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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2002, Volume 99, Issue 3, pp. 1158 - 1163
Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means... 
Enzymes | Chemical equilibrium | Biological Sciences | Metabolites | Plasmids | Terpenoids | Atoms | Biosynthesis | Biochemistry | Diphosphates | Terpenes | Biosynthesis of isoprenoids | Isopentenyl diphosphate | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate | Dimethylallyl diphosphate | PRECURSOR | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | THIAMIN | 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL | biosynthesis of isoprenoids | ENZYME | GENE | ISOPRENOID BIOSYNTHESIS | 5-PHOSPHATE | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate isopentenyl diphosphate | dimethylallyl diphosphate | ISOPENTENYL-DIPHOSPHATE ISOMERASE | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Magnetic Resonance Spectroscopy | Operon | Bacterial Proteins - genetics | Oligodeoxyribonucleotides - chemistry | Enterobacteriaceae - genetics | Molecular Sequence Data | Mevalonic Acid - metabolism | Escherichia coli Proteins | Terpenes - metabolism | Escherichia coli - genetics | Base Sequence | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Oxidoreductases | Mycobacterium tuberculosis - genetics | Physiological aspects | Genetic research | Analysis | Proteins | Phosphates | Metabolism | Genes | ispH gene | mevalonic acid | lytB gene | terpenes | isopentenyl diphosphate | Index Medicus | biosynthesis of isoprenoids‖1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate‖isopentenyl diphosphate‖dimethylallyl diphosphate
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2001, Volume 98, Issue 26, pp. 14837 - 14842
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2003, Volume 100, Issue 4, pp. 1586 - 1591
Journal Article
ELIFE, ISSN 2050-084X, 12/2016, Volume 5
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects,... 
CELLS | ACTIVATION | SUPER-ENHANCERS | SMALL-MOLECULE INHIBITORS | COLORECTAL-CANCER | BIOLOGY | CHEMICAL PROBE | COVALENT CDK7 INHIBITOR | TRANSCRIPTION REGULATION | BETA-CATENIN | DISCOVERY | Mediator Complex - antagonists & inhibitors | Anti-Inflammatory Agents - toxicity | Humans | Treatment Outcome | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Antineoplastic Agents - toxicity | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Animals | Anti-Inflammatory Agents - adverse effects | Heterografts | Antineoplastic Agents - adverse effects | Protein Kinase Inhibitors - toxicity | Anti-Inflammatory Agents - administration & dosage | Hyperplasia - drug therapy | Mice | Cyclin-Dependent Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase 8 - antagonists & inhibitors | Disease Models, Animal | Physiological aspects | Observations | Protein kinases | Protein-protein interactions | Immunoassay | Phosphorylation | Transcription factors | Toxicity | Colorectal cancer | Kinases | Proteins | β-catenin | Intestine | Xenografts | Tumorigenesis | Medical research | Cytokines | Inflammation | RNA polymerase | Gene expression | Studies | Enhancers | Gene amplification | Stem cells | Ligands | Software | Laboratory animals | Pharmaceuticals | Tumors | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2016, Volume 59, Issue 20, pp. 9337 - 9349
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2015, Volume 11, Issue 12, pp. 973 - 980
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 5025 - 5039
Co- and post-translational processing are crucial maturation steps to generate functional proteins. MetAP-2 plays an important role in this process, and... 
BENGAMIDES | POTENT | CHEMISTRY, MEDICINAL | ANGIOGENESIS | ANALOGS | FUMAGILLIN | NITROXOLINE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 3, pp. 1078 - 1101
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2002, Volume 99, Issue 19, pp. 12108 - 12113
Earlier in vivo studies showed the involvement of IspH protein in the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate... 
Proteins | Enzymes | Biological Sciences | Sodium | Plasmids | Chromoplasts | Biosynthesis | Catalytic activity | Diphosphates | Experimental procedures | Cell extracts | IspH | lytB | Isopentenyl diphosphate | Deoxyxylulose | Isoprenoids | PROTEIN | isoprenoids | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | MULTIDISCIPLINARY SCIENCES | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ESCHERICHIA-COLI | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL | isopentenyl diphosphate | deoxyxylulose | 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | ispH | ENZYME | ISOPRENOID BIOSYNTHESIS | NONMEVALONATE PATHWAY | Recombinant Proteins - metabolism | Amino Acid Sequence | Capsicum - enzymology | Escherichia coli - enzymology | Oxidoreductases - metabolism | Oxidoreductases - genetics | Bacterial Proteins - genetics | Molecular Sequence Data | Recombinant Proteins - genetics | Organophosphorus Compounds - metabolism | Capsicum - genetics | Sequence Homology, Amino Acid | Terpenes - chemistry | Animals | DNA, Bacterial - genetics | Escherichia coli Proteins | Terpenes - metabolism | Escherichia coli - genetics | Base Sequence | Cloning, Molecular | Hemiterpenes | Bacterial Proteins - metabolism | Physiological aspects | Research | Cytochemistry | Molecular biology | Terpenes | Gene expression | Bacteria | Chemical reactions | Biochemistry | Index Medicus
Journal Article