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1. Full Text CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species
by Fu, Zhiping and Cheng, Xi and Kuang, Jie and Feng, Haoran and Chen, Lingxie and Liang, Juyong and Shen, Xiaonan and Yuen, Stanley and Peng, Chenghong and Shen, Baiyong and Jin, Zhijian and Qiu, Weihua
Molecular Oncology, ISSN 1574-7891, 04/2018, Volume 12, Issue 4, pp. 529 - 544
As an established anticancer drug, gemcitabine (GEM) is an effective systemic treatment for advanced pancreatic cancer (PC). However, little is known about the... 
chloroquine | lysosomal membrane permeabilization | apoptosis | gemcitabine | reactive oxygen species | OXIDATIVE STRESS | ADENOCARCINOMA | DEATH | AUTOPHAGY | COMBINATION | CHEMOTHERAPY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | DOUBLE-EDGED-SWORD | ACCUMULATION | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - pathology | Deoxycytidine - pharmacology | Male | Neoplasm Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Chloroquine - pharmacology | Animals | Lysosomes - metabolism | Mice, Nude | Cell Line, Tumor | Lysosomes - pathology | Mice | Mice, Inbred BALB C | Deoxycytidine - analogs & derivatives
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2. Convergence rate of the CQ algorithm for split feasibility problems
by Chen, Peipei and He, Hongjin and Liou, Yeong-Cheng and Wen, Ching-Feng
Journal of Nonlinear and Convex Analysis, ISSN 1345-4773, 2018, Volume 19, Issue 3, pp. 381 - 395
The CQ algorithm is one of the most popular solvers for split feasibility problems. In this paper, we first prove that the CQ algorithm is globally convergent... 
Iteration complexity | Split feasibility problem | CQ algorithm | Image deblurring | Acceleration | MATHEMATICS | MATHEMATICS, APPLIED | LINEAR INVERSE PROBLEMS | SETS | LEAST-SQUARES
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3. Chloroquine (CQ) exerts anti-breast cancer through modulating microenvironment and inducing apoptosis
by Yanjun Zhang and Yu Cao and Xiaodan Sun and Yonghui Feng and Yunting Du and Fei Liu and Chunyun Yu and Feng Jin
International Immunopharmacology, ISSN 1567-5769, 01/2017, Volume 42, p. 100
CQ is an anti-malaria drug, which has been used for years. However, there are published articles about its activity in anti-cancers. The aim of this approach... 
Drugs | Vector-borne diseases | Cell survival | Malaria | Secretion | CD8 antigen | Chloroquine | Breast cancer | Lymphocytes T | Macrophages | Survival | Mode of action | Breast | Mice | In vivo methods and tests | In vitro methods and tests | Immune system | Tumors | Cancer | Apoptosis
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4. Full Text Chloroquine (CQ) exerts anti-breast cancer through modulating microenvironment and inducing apoptosis
by Zhang, Yanjun and Cao, Yu and Sun, Xiaodan and Feng, Yonghui and Du, Yunting and Liu, Fei and Yu, Chunyun and Jin, Feng
International Immunopharmacology, ISSN 1567-5769, 01/2017, Volume 42, pp. 100 - 107
CQ is an anti-malaria drug, which has been used for years. However, there are published articles about its activity in anti-cancers. The aim of this approach... 
