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Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2012, Volume 37, Issue 6, pp. 1009 - 1023
Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for... 
NALP1 | LETHAL TOXIN | IN-VIVO | DISEASE | BINDING-PROTEIN | DEATH | INFECTION | IMMUNOLOGY | TIR DOMAIN | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | CASPASE-1 ACTIVATION | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | Dermatitis - immunology | Pancytopenia - immunology | Caspase 1 - metabolism | Interferon-gamma - metabolism | Hematopoiesis - drug effects | Inflammation - metabolism | T-Lymphocytes - metabolism | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Hematopoietic Stem Cells - virology | Hematopoietic Stem Cells - drug effects | Hematopoietic Stem Cells - metabolism | Inflammation - immunology | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Pancytopenia - metabolism | Hematopoiesis - immunology | Animals | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | T-Lymphocytes - immunology | Fluorouracil - pharmacology | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-18 - metabolism | Apoptosis | Dermatitis - metabolism | Chemotherapy | Research | Health aspects | Oncology, Experimental | Immunotherapy | Cancer | Proteins | Medical research | Disease | Councils | Bone marrow | Infections | Grants | Kinases | pyroptosis | inflammasome | IL-18 | progenitor cells | NLRP1 | cytopenia | IL-1β | sepsis
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2008, Volume 100, Issue 15, pp. 1092 - 1103
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2017, Volume 127, Issue 11, pp. 3954 - 3969
Uromodulin-associated kidney disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form of UMOD protein, which is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CASPASE-12 ACTIVATION | UNFOLDED PROTEIN RESPONSE | UMOD GENE | MOUSE MODEL | ENDOPLASMIC-RETICULUM STRESS | FOXO TRANSCRIPTION FACTORS | NF-KAPPA-B | JUVENILE HYPERURICEMIC NEPHROPATHY | TAMM-HORSFALL GLYCOPROTEIN | CELL-DEATH | Tumor Necrosis Factor-alpha - metabolism | Humans | Male | Mutation, Missense | Autophagy | Base Sequence | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Renal Insufficiency - immunology | Uromodulin - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Renal Insufficiency - genetics | Genetic Association Studies | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Uromodulin - metabolism | Mice, Transgenic | Immunity, Innate | Disease Progression | Point Mutation | Animals | Renal Insufficiency - pathology | Endoplasmic Reticulum Stress | Apoptosis | Care and treatment | Gene mutations | Epithelial cells | Glycoproteins | Kidney diseases | Diagnosis | Research | TOR protein | Tumor necrosis factor receptors | Syngeneic grafts | Kinases | Caspase-3 | Proteins | Neurodegeneration | Protein folding | Rodents | Tumor necrosis factor-TNF | Fusion protein | Urine | Activating transcription factor 4 | Caspase | Tumor necrosis factor-α | Epithelium | Nephrons | Fc receptors | Cell death | Point mutation | Renal failure | TRAIL protein | Mutation | Endoplasmic reticulum | Phagocytosis | Kidney transplantation
Journal Article
Journal Article
Nature, ISSN 0028-0836, 09/2006, Volume 443, Issue 7108, pp. 222 - 225
Journal Article