Niche that Mediates Therapeutic Escape
by Fedorenko, Inna V and Wargo, Jennifer A and Flaherty, Keith T and Messina, Jane L and Smalley, Keiran S.M
Journal of investigative dermatology, ISSN 0022-202X, 12/2015, Volume 135, Issue 12, pp. 3115 - 3124
Life Sciences & Biomedicine | Dermatology | Science & Technology | Phosphoinositide-3 Kinase Inhibitors | Fibronectins - analysis | Humans | Proto-Oncogene Proteins c-akt - physiology | Melanoma - pathology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Transforming Growth Factor beta - pharmacology | Vemurafenib | Sulfonamides - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Index Medicus | melanoma | fibroblasts | BRAF | resistance
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4. Full Text PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
by Paraiso, Kim H. T and Xiang, Yun and Rebecca, Vito W and Abel, Ethan V and Chen, Y. Ann and Munko, A. Cecilia and Wood, Elizabeth and Fedorenko, Inna V and Sondak, Vernon K and Anderson, Alexander R. A and Ribas, Antoni and Palma, Maurizia Dalla and Nathanson, Katherine L and Koomen, John M and Messina, Jane L and Smalley, Keiran S. M
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2750 - 2760
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Dermatology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | RNA, Small Interfering - genetics | Up-Regulation | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Bcl-2-Like Protein 11 | Melanoma - genetics | Apoptosis Regulatory Proteins - genetics | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Melanoma - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - deficiency | Membrane Proteins - genetics | PTEN Phosphohydrolase - biosynthesis | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Membrane Proteins - biosynthesis | Membrane Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Mutation | RNA, Small Interfering - administration & dosage | Index Medicus | PTEN | melanoma | BRAF | PLX4032 | therapy | resistance
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5. Full Text NRAS mutant melanoma: Biological behavior and future strategies for therapeutic management
by Fedorenko, I.V and Gibney, G.T and Smalley, K.S.M
Oncogene, ISSN 0950-9232, 06/2013, Volume 32, Issue 25, pp. 3009 - 3018
targeted therapy | Ras | melanoma | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Melanoma - metabolism | Prognosis | Signal Transduction | Skin Neoplasms - therapy | Membrane Proteins - genetics | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Skin Neoplasms - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | GTP Phosphohydrolases - genetics | Melanoma - genetics | Skin Neoplasms - genetics | Mutation | Melanoma - therapy | Proto-Oncogene Proteins B-raf - metabolism | Care and treatment | Ras genes | Gene mutations | Patient outcomes | Melanoma | Genetic aspects | Research | Health aspects | Risk factors | Proteins | Signal transduction | Disease management | Index Medicus
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6. Full Text Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy
by Smalley, Keiran S.M and Fedorenko, Inna V and Kenchappa, Rajappa S and Sahebjam, Solmaz and Forsyth, Peter A
International journal of cancer, ISSN 0020-7136, 09/2016, Volume 139, Issue 6, pp. 1195 - 1201
leptomeninges | melanoma | BRAF | brain | immunotherapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Melanoma - metabolism | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Meningeal Neoplasms - diagnosis | Melanoma - pathology | Molecular Targeted Therapy | Disease Progression | Meningeal Neoplasms - mortality | Meningeal Neoplasms - therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | Protein Kinase Inhibitors - therapeutic use | Immunotherapy | Disease Management | Protein Kinase Inhibitors - pharmacology | Biomarkers, Tumor - antagonists & inhibitors | Meningeal Neoplasms - secondary | Proto-Oncogene Proteins B-raf - metabolism | Development and progression | Metastasis | Melanoma | Medical prognosis | Index Medicus
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7. Full Text Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma
by Fedorenko, Inna V and Paraiso, Kim H.T and Smalley, Keiran S.M
Biochemical pharmacology, ISSN 0006-2952, 08/2011, Volume 82, Issue 3, pp. 201 - 209
Resistance | Vemurafenib | MEK | Melanoma | Cot | BRAF | MAPK | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Biological and medical sciences | Medical sciences | Dermatology | Pharmacology. Drug treatments | Melanoma - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Humans | Antineoplastic Agents - pharmacology | Mutation | Gene Expression Regulation, Neoplastic - physiology | Proto-Oncogene Proteins B-raf - metabolism | Index Medicus | vemurafenib | melanoma | resistance
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8. Full Text Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells
by Fedorenko, I.V and Abel, E.V and Koomen, J.M and Fang, B and Wood, E.R and Chen, Y.A and Fisher, K.J and Iyengar, S and Dahlman, K.B and Wargo, J.A and Flaherty, K.T and Sosman, J.A and Sondak, V.K and Messina, J.L and Gibney, G.T and Smalley, K.S.M
Oncogene, ISSN 0950-9232, 03/2016, Volume 35, Issue 10, pp. 1225 - 1235
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proto-Oncogene Proteins B-raf - deficiency | Cell Survival - drug effects | PTEN Phosphohydrolase - genetics | RNA, Small Interfering - genetics | PTEN Phosphohydrolase - deficiency | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Melanoma - pathology | Fibronectins - metabolism | Gene Knockdown Techniques | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Proteomics | Cell Line, Tumor | Female | Mice | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Integrin alpha5beta1 - metabolism | Care and treatment | Gene mutations | Melanoma | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects | Models | Gene expression | Proteins | Mutation | Cellular biology | Kinases | Index Medicus
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