Breast cancer | Tumor microenvironment | Immunoregulation | Chloroquine | TGF-BETA | AUTOPHAGY | IMMUNOLOGY | MYELOID CELLS | METASTATIC MELANOMA | THERAPY | IMMUNE SUPPRESSION | IN-VIVO | REGULATORY T-CELLS | TUMOR-ASSOCIATED MACROPHAGES | PHARMACOLOGY & PHARMACY | SUPPRESSOR-CELLS | Neoplasm Transplantation | Myeloid-Derived Suppressor Cells - immunology | Apoptosis - drug effects | Humans | Chloroquine - therapeutic use | Myeloid-Derived Suppressor Cells - drug effects | Antineoplastic Agents - therapeutic use | Breast Neoplasms - drug therapy | Animals | Tumor Burden - drug effects | Breast Neoplasms - pathology | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Female | Macrophages - drug effects | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Cellular Microenvironment - drug effects | Transforming Growth Factor beta - metabolism | Macrophages - immunology | Oncology, Experimental | Immunotherapy | Research | T cells | Transforming growth factors | Cancer | Apoptosis
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5. Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice
by Jiang, Yu-Mao and Sun, Dan-Dan and Wang, Zhi-Guo and Li, Tao and Zhao, Xiao-Hang and Jiao, Yue and Liu, Yang and Li, Yu-Juan and Ouyang, Jing-Feng and Wang, Dan-Qiao
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 02/2017, Volume 42, Issue 4, pp. 739 - 745
GABAa receptor | Neurotransmitters | CQ prescription | Proinflammatory cytokine | Cancer invasion induced mirror image pain
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6. Full Text Experimental study of cross-section ratios in the collisions of Cq+ and Oq+ (q = 1–4) on atomic helium in strong-interaction region
by Chen, Xi-Meng (熙萌 陈) and Jiang, Li-Juan (娟娟 #36158;) and Zhou, Peng (鹏周) and Zhou, Chun-Lin (春林 周) and Gao, Zhi-Min (志民 高) and Qiu, Xi-Yu (玺玉 邱) and Cui, Ying (璧崔) and Wang, Xing-An (兴安 王) and Lou, Feng-Jun (凤君 娄) and Lü, Xue-Yang (学阳 吕) and Jia, Juan-Juan (娟娟 贾) and Chen, Lin (林陈) and Shao, Jian-Xiong (剑雄 邵) and Lü, Ying (瑛吕) and Wang, Fan (幡王)
Chinese Physics B, ISSN 1674-1056, 01/2011, Volume 20, Issue 1, p. 013402
We have measured the cross-section ratios of helium induced by Cq+ and Oq+ (q = 1-4) in an energy range from 20 keV/amu to 500 keV/amu, and obtained the... 
GASES | strong-interaction region | SINGLE | PARTICLES | PHYSICS, MULTIDISCIPLINARY | MULTIPLY-CHARGED IONS | IMPACT | HE+ PROJECTILES | STRIPPED CARBON-IONS | competitive relation | ion-atom collisions | CAPTURE | cross-section ratios | DOUBLE-IONIZATION
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7. Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice
by Jiang, Yu-Mao and Sun, Dan-Dan and Wang, Zhi-Guo and Li, Tao and Zhao, Xiao-Liang and Jiao, Yue and Liu, Yang and Li, Yu-Juan and Ouyang, Jing-Feng and Wang, Dan-Qiao
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, ISSN 1001-5302, 02/2017, Volume 42, Issue 4, p. 739
This study aimed to analyze the analgesic effect and related central mechanisms of CQ prescription on cancer invasion induced mirror image pain (CIIMIP)in... 
Analgesics - pharmacology | Neoplasms, Experimental - complications | Neoplasm Invasiveness | Drugs, Chinese Herbal - pharmacology | Male | Taurine - analysis | Spinal Cord - chemistry | Animals | Pain - drug therapy | Mice | Mice, Inbred BALB C | Glycine - analysis | gamma-Aminobutyric Acid - analysis | Glutamic Acid - analysis
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8. Full Text Double Electron Processes in Collisions of Partially Stripped Ions Cq+(q = 1−4) with Helium
by Bao-Wei, Ding and Xi-Meng, Chen and De-Yang, Yu and Hong-Bin, Fu and Zhao-Yuan, Liu and Guang-Zhi, Sun and Yu-Wen, Liu and Yan-Xia, Lu and Jiang-Shan, Xie and Juan, Du and Zhi-Min, Gao and Lin, Chen and Ying, Cui and Jian-Xiong, Shao and Zi-Feng, He and Xiao-Hong, Cai
Chinese Physics Letters, ISSN 0256-307X, 01/2007, Volume 24, Issue 1, pp. 94 - 96
The multi-electron processes are investigated for 17.9-120keV/u C1+, 30-323 keV/u C2+, 120-438 keV/u C3+, 287-480keV/u C4+ incident on a helium target. The... 
