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Current Neuropharmacology, ISSN 1570-159X, 05/2019, Volume 17, Issue 6, pp. 491 - 491
Journal Article
Current Neuropharmacology, ISSN 1570-159X, 2019, Volume 17, Issue 6, pp. 491 - 491
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 05/2019, Volume 563, pp. 273 - 281
Pharmaceutical companies are relying more often on external sources of innovation to boost their discovery research productivity. However, more in-depth... 
Text mining | External innovation | New molecular entities | Innovation ecosystem | New biologic entities | Drug discovery | Approval | CELLS | PHARMACOLOGY & PHARMACY | DISCOVERY | Drugs | Data mining | Pharmaceutical industry | Ecosystems | Drug approval | Innovations
Journal Article
Journal Article
The Journal of pharmacology and experimental therapeutics, 09/2019
Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and significant social and economic impact. Curbing this crisis... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 25, pp. 19012 - 19021
The recently identified small molecule, 3-amino-5-chloro-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylic acid cyclopropylamide (LY2033298), is the first... 
DRUG | GALLAMINE | MODELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | SCHIZOPHRENIA | SWITCH | MUTATIONS | SITE-DIRECTED MUTAGENESIS | BINDING | SELECTIVITY
Journal Article
Advances in pharmacology (San Diego, Calif.), 2019, Volume 86, p. 1
Allosteric modulation of G protein coupled receptors (GPCRs) is rapidly becoming a standard option for development of therapeutics headed to the clinic.... 
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 1997, Volume 17, Issue 14, pp. 5327 - 5333
Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. Within the striatum, CB1 receptors have... 
Adenylate cyclase | Striatum | Dopamine | CB1 receptor | G-protein | D2 receptor | Cannabinoid | SIGNAL-TRANSDUCTION PATHWAYS | BETA-2-ADRENERGIC RECEPTOR | RAT STRIATUM | cannabinoid | BASAL GANGLIA | PHOSPHOLIPASE-C | NEUROSCIENCES | K RU NEUROSCIENCES | CALCIUM INFLUX | CYCLIC-AMP ACCUMULATION | striatum | adenylate cyclase | MOLECULAR-CLONING | dopamine | ADENYLATE-CYCLASE | CHOLERA TOXIN
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2016, Volume 782, p. 70
Identification of synthetic ligands selective for muscarinic receptor subtypes has been challenging due to the high sequence identity and structural homology... 
Neurosciences | Analysis
Journal Article
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7594, pp. 335 - 340
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0188330
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 25, pp. 19012 - 19021
The recently identified small molecule, 3-amino-5-chloro-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxy l ic acid cyclopropylamide (LY2033298), is the first... 
Journal Article
American Journal of Psychiatry, ISSN 0002-953X, 01/2009, Volume 166, Issue 1, pp. 113 - 113
Journal Article
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