TARGET IONIZATION | SINGLE | PHYSICS, MULTIDISCIPLINARY | CAPTURE | DOUBLE-IONIZATION
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9. Full Text Acidocalcisome is required for autophagy in Trypanosoma brucei
by Li, Feng-Jun and He, Cynthia Y
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1978 - 1988
Lysosomes play important roles in autophagy, not only in autophagosome degradation, but also in autophagy initiation. In Trypanosoma brucei, an early divergent... 
acidocalcisome | RNAi, RNA interference | PPi, pyrophosphate | Tbβ3, the β3 subunit of adaptor protein-3 complex in Trypanosoma brucei | bafilomycin A | DAPI, 4′, 6-diamidino-2-phenylindole | ATG, autophagy-related | polyP, polyphosphate | V-H | TOR, target of rapamycin | MTORC1, mechanistic target of rapamycin complex 1 | AP-3, adaptor protein-3 | Tbδ, the δ, subunit of adaptor protein-3 complex in Trypanosoma brucei | BODIPY-CQ, BODIPY-chloroquine | AO, acridine orange | Trypanosoma brucei | ATPase in Trypanosoma brucei | autophagy | protozoan parasite | BafA | ATPase | PtdIns3K, phosphatidylinositol 3-kinase | + | TbVMA1, the subunit A of V-H | CQ, chloroquine | 1 | TbVP1, vacuolar pyrophosphatase in Trypanosoma brucei | acidity | lysosome-related organelle | PtdIns3P, phosphatidylinositol 3-phosphate | TbVPH1, the α, subunit of V-H | T. brucei, Trypanosoma brucei | V-PPase, vacuolar pyrophophatase | ATPase, vacuolar-type H | coumarin-CQ, coumarin-chloroquine | Lysosome-related organelle | Acidity | Acidocalcisome | Autophagy | Protozoan parasite | COMPLEX | RAG GTPASES | MECHANISM | CA2+ RELEASE | VACUOLAR H+-ATPASE | PROTEIN P67 | CELL BIOLOGY | MTORC1 | BAFILOMYCINS | LYSOSOME | INDUCIBLE EXPRESSION SYSTEM | Lysosomes - chemistry | Trypanosoma brucei brucei - metabolism | Humans | Phagosomes - metabolism | Gene Expression Regulation | Phosphates - chemistry | Monensin - chemistry | Calcium - chemistry | Protozoan Proteins - metabolism | Macrolides - chemistry | Chloroquine - chemistry | Organelles - metabolism | Microscopy, Fluorescence | Hydrogen-Ion Concentration
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10. An experimental investigation of the cross-section ratios in the collisions of partially stripped Cq+, Oq+ (q=1-4) on helium atom at the strong-interaction region
by Zhou, Chun-Lin and Shao, Jian-Xiong and Chen, Xi-Meng and Gao, Zhi-Min and Wang, Jun and Sun, Guang-Zhi and Xi, Fa-Yuan and Chen, Yi-Feng and Chen, Lin and Ding, Bao-Wei and Wang, Xing-An and Lou, Feng-Jun and Xu, Jun-Kui and Qiu, Xi-Yu and Wang, Fan and Lü, Ying
Wuli Xuebao/Acta Physica Sinica, ISSN 1000-3290, 08/2009, Volume 58, Issue 8, pp. 5342 - 5349
Ion-atom collisions | Cross-section ratios | Competitive relation | Strong-interaction region
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11. Full Text Linear convergence of gradient projection algorithm for split equality problems
by Shi, Luo-Yi and Ansari, Qamrul Hasan and Yao, Jen-Chih and Wen, Ching-Feng
Optimization, ISSN 0233-1934, 12/2018, Volume 67, Issue 12, pp. 2347 - 2358
In this paper, we consider the varying stepsize gradient projection algorithm (GPA) for solving the split equality problem (SEP) in Hilbert spaces, and study... 
Split equality problems | 40A05 | gradient projection algorithm | 47H10 | CQ algorithm | linear convergence | MATHEMATICS, APPLIED | OPERATIONS RESEARCH & MANAGEMENT SCIENCE | CONVEX FEASIBILITY | Hilbert space | Algorithms | Nonlinear programming | Regularity | Convergence
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12. A new three-step iterative algorithm for solving the split feasibility problem
by Feng, Meiling and Shi, Luoyi and Chen, Rudong
UPB Scientific Bulletin, Series A: Applied Mathematics and Physics, ISSN 1223-7027, 2019, Volume 81, Issue 1, pp. 93 - 102
In this paper, we propose a new three-step iterative algorithm for solving the split feasibility problem in Hilbert space. Under proper assumptions, the... 
Strong convergence | Hilbert space | Three-step iterative | WEAK | MATHEMATICS, APPLIED | PHYSICS, MULTIDISCIPLINARY | SETS | CQ ALGORITHM | STRONG-CONVERGENCE
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13. Full Text Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38δ
by Jiang, Yong and Gram, Hermann and Zhao, Ming and New, Liguo and Gu, Jun and Feng, Lili and Di Padova, Franco and Ulevitch, Richard J and Han, Jiahuai
Journal of Biological Chemistry, ISSN 0021-9258, 11/1997, Volume 272, Issue 48, pp. 30122 - 30128
We have cloned and characterized a new member of the p38 group of mitogen-activated protein kinases here termed p38 delta. Sequence comparisons revealed that... 
GLOMERULONEPHRITIS | CELLS | FISSION YEAST | PHOSPHORYLATION | MAP KINASE | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAJOR ACTIVATOR | CASCADE | STRESS | IDENTIFICATION | SIGNAL-TRANSDUCTION PATHWAY
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14. Full Text Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-x(L) has activity independent of cytochrome c release
by Li, Feng and Srinivasan, Anu and Wang, Yu and Armstrong, Robert C and Tomaselli, Kevin J and Fritz, Lawrence C
Journal of Biological Chemistry, ISSN 0021-9258, 11/1997, Volume 272, Issue 48, pp. 30299 - 30305
Bcl-x(L), an antiapoptotic member of the Bcl-2 family, inhibits programmed cell death in a broad variety of cell types, Recent reports have demonstrated that... 
ENCODES | NUCLEAR-ENVELOPE | BCL-2 | PROTEIN | ENZYME | PRODUCT | MEDIATOR | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPP32 | DEATH | FAMILY
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15. Full Text TGF- β receptor signaling
by Derynck, Rik and Feng, Xin-Hua
BBA - Reviews on Cancer, ISSN 0304-419X, 1997, Volume 1333, Issue 2, pp. F105 - F150
CARCINOMA CELL-LINES | K DA BIOPHYSICS | SERINE-THREONINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | DAUER LARVA DEVELOPMENT | HUMAN ENDOTHELIAL-CELLS | BREAST-CANCER CELLS | MOLECULAR-WEIGHT COMPLEX | BIOPHYSICS | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR (TGF)-BETA RECEPTOR | TRANSFORMING-GROWTH-FACTOR | BONE MORPHOGENETIC PROTEIN-4
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16. Full Text Skeletal and CNS defects in Presenilin-1-deficient mice
by Shen, J and Bronson, RT and Chen, DF and Xia, WM and Selkoe, DJ and Tonegawa, S
CELL, ISSN 0092-8674, 05/1997, Volume 89, Issue 4, pp. 629 - 639
Presenilin-1 (PS1) is the major gene responsible for early-onset familiar Alzheimer's disease (FAD). To understand the normal function of PS1, we have... 
NOTCH1 | GENE | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | K DR CELL BIOLOGY | FAMILIAL ALZHEIMERS-DISEASE | SOMITES | MISSENSE MUTATIONS | CELL BIOLOGY | Alzheimer Disease - etiology | Presenilin-1 | Membrane Proteins - genetics | Humans | Central Nervous System - abnormalities | Nerve Degeneration - genetics | DNA Primers - genetics | Cerebral Hemorrhage - genetics | Central Nervous System - embryology | Gestational Age | Mice, Knockout | Membrane Proteins - deficiency | Phenotype | Animals | Membrane Proteins - physiology | Base Sequence | Mice | Mutation | Alzheimer Disease - genetics | Bone and Bones - abnormalities | Bone and Bones - embryology | Morphogenesis | Embryology | Genetic aspects | Cell differentiation | Alzheimer's disease | Mice as laboratory animals
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17. Full Text Effects of Redox Potential and Hydroxide Inhibition on the pH Activity Profile of Fungal Laccases
by Feng Xu
Journal of Biological Chemistry, ISSN 0021-9258, 01/1997, Volume 272, Issue 2, pp. 924 - 928
The electronic absorption spectrum, susceptibility to fluoride inhibition, redox potential, and substrate turnover of several fungal laccases have been... 
OXIDATION | POLYPHENOL OXIDASES | ELECTRON-TRANSFER | MECHANISM | REDUCTION | ENZYMES | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANTS | Oxidoreductases - antagonists & inhibitors | Hydroxides - metabolism | Oxidation-Reduction | Fungi - enzymology | Sodium Fluoride - pharmacology | Kinetics | Hydrogen-Ion Concentration | Laccase
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18. Full Text Subregion- and cell type-restricted gene knockout in mouse brain
by Tsien, JZ and Chen, DF and Gerber, D and Tom, C and Mercer, EH and Anderson, DJ and Mayford, M and Kandel, ER and Tonegawa, S
CELL, ISSN 0092-8674, 12/1996, Volume 87, Issue 7, pp. 1317 - 1326
Using the phage P1-derived Cre/loxP recombination system, we have developed a method to create mice in which the deletion (knockout) of virtually any gene of... 
SYSTEM | RECOMBINATION | II MUTANT MICE | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | NEURONS | K DR CELL BIOLOGY | LTP | LONG-TERM POTENTIATION | RECEPTOR ANTAGONIST | CELL BIOLOGY | Genetic Engineering - methods | Mice, Knockout - genetics | Promoter Regions, Genetic | Sequence Deletion | Gene Expression | Calcium-Calmodulin-Dependent Protein Kinases - genetics | RNA, Messenger - genetics | Gene Expression Regulation | Mice, Transgenic | Viral Proteins | Gestational Age | Animals | Recombination, Genetic | Mice | Hippocampus - physiology | Integrases - genetics | Genetic aspects | Genetic engineering | Genetic recombination | Methods | Mice as laboratory animals
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19. Full Text Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance
by Feng, Helin and Guo, Peng and Wang, Jin and Chen, Wei and Shan, Baoen and Guo, Yin and Xu, Jianfa and Wang, Ling and Zhang, Yingze
Journal of Bone Oncology, ISSN 2212-1374, 2016, Volume 5, Issue 2, pp. 67 - 73
Abstract Osteosarcoma (OS) responds poorly to radiotherapy, but the mechanism is unclear. We found OS tumor tissues expressed high level of protein HIF-1α, a... 
Hematology, Oncology and Palliative Medicine | Radioresistance | Hypoxia | HIF-1α | Osteosarcoma | Autophagy | LC3 | CARCINOMA-CELLS | STEM-CELLS | HIF-1 alpha | TUMOR HYPOXIA | BNIP3 | BREAST-CANCER | THERAPY | ONCOLOGY | RESISTANCE | RADIOTHERAPY | IONIZING-RADIATION | CONTRIBUTES
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